TTK (TTK protein kinase) - Rat Genome Database

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Gene: TTK (TTK protein kinase) Homo sapiens
Analyze
Symbol: TTK
Name: TTK protein kinase
RGD ID: 1313655
HGNC Page HGNC
Description: Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Predicted to be involved in several processes, including negative regulation of metaphase/anaphase transition of cell cycle; peptidyl-serine phosphorylation; and protein localization to kinetochore. Predicted to act upstream of or within female meiosis chromosome segregation; protein localization to organelle; and protein phosphorylation. Located in cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cancer/testis antigen 96; CT96; dual specificity protein kinase TTK; ESK; FLJ38280; monopolar spindle 1 kinase; monopolar spindle 1-like 1; MPH1; MPS1; MPS1L1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase; PYT
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl680,003,887 - 80,042,527 (+)EnsemblGRCh38hg38GRCh38
GRCh38680,004,147 - 80,042,651 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37680,714,366 - 80,752,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36680,771,078 - 80,808,958 (+)NCBINCBI36hg18NCBI36
Build 34680,771,077 - 80,808,956NCBI
Celera681,132,293 - 81,170,226 (+)NCBI
Cytogenetic Map6q14.1NCBI
HuRef677,937,044 - 77,974,979 (+)NCBIHuRef
CHM1_1680,811,776 - 80,849,705 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (EXP)
3-methylcholanthrene  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (EXP)
aristolochic acid  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbon nanotube  (EXP)
cefaloridine  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
cryptolepine  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
Deguelin  (EXP)
deoxynivalenol  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
Enterolactone  (EXP)
etoposide  (EXP)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (ISO)
genistein  (EXP)
geraniol  (EXP)
GW 4064  (EXP)
irinotecan  (EXP)
kojic acid  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
lucanthone  (EXP)
methamphetamine  (ISO)
methylseleninic acid  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nickel atom  (EXP)
nickel dichloride  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
phytoestrogen  (EXP)
picoxystrobin  (EXP)
piroxicam  (EXP)
potassium chromate  (EXP)
propanal  (EXP)
pyrimidifen  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
rotenone  (EXP,ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
temozolomide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
thifluzamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP)
vincaleukoblastine  (EXP)
vinclozolin  (ISO)
zoledronic acid  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1639825   PMID:1956325   PMID:7678926   PMID:7737118   PMID:9311822   PMID:10366450   PMID:11799066   PMID:11927556   PMID:12351790   PMID:12477932   PMID:12686615   PMID:14657364  
PMID:14702039   PMID:15304323   PMID:15618221   PMID:16080195   PMID:16344560   PMID:16446370   PMID:16864798   PMID:17210994   PMID:17268814   PMID:17388661   PMID:17439397   PMID:17452325  
PMID:17573779   PMID:17728254   PMID:17784873   PMID:17804818   PMID:17981789   PMID:17998396   PMID:18071315   PMID:18082144   PMID:18083840   PMID:18243099   PMID:18452554   PMID:18480048  
PMID:18541701   PMID:18680479   PMID:18794806   PMID:18923149   PMID:19015317   PMID:19018011   PMID:19120698   PMID:19151762   PMID:19273613   PMID:19274768   PMID:19332559   PMID:19459850  
PMID:19530738   PMID:19946888   PMID:20057968   PMID:20100468   PMID:20360068   PMID:20422024   PMID:20467437   PMID:20508983   PMID:20624898   PMID:20624899   PMID:20624901   PMID:20624902  
PMID:20729194   PMID:20861309   PMID:20884615   PMID:20937696   PMID:20980622   PMID:21163887   PMID:21402910   PMID:21475725   PMID:21533207   PMID:21587233   PMID:21778823   PMID:21832049  
PMID:21873635   PMID:21900206   PMID:22045814   PMID:22430208   PMID:22658674   PMID:22660415   PMID:22732840   PMID:22935710   PMID:22939629   PMID:23067341   PMID:23321637   PMID:23383273  
PMID:23388454   PMID:23510141   PMID:23531678   PMID:23569217   PMID:23700430   PMID:23726842   PMID:23933817   PMID:24108125   PMID:24151075   PMID:24187132   PMID:24282275   PMID:24462521  
