IL2 (interleukin 2) - Rat Genome Database

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Gene: IL2 (interleukin 2) Homo sapiens
Symbol: IL2
Name: interleukin 2
RGD ID: 730858
Description: Enables cytokine activity and interleukin-2 receptor binding activity. Involved in leukocyte activation involved in immune response; positive regulation of interleukin-17 production; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within negative regulation of B cell apoptotic process; positive regulation of B cell proliferation; and positive regulation of activated T cell proliferation. Predicted to be located in extracellular space. Implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including COVID-19; Zellweger syndrome; aggressive periodontitis; autoimmune disease (multiple); and uveitis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aldesleukin; IL-2; interleukin-2; involved in regulation of T-cell clonal expansion; lymphokine; T cell growth factor; TCGF
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl4122,451,470 - 122,456,725 (-)EnsemblGRCh38hg38GRCh38
GRCh384122,451,470 - 122,456,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374123,372,625 - 123,377,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,592,075 - 123,597,100 (-)NCBINCBI36hg18NCBI36
Build 344123,730,232 - 123,735,485NCBI
Celera4120,756,030 - 120,761,055 (-)NCBI
Cytogenetic Map4q27NCBI
HuRef4119,099,231 - 119,104,256 (-)NCBIHuRef
CHM1_14123,349,113 - 123,354,138 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (EXP)
Acute Lung Injury  (ISO)
adult T-cell leukemia  (EXP)
aggressive periodontitis  (IEP)
allergic contact dermatitis  (EXP)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (IDA,ISO)
Alzheimer's disease  (IDA,IEP)
Amebic Liver Abscess  (IEP)
amnestic disorder  (EXP)
anemia  (EXP)
anogenital venereal wart  (IEP)
Anorexia  (EXP)
Asthenia  (EXP)
asthma  (IAGP,IEP)
ataxia telangiectasia  (IDA)
atherosclerosis  (ISO)
atopic dermatitis  (IAGP,IDA,IEP,ISO)
atrial fibrillation  (IEP)
autistic disorder  (EXP)
autoimmune hepatitis  (EXP,IEP)
autoimmune thrombocytopenic purpura  (IAGP)
bacterial infectious disease  (IEP)
Behcet's disease  (IAGP)
birdshot chorioretinopathy  (IEP)
Brain Injuries  (EXP)
Brain Neoplasms  (EXP)
bullous pemphigoid  (IDA)
Carcinoma, Lewis Lung  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (IDA)
Choroidal Neovascularization  (IEP)
Chronic Hepatitis B  (IAGP)
Chronic Hepatitis C  (IEP)
colorectal carcinoma  (ISO)
Coronavirus infectious disease  (ISO)
cystitis  (ISO)
disease of cellular proliferation  (EXP)
drug allergy  (IDA)
Drug Eruptions  (EXP)
Entamoebiasis  (EXP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Uveoretinitis  (IDA,ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Melanoma  (IDA)
Experimental Neoplasms  (EXP)
Femoral Fractures  (ISO)
Fever  (EXP)
glioblastoma  (EXP)
glomerulonephritis  (EXP)
Graft vs Host Disease  (IDA,IMP)
Graves Ophthalmopathy  (IDA)
Graves' disease  (IDA)
head and neck squamous cell carcinoma  (IDA)
hepatitis B  (IEP)
hepatitis C  (IEP)
hepatocellular carcinoma  (IDA)
herpes zoster  (IEP)
high grade glioma  (IDA)
human immunodeficiency virus infectious disease  (EXP)
Human Influenza  (IEP)
Hyperalgesia  (ISO)
Hyperkinesis  (EXP)
Hypotension  (EXP)
inflammatory bowel disease  (ISS)
interstitial lung disease  (IDA)
juvenile rheumatoid arthritis  (IEP)
Kidney Neoplasms  (EXP)
Knee Osteoarthritis  (IEP)
leishmaniasis  (ISO)
leukemia  (EXP)
leukopenia  (EXP)
limited scleroderma  (IAGP)
liver cirrhosis  (ISO)
Liver Metastasis  (IDA)
Liver Neoplasms  (EXP)
lung disease  (IEP)
Lung Neoplasms  (EXP)
major depressive disorder  (EXP)
melanoma  (EXP)
Multi-Infarct Dementia  (IEP)
Neoplasm Metastasis  (EXP,IDA)
Neoplasm, Residual  (EXP)
nephrotic syndrome  (EXP)
Neurodevelopmental Disorders  (IAGP)
Neurogenic Inflammation  (ISO)
open-angle glaucoma  (IEP)
Oral Lichen Planus  (IDA)
