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Gene: KLF1 (Kruppel like factor 1) Homo sapiens
Symbol: KLF1
Name: Kruppel like factor 1
Description: This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDAN4; EKLF; EKLF/KLF1; erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; erythroid-specific transcription factor EKLF; HBFQTL6; INLU; Krueppel-like factor 1; Kruppel-like factor 1 (erythroid); monoclonal antibody A3D8; truncated EKLF; truncated erythroid Kruppel-like factor 1; truncated erythroid Kruppel-like factor EKLF/KLF1; truncated Kruppel-like factor 1
Mus musculus (house mouse) : Klf1 (Kruppel-like factor 1 (erythroid))  MGI  Alliance
Rattus norvegicus (Norway rat) : Klf1 (Kruppel like factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klf1 (Kruppel like factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KLF1 (Kruppel like factor 1)
Canis lupus familiaris (dog) : KLF1 (Kruppel like factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klf1 (Kruppel like factor 1)
Sus scrofa (pig) : KLF1 (Kruppel like factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381912,884,422 - 12,887,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,995,236 - 12,998,017 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,856,236 - 12,859,017 (-)NCBINCBI36hg18NCBI36
Build 341912,856,238 - 12,859,017NCBI
Celera1912,884,944 - 12,887,725 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,567,102 - 12,569,883 (-)NCBIHuRef
CHM1_11912,995,734 - 12,998,515 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KLF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319723
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.