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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735504
Species: Homo sapiens
RGD Object: Gene
Symbol: C3
Name: complement C3
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C3multiple interactionsEXP 6480464CTD[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of C3 mRNAPMID:27344345
C3affects expressionISOC3 (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of C3 mRNAPMID:17555576
C3affects expressionISOC3 (Rattus norvegicus)6480464CTDEthinyl Estradiol affects the expression of C3 mRNAPMID:17351261
C3decreases expressionISOC3 (Mus musculus)6480464CTDEthinyl Estradiol results in decreased expression of C3 mRNAPMID:17942748
C3increases expressionISOC3 (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of C3 mRNAPMID:16174780 PMID:19400957 PMID:24096037
C3increases expressionISOC3 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in increased expression of C3 mRNAPMID:10822019 PMID:11331651 PMID:11566438 PMID:12117614 PMID:12399409 PMID:12655037 PMID:15834898 PMID:16140622 PMID:16174780 PMID:16551644 PMID:16639590 PMID:17557909 PMID:19400957 PMID:22062131 PMID:24096037
C3multiple interactionsISOC3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of C3 mRNAPMID:17942748
C3multiple interactionsISOC3 (Rattus norvegicus)6480464CTDDexamethasone promotes the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]; Levonorgestrel inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]; Medroxyprogesterone Acetate inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]; Mifepristone inhibits the reaction [Medroxyprogesterone Acetate inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]]; Mifepristone promotes the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]; Progesterone inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]; trimegestone inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]PMID:11566438 PMID:16639590 PMID:16806946
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