oral squamous cell carcinoma  (IDA)
otitis media  (ISO)
Pain  (EXP)
pancreatic cancer  (IDA)
pemphigus  (IDA)
Perennial Allergic Rhinitis  (IEP)
post-traumatic stress disorder  (IEP)
primary immunodeficiency disease  (IDA)
Prostatic Neoplasms  (EXP)
psoriasis  (IEP)
renal cell carcinoma  (IDA)
rheumatoid arthritis  (IDA)
rhinitis  (IAGP)
sensorineural hearing loss  (IDA)
severe combined immunodeficiency  (IEP)
sinusitis  (IEP)
Sjogren's syndrome  (ISS)
squamous cell carcinoma  (IDA)
Staphylococcal Infections  (ISO)
systemic lupus erythematosus  (IDA)
systemic scleroderma  (IEP)
Takayasu's arteritis  (IAGP,IDA)
tongue squamous cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IDA,ISO)
urinary bladder cancer  (EXP,IDA)
uveitis  (IEP)
Vaginal Neoplasms  (EXP)
viral hepatitis  (IAGP)
vitiligo  (IEP)
Zellweger syndrome  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthaleneacetic acid  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (EXP)
2-ethylhexan-1-ol  (ISO)
2-tert-butylhydroquinone  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4'-epidoxorubicin  (ISO)
4'-hydroxydiclofenac  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-aminobenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroaniline  (EXP)
4-tolyl isocyanate  (ISO)
5'-S-methyl-5'-thioadenosine  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
7,12-dimethyltetraphene  (ISO)
7,8-dihydroxycoumarin  (ISO)
9-cis-retinoic acid  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (EXP)
actinomycin D  (EXP)
adenosine  (ISO)
alclometasone dipropionate  (EXP)
aldehydo-D-glucosamine  (ISO)
aldicarb  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alprazolam  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
amphotericin B  (EXP)
anethole  (ISO)
anthracen-2-amine  (EXP)
arjunolic acid  (ISO)
arotinoid acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
bathocuproine disulfonic acid  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzethonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (ISO)
berberine  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (EXP)
betamethasone valerate  (EXP)
betulin  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
boric acid  (ISO)
boron atom  (ISO)
bromodichloromethane  (ISO)
buprenorphine  (EXP)
butan-1-ol  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP)
calcitriol  (EXP,ISO)
cannabidiol  (ISO)
Cannabinol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
chloromethylisothiazolinone  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
choline  (ISO)
chromium(6+)  (EXP)
ciglitazone  (EXP)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
citral  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
coformycin  (ISO)
copper(II) nitrate  (EXP)
cortisol  (EXP)
coumestrol  (EXP)
crotonaldehyde  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dapsone  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibenzo[a,i]pyrene  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
dichlorvos  (ISO)
diclofenac  (EXP)
dieldrin  (EXP)
diethanolamine  (EXP)
digoxin  (EXP)
diiodine  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (ISO)
dimethyl sulfoxide  (EXP)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (EXP)
diphenylmethane-4,4'-diisocyanate  (ISO)
dipyridamole  (ISO)
doxorubicin  (ISO)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental boron  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
eugenol  (ISO)
famotidine  (ISO)
fenitrothion  (EXP,ISO)
fentanyl  (EXP)
ferric oxide  (ISO)
fluticasone  (EXP)
folic acid  (EXP)
formaldehyde  (EXP,ISO)
fragrance  (EXP)
fructose  (ISO)
fumigaclavine C  (ISO)
fumonisin B1  (ISO)
gamma-linolenic acid  (EXP)
Gastrodin  (ISO)
genistein  (ISO)
geranial  (EXP,ISO)
Goe 6976  (EXP)
graphite  (ISO)
heroin  (EXP)
hexachlorobenzene  (ISO)
histamine  (EXP,ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
imidurea  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP,ISO)
