TIMP2 (TIMP metallopeptidase inhibitor 2) - Rat Genome Database

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Gene: TIMP2 (TIMP metallopeptidase inhibitor 2) Homo sapiens
Analyze
Symbol: TIMP2
Name: TIMP metallopeptidase inhibitor 2
RGD ID: 733906
HGNC Page HGNC:11821
Description: Enables peptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of membrane protein ectodomain proteolysis; response to cytokine; and response to hormone. Predicted to act upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in collagen-containing extracellular matrix. Implicated in Moyamoya disease. Biomarker of several diseases, including Duchenne muscular dystrophy; aortic disease (multiple); carcinoma (multiple); neurodegenerative disease (multiple); and preretinal fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CSC-21K; DDC8; KIAA1731NL; metalloproteinase inhibitor 2; testicular secretory protein Li 57; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,852,977 - 78,925,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,852,977 - 78,925,387 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,849,059 - 76,921,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361774,360,654 - 74,433,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 341774,360,655 - 74,433,067NCBI
Celera1773,446,776 - 73,467,725 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1772,271,475 - 72,343,528 (-)NCBIHuRef
CHM1_11776,912,998 - 76,985,403 (-)NCBICHM1_1
T2T-CHM13v2.01779,747,776 - 79,820,220 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
24,25-Dihydroxyvitamin D  (EXP)
3,4-dihydrocoumarin  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ambroxol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asbestos  (EXP)
atrazine  (ISO)
batimastat  (EXP)
benazepril  (ISO)
benomyl  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C.I. Natural Red 20  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
candesartan  (ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbendazim  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
celecoxib  (ISO)
CGP 52608  (EXP)
chloroquine  (ISO)
choline  (ISO)
Cinobufagin  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
coumarin  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (EXP)
demethoxycurcumin  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
ethanol  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fenvalerate  (ISO)
ferric oxide  (EXP)
Fexofenadine hydrochloride  (EXP)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (ISO)
furosemide  (ISO)
gallic acid  (ISO)
Geniposide pentaacetate  (ISO)
genistein  (EXP)
glucose  (EXP)
Gly-His-Lys  (ISO)
graphene oxide  (ISO)
HET0016  (EXP)
hexachlorobenzene  (ISO)
hinokiflavone  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP,ISO)
indinavir  (ISO)
indometacin  (ISO)
inulin  (ISO)
Isoangustone A  (EXP)
juglone  (EXP)
L-cysteine  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP)
losartan  (ISO)
LY294002  (EXP)
melatonin  (ISO)
menadione  (EXP)
mesalamine  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (ISO)
methylmercury chloride  (EXP)
methylparaben  (EXP)
metoprolol  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (ISO)
nitric oxide  (EXP)
nitrofen  (ISO)
NORCANTHARIDIN  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
omeprazole  (ISO)
oroxylin A  (EXP)
oxaliplatin  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentane-2,3-dione  (ISO)
perfluorobutyric acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
plumbagin  (EXP)
potassium dichromate  (EXP)
pravastatin  (ISO)
prazosin  (ISO)
progesterone  (EXP)
propanal  (EXP)
propofol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
radon atom  (EXP)
radon(0)  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (ISO)
saquinavir  (ISO)
SB 203580  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
Shikonin  (EXP)
simvastatin  (ISO)
solasodine  (EXP)
Soman  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulfapyridine  (EXP)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sumatriptan  (ISO)
sunitinib  (EXP)
T-2 toxin  (EXP,ISO)
tebuconazole  (EXP)
temozolomide  (EXP)
testosterone  (ISO)
tetracaine  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
triclosan  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (ISO)
urethane  (EXP,ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)
wortmannin  (EXP)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
2. Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
3. Effect of losartan on the mRNA expressions of MT3-MMP and TIMP-2 in diabetic kidneys. Ding HL, etal., Rev Diabet Stud. 2005 Winter;2(4):216-20. Epub 2006 Feb 10.
4. Noninvasive diagnosis of bladder cancer by detection of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitor (TIMP-2) in urine. Eissa S, etal., Eur Urol. 2007 Nov;52(5):1388-96. Epub 2007 Apr 10.
5. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
6. [Metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 levels in children and adolescents with type 1 diabetes.] Florys B, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12(3):184-9.
7. Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury. Gipson TS, etal., J Immunol. 1999 Mar 15;162(6):3653-62.
8. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
9. Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions. Graesslin O, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1911-7.
10. Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats. Hu YB, etal., J Gene Med. 2007 Mar;9(3):217-29.
11. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
12. Differential regulation of tissue inhibitor of metalloproteinase mRNA expression in response to intracranial injury. Jaworski DM Glia. 2000 Apr;30(2):199-208.
13. Serum levels of matrix metalloproteinases MMP-2 and MMP-9 and their tissue natural inhibitors in breast tumors. Jinga D, etal., Roum Arch Microbiol Immunol. 2004 Jul-Dec;63(3-4):141-58.
14. Single nucleotide polymorphisms of tissue inhibitor of metalloproteinase genes in familial moyamoya disease. Kang HS, etal., Neurosurgery. 2006 Jun;58(6):1074-80; discussion 1074-80.
15. Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. Kawata N, etal., Urology. 2007 Jun;69(6):1049-53.
16. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
17. The roles of MMP-2/TIMP-2 in extracellular matrix remodelling in the hearts of STZ-induced diabetic rats. Li Q, etal., Acta Cardiol. 2007 Oct;62(5):485-91.
18. Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. Lorenzl S, etal., J Neurol Sci. 2003 Mar 15;207(1-2):71-6.
19. MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. Mendes O, etal., Clin Exp Metastasis. 2007;24(5):341-51. Epub 2007 May 16.
20. Increased circulating matrix metalloproteinase-2 in patients with hypertrophic cardiomyopathy with systolic dysfunction. Noji Y, etal., Circ J. 2004 Apr;68(4):355-60.
21. Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China. Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
22. Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors. Pulukuri SM, etal., Oncogene. 2007 Aug 9;26(36):5229-37. Epub 2007 Feb 26.
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy. Salzmann J, etal., Br J Ophthalmol. 2000 Oct;84(10):1091-6.
25. Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder. Staack A, etal., BMC Urol. 2006 Aug 10;6:19.
26. [mRNA expression analysis of metastatic markers in clear-cell renal cell carcinoma] Struckmann K, etal., Verh Dtsch Ges Pathol. 2005;89:178-83.
27. Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. Trudel D, etal., Hum Pathol. 2008 Mar 7;.
28. Serum tissue inhibitor of metalloproteinase-2 (TIMP-2) and matrix metalloproteinase-2 in complex with the inhibitor (MMP-2:TIMP-2) as prognostic markers in bladder cancer. Vasala K and Turpeenniemi-Hujanen T, Clin Biochem. 2007 Jun;40(9-10):640-4. Epub 2007 Feb 8.
29. Increased mRNA expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy. von Moers A, etal., Acta Neuropathol (Berl). 2005 Mar;109(3):285-93. Epub 2004 Dec 23.
30. Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury. Zhang X, etal., J Neurosci Res. 2006 Aug 1;84(2):278-90.
31. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. Zhao YG, etal., Cancer Res. 2004 Jan 15;64(2):590-8.
Additional References at PubMed
PMID:1427908   PMID:1480041   PMID:1730286   PMID:1869284   PMID:2157214   PMID:2380196   PMID:2554304   PMID:2793861   PMID:7918391   PMID:8112602   PMID:8476862   PMID:8757599  
PMID:8804434   PMID:8810321   PMID:8985130   PMID:9182583   PMID:9410885   PMID:9422789   PMID:9455735   PMID:9573338   PMID:9705310   PMID:9724659   PMID:9736043   PMID:9837731  
PMID:9933646   PMID:10353844   PMID:10764764   PMID:10991943   PMID:11049985   PMID:11420387   PMID:11598182   PMID:11606052   PMID:11757622   PMID:11912288   PMID:12032297   PMID:12034400  
PMID:12147251   PMID:12372458   PMID:12374789   PMID:12406369   PMID:12439941   PMID:12446683   PMID:12470034   PMID:12475252   PMID:12477932   PMID:12479097   PMID:12602913   PMID:12887919  
PMID:12900406   PMID:12970394   PMID:12970724   PMID:14517716   PMID:14598888   PMID:14604886   PMID:14605322   PMID:14654538   PMID:14661256   PMID:14702039   PMID:14710472   PMID:14712492  
PMID:14962256   PMID:14973177   PMID:14983226   PMID:15052627   PMID:15147743   PMID:15193960   PMID:15247230   PMID:15248826   PMID:15277439   PMID:15308656   PMID:15351863   PMID:15489233  
PMID:15489334   PMID:15557756   PMID:15567754   PMID:15628723   PMID:15672858   PMID:15691234   PMID:15691353   PMID:15754326   PMID:15760767   PMID:15797648   PMID:15841325   PMID:15870703  