PMID:24613305   PMID:24764296   PMID:24859455   PMID:24905462   PMID:24934155   PMID:25063032   PMID:25137017   PMID:25246613   PMID:25265012   PMID:25468996   PMID:25731686   PMID:25886724  
PMID:25921289   PMID:25991676   PMID:26068854   PMID:26068855   PMID:26186194   PMID:26202014   PMID:26240331   PMID:26354417   PMID:26398286   PMID:26418879   PMID:26487511   PMID:26496610  
PMID:26531827   PMID:26586430   PMID:26637805   PMID:26638075   PMID:26675261   PMID:26804907   PMID:26953350   PMID:26972000   PMID:27339139   PMID:27383047   PMID:27522003   PMID:27618777  
PMID:27833085   PMID:28072388   PMID:28380042   PMID:28514442   PMID:28718761   PMID:28726638   PMID:28751540   PMID:28759042   PMID:28777004   PMID:28883705   PMID:28986522   PMID:29078282  
PMID:29229926   PMID:29380674   PMID:29395067   PMID:29449217   PMID:29509190   PMID:29568061   PMID:29721084   PMID:30111590   PMID:30463901   PMID:30582207   PMID:30784592   PMID:30785839  
PMID:30890647   PMID:31024071   PMID:31091453   PMID:31253867   PMID:31462741   PMID:31519766   PMID:31586073   PMID:31605696   PMID:31607131   PMID:31720873   PMID:31732153   PMID:31961339  
PMID:32121246   PMID:32219319   PMID:32686724   PMID:32694731   PMID:32877691   PMID:32969465   PMID:33277362   PMID:33282948   PMID:33957083   PMID:34079125  


Genomics

Comparative Map Data
TTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl680,003,887 - 80,042,527 (+)EnsemblGRCh38hg38GRCh38
GRCh38680,004,147 - 80,042,651 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37680,714,366 - 80,752,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36680,771,078 - 80,808,958 (+)NCBINCBI36hg18NCBI36
Build 34680,771,077 - 80,808,956NCBI
Celera681,132,293 - 81,170,226 (+)NCBI
Cytogenetic Map6q14.1NCBI
HuRef677,937,044 - 77,974,979 (+)NCBIHuRef
CHM1_1680,811,776 - 80,849,705 (+)NCBICHM1_1
Ttk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39983,716,704 - 83,754,443 (+)NCBIGRCm39mm39
GRCm39 Ensembl983,716,742 - 83,754,442 (+)Ensembl
GRCm38983,834,651 - 83,872,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl983,834,689 - 83,872,389 (+)EnsemblGRCm38mm10GRCm38
MGSCv37983,728,296 - 83,765,997 (+)NCBIGRCm37mm9NCBIm37
MGSCv36983,631,459 - 83,669,102 (+)NCBImm8
Celera980,934,680 - 80,972,688 (+)NCBICelera
Cytogenetic Map9E2NCBI
Ttk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2884,754,329 - 84,792,653 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl884,754,315 - 84,792,651 (+)Ensembl
Rnor_6.0891,368,065 - 91,405,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl891,368,111 - 91,405,993 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0890,886,724 - 90,924,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4888,906,665 - 88,944,613 (+)NCBIRGSC3.4rn4RGSC3.4
Celera884,402,963 - 84,441,218 (+)NCBICelera
Cytogenetic Map8q31NCBI
Ttk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555027,824,194 - 7,866,879 (+)NCBIChiLan1.0ChiLan1.0
TTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1681,158,143 - 81,196,478 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl681,158,143 - 81,196,478 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0677,887,382 - 77,925,737 (+)NCBIMhudiblu_PPA_v0panPan3
TTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11240,915,733 - 40,959,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1240,915,439 - 40,957,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1240,787,409 - 40,829,802 (+)NCBI
ROS_Cfam_1.01241,678,975 - 41,721,444 (+)NCBI
UMICH_Zoey_3.11240,992,362 - 41,034,814 (+)NCBI
UNSW_CanFamBas_1.01240,969,244 - 41,011,626 (+)NCBI
UU_Cfam_GSD_1.01241,120,015 - 41,162,453 (+)NCBI
Ttk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494676,256,203 - 76,303,738 (+)NCBI
SpeTri2.0NW_00493651010,176,968 - 10,213,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,076,583 - 86,125,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,076,576 - 86,125,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2196,781,685 - 96,828,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,738,849 - 4,779,563 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl134,738,959 - 4,780,627 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040180,959,238 - 181,026,938 (+)NCBIVero_WHO_p1.0
Ttk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248196,631,697 - 6,682,181 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH1535  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37680,751,923 - 80,752,144UniSTSGRCh37