irinotecan  (ISO)
isoeugenol  (ISO)
isoniazide  (EXP)
isophorone diisocyanate  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
lead(II) chloride  (EXP)
lenalidomide  (EXP)
levamisole  (ISO)
linoleic acid  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium carbonate  (EXP)
lithium chloride  (ISO)
lithium hydride  (ISO)
loperamide  (EXP)
LY294002  (EXP)
lycopene  (ISO)
magnesium dihydroxide  (ISO)
malathion  (ISO)
malonaldehyde  (ISO)
mancozeb  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
MC1568  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP)
methadone  (EXP)
methanol  (EXP,ISO)
methiocarb  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl isocyanate  (EXP)
methylmercury chloride  (EXP)
mevinphos  (ISO)
microcystin-LR  (EXP)
mifepristone  (EXP,ISO)
minocycline  (EXP)
mitogen  (EXP,ISO)
mitomycin C  (EXP)
monocrotophos  (ISO)
Monocyte locomotion inhibitory factor  (EXP)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP,ISO)
mycophenolic acid  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
naloxone  (EXP)
naproxen  (ISO)
naringin  (ISO)
neocuproine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP)
nilotinib  (ISO)
nitrofurazone  (EXP)
Nivalenol  (EXP,ISO)
nonanoic acid  (ISO)
notoginsenoside R1  (ISO)
o-anisidine  (EXP)
ochratoxin A  (EXP)
oridonin  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (EXP)
Paeonol  (ISO)
paracetamol  (EXP)
paraoxon  (ISO)
paraquat  (ISO)
PCB138  (EXP)
PD 0325901  (EXP)
pentamidine  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenanthridone  (ISO)
phenethyl caffeate  (EXP)
phenyl benzoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic anhydride  (ISO)
piperazine  (EXP)
piperidine  (EXP,ISO)
piperine  (ISO)
poly(I:C)  (EXP,ISO)
pomalidomide  (EXP)
prednisolone  (ISO)
proanthocyanidin  (ISO)
progesterone  (EXP)
propanil  (ISO)
prostaglandin E2  (EXP)
pyrazoles  (EXP)
Pyridostigmine bromide  (ISO)
pyrimethamine  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ribavirin  (EXP,ISO)
rimexolone  (EXP)
rottlerin  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 203580  (EXP)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium acetate trihydrate  (EXP)
sodium arsenite  (EXP,ISO)
sodium bromate  (EXP)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium hexachloroplatinate  (ISO)
spironolactone  (EXP)
SR 144528  (EXP)
streptozocin  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sumatriptan  (ISO)
Sunset Yellow FCF  (ISO)
syringic acid  (EXP)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
Terfenadine  (EXP)
tert-butanol  (EXP)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-anethole  (ISO)
trans-caffeic acid  (ISO)
trans-isoeugenol  (ISO)
Tributyltin oxide  (ISO)
tributyrin  (EXP)
trichloroacetic acid  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triethanolamine  (EXP)
trimellitic anhydride  (ISO)
tropisetron  (ISO)
Tungsten carbide  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
verrucarin A  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
warfarin  (EXP)
zearalenone  (ISO)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
cell adhesion  (TAS)
cell-cell signaling  (TAS)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
gene expression  (IEA,ISO)
immune response  (TAS)
leukocyte activation involved in immune response  (IDA)
natural killer cell activation  (TAS)
negative regulation of apoptotic process  (TAS)
negative regulation of B cell apoptotic process  (IDA)
negative regulation of heart contraction  (IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of lymphocyte proliferation  (IEA,ISO)
negative regulation of protein phosphorylation  (IEA,ISO)
negative regulation of T-helper 17 cell differentiation  (IEA)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of B cell proliferation  (IDA)
positive regulation of cell growth  (TAS)
