PRKCD (protein kinase C delta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PRKCD (protein kinase C delta) Chlorocebus sabaeus
Analyze
Symbol: PRKCD
Name: protein kinase C delta
RGD ID: 18583957
Description: ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein kinase binding (ortholog); TIR domain binding (ortholog); INVOLVED IN B cell proliferation (ortholog); cellular response to glucose starvation (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN ceramide signaling pathway; eicosanoid signaling pathway; endothelin signaling pathway; ASSOCIATED WITH autoimmune lymphoproliferative syndrome type 3 (ortholog); brain ischemia (ortholog); Burns (ortholog); FOUND IN postsynaptic cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103228642; protein kinase C delta type; uncharacterized LOC103228642; uncharacterized protein LOC103228642
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,561,401 - 14,592,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,565,282 - 14,592,873 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,302,998 - 152,334,406 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
B cell proliferation  (IEA,ISO)
cell chemotaxis  (IEA)
cellular response to angiotensin  (IEA)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (IEA)
cellular response to hydroperoxide  (IEA)
cellular response to insulin stimulus  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to UV  (IEA)
cellular senescence  (IEA)
collagen metabolic process  (ISO)
D-aspartate import across plasma membrane  (ISO)
defense response to bacterium  (IEA)
DNA damage response  (IEA)
immunoglobulin mediated immune response  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
negative regulation of actin filament polymerization  (IEA)
negative regulation of filopodium assembly  (IEA)
negative regulation of glial cell apoptotic process  (IEA)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA)
negative regulation of platelet aggregation  (IEA)
neutrophil activation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of ceramide biosynthetic process  (IEA)
positive regulation of glucose import  (ISO)
positive regulation of glucosylceramide catabolic process  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of protein dephosphorylation  (IEA)
positive regulation of protein import into nucleus  (IEA)
positive regulation of sphingomyelin catabolic process  (IEA)
positive regulation of superoxide anion generation  (IEA)
post-translational protein modification  (IEA)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (IEA)
regulation of ceramide biosynthetic process  (IEA)
regulation of phosphorylation  (ISO)
regulation of primary metabolic process  (IEA)
response to amino acid  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
termination of signal transduction  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PRKCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,561,401 - 14,592,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,565,282 - 14,592,873 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,302,998 - 152,334,406 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PRKCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38353,161,209 - 53,192,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl353,156,009 - 53,192,717 (+)EnsemblGRCh38hg38GRCh38
GRCh37353,195,225 - 53,226,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,170,263 - 53,201,773 (+)NCBINCBI36Build 36hg18NCBI36
Build 34353,170,262 - 53,201,771NCBI
Celera353,162,239 - 53,193,756 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef353,210,511 - 53,276,026 (+)NCBIHuRef
CHM1_1353,146,796 - 53,178,291 (+)NCBICHM1_1
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBIT2T-CHM13v2.0
Prkcd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,317,310 - 30,348,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,317,311 - 30,348,167 (-)EnsemblGRCm39 Ensembl
GRCm381430,595,353 - 30,626,414 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,595,354 - 30,626,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,408,555 - 31,423,498 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,424,378 - 29,447,560 (-)NCBIMGSCv36mm8
Celera1426,853,019 - 26,867,962 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1418.82NCBI
Prkcd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8165,775,681 - 5,806,122 (-)NCBIGRCr8
mRatBN7.2165,769,217 - 5,799,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,769,215 - 5,799,352 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,781,205 - 5,811,322 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0166,926,659 - 6,956,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,779,783 - 5,809,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,655,131 - 6,675,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,588,990 - 6,608,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,954,218 - 5,975,743 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1165,954,214 - 5,975,741 (-)NCBI
Celera169,398,816 - 9,419,806 (+)NCBICelera
Cytogenetic Map16p16NCBI
Prkcd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554303,124,738 - 3,153,274 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554303,125,066 - 3,151,857 (+)NCBIChiLan1.0ChiLan1.0
PRKCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2253,157,598 - 53,189,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1353,162,376 - 53,193,855 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0353,104,137 - 53,135,588 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1354,330,328 - 54,357,910 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl354,330,328 - 54,357,910 (+)Ensemblpanpan1.1panPan2
PRKCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12036,723,491 - 36,751,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2036,723,809 - 36,752,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2036,660,459 - 36,673,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,001,697 - 37,030,998 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,001,704 - 37,031,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,438,983 - 36,452,419 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02036,800,686 - 36,814,133 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,015,742 - 37,029,186 (-)NCBIUU_Cfam_GSD_1.0
Prkcd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,754,028 - 170,788,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,892,366 - 3,923,515 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,892,625 - 3,923,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1335,290,610 - 35,323,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11335,290,835 - 35,323,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,361,707 - 38,390,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Prkcd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,033,130 - 4,059,555 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,035,819 - 4,062,907 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 6 4 25
Low 30 16 35
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011151   ⟹   ENSCSAP00000009231
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2214,565,282 - 14,592,873 (+)Ensembl
RefSeq Acc Id: XM_007984571   ⟹   XP_007982762
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12214,561,466 - 14,592,877 (+)NCBI
Vero_WHO_p1.0NW_023666041152,302,998 - 152,334,406 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007984572   ⟹   XP_007982763
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12214,561,401 - 14,592,877 (+)NCBI
Vero_WHO_p1.0NW_023666041152,302,998 - 152,334,404 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007982762 (Get FASTA)   NCBI Sequence Viewer  
  XP_007982763 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009231
  ENSCSAP00000009231.1
Reference Protein Sequences
RefSeq Acc Id: XP_007982763   ⟸   XM_007984572
- UniProtKB: A0A0D9RKU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982762   ⟸   XM_007984571
- UniProtKB: A0A0D9RKU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009231   ⟸   ENSCSAT00000011151


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013055 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011151.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  nPKC_delta UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PKC_delta UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kin_PKC_delta UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103227755 UniProtKB/TrEMBL
NCBI Gene PRKCD ENTREZGENE
PANTHER PROTEIN KINASE C DELTA TYPE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  PKC_C2 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF PKC_delta UniProtKB/TrEMBL
  Protein_kin_C_delta UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A0D9RKU2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 PRKCD  protein kinase C delta  LOC103228642  uncharacterized LOC103228642  Data merged from RGD:18496191 737654 PROVISIONAL