RGD Reference Report - Activated complement in inflamed aqueous humor. - Rat Genome Database

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Activated complement in inflamed aqueous humor.

Authors: Mondino, BJ  Glovsky, MM  Ghekiere, L 
Citation: Mondino BJ, etal., Invest Ophthalmol Vis Sci. 1984 Jul;25(7):871-3.
RGD ID: 7411736
Pubmed: PMID:6610667   (View Abstract at PubMed)

Activated complement is an important mediator of inflammation. Radioimmunoassay was used to measure levels of C3a, an activated fragment of C3, in aqueous humor. Additionally, immunoelectrophoresis was performed on aqueous humor to detect Factor B and its conversion product, Bb, as well as C3c, a breakdown product of C3. All six samples of normal aqueous humor had no detectable C3a, C3c, or Factor B. All eight samples of aqueous humor from patients with anterior uveitis had measurable levels of C3a. Factor B and C3c were detected in 3/7 samples of inflamed aqueous humor. Factor B was converted fully to Bb in two of these three samples, suggesting alternative pathway activation of complement. Activated complement fragments are present in the aqueous humor of eyes with anterior uveitis and may help mediate the inflammatory process.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
C3Ratanterior uveitis  ISOC3 (Homo sapiens) RGD 
C3Humananterior uveitis  IEP  RGD 
C3Mouseanterior uveitis  ISOC3 (Homo sapiens) RGD 
CFBHumananterior uveitis  IEP  RGD 
CfbRatanterior uveitis  ISOCFB (Homo sapiens) RGD 
CfbMouseanterior uveitis  ISOCFB (Homo sapiens) RGD 


Genes (Rattus norvegicus)
C3  (complement C3) Cfb  (complement factor B)

Genes (Mus musculus)
C3  (complement component 3) Cfb  (complement factor B)

Genes (Homo sapiens)
C3  (complement C3) CFB  (complement factor B)