PMID:15944607   PMID:16036783   PMID:16042227   PMID:16103240   PMID:16135528   PMID:16142392   PMID:16142692   PMID:16237750   PMID:16275157   PMID:16326706   PMID:16424893   PMID:16425263  
PMID:16429190   PMID:16491114   PMID:16623785   PMID:16631927   PMID:16716258   PMID:16728425   PMID:16772717   PMID:16776850   PMID:16940985   PMID:17008230   PMID:17030988   PMID:17067460  
PMID:17071711   PMID:17106248   PMID:17130843   PMID:17203468   PMID:17207965   PMID:17222415   PMID:17226791   PMID:17236757   PMID:17342343   PMID:17350093   PMID:17353931   PMID:17448043  
PMID:17493172   PMID:17493602   PMID:17495113   PMID:17564313   PMID:17589947   PMID:17613170   PMID:17706812   PMID:17786346   PMID:17868665   PMID:17886098   PMID:17893005   PMID:17901377  
PMID:17954022   PMID:17979129   PMID:17991754   PMID:18025061   PMID:18042068   PMID:18177649   PMID:18217401   PMID:18260263   PMID:18265895   PMID:18288718   PMID:18291374   PMID:18301898  
PMID:18424416   PMID:18469019   PMID:18472160   PMID:18474097   PMID:18477480   PMID:18487063   PMID:18498066   PMID:18543216   PMID:18634035   PMID:18674955   PMID:18702016   PMID:19020757  
PMID:19088110   PMID:19141395   PMID:19187648   PMID:19241124   PMID:19267203   PMID:19317417   PMID:19331801   PMID:19358835   PMID:19383344   PMID:19391484   PMID:19431211   PMID:19438747  
PMID:19464975   PMID:19546837   PMID:19551542   PMID:19551841   PMID:19596921   PMID:19640333   PMID:19698156   PMID:19709349   PMID:19723139   PMID:19727008   PMID:19758569   PMID:19821096  
PMID:19844095   PMID:19875168   PMID:19883732   PMID:19889076   PMID:19913121   PMID:19933216   PMID:20041335   PMID:20084057   PMID:20138860   PMID:20149706   PMID:20195229   PMID:20215736  
PMID:20216978   PMID:20233321   PMID:20452482   PMID:20484597   PMID:20485444   PMID:20514432   PMID:20587546   PMID:20598922   PMID:20616161   PMID:20627004   PMID:20628086   PMID:20634891  
PMID:20672350   PMID:20673868   PMID:20685029   PMID:20694560   PMID:20707923   PMID:20718757   PMID:20730428   PMID:20889295   PMID:20940305   PMID:20941509   PMID:20948207   PMID:21086628  
PMID:21148412   PMID:21195432   PMID:21228746   PMID:21254651   PMID:21261731   PMID:21421877   PMID:21427648   PMID:21432777   PMID:21437624   PMID:21454617   PMID:21462296   PMID:21463121  
PMID:21478099   PMID:21526499   PMID:21620625   PMID:21715326   PMID:21732829   PMID:21786179   PMID:21839835   PMID:21871510   PMID:21873635   PMID:22020421   PMID:22051851   PMID:22110735  
PMID:22122951   PMID:22169692   PMID:22200256   PMID:22200690   PMID:22262409   PMID:22270451   PMID:22272343   PMID:22302011   PMID:22374248   PMID:22427646   PMID:22438955   PMID:22511598  
PMID:22512703   PMID:22532131   PMID:22546345   PMID:22551568   PMID:22621753   PMID:22685266   PMID:22730240   PMID:22820140   PMID:22880464   PMID:22883459   PMID:22985025   PMID:22985578  
PMID:23038618   PMID:23195431   PMID:23205572   PMID:23251661   PMID:23264224   PMID:23320481   PMID:23369618   PMID:23371049   PMID:23376485   PMID:23388475   PMID:23388612   PMID:23412981  
PMID:23415672   PMID:23427184   PMID:23472970   PMID:23491141   PMID:23536957   PMID:23563628   PMID:23585206   PMID:23650722   PMID:23661104   PMID:23673111   PMID:23708302   PMID:23769926  
PMID:23791966   PMID:23793312   PMID:23817219   PMID:23824909   PMID:23855590   PMID:23973519   PMID:23979707   PMID:24024966   PMID:24042342   PMID:24068394   PMID:24073280   PMID:24112707  
PMID:24202705   PMID:24210229   PMID:24212294   PMID:24335752   PMID:24355694   PMID:24384769   PMID:24395652   PMID:24403492   PMID:24427326   PMID:24440352   PMID:24444603   PMID:24475101  
PMID:24479343   PMID:24534323   PMID:24591757   PMID:24675717   PMID:24680659   PMID:24710006   PMID:24799419   PMID:24800696   PMID:24819588   PMID:25017104   PMID:25060386   PMID:25128867  
PMID:25136829   PMID:25153995   PMID:25189251   PMID:25259564   PMID:25280484   PMID:25300296   PMID:25405519   PMID:25412957   PMID:25436070   PMID:25524453   PMID:25539555   PMID:25552509  
PMID:25571919   PMID:25579181   PMID:25656607   PMID:25731730   PMID:25771900   PMID:25826490   PMID:25839957   PMID:26067137   PMID:26071077   PMID:26130791   PMID:26148591   PMID:26186194  
