PTEN (phosphatase and tensin homolog) - Rat Genome Database

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Gene: PTEN (phosphatase and tensin homolog) Homo sapiens
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Symbol: PTEN
Name: phosphatase and tensin homolog
RGD ID: 69119
HGNC Page HGNC
Description: Exhibits several functions, including PDZ domain binding activity; anaphase-promoting complex binding activity; and phosphatase activity. Involved in several processes, including dephosphorylation; regulation of cellular protein metabolic process; and regulation of signal transduction. Localizes to several cellular components, including apical plasma membrane; cytoplasmic side of plasma membrane; and nucleoplasm. Implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); macrocephaly-autism syndrome; and nervous system cancer (multiple). Biomarker of several diseases, including PTEN hamartoma tumor syndrome; biliary atresia; cerebral cavernous malformation; in situ carcinoma (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 10q23del; BZS; CWS1; DEC; GLM2; MGC11227; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; phosphatase and tensin-like protein; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTEN1; PTENbeta; PTENepsilon; TEP1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PTENP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1087,863,625 - 87,971,930 (+)EnsemblGRCh38hg38GRCh38
GRCh381087,863,625 - 87,971,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371089,623,382 - 89,731,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361089,613,175 - 89,718,512 (+)NCBINCBI36hg18NCBI36
Build 341089,613,174 - 89,716,382NCBI
Celera1083,369,676 - 83,474,975 (+)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1083,258,013 - 83,363,313 (+)NCBIHuRef
CHM1_11089,905,493 - 90,013,981 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model