C3 (complement C3) - Rat Genome Database

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Gene: C3 (complement C3) Ictidomys tridecemlineatus
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Symbol: C3
Name: complement C3
RGD ID: 12726320
Description: ENCODES a protein that exhibits C5L2 anaphylatoxin chemotactic receptor binding (ortholog); lipid binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); blood coagulation (ortholog); cell surface receptor signaling pathway involved in cell-cell signaling (ortholog); PARTICIPATES IN classical complement pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); acute myocardial infarction (ortholog); FOUND IN cell surface (ortholog); extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,824,886 - 213,849,048 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365883,985,732 - 4,023,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration 7  (ISO)
age related macular degeneration 9  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anterior uveitis  (ISO)
arteriolosclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Carcinoma, Lewis Lung  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic obstructive pulmonary disease  (ISO)
complement component 3 deficiency  (ISO)
congenital hemolytic anemia  (ISO)
conjunctivitis  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
erythema nodosum  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
factor VIII deficiency  (ISO)
focal segmental glomerulosclerosis  (ISO)
focal segmental glomerulosclerosis 1  (ISO)
Fuchs' endothelial dystrophy  (ISO)
glomerulonephritis  (ISO)
Hematuria  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Herpesviridae Infections  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (ISO)
lepromatous leprosy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
mastitis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
Optic Nerve Injuries  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Paratuberculosis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
Penetrating Wounds  (ISO)
pleurisy  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombophilia  (ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Viral Bronchiolitis  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
blood coagulation  (ISO)
cell surface receptor signaling pathway involved in cell-cell signaling  (ISO)
complement activation  (ISO)
complement-dependent cytotoxicity  (ISO)
complement-mediated synapse pruning  (ISO)
innate immune response  (ISO)
neuron remodeling  (ISO)
opsonization  (ISO)
oviduct epithelium development  (ISO)
positive regulation of activation of membrane attack complex  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic cell clearance  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of lipid storage  (ISO)
positive regulation of opsonization  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of type IIa hypersensitivity  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
proteolysis  (ISO)
regulation of complement activation  (ISO)
regulation of complement activation, alternative pathway  (ISO)
regulation of triglyceride biosynthetic process  (ISO)
response to bacterium  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to magnesium ion  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
tolerance induction  (ISO)
vascular associated smooth muscle cell differentiation  (ISO)
vertebrate eye-specific patterning  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
C3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,824,886 - 213,849,048 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365883,985,732 - 4,023,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,677,704 - 6,720,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl196,677,704 - 6,730,562 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,677,715 - 6,720,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,628,846 - 6,671,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,628,877 - 6,671,660NCBI
Celera196,619,402 - 6,662,926 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,440,030 - 6,483,146 (-)NCBIHuRef
CHM1_1196,678,095 - 6,720,521 (-)NCBICHM1_1
T2T-CHM13v2.0196,667,334 - 6,710,056 (-)NCBIT2T-CHM13v2.0
C3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)EnsemblGRCm39 Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBIMGSCv36mm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
C3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.292,087,437 - 2,114,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,087,437 - 2,114,429 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,515,463 - 2,542,310 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.097,864,836 - 7,891,685 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.096,820,692 - 6,847,542 (-)NCBIRnor_WKY
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,728,465 - 8,754,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,407,133 - 6,432,968 (+)NCBICelera
Cytogenetic Map9q12NCBI
C3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,796,663 - 2,824,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,796,601 - 2,824,233 (+)NCBIChiLan1.0ChiLan1.0
C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1196,629,240 - 6,674,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,629,287 - 6,674,699 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,708,211 - 5,753,178 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,566,226 - 53,598,365 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,566,261 - 53,598,761 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,314,550 - 53,347,112 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,220,548 - 54,253,547 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,219,154 - 54,438,066 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,287,896 - 53,320,436 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,735,894 - 53,768,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,965,350 - 53,997,908 (+)NCBIUU_Cfam_GSD_1.0
C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,431,212 - 72,472,228 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,431,470 - 72,471,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,762,013 - 72,820,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2272,950,572 - 72,957,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2qNCBI
C3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,250,422 - 6,289,264 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660811,706,107 - 1,746,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,770,221 - 3,797,946 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,773,816 - 3,798,077 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_013361404   ⟹   XP_013216858
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365883,985,732 - 4,023,221 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040290566   ⟹   XP_040146500
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118213,824,886 - 213,849,048 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040146500 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013216858   ⟸   XM_013361404
- Sequence:
RefSeq Acc Id: XP_040146500   ⟸   XM_040290566


Additional Information

Database Acc Id Source(s)
NCBI Gene C3 ENTREZGENE