PARP1 (poly(ADP-ribose) polymerase 1) - Rat Genome Database

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Gene: PARP1 (poly(ADP-ribose) polymerase 1) Homo sapiens
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Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
RGD ID: 1345118
HGNC Page HGNC
Description: Enables several functions, including identical protein binding activity; pentosyltransferase activity; and protein N-terminus binding activity. Involved in several processes, including DNA metabolic process; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including cellular response to oxidative stress; mitochondrial DNA repair; and regulation of cellular protein localization. Located in mitochondrion; nucleus; and site of double-strand break. Part of protein-DNA complex and transcription regulator complex. Implicated in several diseases, including arthritis; asthma; bacterial meningitis; neurodegenerative disease (multiple); and stomach carcinoma. Biomarker of several diseases, including Huntington's disease; idiopathic pulmonary fibrosis; liver cirrhosis; perinatal necrotizing enterocolitis; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT; ADPRT 1; ADPRT1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) polymerase 1; poly (ADP-ribose) polymerase family, member 1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; poly[ADP-ribose] synthase 1; PPOL
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PARP1P1   PARP1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1226,360,210 - 226,408,154 (-)EnsemblGRCh38hg38GRCh38
GRCh381226,360,691 - 226,408,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371226,548,392 - 226,595,794 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,615,015 - 224,662,424 (-)NCBINCBI36hg18NCBI36
Build 341222,855,240 - 222,902,526NCBI
Celera1199,739,310 - 199,786,722 (-)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1197,065,678 - 197,113,094 (-)NCBIHuRef
CHM1_11227,821,256 - 227,868,667 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model