RGD Reference Report - Complement proteins and C3 anaphylatoxin in the tears of patients with conjunctivitis. - Rat Genome Database

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Complement proteins and C3 anaphylatoxin in the tears of patients with conjunctivitis.

Authors: Ballow, M  Donshik, PC  Mendelson, L 
Citation: Ballow M, etal., J Allergy Clin Immunol. 1985 Sep;76(3):473-6.
RGD ID: 7421524
Pubmed: PMID:3875643   (View Abstract at PubMed)

Previous studies in our laboratory have demonstrated pollen-specific IgG antibodies in the tears of patients with vernal conjunctivitis (VC) and elevated tear IgG levels in patients with contact lens-induced giant papillary conjunctivitis (GPC). Tear secretions were examined for complement (C) proteins to determine the role of this effector system in the pathogenesis of these ocular disorders. The tears of VC (15) and GPC (10) patients with active disease had elevated tear levels of both C3 and factor B. By use of transferrin as a marker for the leakage of plasma proteins into the tears, most C3 was locally produced by the conjunctival tissues. Although immune complexes could not be detected in the tear secretions, increased levels of C3 des Arg were present in the tears that suggested complement activation with the generation of anaphylatoxins. These studies suggest that complement may be important in the inflammatory ocular process of VC and GPC and that the generation of anaphylatoxins (C3a), even by nonimmune mechanisms, may contribute to basophil and mast cell activation with the release of inflammatory mediators into the tear secretions.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
conjunctivitis  ISOC3 (Homo sapiens)7421524; 7421524protein:increased expression:tearRGD 
conjunctivitis  IEP 7421524; 7421524protein:increased expression:tearRGD 
conjunctivitis  ISOCFB (Homo sapiens)7421524; 7421524protein:increased expression:tearRGD 

Objects Annotated

Genes (Rattus norvegicus)
C3  (complement C3)
Cfb  (complement factor B)

Genes (Mus musculus)
C3  (complement component 3)
Cfb  (complement factor B)

Genes (Homo sapiens)
C3  (complement C3)
CFB  (complement factor B)


Additional Information