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Gene: PARP1 (poly(ADP-ribose) polymerase 1) Homo sapiens
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Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
RGD ID: 1345118
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and transferase activity, transferring pentosyl groups. Involved in several processes, including DNA metabolic process; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including mitochondrion; nucleus; and site of double-strand break. Implicated in several diseases, including arthritis; asthma; bacterial meningitis; neurodegenerative disease (multiple); and stomach carcinoma. Biomarker of Huntington's disease; idiopathic pulmonary fibrosis; liver cirrhosis; perinatal necrotizing enterocolitis; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT; ADPRT 1; ADPRT1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) polymerase 1; poly (ADP-ribose) polymerase family, member 1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; poly[ADP-ribose] synthase 1; PPOL
Orthologs:
Mus musculus (house mouse) : Parp1 (poly (ADP-ribose) polymerase family, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Parp1 (poly (ADP-ribose) polymerase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Parp1 (poly(ADP-ribose) polymerase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PARP1 (poly(ADP-ribose) polymerase 1)
Canis lupus familiaris (dog) : PARP1 (poly(ADP-ribose) polymerase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Parp1 (poly(ADP-ribose) polymerase 1)
Sus scrofa (pig) : PARP1 (poly(ADP-ribose) polymerase 1)
Chlorocebus sabaeus (African green monkey) : PARP1 (poly(ADP-ribose) polymerase 1)
Heterocephalus glaber (naked mole-rat) : Parp1 (poly(ADP-ribose) polymerase 1)
more info ...
Related Pseudogenes: PARP1P1   PARP1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1226,360,691 - 226,408,093 (-)EnsemblGRCh38hg38GRCh38
GRCh381226,360,691 - 226,408,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371226,548,392 - 226,595,801 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,615,015 - 224,662,424 (-)NCBINCBI36hg18NCBI36
Build 341222,855,240 - 222,902,526NCBI
Celera1199,739,310 - 199,786,722 (-)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1197,065,678 - 197,113,094 (-)NCBIHuRef
CHM1_11227,821,256 - 227,868,667 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model