DTWD1 (DTW domain containing 1) - Rat Genome Database

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Gene: DTWD1 (DTW domain containing 1) Homo sapiens
Analyze
Symbol: DTWD1
Name: DTW domain containing 1
RGD ID: 1604324
HGNC Page HGNC:30926
Description: Enables tRNA-uridine aminocarboxypropyltransferase activity. Involved in tRNA modification. Located in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DTW domain-containing protein 1; MDS009; MGC111207; tRNA-uridine aminocarboxypropyltransferase 1; x 009 protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: DTWD1P1   DTWD1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381549,621,048 - 49,656,232 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1549,621,037 - 49,656,232 (+)EnsemblGRCh38hg38GRCh38
GRCh371549,913,245 - 49,948,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361547,700,575 - 47,723,154 (+)NCBINCBI36Build 36hg18NCBI36
Celera1526,806,460 - 26,830,571 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1526,744,825 - 26,768,953 (+)NCBIHuRef
CHM1_11550,031,231 - 50,055,328 (+)NCBICHM1_1
T2T-CHM13v2.01547,429,406 - 47,464,635 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DTWD1HumanBloom syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
DTWD1Humancolorectal cancer  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532

1 to 20 of 78 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DTWD1Human17alpha-ethynylestradiol decreases expressionISODtwd1 (Rattus norvegicus)6480464Ethinyl Estradiol results in decreased expression of DTWD1 mRNACTDPMID:17351261
DTWD1Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODtwd1 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DTWD1 promoter]CTDPMID:19654925
DTWD1Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISODtwd1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of DTWD1 mRNACTDPMID:32109520 and PMID:33387578
DTWD1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISODtwd1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of DTWD1 mRNACTDPMID:21570461
DTWD1Human2,4-dinitrotoluene affects expressionISODtwd1 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of DTWD1 mRNACTDPMID:21346803
DTWD1Human2-methylcholine affects expressionEXP 6480464beta-methylcholine affects the expression of DTWD1 mRNACTDPMID:21179406
DTWD1Human5-fluorouracil increases expressionEXP 6480464Fluorouracil results in increased expression of DTWD1 mRNACTDPMID:33770205
DTWD1Human6-propyl-2-thiouracil decreases expressionISODtwd1 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of DTWD1 mRNACTDPMID:30047161
DTWD1Humanacrolein multiple interactionsEXP 6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of DTWD1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of DTWD1 mRNACTDPMID:32699268
DTWD1Humanacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of DTWD1 mRNACTDPMID:32763439
DTWD1Humanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of DTWD1 geneCTDPMID:27153756
DTWD1Humanaflatoxin M1 decreases expressionEXP 6480464Aflatoxin M1 results in decreased expression of DTWD1 mRNACTDPMID:30928695
DTWD1Humanall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of DTWD1 mRNACTDPMID:33167477
DTWD1Humanalpha-pinene multiple interactionsEXP 6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of DTWD1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of DTWD1 mRNACTDPMID:32699268
DTWD1Humanamitrole decreases expressionISODtwd1 (Rattus norvegicus)6480464Amitrole results in decreased expression of DTWD1 mRNACTDPMID:30047161
DTWD1Humanarsenite(3-) multiple interactionsEXP 6480464arsenite promotes the reaction [G3BP1 protein binds to DTWD1 mRNA]CTDPMID:32406909
DTWD1Humanbenzo[a]pyrene multiple interactionsISODtwd1 (Mus musculus)6480464AHR protein affects the reaction [Benzo(a)pyrene affects the expression of DTWD1 mRNA]CTDPMID:22228805
DTWD1Humanbenzo[a]pyrene increases expressionISODtwd1 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of DTWD1 mRNACTDPMID:22228805
DTWD1Humanbisphenol A increases expressionISODtwd1 (Rattus norvegicus)6480464bisphenol A results in increased expression of DTWD1 mRNACTDPMID:25181051
DTWD1Humanbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Fulvestrant] results in increased methylation of DTWD1 geneCTDPMID:31601247