PMID:26191221   PMID:26268417   PMID:26278569   PMID:26329758   PMID:26331622   PMID:26539028   PMID:26551785   PMID:26556867   PMID:26606754   PMID:26765397   PMID:26797672   PMID:26823777  
PMID:26856768   PMID:26978018   PMID:26979530   PMID:27018975   PMID:27033700   PMID:27058373   PMID:27098106   PMID:27142596   PMID:27160811   PMID:27173256   PMID:27174659   PMID:27174941  
PMID:27191265   PMID:27329669   PMID:27342580   PMID:27342582   PMID:27401679   PMID:27412873   PMID:27434116   PMID:27633774   PMID:27834627   PMID:27853937   PMID:27901480   PMID:28003188  
PMID:28035415   PMID:28107490   PMID:28137415   PMID:28139355   PMID:28192449   PMID:28375112   PMID:28382566   PMID:28384717   PMID:28510611   PMID:28514442   PMID:28611215   PMID:28620234  
PMID:28682920   PMID:28731196   PMID:28802022   PMID:28803769   PMID:28871006   PMID:28888475   PMID:28980922   PMID:29035450   PMID:29103203   PMID:29117863   PMID:29145491   PMID:29265076  
PMID:29325453   PMID:29385606   PMID:29393341   PMID:29432996   PMID:29505725   PMID:29658596   PMID:29673878   PMID:29685765   PMID:29753168   PMID:29763380   PMID:29912573   PMID:29930267  
PMID:29941993   PMID:30249138   PMID:30272338   PMID:30284418   PMID:30300282   PMID:30515695   PMID:30562560   PMID:30583769   PMID:30593723   PMID:30676640   PMID:30755371   PMID:30765222  
PMID:30794673   PMID:30982674   PMID:30988064   PMID:31018823   PMID:31032338   PMID:31061410   PMID:31088428   PMID:31119800   PMID:31208828   PMID:31263835   PMID:31273966   PMID:31293204  
PMID:31298305   PMID:31383784   PMID:31545237   PMID:31772230   PMID:31791043   PMID:31836008   PMID:31856559   PMID:31870265   PMID:31887330   PMID:31970775   PMID:32116235   PMID:32296183  
PMID:32296833   PMID:32322062   PMID:32479185   PMID:32495877   PMID:32542727   PMID:32623572   PMID:32661216   PMID:32767336   PMID:32945513   PMID:32955903   PMID:32961536   PMID:32969251  
PMID:33009198   PMID:33023532   PMID:33045111   PMID:33093251   PMID:33270569   PMID:33411755   PMID:33441876   PMID:33471544   PMID:33482846   PMID:33725949   PMID:33731593   PMID:33961781  
PMID:34155539   PMID:34474580   PMID:34487732   PMID:34497265   PMID:34678879   PMID:34732411   PMID:34798882   PMID:34801997   PMID:35013218   PMID:35020251   PMID:35170890   PMID:35274445  
PMID:35294975   PMID:35307071   PMID:35414793   PMID:35469565   PMID:35523402   PMID:35563538   PMID:35604859   PMID:35792273   PMID:35831314   PMID:35834547   PMID:36369321   PMID:36430677  
PMID:36494333   PMID:36624735   PMID:36905423   PMID:36958106   PMID:37914840   PMID:38015626  


Genomics

Comparative Map Data
TIMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,852,977 - 78,925,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,852,977 - 78,925,387 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,849,059 - 76,921,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361774,360,654 - 74,433,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 341774,360,655 - 74,433,067NCBI
Celera1773,446,776 - 73,467,725 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1772,271,475 - 72,343,528 (-)NCBIHuRef
CHM1_11776,912,998 - 76,985,403 (-)NCBICHM1_1
T2T-CHM13v2.01779,747,776 - 79,820,220 (-)NCBIT2T-CHM13v2.0
Timp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911118,191,887 - 118,246,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11118,191,887 - 118,246,566 (-)EnsemblGRCm39 Ensembl
GRCm3811118,301,061 - 118,355,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11118,301,069 - 118,355,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711118,162,375 - 118,216,725 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611118,117,151 - 118,171,501 (-)NCBIMGSCv36mm8
Celera11130,046,014 - 130,100,382 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.09NCBI
Timp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810104,041,604 - 104,089,214 (-)NCBIGRCr8
