C3 (complement C3) - Rat Genome Database

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Gene: C3 (complement C3) Chinchilla lanigera
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Symbol: C3
Name: complement C3
RGD ID: 8719081
Description: ENCODES a protein that exhibits C5L2 anaphylatoxin chemotactic receptor binding (ortholog); lipid binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); complement activation (ortholog); complement receptor mediated signaling pathway (ortholog); PARTICIPATES IN classical complement pathway; ASSOCIATED WITH otitis media; acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cell surface (ortholog); extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: complement component 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,796,663 - 2,824,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,796,601 - 2,824,233 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration 7  (ISO)
age related macular degeneration 9  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anterior uveitis  (ISO)
arteriolosclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Carcinoma, Lewis Lung  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemically-Induced Disorders  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic obstructive pulmonary disease  (ISO)
complement component 3 deficiency  (ISO)
congenital hemolytic anemia  (ISO)
conjunctivitis  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
erythema nodosum  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
factor VIII deficiency  (ISO)
focal segmental glomerulosclerosis  (ISO)
focal segmental glomerulosclerosis 1  (ISO)
Fuchs' endothelial dystrophy  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Hematuria  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Herpesviridae Infections  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (ISO)
lepromatous leprosy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
mastitis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
mucolipidosis type IV  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
Optic Nerve Injuries  (ISO)
otitis media  (IDA)
Otitis Media with Effusion  (ISO)
Paratuberculosis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
Penetrating Wounds  (ISO)
pleurisy  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombophilia  (ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Viral Bronchiolitis  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
complement activation  (ISO)
complement receptor mediated signaling pathway  (ISO)
complement-dependent cytotoxicity  (ISO)
complement-mediated synapse pruning  (ISO)
innate immune response  (ISO)
neuron remodeling  (ISO)
oviduct epithelium development  (ISO)
positive regulation of activation of membrane attack complex  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic cell clearance  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of lipid storage  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of type IIa hypersensitivity  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of triglyceride biosynthetic process  (ISO)
response to bacterium  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to magnesium ion  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
tolerance induction  (ISO)
vascular associated smooth muscle cell differentiation  (ISO)
vertebrate eye-specific patterning  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Role of complement in host defense against pneumococcal otitis media. Sabharwal V, etal., Infect Immun. 2009 Mar;77(3):1121-7. doi: 10.1128/IAI.01148-08. Epub 2009 Jan 12.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
C3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,796,663 - 2,824,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,796,601 - 2,824,233 (+)NCBIChiLan1.0ChiLan1.0
C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,677,704 - 6,720,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,677,704 - 6,730,562 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,677,715 - 6,720,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,628,846 - 6,671,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,628,877 - 6,671,660NCBI
Celera196,619,402 - 6,662,926 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,440,030 - 6,483,146 (-)NCBIHuRef
CHM1_1196,678,095 - 6,720,521 (-)NCBICHM1_1
T2T-CHM13v2.0196,667,334 - 6,710,056 (-)NCBIT2T-CHM13v2.0
C3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)EnsemblGRCm39 Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBIMGSCv36mm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
C3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,174,412 - 2,201,339 (-)NCBIGRCr8
mRatBN7.292,087,437 - 2,114,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,087,437 - 2,114,429 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,515,463 - 2,542,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,864,836 - 7,891,685 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,820,692 - 6,847,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,728,465 - 8,754,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,407,133 - 6,432,968 (+)NCBICelera
Cytogenetic Map9q11NCBI
C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22011,089,251 - 11,133,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,314,594 - 10,360,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,708,211 - 5,753,178 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,629,240 - 6,674,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,629,287 - 6,674,699 (-)Ensemblpanpan1.1panPan2
C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,566,226 - 53,598,365 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,566,261 - 53,598,761 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,314,550 - 53,347,112 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,220,548 - 54,253,547 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,219,154 - 54,438,066 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,287,896 - 53,320,436 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,735,894 - 53,768,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,965,350 - 53,997,908 (+)NCBIUU_Cfam_GSD_1.0
C3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,824,886 - 213,849,048 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365883,985,732 - 4,023,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,431,212 - 72,472,228 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,431,470 - 72,471,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,762,013 - 72,820,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2272,950,572 - 72,957,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2qNCBI
C3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,250,422 - 6,289,264 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660811,706,107 - 1,746,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,770,221 - 3,797,946 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,773,816 - 3,798,077 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000012407   ⟹   ENSCLAP00000012265
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554952,796,663 - 2,824,697 (+)Ensembl
RefSeq Acc Id: XM_005405700   ⟹   XP_005405757
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554952,796,601 - 2,824,233 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005405757 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000012265
  ENSCLAP00000012265.1
RefSeq Acc Id: XP_005405757   ⟸   XM_005405700
- UniProtKB: A0A8C2YNS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000012265   ⟸   ENSCLAT00000012407
Protein Domains
Anaphylatoxin-like   NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008464 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000012407 ENTREZGENE
  ENSCLAT00000012407.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/TrEMBL
  2.20.130.20 UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/TrEMBL
  2.60.120.1540 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.1930 UniProtKB/TrEMBL
  2.60.40.1940 UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/TrEMBL
  6.20.50.160 UniProtKB/TrEMBL
  Anaphylotoxins (complement system) UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/TrEMBL
  Alpha-macroglob_thiol-ester_cl UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/TrEMBL
  Anaphylatoxin_comp_syst UniProtKB/TrEMBL
  Anaphylatoxn_comp_syst_dom UniProtKB/TrEMBL
  C3/4/5_MG1 UniProtKB/TrEMBL
  C3_CUB2 UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/TrEMBL
  MG2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  NTR_complement_C3 UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
NCBI Gene C3 ENTREZGENE
PANTHER MACROGLOBULIN / COMPLEMENT UniProtKB/TrEMBL
  PTHR11412:SF81 UniProtKB/TrEMBL
Pfam A2M UniProtKB/TrEMBL
  A2M_BRD UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  ANATO UniProtKB/TrEMBL
  C3_CUB1 UniProtKB/TrEMBL
  C3_CUB2 UniProtKB/TrEMBL
  MG1 UniProtKB/TrEMBL
  MG2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
  TED_complement UniProtKB/TrEMBL
PRINTS ANAPHYLATOXN UniProtKB/TrEMBL
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/TrEMBL
  ANAPHYLATOXIN_1 UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
SMART A2M UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  ANATO UniProtKB/TrEMBL
  C345C UniProtKB/TrEMBL
  Thiol-ester_cl UniProtKB/TrEMBL
Superfamily-SCOP SSF47686 UniProtKB/TrEMBL
  SSF48239 UniProtKB/TrEMBL
  SSF49410 UniProtKB/TrEMBL
  SSF50242 UniProtKB/TrEMBL
UniProt A0A8C2YNS8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 C3  complement C3    complement component 3  Symbol and/or name change 5135510 APPROVED