1 to 20 of 78 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DTWD1HumantRNA modification involved_inIDA 150520179 PMID:31804502UniProtPMID:31804502
DTWD1HumantRNA modification involved_inIBAPANTHER:PTN001037845 and UniProtKB:Q8N5C7150520179 GO_CentralGO_REF:0000033
DTWD1HumantRNA processing involved_inIEAUniProtKB-KW:KW-0819150520179 UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DTWD1Humannucleus located_inIDA 150520179 PMID:31804502UniProtPMID:31804502
DTWD1Humannucleus is_active_inIBAPANTHER:PTN001037845 and UniProtKB:Q8N5C7150520179 GO_CentralGO_REF:0000033
DTWD1Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
DTWD1Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DTWD1Humantransferase activity enablesIEAUniProtKB-KW:KW-0808150520179 UniProtGO_REF:0000043
DTWD1HumantRNA-uridine aminocarboxypropyltransferase activity enablesIDA 150520179 PMID:31804502UniProtPMID:31804502
DTWD1HumantRNA-uridine aminocarboxypropyltransferase activity enablesIBAPANTHER:PTN001037845 and UniProtKB:Q8N5C7150520179 GO_CentralGO_REF:0000033
DTWD1HumantRNA-uridine aminocarboxypropyltransferase activity enablesIEAEC:2.5.1.25150520179 UniProtGO_REF:0000003


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:21832049   PMID:21873635   PMID:22041458   PMID:26186194   PMID:28514442   PMID:29513927   PMID:29656893   PMID:31804502   PMID:31924336   PMID:32918875   PMID:33961781  



DTWD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381549,621,048 - 49,656,232 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1549,621,037 - 49,656,232 (+)EnsemblGRCh38hg38GRCh38
GRCh371549,913,245 - 49,948,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361547,700,575 - 47,723,154 (+)NCBINCBI36Build 36hg18NCBI36
Celera1526,806,460 - 26,830,571 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1526,744,825 - 26,768,953 (+)NCBIHuRef
CHM1_11550,031,231 - 50,055,328 (+)NCBICHM1_1
T2T-CHM13v2.01547,429,406 - 47,464,635 (+)NCBIT2T-CHM13v2.0
Dtwd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,993,981 - 126,007,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2125,994,061 - 126,007,199 (+)EnsemblGRCm39 Ensembl
GRCm382126,152,085 - 126,165,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,152,141 - 126,165,279 (+)EnsemblGRCm38mm10GRCm38
MGSCv372125,977,877 - 125,991,013 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362125,843,616 - 125,856,717 (+)NCBIMGSCv36mm8
Celera2127,398,624 - 127,411,787 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Dtwd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83133,845,768 - 133,859,965 (+)NCBIGRCr8
mRatBN7.23113,392,402 - 113,409,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,392,457 - 113,408,105 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,275,123 - 117,289,213 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03125,870,640 - 125,884,730 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,531,005 - 123,545,095 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03118,427,790 - 118,443,003 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3118,430,511 - 118,442,098 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,952,331 - 124,968,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43113,583,394 - 113,594,982 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13113,488,966 - 113,500,554 (+)NCBI
Celera3112,247,432 - 112,259,020 (+)NCBICelera
Cytogenetic Map3q36NCBI
Dtwd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,548,237 - 4,568,477 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,550,906 - 4,568,484 (-)NCBIChiLan1.0ChiLan1.0
DTWD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21638,870,365 - 38,906,282 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11543,054,277 - 43,089,582 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01528,578,698 - 28,602,840 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11546,902,304 - 46,926,401 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1546,902,304 - 46,926,401 (+)Ensemblpanpan1.1panPan2
DTWD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13015,683,586 - 15,704,485 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3015,683,624 - 15,704,410 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3015,610,406 - 15,631,308 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03015,827,392 - 15,848,293 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3015,827,430 - 15,848,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13015,750,729 - 15,771,630 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03015,866,166 - 15,887,066 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03015,972,718 - 15,993,621 (+)NCBIUU_Cfam_GSD_1.0
Dtwd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864093,949,498 - 94,034,573 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647111,799,825 - 11,817,712 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647111,799,811 - 11,817,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DTWD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,118,951 - 122,139,272 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11122,121,332 - 122,139,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,792,118 - 135,810,067 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DTWD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666048107,467,719 - 107,495,906 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dtwd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473110,338,503 - 10,356,048 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473110,340,001 - 10,360,918 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in DTWD1
18 total Variants

