PRKCD (protein kinase C delta) - Rat Genome Database

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Gene: PRKCD (protein kinase C delta) Homo sapiens
Analyze
Symbol: PRKCD
Name: protein kinase C delta
RGD ID: 69026
HGNC Page HGNC:9399
Description: Enables enzyme activator activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including cellular response to oxidative stress; positive regulation of metabolic process; and protein modification process. Located in several cellular components, including cytosol; endolysosome; and endoplasmic reticulum. Implicated in autoimmune lymphoproliferative syndrome type 3 and steatotic liver disease. Biomarker of hypertension and portal hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ALPS3; CVID9; MAY1; MGC49908; nPKC-delta; PKCD; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38353,161,209 - 53,192,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl353,156,009 - 53,192,717 (+)EnsemblGRCh38hg38GRCh38
GRCh37353,195,225 - 53,226,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,170,263 - 53,201,773 (+)NCBINCBI36Build 36hg18NCBI36
Build 34353,170,262 - 53,201,771NCBI
Celera353,162,239 - 53,193,756 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef353,210,511 - 53,276,026 (+)NCBIHuRef
CHM1_1353,146,796 - 53,178,291 (+)NCBICHM1_1
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
PRKCDHumanbrain ischemia  ISOPrkcd (Rattus norvegicus)1642524 RGD 
PRKCDHumanBurns  ISOPrkcd (Rattus norvegicus)1642547protein:altered localization:cardiac muscle cellRGD 
PRKCDHumanCardiomegaly  ISOPrkcd (Rattus norvegicus)1581271associated with HypertensionRGD 
PRKCDHumanExperimental Diabetes Mellitus  ISOPrkcd (Rattus norvegicus)1642532protein:increased expression:kidneyRGD 
PRKCDHumanhyperinsulinism  ISOPrkcd (Rattus norvegicus)1625605 RGD 
PRKCDHumanhypertension  IEP 1642534protein:increased expression:heart and fibroblastRGD 
PRKCDHumanhypertension  ISOPrkcd (Rattus norvegicus)1581271 RGD 
PRKCDHumanInsulin Resistance  ISOPrkcd (Mus musculus)1642527associated with Obesity and protein:increased activity:adipocyteRGD 
PRKCDHumanInsulin Resistance  ISOPrkcd (Rattus norvegicus)729667protein:altered localization:nucleusRGD 
PRKCDHumanLeft Ventricular Hypertrophy  ISOPrkcd (Rattus norvegicus)1581272 RGD 
PRKCDHumanmuscular disease  ISOPrkcd (Rattus norvegicus)1642535associated with Diabetes Mellitus more ...RGD 
PRKCDHumanMyocardial Ischemia  ISOPrkcd (Rattus norvegicus)1642550mRNA more ...RGD 
PRKCDHumanMyocardial Reperfusion Injury  ISOPrkcd (Rattus norvegicus)1642542protein:decreased expression:heartRGD 
PRKCDHumanobesity  ISOPrkcd (Rattus norvegicus)1642533protein:decreased expression:heart ventricleRGD 
PRKCDHumanportal hypertension  IEP 1642521mRNA:decreased expression:spleen and macrophageRGD 
PRKCDHumanrestrictive cardiomyopathy  ISOPrkcd (Rattus norvegicus)1642535associated with Diabetes Mellitus more ...RGD 
PRKCDHumanRight Ventricular Hypertrophy  ISOPrkcd (Rattus norvegicus)1581272 RGD 
PRKCDHumansteatotic liver disease  IDA 1642523 RGD 
PRKCDHumanStroke  ISOPrkcd (Rattus norvegicus)1642524 RGD 
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Original Reference(s)
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:28492532 and PMID:30257684
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:11976687 more ...
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:28492532
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:11976687 more ...
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:28492532
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:11976687 more ...
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:25741868
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:28492532
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:28492532
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:11976687 more ...
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:25741868 and PMID:28492532
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:34264265
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:24033266 more ...
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:17576681 more ...
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:17576681 more ...
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:23430113 more ...