positive regulation of cell population proliferation  (TAS)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of dendritic spine development  (IEA,ISO)
positive regulation of immunoglobulin production  (IGI,ISO)
positive regulation of inflammatory response  (IC)
positive regulation of interferon-gamma production  (IEA,ISO)
positive regulation of interleukin-17 production  (IDA)
positive regulation of isotype switching to IgG isotypes  (IEA,ISO)
positive regulation of kinase activity  (IEA)
positive regulation of plasma cell differentiation  (IGI)
positive regulation of protein phosphorylation  (ISO)
positive regulation of regulatory T cell differentiation  (IEA,ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of tissue remodeling  (IC)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA,ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
regulation of T cell homeostatic proliferation  (IEA,ISO)
response to ethanol  (IEA,ISO)
T cell differentiation  (TAS)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype

References - curated
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PMID:24887424   PMID:24919928   PMID:24999042   PMID:24999842   PMID:25001463   PMID:25036364   PMID:25056899   PMID:25080789   PMID:25088788   PMID:25089268   PMID:25122797   PMID:25173083  
PMID:25210803   PMID:25234720   PMID:25240755   PMID:25253569   PMID:25271022   PMID:25292096   PMID:25309925   PMID:25322151   PMID:25341640   PMID:25347332   PMID:25377634   PMID:25416216  
PMID:25424734   PMID:25481744   PMID:25516298   PMID:25560300   PMID:25577895   PMID:25626682   PMID:25672398   PMID:25672756   PMID:25736261   PMID:25743240   PMID:25747600   PMID:25753532  
PMID:25784743   PMID:25809376   PMID:25966134   PMID:25991472   PMID:26026122   PMID:26046454   PMID:26085358   PMID:26086100   PMID:26116899   PMID:26152718   PMID:26186194   PMID:26281156  
PMID:26293045   PMID:26396258   PMID:26403459   PMID:26440592   PMID:26457438   PMID:26492563   PMID:26498252   PMID:26561569   PMID:26572555   PMID:26609634   PMID:26654556   PMID:26722428  
PMID:26751822   PMID:26771888   PMID:26917059   PMID:26928938   PMID:26934083   PMID:26952371   PMID:27040810   PMID:27145859   PMID:27155816   PMID:27193732   PMID:27195783   PMID:27206670  
PMID:27235588   PMID:27255473   PMID:27322555   PMID:27356894   PMID:27450011   PMID:27519475   PMID:27560779   PMID:27563819   PMID:27601468   PMID:27630356   PMID:27697858   PMID:27708334  
PMID:27718431   PMID:27748271   PMID:27819269   PMID:27848966   PMID:27901054   PMID:28142109   PMID:28159384   PMID:28268223   PMID:28274688   PMID:28295230   PMID:28377612   PMID:28429264  
PMID:28458166   PMID:28471123   PMID:28486207   PMID:28507024   PMID:28514442   PMID:28551309   PMID:28645874   PMID:28646040   PMID:28655861   PMID:28685527   PMID:28694325   PMID:28713071  
PMID:28716814   PMID:28750002   PMID:28802832   PMID:28838891   PMID:28843235   PMID:28916655   PMID:28922104   PMID:29246655   PMID:29250766   PMID:29257244   PMID:29288086   PMID:29313232  
PMID:29400002   PMID:29443657   PMID:29491471   PMID:29636345   PMID:29664031   PMID:29677473   PMID:29691298   PMID:29724678   PMID:29911835   PMID:29980618   PMID:29993342   PMID:30072687  
PMID:30089912   PMID:30104686   PMID:30120106   PMID:30139310   PMID:30150979   PMID:30205963   PMID:30550567   PMID:30721117   PMID:30729267   PMID:30944470   PMID:30973108   PMID:31006082  
PMID:31012357   PMID:31101173   PMID:31101174   PMID:31262730   PMID:31344552   PMID:31388197   PMID:31393896   PMID:31483515   PMID:31519598   PMID:31869309   PMID:31906759   PMID:31978095  
PMID:32006876   PMID:32054394   PMID:32075624   PMID:32225009   PMID:32432788   PMID:32599588   PMID:32620160   PMID:32795376   PMID:33004937   PMID:33145806   PMID:33163049   PMID:33169590  
PMID:33413198   PMID:33432230   PMID:33787515   PMID:33917265   PMID:34360753  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl4122,451,470 - 122,456,725 (-)EnsemblGRCh38hg38GRCh38