1 to 10 of 47 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 15q21.1-21.3(chr15:46042302-54195828)x1 copy number loss See cases [RCV000051619] Chr15:46042302..54195828 [GRCh38]
Chr15:46334500..54488025 [GRCh37]
Chr15:44121792..52275317 [NCBI36]
Chr15:15q21.1-21.3
pathogenic
GRCh38/hg38 15q21.1-21.3(chr15:48695331-53923002)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]|See cases [RCV000051620] Chr15:48695331..53923002 [GRCh38]
Chr15:48987528..54215199 [GRCh37]
Chr15:46774820..52002491 [NCBI36]
Chr15:15q21.1-21.3
pathogenic
GRCh38/hg38 15q21.1-21.2(chr15:47460844-52494222)x1 copy number loss See cases [RCV000135639] Chr15:47460844..52494222 [GRCh38]
Chr15:47753041..52786419 [GRCh37]
Chr15:45540333..50573711 [NCBI36]
Chr15:15q21.1-21.2
pathogenic
GRCh38/hg38 15q21.1-21.2(chr15:49064333-50176783)x1 copy number loss See cases [RCV000137613] Chr15:49064333..50176783 [GRCh38]
Chr15:49356530..50468980 [GRCh37]
Chr15:47143822..48256272 [NCBI36]
Chr15:15q21.1-21.2
uncertain significance
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q21.1-21.2(chr15:48940736-51309941)x1 copy number loss See cases [RCV000447625] Chr15:48940736..51309941 [GRCh37]
Chr15:15q21.1-21.2
uncertain significance
GRCh37/hg19 15q21.1-21.2(chr15:47574384-50369056)x1 copy number loss See cases [RCV000447640] Chr15:47574384..50369056 [GRCh37]
Chr15:15q21.1-21.2
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q15.1-21.2(chr15:41689327-52446981)x1 copy number loss See cases [RCV000448968] Chr15:41689327..52446981 [GRCh37]
Chr15:15q15.1-21.2
pathogenic
GRCh37/hg19 15q21.2(chr15:49656531-50165554)x3 copy number gain See cases [RCV000512119] Chr15:49656531..50165554 [GRCh37]
Chr15:15q21.2
likely benign
1 to 10 of 47 rows

Predicted Target Of
Summary Value
Count of predictions:2327
Count of miRNA genes:862
Interacting mature miRNAs:1016
Transcripts:ENST00000251250, ENST00000329873, ENST00000403028, ENST00000415425, ENST00000557968, ENST00000557988, ENST00000558653, ENST00000559164, ENST00000559223, ENST00000559405, ENST00000560632, ENST00000560735, ENST00000561188
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1643273BW330_HBody Weight QTL 330 (human)1.050.014Body weightbody mass index152686671952866719Human
1559411SCL107_HSerum cholesterol level QTL 107 (human)3.88Lipid leveltriglyceride152654355252543552Human
2299958PRSTS330_HProstate tumor susceptibility QTL 330 (human)1.020.0151Prostate tumor susceptibility153479023060790230Human
1559354LDLPS4_HLow density lipoprotein particle size QTL 4 (human)2.20.019LDL particle size153479023060790230Human
406944143GWAS593119_Htrait in response to buspirone, trait in response to citalopram, antidepressant-induced dizziness, response to antidepressant QTL GWAS593119 (human)0.0000005trait in response to buspirone, trait in response to citalopram, antidepressant-induced dizziness, response to antidepressant154964764949647650Human

RH98968  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371549,935,574 - 49,935,744UniSTSGRCh37
Build 361547,722,866 - 47,723,036RGDNCBI36
Celera1526,828,812 - 26,828,982RGD
Cytogenetic Map15q21.2UniSTS
HuRef1526,767,194 - 26,767,364UniSTS
GeneMap99-GB4 RH Map15167.92UniSTS
RH47894  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371549,936,641 - 49,936,779UniSTSGRCh37
Build 361547,723,933 - 47,724,071RGDNCBI36
Celera1526,829,879 - 26,830,017RGD
Cytogenetic Map15q21.2UniSTS
HuRef1526,768,261 - 26,768,399UniSTS
GeneMap99-GB4 RH Map15164.79UniSTS
SHGC-57453  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371549,936,939 - 49,937,270UniSTSGRCh37
Build 361547,724,231 - 47,724,562RGDNCBI36
Celera1526,830,177 - 26,830,508RGD
Cytogenetic Map15q21.2UniSTS
HuRef1526,768,559 - 26,768,890UniSTS
TNG Radiation Hybrid Map1515704.0UniSTS
RH48819  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371549,937,096 - 49,937,269UniSTSGRCh37
Build 361547,724,388 - 47,724,561RGDNCBI36
Celera1526,830,334 - 26,830,507RGD
Cytogenetic Map15q21.2UniSTS
HuRef1526,768,716 - 26,768,889UniSTS
GeneMap99-GB4 RH Map15167.92UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1


1 to 30 of 36 rows
RefSeq Transcripts NM_001144955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC018927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF168717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 36 rows