Build 36680,808,642 - 80,808,863RGDNCBI36
Celera681,169,905 - 81,170,126RGD
Cytogenetic Map6q13-q21UniSTS
HuRef677,974,658 - 77,974,879UniSTS
TTK_7894  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37680,751,863 - 80,752,335UniSTSGRCh37
Build 36680,808,582 - 80,809,054RGDNCBI36
Celera681,169,845 - 81,170,317RGD
HuRef677,974,598 - 77,975,070UniSTS
D6S2407  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37680,747,538 - 80,747,694UniSTSGRCh37
Build 36680,804,257 - 80,804,413RGDNCBI36
Celera681,165,516 - 81,165,672RGD
Cytogenetic Map6q13-q21UniSTS
HuRef677,970,269 - 77,970,425UniSTS
Marshfield Genetic Map689.83UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR376A2hsa-miR-376a-3pTarbaseexternal_infoReporter GenePOSITIVE
MIR376A1hsa-miR-376a-3pTarbaseexternal_infoReporter GenePOSITIVE

Predicted Target Of
Summary Value
Count of predictions:883
Count of miRNA genes:512
Interacting mature miRNAs:549
Transcripts:ENST00000230510, ENST00000369798, ENST00000430061, ENST00000502580, ENST00000504040, ENST00000504590, ENST00000509313, ENST00000509894, ENST00000511260, ENST00000515751
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 168 15 59 47 634 51 264 56 102 75 625 275 9 1 2
Low 790 317 511 199 670 124 1452 54 123 166 294 571 77 203 716 3
Below cutoff 1419 2561 1118 348 629 262 2405 1796 3407 172 529 761 87 1 996 1838

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001166691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK095599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU154042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX775733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA853919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM619913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA807018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA807081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA885921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA886355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA886789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA887223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB234920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB243620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB254235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB257208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB264129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB276749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB311560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB313850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB318844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB359909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB819644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB820078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000230510   ⟹   ENSP00000230510
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,004,147 - 80,042,527 (+)Ensembl
RefSeq Acc Id: ENST00000369798   ⟹   ENSP00000358813
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,004,649 - 80,042,527 (+)Ensembl
RefSeq Acc Id: ENST00000430061
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,005,941 - 80,011,553 (+)Ensembl
RefSeq Acc Id: ENST00000502580   ⟹   ENSP00000424851
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,004,710 - 80,008,440 (+)Ensembl
RefSeq Acc Id: ENST00000504040   ⟹   ENSP00000427483
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,005,802 - 80,010,871 (+)Ensembl
RefSeq Acc Id: ENST00000504590
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,037,553 - 80,040,271 (+)Ensembl
RefSeq Acc Id: ENST00000509313   ⟹   ENSP00000421406
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,004,650 - 80,008,416 (+)Ensembl
RefSeq Acc Id: ENST00000509894   ⟹   ENSP00000422936
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,003,887 - 80,042,527 (+)Ensembl
RefSeq Acc Id: ENST00000511260   ⟹   ENSP00000421636
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,004,834 - 80,008,475 (+)Ensembl
RefSeq Acc Id: ENST00000515751
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,013,455 - 80,027,950 (+)Ensembl
RefSeq Acc Id: ENST00000627129   ⟹   ENSP00000487202
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl680,005,844 - 80,007,838 (+)Ensembl
RefSeq Acc Id: NM_001166691   ⟹   NP_001160163