mRatBN7.210103,541,199 - 103,590,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,531,505 - 103,590,611 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,643,337 - 108,691,010 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010108,106,467 - 108,154,150 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,463,707 - 103,511,317 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010107,338,465 - 107,386,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10107,338,465 - 107,386,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,973,463 - 107,021,070 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410108,310,473 - 108,358,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110108,324,976 - 108,373,325 (-)NCBI
Celera10102,103,187 - 102,150,797 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Timp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555063,768,646 - 3,813,820 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555063,769,113 - 3,812,896 (+)NCBIChiLan1.0ChiLan1.0
TIMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,901,178 - 94,974,364 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,731,234 - 99,804,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,928,692 - 73,001,892 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11778,476,807 - 78,495,885 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1778,476,807 - 78,495,649 (-)Ensemblpanpan1.1panPan2
TIMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,521,882 - 2,533,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,521,882 - 2,533,989 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,159,531 - 3,168,419 (+)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha93,146,850 - 3,191,997 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,140,666 - 3,188,540 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.193,175,669 - 3,184,556 (+)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.193,162,992 - 3,208,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,288,768 - 3,333,886 (+)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.093,301,440 - 3,310,326 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,369,678 - 3,414,817 (+)NCBIUU_Cfam_GSD_1.0
Timp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,160,813 - 3,179,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365943,232,355 - 3,244,241 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365943,232,433 - 3,244,241 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,254,493 - 3,300,834 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,254,794 - 3,300,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2123,294,254 - 3,340,447 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,819,591 - 70,850,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,819,139 - 70,850,471 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607741,956,134 - 42,029,058 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248018,228,357 - 8,270,982 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248018,228,618 - 8,270,606 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TIMP2
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q25.3(chr17:78901959-83086677)x3 copy number gain See cases [RCV000050934] Chr17:78901959..83086677 [GRCh38]
Chr17:76898041..81044553 [GRCh37]
Chr17:74409636..78637842 [NCBI36]
Chr17:17q25.3		 pathogenic
GRCh38/hg38 17q25.3(chr17:78092236-83086677)x3 copy number gain See cases [RCV000050685] Chr17:78092236..83086677 [GRCh38]
Chr17:76088317..81044553 [GRCh37]
Chr17:73599912..78637842 [NCBI36]
Chr17:17q25.3		 pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3		 pathogenic
GRCh38/hg38 17q25.3(chr17:78918650-83021095)x3 copy number gain See cases [RCV000052497] Chr17:78918650..83021095 [GRCh38]
Chr17:76914732..80978971 [GRCh37]
Chr17:74426327..78572260 [NCBI36]
Chr17:17q25.3		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q25.3(chr17:78225356-80099979)x1 copy number loss See cases [RCV000135703] Chr17:78225356..80099979 [GRCh38]
Chr17:76221437..78073778 [GRCh37]
Chr17:73733032..75688373 [NCBI36]
Chr17:17q25.3		 likely pathogenic
GRCh38/hg38 17q25.3(chr17:78484862-79436025)x4 copy number gain See cases [RCV000141790] Chr17:78484862..79436025 [GRCh38]
Chr17:76480944..77432107 [GRCh37]
Chr17:73992539..74943702 [NCBI36]
Chr17:17q25.3		 uncertain significance