GRCh384122,451,470 - 122,456,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374123,372,625 - 123,377,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,592,075 - 123,597,100 (-)NCBINCBI36hg18NCBI36
Build 344123,730,232 - 123,735,485NCBI
Celera4120,756,030 - 120,761,055 (-)NCBI
Cytogenetic Map4q27NCBI
HuRef4119,099,231 - 119,104,256 (-)NCBIHuRef
CHM1_14123,349,113 - 123,354,138 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39337,174,862 - 37,180,103 (-)NCBIGRCm39mm39
GRCm39 Ensembl337,174,672 - 37,180,108 (-)Ensembl
GRCm38337,120,713 - 37,125,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,120,523 - 37,125,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,019,635 - 37,024,876 (-)NCBIGRCm37mm9NCBIm37
MGSCv36337,312,271 - 37,317,502 (-)NCBImm8
Celera337,007,247 - 37,012,480 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.3NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22120,004,862 - 120,009,566 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2120,004,862 - 120,009,566 (-)Ensembl
Rnor_6.02123,847,150 - 123,851,854 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,847,150 - 123,851,854 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,460,866 - 143,465,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,655,005 - 123,659,709 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12123,599,966 - 123,604,671 (-)NCBI
Celera2114,959,889 - 114,964,593 (-)NCBICelera
Cytogenetic Map2q25NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542818,162,467 - 18,168,265 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,163,010 - 18,168,157 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.14125,782,563 - 125,787,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,782,563 - 125,787,984 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04114,637,328 - 114,642,586 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11917,750,780 - 17,756,394 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,750,780 - 17,756,394 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,968,837 - 17,974,439 (+)NCBI
ROS_Cfam_1.01917,869,103 - 17,874,712 (+)NCBI
UMICH_Zoey_3.11917,821,680 - 17,827,284 (+)NCBI
UNSW_CanFamBas_1.01918,101,949 - 18,107,555 (+)NCBI
UU_Cfam_GSD_1.01918,572,248 - 18,577,858 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530165,520,154 - 65,524,908 (+)NCBI
SpeTri2.0NW_0049366621,594,953 - 1,599,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl8101,640,944 - 101,645,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,640,938 - 101,645,683 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,797,437 - 108,802,149 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1769,729,635 - 69,736,279 (-)NCBI
ChlSab1.1 Ensembl769,730,282 - 69,734,969 (-)Ensembl
Vero_WHO_p1.0NW_02366603748,691,838 - 48,697,094 (-)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247772,885,537 - 2,890,453 (-)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,373,579 - 123,373,821UniSTSGRCh37
Build 364123,593,029 - 123,593,271RGDNCBI36
Celera4120,756,984 - 120,757,226RGD
Cytogenetic Map4q26-q27UniSTS
HuRef4119,100,185 - 119,100,427UniSTS
TNG Radiation Hybrid Map476674.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,375,618 - 123,375,944UniSTSGRCh37
Build 364123,595,068 - 123,595,394RGDNCBI36
Celera4120,759,023 - 120,759,349RGD
Cytogenetic Map4q26-q27UniSTS
HuRef4119,102,224 - 119,102,550UniSTS
TNG Radiation Hybrid Map476677.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,374,283 - 123,374,641UniSTSGRCh37
Build 364123,593,733 - 123,594,091RGDNCBI36
Celera4120,757,688 - 120,758,046RGD
Cytogenetic Map4q26-q27UniSTS
HuRef4119,100,889 - 119,101,247UniSTS
GeneMap99-GB4 RH Map4560.59UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,377,573 - 123,378,007UniSTSGRCh37
Build 364123,597,023 - 123,597,457RGDNCBI36
Celera4120,760,978 - 120,761,412RGD
Cytogenetic Map4q26-q27UniSTS