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38680,004,649 - 80,042,527 (+)NCBI
GRCh37680,714,322 - 80,752,244 (+)ENTREZGENE
HuRef677,937,044 - 77,974,979 (+)ENTREZGENE
CHM1_1680,811,776 - 80,849,705 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003318   ⟹   NP_003309
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38680,004,649 - 80,042,527 (+)NCBI
GRCh37680,714,322 - 80,752,244 (+)ENTREZGENE
Build 36680,771,078 - 80,808,958 (+)NCBI Archive
HuRef677,937,044 - 77,974,979 (+)ENTREZGENE
CHM1_1680,811,776 - 80,849,705 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011536099   ⟹   XP_011534401
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38680,004,147 - 80,042,651 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011536100   ⟹   XP_011534402
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38680,004,628 - 80,042,651 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017011242   ⟹   XP_016866731
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38680,004,147 - 80,042,651 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001160163 (Get FASTA)   NCBI Sequence Viewer  
  NP_003309 (Get FASTA)   NCBI Sequence Viewer  
  XP_011534401 (Get FASTA)   NCBI Sequence Viewer  
  XP_011534402 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866731 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH00633 (Get FASTA)   NCBI Sequence Viewer  
  AAH32858 (Get FASTA)   NCBI Sequence Viewer  
  BAF85149 (Get FASTA)   NCBI Sequence Viewer  
  BAG38059 (Get FASTA)   NCBI Sequence Viewer  
  CAA49912 (Get FASTA)   NCBI Sequence Viewer  
  CAE11566 (Get FASTA)   NCBI Sequence Viewer  
  CAV33297 (Get FASTA)   NCBI Sequence Viewer  
  CCO75436 (Get FASTA)   NCBI Sequence Viewer  
  CCO75438 (Get FASTA)   NCBI Sequence Viewer  
  CCQ77693 (Get FASTA)   NCBI Sequence Viewer  
  CCQ77702 (Get FASTA)   NCBI Sequence Viewer  
  CCQ77711 (Get FASTA)   NCBI Sequence Viewer  
  CCQ77720 (Get FASTA)   NCBI Sequence Viewer  
  CDH48199 (Get FASTA)   NCBI Sequence Viewer  
  CDH61621 (Get FASTA)   NCBI Sequence Viewer  
  CDH61675 (Get FASTA)   NCBI Sequence Viewer  
  CDH61694 (Get FASTA)   NCBI Sequence Viewer  
  CDH88992 (Get FASTA)   NCBI Sequence Viewer  
  CDH92530 (Get FASTA)   NCBI Sequence Viewer  
  CDH92544 (Get FASTA)   NCBI Sequence Viewer  
  CDH92555 (Get FASTA)   NCBI Sequence Viewer  
  CDH92802 (Get FASTA)   NCBI Sequence Viewer  
  CDH92899 (Get FASTA)   NCBI Sequence Viewer  
  CDI44674 (Get FASTA)   NCBI Sequence Viewer  
  CDI44683 (Get FASTA)   NCBI Sequence Viewer  
  EAW48699 (Get FASTA)   NCBI Sequence Viewer  
  EAW48700 (Get FASTA)   NCBI Sequence Viewer  
  P33981 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001160163   ⟸   NM_001166691
- Peptide Label: isoform 2
- UniProtKB: P33981 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_003309   ⟸   NM_003318
- Peptide Label: isoform 1
- UniProtKB: P33981 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011534402   ⟸   XM_011536100
- Peptide Label: isoform X2
- UniProtKB: P33981 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011534401   ⟸   XM_011536099
- Peptide Label: isoform X1
- UniProtKB: P33981 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866731   ⟸   XM_017011242
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000424851   ⟸   ENST00000502580
RefSeq Acc Id: ENSP00000427483   ⟸   ENST00000504040
RefSeq Acc Id: ENSP00000230510   ⟸   ENST00000230510
RefSeq Acc Id: ENSP00000421406   ⟸   ENST00000509313
RefSeq Acc Id: ENSP00000487202   ⟸   ENST00000627129
RefSeq Acc Id: ENSP00000422936   ⟸   ENST00000509894
RefSeq Acc Id: ENSP00000421636   ⟸   ENST00000511260
RefSeq Acc Id: ENSP00000358813   ⟸   ENST00000369798
Protein Domains
Protein kinase

Promoters
RGD ID:7208563
Promoter ID:EPDNEW_H10028
Type:initiation region
Name:TTK_1
Description:TTK protein kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38680,004,650 - 80,004,710EPDNEW
RGD ID:6804902
Promoter ID:HG_KWN:54190
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001166691,   NM_003318,   OTTHUMT00000041317
Position:
Human AssemblyChrPosition (strand)Source
Build 36680,770,161 - 80,771,072 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001166691.1(TTK):c.918C>T (p.Cys306=) single nucleotide variant Malignant melanoma [RCV000067474] Chr6:80013300 [GRCh38]
Chr6:80723017 [GRCh37]
Chr6:80779736 [NCBI36]
Chr6:6q14.1
