KIF2C (kinesin family member 2C) - Rat Genome Database

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Gene: KIF2C (kinesin family member 2C) Homo sapiens
Analyze
Symbol: KIF2C
Name: kinesin family member 2C
RGD ID: 734428
HGNC Page HGNC
Description: Exhibits microtubule plus-end binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore; microtubule cytoskeleton organization; and regulation of chromosome segregation. Localizes to kinetochore and microtubule plus-end. Predicted to colocalize with cytoplasmic microtubule. Biomarker of colorectal cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CT139; kinesin-like 6; kinesin-like protein 6; kinesin-like protein KIF2C; kinesin-related protein 2; KNSL6; MCAK; mitotic centromere-associated kinesin; testis tissue sperm-binding protein Li 68n
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl144,739,818 - 44,767,767 (+)EnsemblGRCh38hg38GRCh38
GRCh38144,739,704 - 44,767,767 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37145,205,509 - 45,233,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36144,978,138 - 45,006,003 (+)NCBINCBI36hg18NCBI36
Build 34144,874,643 - 44,902,506NCBI
Celera143,488,387 - 43,516,329 (+)NCBI
Cytogenetic Map1p34.1NCBI
HuRef143,319,109 - 43,346,516 (+)NCBIHuRef
CHM1_1145,321,397 - 45,349,350 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4-diaminotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
acetamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cefaloridine  (ISO)
chloroprene  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
Enterolactone  (EXP)
erythromycin estolate  (ISO)
fenvalerate  (ISO)
furan  (ISO)
genistein  (EXP)
geraniol  (EXP)
glycidol  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP)
isoflavones  (EXP)
leflunomide  (EXP)
lucanthone  (EXP)
menadione  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nickel atom  (EXP)
oxaliplatin  (ISO)
palbociclib  (EXP)
paracetamol  (EXP)
PCB138  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phytoestrogen  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sophoraflavanone B  (ISO)
sunitinib  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
tioguanine  (ISO)
topotecan  (ISO)
trans-caffeic acid  (EXP)
tremolite asbestos  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
zaragozic acid A  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

References

Additional References at PubMed
PMID:9434124   PMID:9700166   PMID:10600236   PMID:11092768   PMID:11256614   PMID:11416179   PMID:11466324   PMID:12383881   PMID:12446739   PMID:12477932   PMID:12620232   PMID:14699064  
PMID:14718566   PMID:14960279   PMID:15302853   PMID:15304328   PMID:15479732   PMID:15489334   PMID:15635413   PMID:15775983   PMID:15843429   PMID:15883193   PMID:16243029   PMID:16344560  
PMID:16450057   PMID:16672973   PMID:16751065   PMID:17081983   PMID:17485487   PMID:17538014   PMID:17620599   PMID:17653072   PMID:17944972   PMID:17968321   PMID:17986458   PMID:18029348  
PMID:18039936   PMID:18434591   PMID:18440323   PMID:18635958   PMID:18663358   PMID:18809577   PMID:18843200   PMID:19001124   PMID:19060894   PMID:19490893   PMID:19543227   PMID:19632184  
PMID:19738201   PMID:19931454   PMID:19937794   PMID:19946888   PMID:20368358   PMID:20406800   PMID:20467437   PMID:20508983   PMID:20889715   PMID:21078677   PMID:21165574   PMID:21244100  
PMID:21426902   PMID:21471284   PMID:21566458   PMID:21602793   PMID:21820309   PMID:21832049   PMID:21873635   PMID:21873978   PMID:21900206   PMID:21988832   PMID:22118464   PMID:22130050  
PMID:22363599   PMID:22403406   PMID:22422706   PMID:22492725   PMID:22658674   PMID:22990118   PMID:23001180   PMID:23055517   PMID:23098759   PMID:23281010   PMID:23564489   PMID:23595990  
PMID:23830822   PMID:23891108   PMID:24240690   PMID:24255178   PMID:24847103   PMID:24931513   PMID:25002494   PMID:25002679   PMID:25281560   PMID:25504441   PMID:25609649   PMID:25921289  
PMID:26055718   PMID:26148251   PMID:26186194   PMID:26206521   PMID:26323690   PMID:26344197   PMID:26496610   PMID:26638075   PMID:26733216   PMID:26912793   PMID:26972000   PMID:27114546  
PMID:27146484   PMID:27173435   PMID:27563815   PMID:27637333   PMID:27698945   PMID:27733589   PMID:27881713   PMID:28298485   PMID:28514442   PMID:28675297   PMID:29162697   PMID:29244835  
PMID:29459360   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29549242   PMID:29568061   PMID:29656893   PMID:30217970   PMID:30463901   PMID:30561431   PMID:30578316   PMID:30804502  
PMID:30883337   PMID:31048545   PMID:31091453   PMID:31328811   PMID:31527615   PMID:31586073   PMID:31615875   PMID:31746663   PMID:32129710   PMID:32328631   PMID:32354205   PMID:32786267  
PMID:32877691   PMID:33001583  