HuRef4119,104,179 - 119,104,613UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,372,890 - 123,372,989UniSTSGRCh37
Build 364123,592,340 - 123,592,439RGDNCBI36
Celera4120,756,295 - 120,756,394RGD
HuRef4119,099,496 - 119,099,595UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,372,707 - 123,372,906UniSTSGRCh37
Build 364123,592,157 - 123,592,356RGDNCBI36
Celera4120,756,112 - 120,756,311RGD
Cytogenetic Map4q26-q27UniSTS
HuRef4119,099,313 - 119,099,512UniSTS
TNG Radiation Hybrid Map476660.0UniSTS
Stanford-G3 RH Map46912.0UniSTS
Whitehead-YAC Contig Map4 UniSTS
GeneMap99-G3 RH Map46858.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q26-q27UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,372,519 - 123,372,972UniSTSGRCh37
Celera4120,755,924 - 120,756,377UniSTS
HuRef4119,099,125 - 119,099,578UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q26-q27UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR181Chsa-miR-181c-5pMirtarbaseexternal_infoReporter assay;qRT-PCR;OtherFunctional MTI21112091

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:124
Interacting mature miRNAs:126
Transcripts:ENST00000226730, ENST00000477645
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
Medium 2 1 1 1
Low 162 56 114 15 237 14 60 2 14 22 57 266 1 80 26
Below cutoff 838 746 643 228 492 156 1295 200 568 129 606 833 73 499 740


Nucleotide Sequences
RefSeq Transcripts NG_016779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A14844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC022489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF031845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF359939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF532913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ006884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY283686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY523040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ847559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ231169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ861285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM863577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC025835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S82692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U25676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X01586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000226730   ⟹   ENSP00000226730
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4122,451,470 - 122,456,725 (-)Ensembl
RefSeq Acc Id: ENST00000477645
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4122,451,718 - 122,456,440 (-)Ensembl
RefSeq Acc Id: NM_000586   ⟹   NP_000577
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh384122,451,470 - 122,456,725 (-)NCBI
GRCh374123,372,625 - 123,377,650 (-)ENTREZGENE
Build 364123,592,075 - 123,597,100 (-)NCBI Archive
HuRef4119,099,231 - 119,104,256 (-)ENTREZGENE
CHM1_14123,349,113 - 123,354,138 (-)NCBI
Protein Sequences
Protein RefSeqs NP_000577 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA59139 (Get FASTA)   NCBI Sequence Viewer  
  AAA59140 (Get FASTA)   NCBI Sequence Viewer  
  AAA59141 (Get FASTA)   NCBI Sequence Viewer  
  AAA70092 (Get FASTA)   NCBI Sequence Viewer  
  AAA98792 (Get FASTA)   NCBI Sequence Viewer  
  AAB46883 (Get FASTA)   NCBI Sequence Viewer  
  AAB86861 (Get FASTA)   NCBI Sequence Viewer  
  AAD14263 (Get FASTA)   NCBI Sequence Viewer  
  AAD14264 (Get FASTA)   NCBI Sequence Viewer  
  AAD48509 (Get FASTA)   NCBI Sequence Viewer  
  AAG53575 (Get FASTA)   NCBI Sequence Viewer  
  AAH66254 (Get FASTA)   NCBI Sequence Viewer  
  AAH66255 (Get FASTA)   NCBI Sequence Viewer  
  AAH66256 (Get FASTA)   NCBI Sequence Viewer  
  AAH66257 (Get FASTA)   NCBI Sequence Viewer  
  AAH70338 (Get FASTA)   NCBI Sequence Viewer  
  AAK26665 (Get FASTA)   NCBI Sequence Viewer  
  AAM97916 (Get FASTA)   NCBI Sequence Viewer  