Ensembl Acc Id: ENST00000251250   ⟹   ENSP00000251250
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,099 - 49,656,232 (+)Ensembl
Ensembl Acc Id: ENST00000403028   ⟹   ENSP00000385399
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,048 - 49,656,232 (+)Ensembl
Ensembl Acc Id: ENST00000557968   ⟹   ENSP00000452628
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,037 - 49,629,967 (+)Ensembl
Ensembl Acc Id: ENST00000557988   ⟹   ENSP00000453686
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,074 - 49,643,657 (+)Ensembl
Ensembl Acc Id: ENST00000558653   ⟹   ENSP00000453529
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,065 - 49,643,610 (+)Ensembl
Ensembl Acc Id: ENST00000559164   ⟹   ENSP00000453071
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,080 - 49,634,614 (+)Ensembl
Ensembl Acc Id: ENST00000559223
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,045 - 49,634,730 (+)Ensembl
Ensembl Acc Id: ENST00000559405   ⟹   ENSP00000452685
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,085 - 49,632,177 (+)Ensembl
Ensembl Acc Id: ENST00000560632   ⟹   ENSP00000453649
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,082 - 49,634,595 (+)Ensembl
Ensembl Acc Id: ENST00000560735
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,080 - 49,631,060 (+)Ensembl
Ensembl Acc Id: ENST00000561188
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,621,069 - 49,625,521 (+)Ensembl
RefSeq Acc Id: NM_001144955   ⟹   NP_001138427
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,656,232 (+)NCBI
GRCh371549,913,226 - 49,937,333 (+)RGD
Celera1526,806,460 - 26,830,571 (+)RGD
HuRef1526,744,825 - 26,768,953 (+)ENTREZGENE
CHM1_11550,031,231 - 50,055,328 (+)NCBI
T2T-CHM13v2.01547,429,430 - 47,464,635 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020234   ⟹   NP_064619
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,656,232 (+)NCBI
GRCh371549,913,226 - 49,937,333 (+)RGD
Build 361547,700,575 - 47,723,154 (+)NCBI Archive
Celera1526,806,460 - 26,830,571 (+)RGD
HuRef1526,744,825 - 26,768,953 (+)ENTREZGENE
CHM1_11550,031,231 - 50,055,328 (+)NCBI
T2T-CHM13v2.01547,429,430 - 47,464,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011521815   ⟹   XP_011520117
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,656,232 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017022423   ⟹   XP_016877912
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,640,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017022424   ⟹   XP_016877913
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,640,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017022425   ⟹   XP_016877914
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,656,232 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017022426   ⟹   XP_016877915
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,656,232 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047432879   ⟹   XP_047288835
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,640,823 (+)NCBI
RefSeq Acc Id: XM_047432880   ⟹   XP_047288836
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,640,823 (+)NCBI
RefSeq Acc Id: XM_047432881   ⟹   XP_047288837
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,656,232 (+)NCBI
RefSeq Acc Id: XM_054378478   ⟹   XP_054234453
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01547,429,430 - 47,448,582 (+)NCBI
RefSeq Acc Id: XM_054378479   ⟹   XP_054234454
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01547,429,406 - 47,448,582 (+)NCBI
RefSeq Acc Id: XM_054378480   ⟹   XP_054234455
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01547,429,430 - 47,448,582 (+)NCBI
RefSeq Acc Id: XM_054378481   ⟹   XP_054234456
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01547,429,406 - 47,448,582 (+)NCBI
RefSeq Acc Id: XM_054378482   ⟹   XP_054234457
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01547,429,430 - 47,462,851 (+)NCBI
RefSeq Acc Id: XM_054378483   ⟹   XP_054234458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01547,429,416 - 47,462,851 (+)NCBI
RefSeq Acc Id: XM_054378484   ⟹   XP_054234459
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01547,429,430 - 47,462,851 (+)NCBI
RefSeq Acc Id: XM_054378485   ⟹   XP_054234460
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01547,429,417 - 47,462,851 (+)NCBI
1 to 30 of 33 rows
Protein RefSeqs NP_001138427 (Get FASTA)   NCBI Sequence Viewer  
  NP_064619 (Get FASTA)   NCBI Sequence Viewer  
  XP_011520117 (Get FASTA)   NCBI Sequence Viewer  
  XP_016877912 (Get FASTA)   NCBI Sequence Viewer  
  XP_016877913 (Get FASTA)   NCBI Sequence Viewer  
  XP_016877914 (Get FASTA)   NCBI Sequence Viewer  
  XP_016877915 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288835 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288836 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288837 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234453 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234454 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234455 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234456 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234457 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234458 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234459 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234460 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF87319 (Get FASTA)   NCBI Sequence Viewer  
  AAH18028 (Get FASTA)   NCBI Sequence Viewer  
  AAH32535 (Get FASTA)   NCBI Sequence Viewer  
  AAH93073 (Get FASTA)   NCBI Sequence Viewer  
  BAF82873 (Get FASTA)   NCBI Sequence Viewer  
  EAW77377 (Get FASTA)   NCBI Sequence Viewer  
  EAW77378 (Get FASTA)   NCBI Sequence Viewer  
  EAW77379 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000251250
  ENSP00000251250.6
  ENSP00000385399
  ENSP00000385399.3
1 to 30 of 33 rows
1 to 5 of 26 rows
1 to 5 of 26 rows
RefSeq Acc Id: NP_064619   ⟸   NM_020234
- UniProtKB: Q8WVG9 (UniProtKB/Swiss-Prot),   Q567Q3 (UniProtKB/Swiss-Prot),   Q9NRU6 (UniProtKB/Swiss-Prot),   Q8N5C7 (UniProtKB/Swiss-Prot),   A8K2B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138427   ⟸   NM_001144955
- UniProtKB: Q8WVG9 (UniProtKB/Swiss-Prot),   Q567Q3 (UniProtKB/Swiss-Prot),   Q9NRU6 (UniProtKB/Swiss-Prot),   Q8N5C7 (UniProtKB/Swiss-Prot),   A8K2B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011520117   ⟸   XM_011521815
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016877912   ⟸   XM_017022423
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016877914   ⟸   XM_017022425
- Peptide Label: isoform X2
- Sequence:
DTW

