RGD Reference Report - Circulating immune complexes and complement levels in hemophilic children. - Rat Genome Database

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Circulating immune complexes and complement levels in hemophilic children.

Authors: Verroust, F  Adam, C  Kourilsky, O  Allain, JP  Verroust, P 
Citation: Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30.
RGD ID: 11041156
Pubmed: PMID:6912882   (View Abstract at PubMed)

Immune complexes and complement levels were assayed in sera from a group of 69 hemophilic children. Using the Raji cell radioimmune assay and the C1q binding assay, abnormally high levels of circulating immune complexes were rarely found in the group of hemophiliacs which did not differ statistically from the control population. These results do not exclude the presence of low and transient levels of immune complexes in the circulation, but indicate that hemophiliacs are not exposed to increased immune complex loads similar to those found in immune complex diseases. By contrast frequent abnormalities of the complement system were found. Complement levels were elevated in a large percentage of patients, reaching statistical significance for C3, C4, C5, Factor B and Properdin. Levels of the C3 breakdown product C3d were significantly raised suggesting intravascular complement activation. The significance of these abnormalities is discussed in relation to perfusion of Factor VIII preparations.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
factor VIII deficiency  ISOC3 (Homo sapiens)11041156; 11041156protein:increased expression:bloodRGD 
factor VIII deficiency  IEP 11041156; 11041156; 11041156; 11041156protein:increased expression:bloodRGD 
factor VIII deficiency  ISOC5 (Homo sapiens)11041156; 11041156protein:increased expression:bloodRGD 
factor VIII deficiency  ISOCFB (Homo sapiens)11041156; 11041156protein:increased expression:bloodRGD 
factor VIII deficiency  ISOCFP (Homo sapiens)11041156; 11041156protein:increased expression:bloodRGD 

Objects Annotated

Genes (Rattus norvegicus)
C3  (complement C3)
C5  (complement C5)
Cfb  (complement factor B)
Cfp  (complement factor properdin)

Genes (Mus musculus)
C3  (complement component 3)
Cfb  (complement factor B)
Cfp  (complement factor properdin)
Hc  (hemolytic complement)

Genes (Homo sapiens)
C3  (complement C3)
C5  (complement C5)
CFB  (complement factor B)
CFP  (complement factor properdin)


Additional Information