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3		 pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000447539] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3		 pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:64241326-81041938)x3 copy number gain See cases [RCV000447577] Chr17:64241326..81041938 [GRCh37]
Chr17:17q24.2-25.3		 pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000510919] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:67002415-81041938)x3 copy number gain See cases [RCV000512573] Chr17:67002415..81041938 [GRCh37]
Chr17:17q24.2-25.3		 pathogenic
GRCh37/hg19 17q25.3(chr17:76552611-81041938)x3 copy number gain not provided [RCV000683965] Chr17:76552611..81041938 [GRCh37]
Chr17:17q25.3		 likely pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:63689671-81041938)x3 copy number gain not provided [RCV000683952] Chr17:63689671..81041938 [GRCh37]
Chr17:17q24.1-25.3		 pathogenic
GRCh37/hg19 17q25.3(chr17:76470653-77095130)x4 copy number gain not provided [RCV000683964] Chr17:76470653..77095130 [GRCh37]
Chr17:17q25.3		 uncertain significance
GRCh37/hg19 17q25.3(chr17:76676371-77287185)x3 copy number gain not provided [RCV000683966] Chr17:76676371..77287185 [GRCh37]
Chr17:17q25.3		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_003255.5(TIMP2):c.446A>T (p.Gln149Leu) single nucleotide variant Inborn genetic diseases [RCV003242957] Chr17:78857541 [GRCh38]
Chr17:76853623 [GRCh37]
Chr17:17q25.3		 uncertain significance
GRCh37/hg19 17q24.1-25.3(chr17:62778720-81041938)x3 copy number gain not provided [RCV000849900] Chr17:62778720..81041938 [GRCh37]
Chr17:17q24.1-25.3		 pathogenic
GRCh37/hg19 17q25.3(chr17:76857398-77308782)x3 copy number gain not provided [RCV000847151] Chr17:76857398..77308782 [GRCh37]
Chr17:17q25.3		 uncertain significance
GRCh37/hg19 17q25.3(chr17:76857398-77308782)x3 copy number gain not provided [RCV000847163] Chr17:76857398..77308782 [GRCh37]
Chr17:17q25.3		 uncertain significance
GRCh37/hg19 17q25.1-25.3(chr17:73261871-78608763)x3 copy number gain not provided [RCV001006919] Chr17:73261871..78608763 [GRCh37]
Chr17:17q25.1-25.3		 pathogenic
GRCh37/hg19 17q25.3(chr17:76852029-77297898)x3 copy number gain not provided [RCV001259906] Chr17:76852029..77297898 [GRCh37]
Chr17:17q25.3		 uncertain significance
GRCh37/hg19 17q25.3(chr17:76770309-77174429) copy number gain not specified [RCV002052606] Chr17:76770309..77174429 [GRCh37]
Chr17:17q25.3		 uncertain significance
GRCh37/hg19 17q25.3(chr17:76852379-77297300)x3 copy number gain not provided [RCV001827821] Chr17:76852379..77297300 [GRCh37]
Chr17:17q25.3		 uncertain significance
NC_000017.10:g.(?_76851749)_(77758841_?)dup duplication Idiopathic generalized epilepsy [RCV001875218] Chr17:76851749..77758841 [GRCh37]
Chr17:17q25.3		 uncertain significance
NC_000017.10:g.(?_76851749)_(78367298_?)dup duplication Pityriasis rubra pilaris [RCV003122634] Chr17:76851749..78367298 [GRCh37]
Chr17:17q25.3		 uncertain significance
GRCh37/hg19 17q25.1-25.3(chr17:73481509-81043199)x3 copy number gain not provided [RCV002276051] Chr17:73481509..81043199 [GRCh37]
Chr17:17q25.1-25.3		 pathogenic
NM_003255.5(TIMP2):c.623C>T (p.Ala208Val) single nucleotide variant Inborn genetic diseases [RCV002687332] Chr17:78855707 [GRCh38]
Chr17:76851789 [GRCh37]
Chr17:17q25.3		 uncertain significance
NM_003255.5(TIMP2):c.349G>A (p.Glu117Lys) single nucleotide variant Inborn genetic diseases [RCV002841752] Chr17:78857638 [GRCh38]
Chr17:76853720 [GRCh37]
Chr17:17q25.3		 uncertain significance
NM_003255.5(TIMP2):c.518T>C (p.Leu173Pro) single nucleotide variant Inborn genetic diseases [RCV002701650] Chr17:78855812 [GRCh38]
Chr17:76851894 [GRCh37]
Chr17:17q25.3		 uncertain significance
NM_003255.5(TIMP2):c.391G>A (p.Val131Met) single nucleotide variant Inborn genetic diseases [RCV003178971] Chr17:78857596 [GRCh38]
Chr17:76853678 [GRCh37]
Chr17:17q25.3		 uncertain significance
NM_003255.5(TIMP2):c.358G>A (p.Gly120Ser) single nucleotide variant Inborn genetic diseases [RCV003190272] Chr17:78857629 [GRCh38]
Chr17:76853711 [GRCh37]
Chr17:17q25.3		 uncertain significance
NM_003255.5(TIMP2):c.67C>T (p.Pro23Ser) single nucleotide variant Inborn genetic diseases [RCV003173605] Chr17:78925022 [GRCh38]