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:26546672 and PMID:28492532
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVar 
PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:23666743
PRKCDHumangenetic disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
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Original Reference(s)
PRKCDHumanChemical and Drug Induced Liver Injury  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:30393195
PRKCDHumanExperimental Diabetes Mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12198386
PRKCDHumanExperimental Liver Cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
PRKCDHumanFever  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:31422080 and PMID:32437895
PRKCDHumanhypertension  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23973649
PRKCDHumanHypothermia  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:30366073
PRKCDHumanIntestinal Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:11983831
PRKCDHumanmetabolic dysfunction-associated steatotic liver disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:29341352
PRKCDHumanParkinsonism  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:15681813
PRKCDHumantoxic encephalopathy  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22512859
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PRKCDHumanautoimmune lymphoproliferative syndrome type 3  IAGP 7240710 OMIM 

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Original Reference(s)
PRKCDHuman(+)-pilocarpine increases expressionISOPrkcd (Rattus norvegicus)6480464Pilocarpine results in increased expression of PRKCD proteinCTDPMID:15058486
PRKCDHuman(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464epigallocatechin gallate inhibits the reaction [Histamine results in increased phosphorylation of PRKCD protein] and epigallocatechin gallate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein]CTDPMID:23333628
PRKCDHuman(S)-amphetamine increases expressionISOPrkcd (Rattus norvegicus)6480464Dextroamphetamine results in increased expression of PRKCD mRNA and Dextroamphetamine results in increased expression of PRKCD proteinCTDPMID:19497417
PRKCDHuman(S)-nicotine decreases expressionISOPrkcd (Mus musculus)6480464Nicotine results in decreased expression of PRKCD mRNACTDPMID:21955143
PRKCDHuman1,2-dimethylhydrazine increases expressionISOPrkcd (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PRKCD mRNACTDPMID:22206623
PRKCDHuman1,2-dimethylhydrazine multiple interactionsISOPrkcd (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PRKCD mRNA]CTDPMID:22206623
PRKCDHuman1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactionsISOPrkcd (Rattus norvegicus)64804641-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein] and 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]CTDPMID:14678745
PRKCDHuman1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile multiple interactionsEXP 6480464Citalopram inhibits the reaction [convulxin results in increased phosphorylation of PRKCD protein]CTDPMID:30592962
PRKCDHuman1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionISOPrkcd (Rattus norvegicus)6480464Citalopram results in increased expression of PRKCD mRNACTDPMID:28467792
PRKCDHuman17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PRKCD mRNACTDPMID:15757668 and PMID:32387340
PRKCDHuman17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of PRKCD mRNACTDPMID:30165855
PRKCDHuman2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPrkcd (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PRKCD mRNACTDPMID:15251184
PRKCDHuman2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPrkcd (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PRKCD mRNACTDPMID:21570461 and PMID:24680724
PRKCDHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PRKCD mRNACTDPMID:23152189
PRKCDHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPrkcd (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of PRKCD mRNACTDPMID:20959002 more ...
PRKCDHuman2,3,7,8-tetrachlorodibenzodioxine increases localizationISOPrkcd (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased localization of PRKCD proteinCTDPMID:17222441
PRKCDHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPrkcd (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PRKCD mRNACTDPMID:15251184 and PMID:33956508
PRKCDHuman2,6-dimethoxyphenol multiple interactionsEXP 6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in increased expression of and affects the localization of PRKCD proteinCTDPMID:38598786
PRKCDHuman2-butoxyethanol decreases expressionISOPrkcd (Mus musculus)6480464n-butoxyethanol results in decreased expression of PRKCD mRNACTDPMID:19812364
PRKCDHuman2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid multiple interactionsISOPrkcd (Rattus norvegicus)6480464anacardic acid inhibits the reaction [Paraquat results in increased cleavage of and results in increased activity of PRKCD protein]CTDPMID:21777615

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Biological Process
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Original Reference(s)
PRKCDHumanactivation of protein kinase activity involved_inIDA 150520179 PMID:10713049ParkinsonsUK-UCLPMID:10713049
PRKCDHumanapoptotic process involved_inIEAUniProtKB-KW:KW-0053150520179 UniProtGO_REF:0000043
PRKCDHumanapoptotic process involved_inIDA 150520179 PMID:10770950 and PMID:12649167UniProtPMID:10770950 and PMID:12649167
PRKCDHumanB cell proliferation acts_upstream_of_or_withinIEAUniProtKB:P28867 and ensembl:ENSMUSP00000107829150520179 EnsemblGO_REF:0000107
PRKCDHumancell chemotaxis involved_inIMP 150520179 PMID:24008408UniProtPMID:24008408
PRKCDHumancellular response to angiotensin involved_inIDA 150520179 PMID:18285462UniProtPMID:18285462
PRKCDHumancellular response to fatty acid involved_inTAS 150520179 PMID:14583092BHF-UCLPMID:14583092
PRKCDHumancellular response to glucose starvation  ISOPrkcd (Rattus norvegicus)9068941 RGDPMID:17728702 and REF_RGD_ID:1642520
PRKCDHumancellular response to hydrogen peroxide involved_inIDA 150520179 PMID:10713049ParkinsonsUK-UCLPMID:10713049
PRKCDHumancellular response to hydroperoxide involved_inIDA 150520179 PMID:19059439UniProtPMID:19059439
PRKCDHumancellular response to insulin stimulus  ISOPrkcd (Rattus norvegicus)9068941 RGDPMID:17046201 and REF_RGD_ID:1642545
PRKCDHumancellular response to oxidative stress involved_inISOPrkcd (Rattus norvegicus)9068941PMID:21696630CACAOPMID:21696630 and REF_RGD_ID:10047294
PRKCDHumancellular response to UV involved_inIDA 150520179 PMID:17303575UniProtPMID:17303575
PRKCDHumancellular senescence involved_inIMP 150520179 PMID:15282327BHF-UCLPMID:15282327
PRKCDHumancollagen metabolic process  ISOPrkcd (Rattus norvegicus)9068941 RGDPMID:17728702 and REF_RGD_ID:1642520
PRKCDHumanD-aspartate import across plasma membrane  ISOPrkcd (Rattus norvegicus)9068941 RGDPMID:17364745 and REF_RGD_ID:1642541
PRKCDHumandefense response to bacterium involved_inISSUniProtKB:P28867150520179 UniProtGO_REF:0000024
PRKCDHumandefense response to bacterium involved_inIEAUniProtKB:P28867 and ensembl:ENSMUSP00000107829150520179 EnsemblGO_REF:0000107
PRKCDHumanDNA damage response involved_inIMP 150520179 PMID:17938203UniProtPMID:17938203
PRKCDHumanFc-gamma receptor signaling pathway involved in phagocytosis involved_inTAS 150520179 ReactomeReactome:R-HSA-2029480
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Cellular Component
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Original Reference(s)
PRKCDHumanazurophil granule lumen located_inTAS 150520179 ReactomeReactome:R-HSA-6798751
PRKCDHumancell-cell junction located_inIEAUniProtKB:P28867 and ensembl:ENSMUSP00000107829150520179 EnsemblGO_REF:0000107
PRKCDHumancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
PRKCDHumancytoplasm located_inIEAUniProtKB:P28867 and ensembl:ENSMUSP00000107829150520179 EnsemblGO_REF:0000107
PRKCDHumancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
PRKCDHumancytoplasm located_inIDA 150520179 PMID:15632189 more ...UniProtPMID:15632189 more ...
PRKCDHumancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-111970 more ...
PRKCDHumancytosol located_inIDA 150520179 PMID:10770950 more ...UniProtGO_REF:0000052 more ...
PRKCDHumanendolysosome located_inIDA 150520179 PMID:17303575UniProtPMID:17303575
PRKCDHumanendomembrane system located_inIEAUniProtKB-SubCell:SL-0147150520179 UniProtGO_REF:0000044
PRKCDHumanendoplasmic reticulum located_inIDA 150520179 PMID:15774464 and PMID:18556656UniProtPMID:15774464 and PMID:18556656
PRKCDHumanextracellular exosome located_inHDA 150520179 PMID:19056867UniProtPMID:19056867
PRKCDHumanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-6798751
PRKCDHumanmembrane located_inIEAUniProtKB-SubCell:SL-0162150520179 UniProtGO_REF:0000044
PRKCDHumanmembrane located_inIEAUniProtKB:P28867 and ensembl:ENSMUSP00000107829150520179 EnsemblGO_REF:0000107
PRKCDHumanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
PRKCDHumanmitochondrion located_inIEAUniProtKB-SubCell:SL-0173150520179 UniProtGO_REF:0000044
PRKCDHumanmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
PRKCDHumannuclear matrix located_inIEAUniProtKB:P28867 and ensembl:ENSMUSP00000107829150520179 EnsemblGO_REF:0000107
PRKCDHumannucleoplasm located_inTAS 150520179 ReactomeReactome:R-HSA-450533
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Molecular Function
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PRKCDHumanATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
PRKCDHumanATP binding enablesIEAInterPro:IPR000719 more ...150520179 InterProGO_REF:0000002
PRKCDHumanATP binding enablesIEAUniRule:UR001503341150520179 UniProtGO_REF:0000104
PRKCDHumandiacylglycerol-dependent serine/threonine kinase activity enablesEXP 150520179 PMID:12391145 and PMID:18285462ReactomePMID:12391145 and PMID:18285462
PRKCDHumandiacylglycerol-dependent serine/threonine kinase activity enablesIEAEC:2.7.11.13150520179 UniProtGO_REF:0000003
PRKCDHumandiacylglycerol-dependent serine/threonine kinase activity enablesIEAARBA:ARBA00027157150520179 UniProtGO_REF:0000117
PRKCDHumandiacylglycerol-dependent serine/threonine kinase activity enablesTAS 150520179 ReactomeReactome:R-HSA-198314 more ...