Genomics

Comparative Map Data
KIF2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl144,739,818 - 44,767,767 (+)EnsemblGRCh38hg38GRCh38
GRCh38144,739,704 - 44,767,767 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37145,205,509 - 45,233,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36144,978,138 - 45,006,003 (+)NCBINCBI36hg18NCBI36
Build 34144,874,643 - 44,902,506NCBI
Celera143,488,387 - 43,516,329 (+)NCBI
Cytogenetic Map1p34.1NCBI
HuRef143,319,109 - 43,346,516 (+)NCBIHuRef
CHM1_1145,321,397 - 45,349,350 (+)NCBICHM1_1
Kif2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394117,016,830 - 117,039,821 (-)NCBIGRCm39mm39
GRCm39 Ensembl4117,016,836 - 117,039,836 (-)Ensembl
GRCm384117,159,633 - 117,182,624 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4117,159,639 - 117,182,639 (-)EnsemblGRCm38mm10GRCm38
MGSCv374116,832,239 - 116,855,229 (-)NCBIGRCm37mm9NCBIm37
MGSCv364116,657,593 - 116,680,496 (-)NCBImm8
MGSCv364114,927,056 - 114,944,901 (-)NCBImm8
Celera4115,898,246 - 115,917,726 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.42NCBI
Kif2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25130,637,347 - 130,662,680 (-)NCBI
Rnor_6.0 Ensembl5136,027,934 - 136,053,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05136,027,923 - 136,053,268 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05139,820,990 - 139,846,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45137,473,698 - 137,498,974 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15137,479,397 - 137,500,542 (-)NCBI
Celera5129,158,808 - 129,184,100 (-)NCBICelera
Cytogenetic Map5q36NCBI
Kif2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546413,453,217 - 13,475,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546413,453,637 - 13,475,447 (-)NCBIChiLan1.0ChiLan1.0
KIF2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1145,408,736 - 45,436,844 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl145,408,734 - 45,436,844 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0144,042,565 - 44,070,922 (+)NCBIMhudiblu_PPA_v0panPan3
KIF2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11515,558,024 - 15,579,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1515,558,021 - 15,579,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1515,678,810 - 15,699,980 (-)NCBI
ROS_Cfam_1.01515,709,388 - 15,730,544 (-)NCBI
UMICH_Zoey_3.11515,511,198 - 15,532,391 (-)NCBI
UNSW_CanFamBas_1.01515,577,722 - 15,598,980 (-)NCBI
UU_Cfam_GSD_1.01515,651,928 - 15,673,111 (-)NCBI
Kif2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,141,752 - 60,175,391 (+)NCBI
SpeTri2.0NW_00493647425,967,095 - 26,000,678 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6166,556,774 - 166,577,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16166,556,765 - 166,577,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26154,001,824 - 154,022,498 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KIF2C
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12088,023,250 - 88,054,715 (-)NCBI
ChlSab1.1 Ensembl2088,023,207 - 88,055,176 (-)Ensembl
Kif2c
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624906633,635 - 660,149 (+)NCBI

Position Markers
STS-U63743  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,232,865 - 45,233,031UniSTSGRCh37
Build 36145,005,452 - 45,005,618RGDNCBI36
Celera143,515,755 - 43,515,921RGD
Cytogenetic Map1p34.1UniSTS
HuRef143,345,942 - 43,346,108UniSTS
GeneMap99-GB4 RH Map1142.93UniSTS
NCBI RH Map1294.0UniSTS
RH123469  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,213,435 - 45,213,711UniSTSGRCh37
Build 36144,986,022 - 44,986,298RGDNCBI36
Celera143,496,332 - 43,496,608RGD
Cytogenetic Map1p34.1UniSTS
HuRef143,326,466 - 43,326,742UniSTS
TNG Radiation Hybrid Map124560.0UniSTS
D1S1340  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,205,571 - 45,205,730UniSTSGRCh37
Build 36144,978,158 - 44,978,317RGDNCBI36
Celera143,488,468 - 43,488,627RGD
Cytogenetic Map1p34.1UniSTS
HuRef143,319,190 - 43,319,349UniSTS
KIF2C_9208  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,232,819 - 45,233,375UniSTSGRCh37
GRCh37172,204,005 - 72,204,537UniSTSGRCh37
Build 36145,005,406 - 45,005,962RGDNCBI36
Celera143,515,709 - 43,516,265RGD
Celera170,492,977 - 70,493,509UniSTS
HuRef170,314,512 - 70,315,044UniSTS
HuRef143,345,896 - 43,346,452UniSTS
SHGC-74693  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,233,049 - 45,233,185UniSTSGRCh37
Build 36145,005,636 - 45,005,772RGDNCBI36
Celera143,515,939 - 43,516,075RGD
Cytogenetic Map1p34.1UniSTS
HuRef143,346,126 - 43,346,262UniSTS
TNG Radiation Hybrid Map124573.0UniSTS
GeneMap99-GB4 RH Map1130.08UniSTS
NCBI RH Map1294.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR423hsa-miR-423-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350