Chr17:76921104 [GRCh37]
Chr17:17q25.3		 uncertain significance
NM_001243540.2(CEP295NL):c.267C>T (p.Gly89=) single nucleotide variant not provided [RCV003421528] Chr17:78892237 [GRCh38]
Chr17:76888319 [GRCh37]
Chr17:17q25.3		 likely benign
GRCh37/hg19 17q25.3(chr17:76905755-77611113)x3 copy number gain not provided [RCV003485166] Chr17:76905755..77611113 [GRCh37]
Chr17:17q25.3		 uncertain significance
NM_003255.5(TIMP2):c.36C>T (p.Leu12=) single nucleotide variant TIMP2-related condition [RCV003919570] Chr17:78925053 [GRCh38]
Chr17:76921135 [GRCh37]
Chr17:17q25.3		 benign
NM_003255.5(TIMP2):c.618C>T (p.Gly206=) single nucleotide variant TIMP2-related condition [RCV003949180] Chr17:78855712 [GRCh38]
Chr17:76851794 [GRCh37]
Chr17:17q25.3		 likely benign
NM_003255.5(TIMP2):c.147G>A (p.Ala49=) single nucleotide variant TIMP2-related condition [RCV003926982] Chr17:78873903 [GRCh38]
Chr17:76869985 [GRCh37]
Chr17:17q25.3		 likely benign
NM_003255.5(TIMP2):c.303G>A (p.Ser101=) single nucleotide variant TIMP2-related condition [RCV003974615] Chr17:78870935 [GRCh38]
Chr17:76867017 [GRCh37]
Chr17:17q25.3		 benign
NM_003255.5(TIMP2):c.231+8T>C single nucleotide variant TIMP2-related condition [RCV003911599] Chr17:78873811 [GRCh38]
Chr17:76869893 [GRCh37]
Chr17:17q25.3		 benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR519Chsa-miR-519c-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22262409
MIR200Bhsa-miR-200b-3pOncomiRDBexternal_infoNANA23205572

Predicted Target Of
Summary Value
Count of predictions:7194
Count of miRNA genes:1116
Interacting mature miRNAs:1355
Transcripts:ENST00000262768, ENST00000536189, ENST00000585421, ENST00000586057, ENST00000592761
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH71380  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,851,702 - 76,851,824UniSTSGRCh37
Build 361774,363,297 - 74,363,419RGDNCBI36
Celera1773,449,418 - 73,449,540RGD
Cytogenetic Map17q25UniSTS
HuRef1772,274,117 - 72,274,239UniSTS
GeneMap99-GB4 RH Map17512.35UniSTS
NCBI RH Map17810.0UniSTS
D17S815E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,849,651 - 76,849,740UniSTSGRCh37
Build 361774,361,246 - 74,361,335RGDNCBI36
Celera1773,447,368 - 73,447,457RGD
Cytogenetic Map17q25UniSTS
HuRef1772,272,067 - 72,272,156UniSTS
D13S1217  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,849,386 - 76,849,444UniSTSGRCh37
Build 361774,360,981 - 74,361,039RGDNCBI36
Celera1773,447,103 - 73,447,161RGD
Cytogenetic Map17q25UniSTS
HuRef1772,271,802 - 72,271,860UniSTS
RH46997  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,849,732 - 76,849,862UniSTSGRCh37
Build 361774,361,327 - 74,361,457RGDNCBI36
Celera1773,447,449 - 73,447,579RGD
Cytogenetic Map17q25UniSTS
HuRef1772,272,148 - 72,272,278UniSTS
GeneMap99-GB4 RH Map17512.35UniSTS
NCBI RH Map17810.0UniSTS
Cda13g07  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,849,369 - 76,849,618UniSTSGRCh37
Build 361774,360,964 - 74,361,213RGDNCBI36
Celera1773,447,086 - 73,447,335RGD
Cytogenetic Map17q25UniSTS
HuRef1772,271,785 - 72,272,034UniSTS
GeneMap99-GB4 RH Map17509.09UniSTS
NCBI RH Map17810.0UniSTS
HSC13G072  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,849,347 - 76,849,623UniSTSGRCh37
Build 361774,360,942 - 74,361,218RGDNCBI36
Celera1773,447,064 - 73,447,340RGD
Cytogenetic Map17q25UniSTS
HuRef1772,271,763 - 72,272,039UniSTS
RH65725  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q25UniSTS
HuRef1772,272,644 - 72,272,829UniSTS
GeneMap99-GB4 RH Map17512.35UniSTS
NCBI RH Map17810.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 5 686 405 6 27 117 7 1 40 352 1
Medium 2395 2271 1642 544 1424 385 3874 2110 3658 411 1339 1593 174 1 1164 2358 5 2
Low 35 30 84 80 130 80 78 81 49 8 4 13 78
Below cutoff 4 3 256

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC022966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC100788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL110197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB571110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB668241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S48568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S68860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262768   ⟹   ENSP00000262768