PRKCDHumandiacylglycerol-dependent serine/threonine kinase activity enablesIEAInterPro:IPR014376 more ...150520179 InterProGO_REF:0000002
PRKCDHumandiacylglycerol-dependent, calcium-independent serine/threonine kinase activity  ISOPrkcd (Rattus norvegicus)9068941 RGDPMID:1915352 and REF_RGD_ID:1642551
PRKCDHumandiacylglycerol-dependent, calcium-independent serine/threonine kinase activity enablesIEAUniProtKB:P28867 and ensembl:ENSMUSP00000107829150520179 EnsemblGO_REF:0000107
PRKCDHumandiacylglycerol-dependent, calcium-independent serine/threonine kinase activity enablesISSUniProtKB:P28867150520179 UniProtGO_REF:0000024
PRKCDHumandiacylglycerol-dependent, calcium-independent serine/threonine kinase activity enablesTAS 150520179 PMID:14583092BHF-UCLPMID:14583092
PRKCDHumanenzyme activator activity enablesIDA 150520179 PMID:16611985UniProtPMID:16611985
PRKCDHumanenzyme binding enablesIPIUniProtKB:Q02880150520179 PMID:16611985UniProtPMID:16611985
PRKCDHumanenzyme binding enablesIPIUniProtKB:Q9HAW8150520179 PMID:18556656BHF-UCLPMID:18556656
PRKCDHumaninsulin receptor substrate binding enablesISSUniProtKB:P28867150520179 BHF-UCLGO_REF:0000024
PRKCDHumaninsulin receptor substrate binding enablesIEAUniProtKB:P28867 and ensembl:ENSMUSP00000107829150520179 EnsemblGO_REF:0000107
PRKCDHumankinase activity enablesIEAUniProtKB-KW:KW-0418150520179 UniProtGO_REF:0000043
PRKCDHumanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
PRKCDHumannon-membrane spanning protein tyrosine kinase activity enablesIEAEC:2.7.10.2150520179 UniProtGO_REF:0000003
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
PRKCDHumangonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGhsa:04912
PRKCDHumanneurotrophic factor signaling pathway  IEA 6907045 KEGGhsa:04722
PRKCDHumantype 2 diabetes mellitus pathway   IEA 6907045 KEGGhsa:04930

Imported Annotations - PID (archival)

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Original Reference(s)
PRKCDHumanAbsent isohemagglutinin level  IAGP 8699517 HPOMIM:615559
PRKCDHumanAlopecia  IAGP 8699517 HPOMIM:615559
PRKCDHumanAnticardiolipin IgG antibody positivity  IAGP 8699517 HPOMIM:615559
PRKCDHumanAntinuclear antibody positivity  IAGP 8699517 HPOMIM:615559
PRKCDHumanArthritis  IAGP 8699517 HPOMIM:615559
PRKCDHumanAutoimmune hemolytic anemia  IAGP 8699517 HPOMIM:615559
PRKCDHumanAutoimmune thrombocytopenia  IAGP 8699517 HPOMIM:615559
PRKCDHumanAutoimmunity  IAGP 8699517 HPOMIM:615559
PRKCDHumanAutosomal recessive inheritance  IAGP 8699517 HPOMIM:615559
PRKCDHumanDecreased circulating complement C3 concentration  IAGP 8699517 HPOMIM:615559
PRKCDHumanDecreased circulating complement C4 concentration  IAGP 8699517 HPOMIM:615559
PRKCDHumanDecreased proportion of class-switched memory B cells  IAGP 8699517 HPOMIM:615559
PRKCDHumanDecreased proportion of memory B cells  IAGP 8699517 HPOMIM:615559
PRKCDHumanElevated circulating alanine aminotransferase concentration  IAGP 8699517 HPOMIM:615559
PRKCDHumanElevated circulating aspartate aminotransferase concentration  IAGP 8699517 HPOMIM:615559
PRKCDHumanElevated circulating C-reactive protein concentration  IAGP 8699517 HPOMIM:615559
PRKCDHumanElevated erythrocyte sedimentation rate  IAGP 8699517 HPOMIM:615559
PRKCDHumanErythematous macule  IAGP 8699517 HPOMIM:615559
PRKCDHumanFollicular hyperplasia  IAGP 8699517 HPOMIM:615559
PRKCDHumanGeneralized lymphadenopathy  IAGP 8699517 HPOMIM:615559
1 to 20 of 42 rows

1 to 20 of 24 rows
#
Reference Title
Reference Citation
1. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Avignon A, etal., Diabetes. 1996 Oct;45(10):1396-404.
2. Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy. Braun MU, etal., Mol Cell Biochem. 2004 Jul;262(1-2):135-43.
3. DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Bright R, etal., Brain Res. 2007 May 4;1144:146-55. Epub 2007 Feb 2.
4. A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis. Calvert VS, etal., Hepatology. 2007 Jul;46(1):166-72.
5. Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats. Fareh J, etal., J Mol Cell Cardiol. 2000 Apr;32(4):665-76.
6. Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. Giles TD, etal., Am J Physiol. 1998 Jan;274(1 Pt 2):H295-307.
7. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
8. Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney. Ha H, etal., Am J Kidney Dis. 2001 Oct;38(4 Suppl 1):S204-7.
9. Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. Johnsen DD, etal., Mol Cell Biochem. 2005 Feb;270(1-2):63-9.
10. Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms. Karagulova G, etal., J Pharmacol Exp Ther. 2007 May;321(2):517-25. Epub 2007 Feb 22.
11. Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Kuriyama M, etal., Biochem Biophys Res Commun. 2004 Dec 17;325(3):843-51.
12. Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. Lam TK, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E682-91.
13. Obesity is associated with impaired ventricular protein kinase C-MAP kinase signaling and altered ANP mRNA expression in the heart of adult Zucker rats. Morabito D, etal., J Investig Med. 2001 Jul;49(4):310-8.
14. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
1 to 20 of 24 rows
1 to 10 of 60 rows
PMID:1677563   PMID:1694174   PMID:1832084   PMID:1848190   PMID:1939065   PMID:1970444   PMID:2139676   PMID:2182321   PMID:2984676   PMID:2987962   PMID:3259291   PMID:7543024  
PMID:7559455   PMID:7575560   PMID:7588787   PMID:7642615   PMID:7690989   PMID:7706316   PMID:7781068   PMID:7850771   PMID:7876252   PMID:7890750   PMID:7925449   PMID:7988719  
PMID:8089108   PMID:8188219   PMID:8206685   PMID:8357834   PMID:8429024   PMID:8473314   PMID:8599832   PMID:8621384   PMID:8621594   PMID:8627654   PMID:8647875   PMID:8810272  
PMID:8824244   PMID:8914829   PMID:8976194   PMID:8999860   PMID:8999969   PMID:9139733   PMID:9151826   PMID:9166747   PMID:9305920   PMID:9343414   PMID:9355737   PMID:9427282  
PMID:9446795   PMID:9671211   PMID:9679146   PMID:9705322   PMID:9735171   PMID:9748166   PMID:9771888   PMID:9774685   PMID:9804763   PMID:9819435   PMID:9832145   PMID:9857183  
PMID:9872331   PMID:10022904   PMID:10090741   PMID:10206975   PMID:10212259   PMID:10329716   PMID:10383400   PMID:10383403   PMID:10433554   PMID:10446219   PMID:10491200   PMID:10521505  
PMID:10542228   PMID:10542257   PMID:10628374   PMID:10641798   PMID:10646504   PMID:10698949   PMID:10713049   PMID:10737616   PMID:10770950   PMID:10831594   PMID:10843712   PMID:10945993  
PMID:10948194   PMID:11020388   PMID:11035810   PMID:11042191   PMID:11044099   PMID:11053353   PMID:11078718   PMID:11085981   PMID:11141237   PMID:11145703   PMID:11154208   PMID:11171046  
PMID:11266508   PMID:11278470   PMID:11335711   PMID:11350938   PMID:11352632   PMID:11381116   PMID:11389095   PMID:11415434   PMID:11438522   PMID:11463380   PMID:11466390   PMID:11502742  
PMID:11504923   PMID:11517230   PMID:11555640   PMID:11558579   PMID:11571229   PMID:11577086   PMID:11676480   PMID:11700305   PMID:11713246   PMID:11723252   PMID:11732925   PMID:11744693  
1 to 10 of 60 rows



PRKCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38353,161,209 - 53,192,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl353,156,009 - 53,192,717 (+)EnsemblGRCh38hg38GRCh38
GRCh37353,195,225 - 53,226,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,170,263 - 53,201,773 (+)NCBINCBI36Build 36hg18NCBI36
Build 34353,170,262 - 53,201,771NCBI
Celera353,162,239 - 53,193,756 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef353,210,511 - 53,276,026 (+)NCBIHuRef
CHM1_1353,146,796 - 53,178,291 (+)NCBICHM1_1
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBIT2T-CHM13v2.0
Prkcd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,317,310 - 30,348,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,317,311 - 30,348,167 (-)EnsemblGRCm39 Ensembl
GRCm381430,595,353 - 30,626,414 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,595,354 - 30,626,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,408,555 - 31,423,498 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,424,378 - 29,447,560 (-)NCBIMGSCv36mm8
Celera1426,853,019 - 26,867,962 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1418.82NCBI
Prkcd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8165,775,681 - 5,806,122 (-)NCBIGRCr8
mRatBN7.2165,769,217 - 5,799,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,769,215 - 5,799,352 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,781,205 - 5,811,322 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0166,926,659 - 6,956,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,779,783 - 5,809,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,655,131 - 6,675,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,588,990 - 6,608,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,954,218 - 5,975,743 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1165,954,214 - 5,975,741 (-)NCBI
Celera169,398,816 - 9,419,806 (+)NCBICelera
Cytogenetic Map16p16NCBI
Prkcd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554303,124,738 - 3,153,274 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554303,125,066 - 3,151,857 (+)NCBIChiLan1.0ChiLan1.0
PRKCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2253,157,598 - 53,189,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1353,162,376 - 53,193,855 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0353,104,137 - 53,135,588 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1354,330,328 - 54,357,910 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl354,330,328 - 54,357,910 (+)Ensemblpanpan1.1panPan2
PRKCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12036,723,491 - 36,751,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2036,723,809 - 36,752,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2036,660,459 - 36,673,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,001,697 - 37,030,998 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,001,704 - 37,031,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,438,983 - 36,452,419 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02036,800,686 - 36,814,133 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,015,742 - 37,029,186 (-)NCBIUU_Cfam_GSD_1.0
