RGD Reference Report - A role for immune complexes in enhanced respiratory syncytial virus disease. - Rat Genome Database

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A role for immune complexes in enhanced respiratory syncytial virus disease.

Authors: Polack, FP  Teng, MN  Collins, PL  Prince, GA  Exner, M  Regele, H  Lirman, DD  Rabold, R  Hoffman, SJ  Karp, CL  Kleeberger, SR  Wills-Karp, M  Karron, RA 
Citation: Polack FP, etal., J Exp Med. 2002 Sep 16;196(6):859-65.
RGD ID: 5129513
Pubmed: (View Article at PubMed) PMID:12235218

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
C3  (complement C3)

Genes (Mus musculus)
C3  (complement component 3)

Genes (Homo sapiens)
C3  (complement C3)

Additional Information