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Gene: DLK1 (delta like non-canonical Notch ligand 1) Homo sapiens
Symbol: DLK1
Name: delta like non-canonical Notch ligand 1
Description: Predicted to have calcium ion binding activity. Involved in negative regulation of Notch signaling pathway. Localizes to extracellular space. Biomarker of biliary atresia and malignant glioma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: delta-like 1 homolog; delta-like 1 homolog (Drosophila); delta-like homolog (drosophila); Delta1; DLK; DLK-1; FA1; fetal antigen 1; pG2; preadipocyte factor 1; Pref-1; PREF1; protein delta homolog 1; secredeltin; ZOG
Mus musculus (house mouse) : Dlk1 (delta like non-canonical Notch ligand 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dlk1 (delta like non-canonical Notch ligand 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlk1 (delta like non-canonical Notch ligand 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DLK1 (delta like non-canonical Notch ligand 1)
Canis lupus familiaris (dog) : DLK1 (delta like non-canonical Notch ligand 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlk1 (delta like non-canonical Notch ligand 1)
Sus scrofa (pig) : DLK1 (delta like non-canonical Notch ligand 1)
Chlorocebus sabaeus (African green monkey) : DLK1 (delta like non-canonical Notch ligand 1)
Heterocephalus glaber (naked mole-rat) : Dlk1 (delta like non-canonical Notch ligand 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl14100,725,705 - 100,738,224 (+)EnsemblGRCh38hg38GRCh38
GRCh3814100,726,892 - 100,738,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714101,193,202 - 101,201,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,263,006 - 100,271,213 (+)NCBINCBI36hg18NCBI36
Build 3414100,263,005 - 100,271,210NCBI
Celera1481,247,286 - 81,255,551 (+)NCBI
Cytogenetic Map14q32.2NCBI
HuRef1481,373,717 - 81,381,968 (+)NCBIHuRef
CHM1_114101,130,974 - 101,142,342 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DLK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732542
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.