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Gene: SMPD2 (sphingomyelin phosphodiesterase 2) Homo sapiens
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Symbol: SMPD2
Name: sphingomyelin phosphodiesterase 2
RGD ID: 732430
Description: Predicted to have sphingomyelin phosphodiesterase activity. Predicted to be involved in ceramide biosynthetic process; sphingolipid catabolic process; and sphingomyelin metabolic process. Predicted to localize to caveola and endoplasmic reticulum.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ISC1; lyso-PAF-PLC; lyso-platelet-activating factor-phospholipase C; N-SMase; neutral sphingomyelinase; NSMASE; NSMASE1; sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Orthologs:
Mus musculus (house mouse) : Smpd2 (sphingomyelin phosphodiesterase 2, neutral)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smpd2 (sphingomyelin phosphodiesterase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smpd2 (sphingomyelin phosphodiesterase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SMPD2 (sphingomyelin phosphodiesterase 2)
Canis lupus familiaris (dog) : SMPD2 (sphingomyelin phosphodiesterase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smpd2 (sphingomyelin phosphodiesterase 2)
Sus scrofa (pig) : SMPD2 (sphingomyelin phosphodiesterase 2)
Chlorocebus sabaeus (African green monkey) : SMPD2 (sphingomyelin phosphodiesterase 2)
Heterocephalus glaber (naked mole-rat) : Smpd2 (sphingomyelin phosphodiesterase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6109,440,724 - 109,443,919 (+)EnsemblGRCh38hg38GRCh38
GRCh386109,440,721 - 109,443,922 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376109,761,849 - 109,765,125 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366109,868,624 - 109,871,815 (+)NCBINCBI36hg18NCBI36
Build 346109,868,658 - 109,871,814NCBI
Celera6110,508,515 - 110,511,706 (+)NCBI
Cytogenetic Map6q21NCBI
HuRef6107,328,017 - 107,331,208 (+)NCBIHuRef
CHM1_16110,025,014 - 110,028,205 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SMPD2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732430
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.