not provided
GRCh38/hg38 6q14.1-14.2(chr6:78912019-84096427)x1 copy number loss See cases [RCV000137752] Chr6:78912019..84096427 [GRCh38]
Chr6:79621736..84806146 [GRCh37]
Chr6:79678455..84862865 [NCBI36]
Chr6:6q14.1-14.2
uncertain significance
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1
pathogenic
GRCh38/hg38 6q12-14.2(chr6:64549655-83426791)x1 copy number loss See cases [RCV000142527] Chr6:64549655..83426791 [GRCh38]
Chr6:65259548..84136510 [GRCh37]
Chr6:65316269..84193229 [NCBI36]
Chr6:6q12-14.2
pathogenic
GRCh38/hg38 6q14.1(chr6:78661176-80245532)x1 copy number loss See cases [RCV000143199] Chr6:78661176..80245532 [GRCh38]
Chr6:79370893..80955249 [GRCh37]
Chr6:79427612..81011968 [NCBI36]
Chr6:6q14.1
uncertain significance
GRCh38/hg38 6q14.1-16.1(chr6:75926199-92710793)x1 copy number loss See cases [RCV000143505] Chr6:75926199..92710793 [GRCh38]
Chr6:76635916..93420511 [GRCh37]
Chr6:76692636..93477232 [NCBI36]
Chr6:6q14.1-16.1
pathogenic
NM_003318.5(TTK):c.2089G>T (p.Asp697Tyr) single nucleotide variant Pancreatic Neoplasms [RCV000423313] Chr6:80038006 [GRCh38]
Chr6:80747723 [GRCh37]
Chr6:6q14.1
likely pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q13-14.2(chr6:73674612-84829774)x1 copy number loss not provided [RCV000682681] Chr6:73674612..84829774 [GRCh37]
Chr6:6q13-14.2
pathogenic
GRCh37/hg19 6q14.1(chr6:80480799-81040515)x3 copy number gain not provided [RCV000682687] Chr6:80480799..81040515 [GRCh37]
Chr6:6q14.1
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_003318.5(TTK):c.615A>G (p.Ala205=) single nucleotide variant not provided [RCV000925235] Chr6:80011435 [GRCh38]
Chr6:80721152 [GRCh37]
Chr6:6q14.1
likely benign
NM_003318.5(TTK):c.2392+9T>A single nucleotide variant not provided [RCV000969784] Chr6:80040289 [GRCh38]
Chr6:80750006 [GRCh37]
Chr6:6q14.1
benign
NM_003318.5(TTK):c.1230G>A (p.Pro410=) single nucleotide variant not provided [RCV000971527] Chr6:80022445 [GRCh38]
Chr6:80732162 [GRCh37]
Chr6:6q14.1
benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6q14.1(chr6:78216253-82753743)x3 copy number gain not provided [RCV000846973] Chr6:78216253..82753743 [GRCh37]
Chr6:6q14.1
uncertain significance
GRCh37/hg19 6q14.1(chr6:80557845-80897919)x1 copy number loss not provided [RCV000845729] Chr6:80557845..80897919 [GRCh37]
Chr6:6q14.1
uncertain significance
NM_003318.5(TTK):c.1269C>G (p.Thr423=) single nucleotide variant not provided [RCV000955362] Chr6:80026389 [GRCh38]
Chr6:80736106 [GRCh37]
Chr6:6q14.1
likely benign
NM_003318.5(TTK):c.2467A>C (p.Asn823His) single nucleotide variant not provided [RCV000888599] Chr6:80040680 [GRCh38]
Chr6:80750397 [GRCh37]
Chr6:6q14.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12401 AgrOrtholog
COSMIC TTK COSMIC
Ensembl Genes ENSG00000112742 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000230510 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000358813 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000421406 UniProtKB/TrEMBL
  ENSP00000421636 UniProtKB/TrEMBL
  ENSP00000422936 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000424851 UniProtKB/TrEMBL
  ENSP00000427483 UniProtKB/TrEMBL
  ENSP00000487202 UniProtKB/TrEMBL
Ensembl Transcript ENST00000230510 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000369798 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000502580 UniProtKB/TrEMBL
  ENST00000504040 UniProtKB/TrEMBL
  ENST00000509313 UniProtKB/TrEMBL
  ENST00000509894 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000511260 UniProtKB/TrEMBL
  ENST00000627129 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000112742 GTEx
HGNC ID HGNC:12401 ENTREZGENE
Human Proteome Map TTK Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kin_Mps1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7272 UniProtKB/Swiss-Prot
NCBI Gene 7272 ENTREZGENE
OMIM 604092 OMIM
PANTHER PTHR22974:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB PA37066 PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
UniProt D6REX1_HUMAN UniProtKB/TrEMBL
  D6RF82_HUMAN UniProtKB/TrEMBL
  D6RFY1_HUMAN UniProtKB/TrEMBL
  D6RIC6_HUMAN UniProtKB/TrEMBL
  P33981 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K8U5 UniProtKB/Swiss-Prot
  B2RDW2 UniProtKB/Swiss-Prot
  E1P543 UniProtKB/Swiss-Prot
  Q15272 UniProtKB/Swiss-Prot
  Q5TCS0 UniProtKB/Swiss-Prot
  Q9BW51 UniProtKB/Swiss-Prot
  Q9NTM0 UniProtKB/Swiss-Prot