  AAP35033 (Get FASTA)   NCBI Sequence Viewer  
  AAS17753 (Get FASTA)   NCBI Sequence Viewer  
  ABB20900 (Get FASTA)   NCBI Sequence Viewer  
  ABI20697 (Get FASTA)   NCBI Sequence Viewer  
  BAG70139 (Get FASTA)   NCBI Sequence Viewer  
  BAG70268 (Get FASTA)   NCBI Sequence Viewer  
  CAA01199 (Get FASTA)   NCBI Sequence Viewer  
  CAA07317 (Get FASTA)   NCBI Sequence Viewer  
  CAA23827 (Get FASTA)   NCBI Sequence Viewer  
  CAA25292 (Get FASTA)   NCBI Sequence Viewer  
  CAA25742 (Get FASTA)   NCBI Sequence Viewer  
  CAA47701 (Get FASTA)   NCBI Sequence Viewer  
  CAH18032 (Get FASTA)   NCBI Sequence Viewer  
  CAT16485 (Get FASTA)   NCBI Sequence Viewer  
  CBH19848 (Get FASTA)   NCBI Sequence Viewer  
  CBX47490 (Get FASTA)   NCBI Sequence Viewer  
  EAX05227 (Get FASTA)   NCBI Sequence Viewer  
  P60568 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_000577   ⟸   NM_000586
- Peptide Label: precursor
- UniProtKB: P60568 (UniProtKB/Swiss-Prot),   Q0GK43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000226730   ⟸   ENST00000226730

RGD ID:6868416
Promoter ID:EPDNEW_H7373
Type:single initiation site
Description:interleukin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh384122,456,492 - 122,456,552EPDNEW
RGD ID:6802382
Promoter ID:HG_KWN:49057
SO ACC ID:SO:0000170
Tissues & Cell Lines:CD4+TCell
Transcripts:OTTHUMT00000256715,   OTTHUMT00000316449
Human AssemblyChrPosition (strand)Source
Build 364123,596,686 - 123,597,186 (-)MPROMDB
RGD ID:6850116
Promoter ID:EP07114
Type:single initiation site
Description:Interleukin-2, T-cell growth factor, IL2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database,
Notes:homology_group=Homology group 47; Mammalian interleukin-2
Experiment Methods:Primer extension
Regulation:T (repressed by or weakly expressed in) lymphocytes; (induced by or strongly expressed in) antigen
Human AssemblyChrPosition (strand)Source
Build 364123,597,097 - 123,597,157EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
GRCh38/hg38 4q26-31.21(chr4:116630862-145429900)x1 copy number loss See cases [RCV000053321] Chr4:116630862..145429900 [GRCh38]
Chr4:117552018..146351052 [GRCh37]
Chr4:117771466..146570502 [NCBI36]
NM_000586.3(IL2):c.226C>T (p.Leu76Phe) single nucleotide variant Malignant melanoma [RCV000060907] Chr4:122453835 [GRCh38]
Chr4:123374990 [GRCh37]
Chr4:123594440 [NCBI36]
not provided
GRCh38/hg38 4q26-28.3(chr4:117351881-133565667)x1 copy number loss See cases [RCV000143207] Chr4:117351881..133565667 [GRCh38]
Chr4:118273037..134486822 [GRCh37]
Chr4:118492485..134706272 [NCBI36]
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
GRCh37/hg19 4q26-28.2(chr4:116307857-129302960)x1 copy number loss not provided [RCV000682448] Chr4:116307857..129302960 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
GRCh37/hg19 4q27(chr4:123090820-123377483)x3 copy number gain not provided [RCV000743948] Chr4:123090820..123377483 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Single allele deletion Neurodevelopmental disorder [RCV000787448] Chr4:116624547..126168646 [GRCh37]
likely pathogenic
GRCh37/hg19 4q26-28.2(chr4:116833638-130232122) copy number loss Behavioral abnormality [RCV001352657] Chr4:116833638..130232122 [GRCh37]

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6001 AgrOrtholog
Ensembl Genes ENSG00000109471 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000226730 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000226730 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000109471 GTEx
Human Proteome Map IL2 Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3558 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
OMIM 147680 OMIM
Pfam IL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA195 PharmGKB
SMART IL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt IL2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q13169_HUMAN UniProtKB/TrEMBL
UniProt Secondary P01585 UniProtKB/Swiss-Prot