Prkcd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,754,028 - 170,788,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,892,366 - 3,923,515 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,892,625 - 3,923,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1335,290,610 - 35,323,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11335,290,835 - 35,323,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,361,707 - 38,390,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,561,401 - 14,592,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,565,282 - 14,592,873 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,302,998 - 152,334,406 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkcd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,033,130 - 4,059,555 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,035,819 - 4,062,907 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in PRKCD
510 total Variants

1 to 10 of 578 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_006254.4(PRKCD):c.1743+8C>T single nucleotide variant Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD [RCV000554360] Chr3:53189254 [GRCh38]
Chr3:53223270 [GRCh37]
Chr3:3p21.1		 benign
NM_006254.4(PRKCD):c.1926G>A (p.Ala642=) single nucleotide variant Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD [RCV000526084]|not provided [RCV001692189] Chr3:53192161 [GRCh38]
Chr3:53226177 [GRCh37]
Chr3:3p21.1		 benign
NM_006254.4(PRKCD):c.890G>A (p.Arg297Lys) single nucleotide variant Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD [RCV000544622] Chr3:53185605 [GRCh38]
Chr3:53219621 [GRCh37]
Chr3:3p21.1		 uncertain significance
NM_006254.4(PRKCD):c.1176G>A (p.Glu392=) single nucleotide variant Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD [RCV001395766]|PRKCD-related disorder [RCV003935520]|not provided [RCV004711182] Chr3:53186256 [GRCh38]
Chr3:53220272 [GRCh37]
Chr3:3p21.1		 likely benign
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3		 pathogenic
NM_006254.3(PRKCD):c.1934C>T (p.Ser645Phe) single nucleotide variant Malignant melanoma [RCV000060848] Chr3:53192169 [GRCh38]
Chr3:53226185 [GRCh37]
Chr3:53201225 [NCBI36]
Chr3:3p21.1		 not provided
NM_006254.4(PRKCD):c.1352+1G>A single nucleotide variant Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD [RCV000074607] Chr3:53186696 [GRCh38]
Chr3:53220712 [GRCh37]
Chr3:3p21.1		 pathogenic
NM_006254.4(PRKCD):c.1528G>A (p.Gly510Ser) single nucleotide variant Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD [RCV000144965] Chr3:53188832 [GRCh38]
Chr3:53222848 [GRCh37]
Chr3:3p21.1		 pathogenic|not provided
NM_006254.4(PRKCD):c.1840C>T (p.Arg614Trp) single nucleotide variant Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD [RCV000144966]|not provided [RCV003105796] Chr3:53189969 [GRCh38]
Chr3:53223985 [GRCh37]
Chr3:3p21.1		 pathogenic|likely pathogenic|uncertain significance|not provided
GRCh38/hg38 3p21.2-14.3(chr3:51394434-55064449)x1 copy number loss See cases [RCV000143631] Chr3:51394434..55064449 [GRCh38]
Chr3:51431865..55098476 [GRCh37]
Chr3:51406905..55073516 [NCBI36]
Chr3:3p21.2-14.3		 likely pathogenic
1 to 10 of 578 rows

Predicted Target Of
Summary Value
Count of predictions:1861
Count of miRNA genes:831
Interacting mature miRNAs:992
Transcripts:ENST00000330452, ENST00000394729, ENST00000464818, ENST00000477794, ENST00000478843, ENST00000487897
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 14 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597160086GWAS1256160_H3-aminoisobutyrate measurement QTL GWAS1256160 (human)0.0000053-aminoisobutyrate measurement35319204553192046Human
597059860GWAS1155934_Hadolescent idiopathic scoliosis QTL GWAS1155934 (human)1e-34adolescent idiopathic scoliosis35316506453165065Human
1298487BFD1_HBody fluid distribution QTL 1 (human)3.94Body fluid distributionimpedance ratio33638071262380712Human
597240592GWAS1336666_HBMI-adjusted waist circumference QTL GWAS1336666 (human)5e-10body size trait (VT:0100005)35319117753191178Human
1298489RA4_HRheumatoid arthritis QTL 4 (human)0.0283Joint/bone inflammationrheumatoid arthritis33638071262380712Human
1643509BW293_HBody Weight QTL 293 (human)1.42Body weightBMI33638071262380712Human
1331643COPD16_HChronic obstructive pulmonary disease QTL 16 (human)1.07Chronic airflow obstructionpost-BD FEV1 minus pre-BD FEV1/pre-BD FEV1 x 10034938065175380651Human
597049223GWAS1145297_HBMI-adjusted waist-hip ratio QTL GWAS1145297 (human)2e-10body size trait (VT:0100005)35318178353181784Human
597164459GWAS1260533_Hnon-alcoholic fatty liver disease QTL GWAS1260533 (human)5e-08non-alcoholic fatty liver disease35318635953186360Human
597063074GWAS1159148_HBMI-adjusted waist circumference QTL GWAS1159148 (human)0.0000008body size trait (VT:0100005)35317084853170849Human

1 to 10 of 14 rows
RH119270  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,187,311 - 53,187,601UniSTSGRCh37
Build 36353,162,351 - 53,162,641RGDNCBI36
Celera353,154,334 - 53,154,624RGD
Cytogenetic Map3p21.31UniSTS
HuRef353,236,636 - 53,236,926UniSTS
TNG Radiation Hybrid Map333104.0UniSTS
D2S2845  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,226,338 - 53,226,505UniSTSGRCh37
Build 36353,201,378 - 53,201,545RGDNCBI36
