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Gene: HLA-A (major histocompatibility complex, class I, A) Homo sapiens
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Symbol: HLA-A
Name: major histocompatibility complex, class I, A
Description: Exhibits several functions, including TAP complex binding activity; beta-2-microglobulin binding activity; and signaling receptor binding activity. Involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway; regulation of lymphocyte mediated immunity; and response to bacterium. Localizes to several cellular components, including Golgi medial cisterna; MHC class I protein complex; and endoplasmic reticulum. Implicated in Stevens-Johnson syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen presenting molecule; aw-19; aw-24; Aw-33; aw-34; aw-36; aw-43; aw-66; Aw-68; Aw-69; Aw-74; aw-80; FLJ26655; HLA A; HLA class I antigen; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA class I histocompatibility antigen, A-10 alpha chain; HLA class I histocompatibility antigen, A-23 alpha chain; HLA class I histocompatibility antigen, A-24 alpha chain; HLA class I histocompatibility antigen, A-25 alpha chain; HLA class I histocompatibility antigen, A-26 alpha chain; HLA class I histocompatibility antigen, A-28 alpha chain; HLA class I histocompatibility antigen, A-29 alpha chain; HLA class I histocompatibility antigen, A-30 alpha chain; HLA class I histocompatibility antigen, A-31 alpha chain; HLA class I histocompatibility antigen, A-33 alpha chain; HLA class I histocompatibility antigen, A-34 alpha chain; HLA class I histocompatibility antigen, A-36 alpha chain; HLA class I histocompatibility antigen, A-43 alpha chain; HLA class I histocompatibility antigen, A-66 alpha chain; HLA class I histocompatibility antigen, A-74 alpha chain; HLA class I histocompatibility antigen, A-80 alpha chain; HLA class I histocompatibility antigen, A-9 alpha chain; HLA locus; HLA-A locus alpha 2 domain; HLA-A null; HLA-A11; HLA-A33; HLA-Aw33.1; HLA-DQB1; HLA-DRB1; HLAA; leucocyte antigen A; leucocyte antigen class I; leukocyte antigen class I-A; LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-1 alpha chain; MCH class I antigen; MHC class 1 antigen; MHC class I anti; MHC Class I antigen; MHC class I antigen A*1; MHC class I antigen A*11; MHC class I antigen A*2; MHC class I antigen A*23; MHC class I antigen A*24; MHC class I antigen A*25; MHC class I antigen A*26; MHC class I antigen A*29; MHC class I antigen A*3; MHC class I antigen A*30; MHC class I antigen A*31; MHC class I antigen A*32; MHC class I antigen A*33; MHC class I antigen A*34; MHC class I antigen A*36; MHC class I antigen A*43; MHC class I antigen A*66; MHC class I antigen A*68; MHC class I antigen A*69; MHC class I antigen A*74; MHC class I antigen A*80; MHC class I antigen heavy chain; MHC class I antigen HLA-A heavy chain; MHC class I antigen HLA-A33; MHC class I antigene; MHC class II antigen; MHC classI antigen; MHC leukocyte antigen; truncated MHC class I antigen
Orthologs:
Mus musculus (house mouse) : H2-Q1 (histocompatibility 2, Q region locus 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : LOC100364500 (RT1 class I, locus CE11-like)  Alliance
Canis lupus familiaris (dog) : DLA88 (MHC class I DLA-88)
more info ...
Related Pseudogenes: HLA-H   HLA-J   HLA-K   HLA-U   HLA-W  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl629,941,260 - 29,945,884 (+)EnsemblGRCh38hg38GRCh38
GRCh38629,942,532 - 29,945,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37629,910,247 - 29,913,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,018,310 - 30,021,633 (+)NCBINCBI36hg18NCBI36
Build 34630,018,309 - 30,021,632NCBI
Celera631,508,544 - 31,511,881 (+)NCBI
Cytogenetic Map6p22.1NCBI
HuRef629,655,296 - 29,712,161 (+)NCBIHuRef
CHM1_1629,857,559 - 29,915,772 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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