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,852,977 - 78,925,387 (-)Ensembl
RefSeq Acc Id: ENST00000536189   ⟹   ENSP00000441724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,852,977 - 78,922,401 (-)Ensembl
RefSeq Acc Id: ENST00000585421   ⟹   ENSP00000467584
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,852,977 - 78,874,150 (-)Ensembl
RefSeq Acc Id: ENST00000586057   ⟹   ENSP00000468296
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,852,981 - 78,874,089 (-)Ensembl
RefSeq Acc Id: ENST00000586713   ⟹   ENSP00000465968
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,855,568 - 78,903,215 (-)Ensembl
RefSeq Acc Id: ENST00000592761   ⟹   ENSP00000464930
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,855,542 - 78,874,136 (-)Ensembl
RefSeq Acc Id: ENST00000706922   ⟹   ENSP00000516642
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,855,574 - 78,874,100 (-)Ensembl
RefSeq Acc Id: ENST00000706923   ⟹   ENSP00000516643
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,855,576 - 78,874,106 (-)Ensembl
RefSeq Acc Id: NM_003255   ⟹   NP_003246
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,852,977 - 78,925,387 (-)NCBI
GRCh371776,849,059 - 76,921,472 (-)ENTREZGENE
Build 361774,360,654 - 74,433,067 (-)NCBI Archive
HuRef1772,271,475 - 72,343,528 (-)ENTREZGENE
CHM1_11776,912,998 - 76,985,403 (-)NCBI
T2T-CHM13v2.01779,747,776 - 79,820,220 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_003246   ⟸   NM_003255
- Peptide Label: precursor
- UniProtKB: Q93006 (UniProtKB/Swiss-Prot),   Q16121 (UniProtKB/Swiss-Prot),   Q9UDF7 (UniProtKB/Swiss-Prot),   P16035 (UniProtKB/Swiss-Prot),   A0A140VK57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000467584   ⟸   ENST00000585421
RefSeq Acc Id: ENSP00000468296   ⟸   ENST00000586057
RefSeq Acc Id: ENSP00000441724   ⟸   ENST00000536189
RefSeq Acc Id: ENSP00000262768   ⟸   ENST00000262768
RefSeq Acc Id: ENSP00000464930   ⟸   ENST00000592761
RefSeq Acc Id: ENSP00000516642   ⟸   ENST00000706922
RefSeq Acc Id: ENSP00000465968   ⟸   ENST00000586713
RefSeq Acc Id: ENSP00000516643   ⟸   ENST00000706923
Protein Domains
NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16035-F1-model_v2 AlphaFold P16035 1-220 view protein structure

Promoters
RGD ID:6794617
Promoter ID:HG_KWN:27285
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   NB4
Transcripts:NM_003255
Position:
Human AssemblyChrPosition (strand)Source
Build 361774,432,796 - 74,433,296 (-)MPROMDB
RGD ID:7236529
Promoter ID:EPDNEW_H24010
Type:initiation region
Name:TIMP2_1
Description:TIMP metallopeptidase inhibitor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,925,387 - 78,925,447EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11821 AgrOrtholog
COSMIC TIMP2 COSMIC
Ensembl Genes ENSG00000035862 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000262768 ENTREZGENE
  ENST00000262768.11 UniProtKB/Swiss-Prot
  ENST00000536189.6 UniProtKB/TrEMBL
  ENST00000585421.5 UniProtKB/TrEMBL
  ENST00000586057.5 UniProtKB/TrEMBL
  ENST00000586713.6 UniProtKB/TrEMBL
  ENST00000706922.1 UniProtKB/TrEMBL
  ENST00000706923.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000035862 GTEx
HGNC ID HGNC:11821 ENTREZGENE
Human Proteome Map TIMP2 Human Proteome Map
InterPro Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7077 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7077 ENTREZGENE
OMIM 188825 OMIM
PANTHER PTHR11844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11844:SF24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36527 PharmGKB
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VK57 ENTREZGENE, UniProtKB/TrEMBL
  A0A9L9PXQ8_HUMAN UniProtKB/TrEMBL
  A0A9L9PYH5_HUMAN UniProtKB/TrEMBL
  B4DFW2_HUMAN UniProtKB/TrEMBL
  P16035 ENTREZGENE
  Q16121 ENTREZGENE
  Q93006 ENTREZGENE
  Q9UDF7 ENTREZGENE
  TIMP2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary K7EL90 UniProtKB/TrEMBL
  Q16121 UniProtKB/Swiss-Prot
  Q93006 UniProtKB/Swiss-Prot
  Q9UDF7 UniProtKB/Swiss-Prot