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Gene: HSPB1 (heat shock protein family B (small) member 1) Homo sapiens
Symbol: HSPB1
Name: heat shock protein family B (small) member 1
Description: Exhibits protein folding chaperone; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of angiogenesis; and positive regulation of endothelial cell migration. Localizes to the cytoplasm and nucleus. Implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Biomarker of focal segmental glomerulosclerosis and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 28 kDa heat shock protein; CMT2F; DKFZp586P1322; epididymis secretory protein Li 102; estrogen-regulated 24 kDa protein; heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; heat shock protein beta-1; HEL-S-102; HMN2B; HS.76067; HSP 27; Hsp25; HSP27; HSP28; SRP27; stress-responsive protein 27
Mus musculus (house mouse) : Hspb1 (heat shock protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hspb1 (heat shock protein family B (small) member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspb1 (heat shock protein family B (small) member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPB1 (heat shock protein family B (small) member 1)
Canis lupus familiaris (dog) : HSPB1 (heat shock protein family B (small) member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspb1 (heat shock protein family B (small) member 1)
Sus scrofa (pig) : HSPB1 (heat shock protein family B (small) member 1)
Heterocephalus glaber (naked mole-rat) : Hspb1 (heat shock protein family B (small) member 1)
more info ...
Related Pseudogenes: HSPB1P1   HSPB1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl776,302,673 - 76,304,295 (+)Ensembl
GRCh38776,302,673 - 76,304,292 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37775,931,875 - 75,933,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,769,859 - 75,771,548 (+)NCBINCBI36hg18NCBI36
Build 34775,576,573 - 75,578,263NCBI
Celera770,800,374 - 70,802,113 (+)NCBI
Cytogenetic Map7q11.23NCBI
HuRef771,018,196 - 71,019,935 (+)NCBIHuRef
CHM1_1775,861,968 - 75,863,707 (+)NCBICHM1_1
CRA_TCAGchr7v2775,264,939 - 75,266,678 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSPB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732480
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.