Predicted Target Of
Summary Value
Count of predictions:2789
Count of miRNA genes:812
Interacting mature miRNAs:966
Transcripts:ENST00000372217, ENST00000372218, ENST00000372222, ENST00000372224, ENST00000423289, ENST00000452259, ENST00000455186, ENST00000472235, ENST00000480574, ENST00000493027
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 246 31 84 71 717 74 330 60 125 90 667 306 10 24 3
Low 1904 2140 1284 304 1017 155 2995 929 1786 243 762 1291 150 832 1860 1
Below cutoff 283 813 354 246 214 234 1027 1199 1800 85 21 11 12 372 901

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001297655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001297656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001297657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011540540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011540541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB264115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL046197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU130795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY026505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU615368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR450302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB045012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC399082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC404550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000372217   ⟹   ENSP00000361291
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl144,746,406 - 44,767,767 (+)Ensembl
RefSeq Acc Id: ENST00000372224   ⟹   ENSP00000361298
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl144,739,837 - 44,767,767 (+)Ensembl
RefSeq Acc Id: ENST00000423289   ⟹   ENSP00000402172
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl144,760,480 - 44,762,613 (+)Ensembl
RefSeq Acc Id: ENST00000452259   ⟹   ENSP00000410346
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl144,739,818 - 44,757,971 (+)Ensembl
RefSeq Acc Id: ENST00000455186   ⟹   ENSP00000395050
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl144,739,953 - 44,756,148 (+)Ensembl
RefSeq Acc Id: ENST00000472235
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl144,762,140 - 44,766,879 (+)Ensembl
RefSeq Acc Id: ENST00000480574
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl144,746,406 - 44,753,153 (+)Ensembl
RefSeq Acc Id: ENST00000493027
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl144,739,825 - 44,757,968 (+)Ensembl
RefSeq Acc Id: NM_001297655   ⟹   NP_001284584
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,739,837 - 44,767,767 (+)NCBI
CHM1_1145,321,397 - 45,349,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001297656   ⟹   NP_001284585
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,746,394 - 44,767,767 (+)NCBI
CHM1_1145,327,945 - 45,349,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001297657   ⟹   NP_001284586
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,746,394 - 44,767,767 (+)NCBI
CHM1_1145,327,945 - 45,349,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006845   ⟹   NP_006836
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,739,837 - 44,767,767 (+)NCBI
GRCh37145,205,396 - 45,233,439 (+)NCBI
Build 36144,978,138 - 45,006,003 (+)NCBI Archive
HuRef143,319,109 - 43,346,516 (+)ENTREZGENE
CHM1_1145,321,397 - 45,349,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011540540   ⟹   XP_011538842
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,739,704 - 44,767,750 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011540541   ⟹   XP_011538843
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,746,425 - 44,767,750 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006836   ⟸   NM_006845
- Peptide Label: isoform 1
- UniProtKB: Q99661 (UniProtKB/Swiss-Prot),   A0A140VKF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001284584   ⟸   NM_001297655
- Peptide Label: isoform 2
- UniProtKB: Q99661 (UniProtKB/Swiss-Prot),   B7Z6Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001284585   ⟸   NM_001297656
- Peptide Label: isoform 3
- UniProtKB: Q99661 (UniProtKB/Swiss-Prot),   B7Z7M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001284586   ⟸   NM_001297657
- Peptide Label: isoform 4
- UniProtKB: Q99661 (UniProtKB/Swiss-Prot),   B7Z7M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011538842   ⟸   XM_011540540
- Peptide Label: isoform X1
- UniProtKB: B7Z7M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011538843   ⟸   XM_011540541
- Peptide Label: isoform X1
- UniProtKB: B7Z7M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000402172   ⟸   ENST00000423289
RefSeq Acc Id: ENSP00000361291   ⟸   ENST00000372217
RefSeq Acc Id: ENSP00000361298   ⟸   ENST00000372224
RefSeq Acc Id: ENSP00000410346   ⟸   ENST00000452259
RefSeq Acc Id: ENSP00000395050   ⟸   ENST00000455186
Protein Domains
Kinesin motor