Celera353,193,360 - 53,193,527RGD
Cytogenetic Map3p21.31UniSTS
HuRef353,275,630 - 53,275,797UniSTS
RH12466  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,226,464 - 53,226,625UniSTSGRCh37
Build 36353,201,504 - 53,201,665RGDNCBI36
Celera353,193,486 - 53,193,647RGD
Cytogenetic Map3p21.31UniSTS
HuRef353,275,756 - 53,275,917UniSTS
GeneMap99-GB4 RH Map3164.74UniSTS
A007D36  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,226,574 - 53,226,727UniSTSGRCh37
Build 36353,201,614 - 53,201,767RGDNCBI36
Celera353,193,596 - 53,193,750RGD
Cytogenetic Map3p21.31UniSTS
HuRef353,275,866 - 53,276,020UniSTS
GeneMap99-GB4 RH Map3161.8UniSTS
PRKCD_2760  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,226,081 - 53,226,504UniSTSGRCh37
Build 36353,201,121 - 53,201,544RGDNCBI36
Celera353,193,103 - 53,193,526RGD
HuRef353,275,373 - 53,275,796UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 5 624 1950 465 2270 7304 6470 53 3734 1 852 1743 1617 174 1


1 to 30 of 31 rows
RefSeq Transcripts NG_033864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_212539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047448564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002959550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007095706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008486749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW293041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE048101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD369320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ516383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB775496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 31 rows

Ensembl Acc Id: ENST00000330452   ⟹   ENSP00000331602
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,161,209 - 53,192,717 (+)Ensembl
Ensembl Acc Id: ENST00000394729   ⟹   ENSP00000378217
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,161,120 - 53,192,717 (+)Ensembl
Ensembl Acc Id: ENST00000464818   ⟹   ENSP00000419629
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,165,129 - 53,184,973 (+)Ensembl
Ensembl Acc Id: ENST00000477794   ⟹   ENSP00000498857
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,161,241 - 53,178,537 (+)Ensembl
Ensembl Acc Id: ENST00000478843   ⟹   ENSP00000419726
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,156,009 - 53,179,694 (+)Ensembl
Ensembl Acc Id: ENST00000487897   ⟹   ENSP00000418106
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,161,521 - 53,181,267 (+)Ensembl
Ensembl Acc Id: ENST00000650739   ⟹   ENSP00000498623
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,161,356 - 53,192,558 (+)Ensembl
Ensembl Acc Id: ENST00000650940   ⟹   ENSP00000499184
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,168,741 - 53,184,971 (+)Ensembl
Ensembl Acc Id: ENST00000651505   ⟹   ENSP00000498262
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,181,260 - 53,192,577 (+)Ensembl
Ensembl Acc Id: ENST00000652449   ⟹   ENSP00000498400
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,161,217 - 53,192,487 (+)Ensembl
Ensembl Acc Id: ENST00000654719   ⟹   ENSP00000499558
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,168,797 - 53,192,454 (+)Ensembl
Ensembl Acc Id: ENST00000697588   ⟹   ENSP00000513355
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,161,526 - 53,192,622 (+)Ensembl
Ensembl Acc Id: ENST00000697589
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,182,546 - 53,192,677 (+)Ensembl
Ensembl Acc Id: ENST00000697590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl353,188,306 - 53,192,622 (+)Ensembl
RefSeq Acc Id: NM_001316327   ⟹   NP_001303256
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,161,507 - 53,192,717 (+)NCBI
CHM1_1353,147,110 - 53,178,291 (+)NCBI
T2T-CHM13v2.0353,194,417 - 53,225,596 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001354676   ⟹   NP_001341605
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,168,703 - 53,192,717 (+)NCBI
T2T-CHM13v2.0353,201,611 - 53,225,596 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001354678   ⟹   NP_001341607
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,168,703 - 53,192,717 (+)NCBI
T2T-CHM13v2.0353,201,611 - 53,225,596 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001354679   ⟹   NP_001341608
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,161,209 - 53,192,717 (+)NCBI
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001354680   ⟹   NP_001341609
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,161,209 - 53,192,717 (+)NCBI
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006254   ⟹   NP_006245
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,161,209 - 53,192,717 (+)NCBI
GRCh37353,195,223 - 53,226,733 (+)ENTREZGENE
Build 36353,170,263 - 53,201,773 (+)NCBI Archive
HuRef353,210,511 - 53,276,026 (+)ENTREZGENE
CHM1_1353,146,796 - 53,178,291 (+)NCBI
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBI
Sequence:
RefSeq Acc Id: NM_212539   ⟹   NP_997704
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,161,209 - 53,192,717 (+)NCBI
GRCh37353,195,223 - 53,226,733 (+)ENTREZGENE
Build 36353,170,263 - 53,201,773 (+)NCBI Archive
