Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: KLF1 (Kruppel like factor 1) Homo sapiens
Analyze
Symbol: KLF1
Name: Kruppel like factor 1
Description: This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDAN4; EKLF; EKLF/KLF1; erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; erythroid-specific transcription factor EKLF; HBFQTL6; INLU; Krueppel-like factor 1; Kruppel-like factor 1 (erythroid); monoclonal antibody A3D8; truncated EKLF; truncated erythroid Kruppel-like factor 1; truncated erythroid Kruppel-like factor EKLF/KLF1; truncated Kruppel-like factor 1
Orthologs:
Mus musculus (house mouse) : Klf1 (Kruppel-like factor 1 (erythroid))  MGI  Alliance
Rattus norvegicus (Norway rat) : Klf1 (Kruppel like factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klf1 (Kruppel like factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KLF1 (Kruppel like factor 1)
Canis lupus familiaris (dog) : KLF1 (Kruppel like factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klf1 (Kruppel like factor 1)
Sus scrofa (pig) : KLF1 (Kruppel like factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,884,422 - 12,887,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,995,236 - 12,998,017 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,856,236 - 12,859,017 (-)NCBINCBI36hg18NCBI36
Build 341912,856,238 - 12,859,017NCBI
Celera1912,884,944 - 12,887,725 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,567,102 - 12,569,883 (-)NCBIHuRef
CHM1_11912,995,734 - 12,998,515 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KLF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319723
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.