Promoters
RGD ID:6855314
Promoter ID:EPDNEW_H822
Type:initiation region
Name:KIF2C_1
Description:kinesin family member 2C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H823  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,739,862 - 44,739,922EPDNEW
RGD ID:6855316
Promoter ID:EPDNEW_H823
Type:initiation region
Name:KIF2C_2
Description:kinesin family member 2C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H822  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,746,413 - 44,746,473EPDNEW
RGD ID:6785252
Promoter ID:HG_KWN:2446
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000372218,   ENST00000372222,   OTTHUMT00000023180,   OTTHUMT00000023182,   OTTHUMT00000023183,   OTTHUMT00000090772
Position:
Human AssemblyChrPosition (strand)Source
Build 36144,977,706 - 44,978,206 (+)MPROMDB
RGD ID:6785888
Promoter ID:HG_KWN:2447
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ENST00000372217,   OTTHUMT00000023184
Position:
Human AssemblyChrPosition (strand)Source
Build 36144,984,646 - 44,985,146 (+)MPROMDB
RGD ID:6785889
Promoter ID:HG_KWN:2448
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000023415
Position:
Human AssemblyChrPosition (strand)Source
Build 36144,997,946 - 44,999,032 (+)MPROMDB
RGD ID:6785890
Promoter ID:HG_KWN:2450
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000023416
Position:
Human AssemblyChrPosition (strand)Source
Build 36144,999,916 - 45,000,416 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p34.1(chr1:44713837-45282899)x3 copy number gain See cases [RCV000051129] Chr1:44713837..45282899 [GRCh38]
Chr1:45179509..45748571 [GRCh37]
Chr1:44952096..45521158 [NCBI36]
Chr1:1p34.1
uncertain significance
GRCh38/hg38 1p34.3-33(chr1:39479787-47688131)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|See cases [RCV000051817] Chr1:39479787..47688131 [GRCh38]
Chr1:39945459..48153803 [GRCh37]
Chr1:39718046..47926390 [NCBI36]
Chr1:1p34.3-33
pathogenic
GRCh38/hg38 1p34.3-34.1(chr1:38222737-45636176)x3 copy number gain See cases [RCV000051803] Chr1:38222737..45636176 [GRCh38]
Chr1:38688409..46101848 [GRCh37]
Chr1:38460996..45874435 [NCBI36]
Chr1:1p34.3-34.1
pathogenic
GRCh38/hg38 1p34.1(chr1:43896056-44867736)x3 copy number gain See cases [RCV000142581] Chr1:43896056..44867736 [GRCh38]
Chr1:44361728..45333408 [GRCh37]
Chr1:44134315..45105995 [NCBI36]
Chr1:1p34.1
uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease, dominant intermediate C [RCV000708276] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
GRCh37/hg19 1p34.1(chr1:44810778-45216633)x3 copy number gain not provided [RCV001005081] Chr1:44810778..45216633 [GRCh37]
Chr1:1p34.1
uncertain significance
GRCh37/hg19 1p34.1(chr1:44424878-45207102)x1 copy number loss not provided [RCV001005080] Chr1:44424878..45207102 [GRCh37]
Chr1:1p34.1
uncertain significance
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease, dominant intermediate C [RCV001308684] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6393 AgrOrtholog
COSMIC KIF2C COSMIC
Ensembl Genes ENSG00000142945 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000361291 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000361298 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000395050 UniProtKB/TrEMBL
  ENSP00000402172 UniProtKB/TrEMBL
  ENSP00000410346 UniProtKB/TrEMBL
Ensembl Transcript ENST00000372217 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000372224 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000423289 UniProtKB/TrEMBL
  ENST00000452259 UniProtKB/TrEMBL
  ENST00000455186 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000142945 GTEx
HGNC ID HGNC:6393 ENTREZGENE
Human Proteome Map KIF2C Human Proteome Map
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:11004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 11004 ENTREZGENE
OMIM 604538 OMIM
PANTHER PTHR24115 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kinesin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30182 PharmGKB
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART KISc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VKF1 ENTREZGENE, UniProtKB/TrEMBL
  B7Z6Q6 ENTREZGENE, UniProtKB/TrEMBL
  B7Z7M6 ENTREZGENE, UniProtKB/TrEMBL
  H0Y5Z9_HUMAN UniProtKB/TrEMBL
  KIF2C_HUMAN UniProtKB/Swiss-Prot
  Q5JR89_HUMAN UniProtKB/TrEMBL
  Q5JR91_HUMAN UniProtKB/TrEMBL
  Q99661 ENTREZGENE
UniProt Secondary B3ITR9 UniProtKB/Swiss-Prot
  E9PDS6 UniProtKB/TrEMBL
  Q5JR88 UniProtKB/Swiss-Prot
  Q6ICU1 UniProtKB/Swiss-Prot
  Q96C18 UniProtKB/Swiss-Prot
  Q96HB8 UniProtKB/Swiss-Prot
  Q9BWV8 UniProtKB/Swiss-Prot