Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: IL2 (interleukin 2) Homo sapiens
Symbol: IL2
Name: interleukin 2
RGD ID: 730858
Description: Exhibits cytokine activity and interleukin-2 receptor binding activity. Involved in several processes, including negative regulation of B cell apoptotic process; positive regulation of lymphocyte proliferation; and positive regulation of macromolecule metabolic process. Predicted to localize to extracellular space. Implicated in several diseases, including auditory system disease (multiple); autoimmune hypersensitivity disease (multiple); carcinoma (multiple); dermatitis (multiple); and vasculitis (multiple). Biomarker of several diseases, including COVID-19; Zellweger syndrome; aggressive periodontitis; autoimmune hypersensitivity disease (multiple); and uveitis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aldesleukin; IL-2; interleukin-2; involved in regulation of T-cell clonal expansion; lymphokine; T cell growth factor; TCGF
Mus musculus (house mouse) : Il2 (interleukin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il2 (interleukin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2 (interleukin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2 (interleukin 2)
Canis lupus familiaris (dog) : IL2 (interleukin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2 (interleukin 2)
Sus scrofa (pig) : IL2 (interleukin 2)
Chlorocebus sabaeus (African green monkey) : IL2 (interleukin 2)
Heterocephalus glaber (naked mole-rat) : Il2 (interleukin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl4122,451,470 - 122,456,725 (-)EnsemblGRCh38hg38GRCh38
GRCh384122,451,470 - 122,456,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374123,372,625 - 123,377,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,592,075 - 123,597,100 (-)NCBINCBI36hg18NCBI36
Build 344123,730,232 - 123,735,485NCBI
Celera4120,756,030 - 120,761,055 (-)NCBI
Cytogenetic Map4q27NCBI
HuRef4119,099,231 - 119,104,256 (-)NCBIHuRef
CHM1_14123,349,113 - 123,354,138 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IL2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730858
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.