GWAS608135_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS608135_H (age-related macular degeneration, COVID-19 QTL GWAS608135 (human)) Homo sapiens

Symbol: GWAS608135_H
Name: age-related macular degeneration, COVID-19 QTL GWAS608135 (human)
RGD ID: 406959159
Trait: age-related macular degeneration, COVID-19
LOD Score: Not Available
P Value: 2.0E-71
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38196,716,268 - 6,716,269RGD_MAPPER_PIPELINEGRCh38
GRCh37196,716,279 - 6,716,280RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
735504C3complement C31966777046720650Human

Position Markers

Peak: (rs11569415)
Human AssemblyChrPosition (strand)Source
GRCh38196,716,268 - 6,716,269RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298499UAE1_HUrinary albumin excretion QTL 1 (human)2.730.0009Urinary albumin excretionurine albumin:creatinine ratio (ACR)19116075902Human
1643451SLIPL6_HSerum lipid level QTL 6 (human)2.190.0008Lipid level19116075902Human
407291299GWAS940275_Hcomplement C3B measurement QTL GWAS940275 (human)1e-13complement protein amount (VT:0010033)1967162686716269Human
406950196GWAS599172_Hprotein measurement QTL GWAS599172 (human)1e-35protein measurement1967162686716269Human
1581534BP76_HBlood pressure QTL 76 (human)20.001Blood pressurepulse pressure19116075902Human
406959159GWAS608135_Hage-related macular degeneration, COVID-19 QTL GWAS608135 (human)2e-71age-related macular degeneration, COVID-191967162686716269Human
1581535BP65_HBlood pressure QTL 65 (human)3.10.001Blood pressurepulse pressure19116075902Human
406993017GWAS641993_Hage-related macular degeneration QTL GWAS641993 (human)2e-10age-related macular degeneration1967162686716269Human
2314591INSUL4_HInsulin level QTL 4 (human)3.80.000038Insulin levelfasting19116075902Human
406946268GWAS595244_Hprotein measurement QTL GWAS595244 (human)2e-19protein measurement1967162686716269Human
1298476BP3_HBlood pressure QTL 3 (human)2.4Blood pressuresystolic19116075902Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS595244_H GCST90249109 Prion-like protein doppel levels 10,708 European ancestry individuals A 0.21 2E-19 18.699 rs11569415 0.149 protein measurement (EFO:0004747)
 PMID:34648354
GWAS599172_H GCST90246984 Centromere protein V levels 10,708 European ancestry individuals A 0.21 1E-35 35 rs11569415 0.206 protein measurement (EFO:0004747)
 PMID:34648354
GWAS608135_H GCST90250833 Age-related macular degeneration or COVID-19 hospitalization (MTAG) 16,144 European ancestry AMD cases, 9,986 European ancestry COVID-19 hospitalization cases, 1,895,495 European ancestry controls ? NR 2E-71 70.699 rs11569415 0.15 age-related macular degeneration (EFO:0001365)
 PMID:36614910
None Available GCST90250832 Age-related macular degeneration or COVID-19 critical illness (MTAG) 16,144 European ancestry AMD cases, 5,101 European ancestry COVID-19 critical illness cases, 1,401,064 European ancestry controls ? NR 2E-71 70.699 rs11569415 0.15 age-related macular degeneration (EFO:0001365)
 PMID:36614910
None Available GCST90250834 Age-related macular degeneration or COVID-19 infection (MTAG) 16,144 European ancestry AMD cases, 38,984 European ancestry COVID-19 infection cases, 1,662,607 European ancestry controls ? NR 2E-71 70.699 rs11569415 0.15 age-related macular degeneration (EFO:0001365)
 PMID:36614910
GWAS641993_H GCST010723 Early age-related macular degeneration 14,034 European ancestry cases, 91,214 European ancestry controls A 0.21 2E-10 9.699 rs11569415 1.12 age-related macular degeneration (EFO:0001365)
 PMID:32843070
GWAS940275_H GCST90162092 Complement C3b levels 2,935 Qatari ancestry individuals A 0.11431 1E-13 13 rs11569415 0.311435 complement C3B measurement (EFO:0020275)
 PMID:36168886
Database Acc Id Source(s)
GWAS Catalog GCST90250832 GWAS Catalog
  GCST90250833 GWAS Catalog
  GCST90250834 GWAS Catalog

RGD Curation Notes
Note Type Note Reference