HuRef353,210,511 - 53,276,026 (+)ENTREZGENE
CHM1_1353,146,796 - 53,178,291 (+)NCBI
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047448564   ⟹   XP_047304520
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,162,482 - 53,192,717 (+)NCBI
RefSeq Acc Id: XR_007095706
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,168,703 - 53,186,693 (+)NCBI
RefSeq Acc Id: XR_008486749
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0353,201,611 - 53,219,599 (+)NCBI
1 to 5 of 20 rows
1 to 5 of 20 rows
RefSeq Acc Id: NP_006245   ⟸   NM_006254
- Peptide Label: isoform c
- UniProtKB: Q15144 (UniProtKB/Swiss-Prot),   B2R834 (UniProtKB/Swiss-Prot),   B0KZ81 (UniProtKB/Swiss-Prot),   Q86XJ6 (UniProtKB/Swiss-Prot),   Q05655 (UniProtKB/Swiss-Prot),   B4DFV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_997704   ⟸   NM_212539
- Peptide Label: isoform c
- UniProtKB: Q15144 (UniProtKB/Swiss-Prot),   B2R834 (UniProtKB/Swiss-Prot),   B0KZ81 (UniProtKB/Swiss-Prot),   Q86XJ6 (UniProtKB/Swiss-Prot),   Q05655 (UniProtKB/Swiss-Prot),   B4DFV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303256   ⟸   NM_001316327
- Peptide Label: isoform c
- UniProtKB: Q15144 (UniProtKB/Swiss-Prot),   B2R834 (UniProtKB/Swiss-Prot),   B0KZ81 (UniProtKB/Swiss-Prot),   Q86XJ6 (UniProtKB/Swiss-Prot),   Q05655 (UniProtKB/Swiss-Prot),   B4DFV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001341609   ⟸   NM_001354680
- Peptide Label: isoform c
- UniProtKB: Q15144 (UniProtKB/Swiss-Prot),   Q05655 (UniProtKB/Swiss-Prot),   B2R834 (UniProtKB/Swiss-Prot),   B0KZ81 (UniProtKB/Swiss-Prot),   Q86XJ6 (UniProtKB/Swiss-Prot),   B4DFV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001341608   ⟸   NM_001354679
- Peptide Label: isoform c
- UniProtKB: Q15144 (UniProtKB/Swiss-Prot),   Q05655 (UniProtKB/Swiss-Prot),   B2R834 (UniProtKB/Swiss-Prot),   B0KZ81 (UniProtKB/Swiss-Prot),   Q86XJ6 (UniProtKB/Swiss-Prot),   B4DFV1 (UniProtKB/TrEMBL)
- Sequence:
AGC-kinase C-terminal   C2   Phorbol-ester/DAG-type   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-Q05655-F1-model_v2 AlphaFold Q05655 1-676 view protein structure

RGD ID:6864732
Promoter ID:EPDNEW_H5531
Type:initiation region
Name:PRKCD_1
Description:protein kinase C delta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5532  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,161,217 - 53,161,277EPDNEW
RGD ID:6864734
Promoter ID:EPDNEW_H5532
Type:initiation region
Name:PRKCD_2
Description:protein kinase C delta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5531  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,168,741 - 53,168,801EPDNEW
RGD ID:6801451
Promoter ID:HG_KWN:45281
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000257818,   OTTHUMT00000257819,   OTTHUMT00000257820
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,170,099 - 53,170,599 (+)MPROMDB
RGD ID:6812371
Promoter ID:HG_ACW:54052
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:PRKCD.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,177,239 - 53,177,739 (+)MPROMDB
RGD ID:6801450
Promoter ID:HG_KWN:45282
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000394727,   UC003DGN.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,188,591 - 53,189,091 (+)MPROMDB
RGD ID:6815450
Promoter ID:HG_MRA:11072
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:AK130150
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,189,626 - 53,190,126 (+)MPROMDB
RGD ID:6801453
Promoter ID:HG_KWN:45283
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC010HMT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,191,811 - 53,192,837 (+)MPROMDB
RGD ID:6812372
Promoter ID:HG_ACW:54054
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:PRKCD.DAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,194,816 - 53,195,316 (+)MPROMDB
RGD ID:6812373
Promoter ID:HG_ACW:54055
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:PRKCD.FAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,195,376 - 53,197,477 (+)MPROMDB


1 to 40 of 74 rows
Database
Acc Id
Source(s)
COSMIC PRKCD COSMIC
Ensembl Genes ENSG00000163932 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000330452 ENTREZGENE
  ENST00000330452.8 UniProtKB/Swiss-Prot
  ENST00000394729 ENTREZGENE
  ENST00000394729.6 UniProtKB/Swiss-Prot
  ENST00000650739 ENTREZGENE
  ENST00000650739.1 UniProtKB/Swiss-Prot
  ENST00000652449 ENTREZGENE
  ENST00000652449.1 UniProtKB/Swiss-Prot
  ENST00000654719.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
GTEx ENSG00000163932 GTEx
HGNC ID HGNC:9399 ENTREZGENE
Human Proteome Map PRKCD Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  nPKC_delta UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PKC_delta UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kin_PKC_delta UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report hsa:5580 UniProtKB/Swiss-Prot
NCBI Gene 5580 ENTREZGENE
OMIM 176977 OMIM
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  PKC_C2 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
1 to 40 of 74 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 PRKCD  protein kinase C delta  PRKCD  protein kinase C, delta  Symbol and/or name change 5135510 APPROVED