Name Modeler Protein Id AA Range Protein Structure
AF-Q8N5C7-F1-model_v2 AlphaFold Q8N5C7 1-304 view protein structure

RGD ID:6792237
Promoter ID:HG_KWN:21337
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000329873,   ENST00000354658,   NM_001144955,   NM_152647,   OTTHUMT00000254431,   UC001ZXM.2,   UC001ZXO.1,   UC001ZXP.2,   UC001ZXR.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361547,700,301 - 47,701,152 (+)MPROMDB
RGD ID:7229453
Promoter ID:EPDNEW_H20472
Type:initiation region
Name:DTWD1_1
Description:DTW domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,621,048 - 49,621,108EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
COSMIC DTWD1 COSMIC
Ensembl Genes ENSG00000104047 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000251250 ENTREZGENE
  ENST00000251250.7 UniProtKB/Swiss-Prot
  ENST00000403028 ENTREZGENE
  ENST00000403028.8 UniProtKB/Swiss-Prot
  ENST00000557968.5 UniProtKB/Swiss-Prot
  ENST00000558653.5 UniProtKB/Swiss-Prot
GTEx ENSG00000104047 GTEx
HGNC ID HGNC:30926 ENTREZGENE
Human Proteome Map DTWD1 Human Proteome Map
InterPro DTW UniProtKB/Swiss-Prot
  tRNA_Mod/Golgi_Maint UniProtKB/Swiss-Prot
KEGG Report hsa:56986 UniProtKB/Swiss-Prot
NCBI Gene 56986 ENTREZGENE
OMIM 621116 OMIM
PANTHER NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1 UniProtKB/Swiss-Prot
  TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1 UniProtKB/Swiss-Prot
Pfam DTW UniProtKB/Swiss-Prot
PharmGKB PA142671942 PharmGKB
SMART DTW UniProtKB/Swiss-Prot
UniProt A8K2B9 ENTREZGENE, UniProtKB/TrEMBL
  DTWD1_HUMAN UniProtKB/Swiss-Prot
  H0YK73_HUMAN UniProtKB/TrEMBL
  H0YL61_HUMAN UniProtKB/TrEMBL
  H0YML0_HUMAN UniProtKB/TrEMBL
  H0YMP4_HUMAN UniProtKB/TrEMBL
  Q567Q3 ENTREZGENE
  Q8N5C7 ENTREZGENE
  Q8WVG9 ENTREZGENE
  Q9NRU6 ENTREZGENE
UniProt Secondary Q567Q3 UniProtKB/Swiss-Prot
  Q8WVG9 UniProtKB/Swiss-Prot
  Q9NRU6 UniProtKB/Swiss-Prot
1 to 34 of 34 rows