VTN (vitronectin) - Rat Genome Database

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Gene: VTN (vitronectin) Homo sapiens
Analyze
Symbol: VTN
Name: vitronectin
RGD ID: 736955
HGNC Page HGNC:12724
Description: Enables integrin binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of vascular endothelial growth factor signaling pathway; and smooth muscle cell-matrix adhesion. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Part of peptidase inhibitor complex and protein complex involved in cell-matrix adhesion. Implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Biomarker of coronary artery disease and diabetic retinopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: complement S-protein; epibolin; S-protein; serum spreading factor; serum-spreading factor; somatomedin B; V75; vitronectin (serum spreading factor, somatomedin B, complement S-protein); VN; VNT
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,367,284 - 28,370,307 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,367,284 - 28,373,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,694,305 - 26,697,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,718,425 - 23,721,500 (-)NCBINCBI36Build 36hg18NCBI36
Build 341723,718,424 - 23,721,844NCBI
Celera1723,556,056 - 23,559,131 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,902,707 - 22,905,782 (-)NCBIHuRef
CHM1_11726,757,231 - 26,760,306 (-)NCBICHM1_1
T2T-CHM13v2.01729,309,135 - 29,312,158 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows

  
Object Symbol
Species
Term
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Evidence
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Reference
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Source
Original Reference(s)
VTNHumanAlveolar Bone Loss treatmentISORGD:3967329956421associated with periodontal diseaseRGD 
VTNHumanChurg-Strauss syndrome  IDA 1580817 RGD 
VTNHumancoronary artery disease  IEP 1580816 RGD 
VTNHumanDiabetic Nephropathies  ISORGD:396710003096associated with Diabetes Mellitus, Experimental;protein:increased expression:glomerulusRGD 
VTNHumandiabetic retinopathy  IEP 1580818 RGD 
VTNHumandiabetic retinopathy  ISORGD:396710040982associated with Diabetes Mellitus, ExperimentalRGD 
VTNHumanExperimental Seizures  ISORGD:396710003102 RGD 
VTNHumangranulomatosis with polyangiitis  IDA 1580817 RGD 
VTNHumanproteinuria  ISORGD:396710003089associated with Mesangial Proliferative GlomerulonephritisRGD 
VTNHumanRadiation Pneumonitis  IEP 5129484Protein: increased expression: plasmaRGD 
VTNHumanthrombosis  IDA 1580815 RGD 
1 to 11 of 11 rows
Object Symbol
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Original Reference(s)
VTNHumanCrohn's disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19751734
VTNHumanliver cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:26396155

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Object Symbol
Species
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Reference
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Original Reference(s)
VTNHuman(+)-catechin multiple interactionsEXP 6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of VTN mRNACTDPMID:24763279
VTNHuman(1->4)-beta-D-glucan multiple interactionsISORGD:7369566480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of VTN mRNACTDPMID:36331819
VTNHuman1,3,5-trinitro-1,3,5-triazinane decreases expressionISORGD:39676480464cyclonite results in decreased expression of VTN mRNACTDPMID:25559034
VTNHuman17beta-estradiol multiple interactionsEXP 6480464[Progesterone co-treated with Estradiol] results in increased expression of VTN mRNACTDPMID:20226447
VTNHuman17beta-estradiol multiple interactionsISORGD:39676480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of VTN mRNACTDPMID:32741896
VTNHuman17beta-estradiol increases expressionISORGD:7369566480464Estradiol results in increased expression of VTN mRNACTDPMID:39298647
VTNHuman17beta-estradiol 3-benzoate multiple interactionsISORGD:39676480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of VTN mRNACTDPMID:32741896
VTNHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of VTN mRNACTDPMID:12377990
VTNHuman2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:7369566480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to VTN promoter]CTDPMID:19654925
VTNHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:39676480464Tetrachlorodibenzodioxin results in decreased expression of VTN mRNACTDPMID:19692669|PMID:34747641
VTNHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:7369566480464Tetrachlorodibenzodioxin results in increased expression of VTN mRNACTDPMID:19770486
VTNHuman2,3,7,8-Tetrachlorodibenzofuran decreases expressionISORGD:396764804642,3,7,8-tetrachlorodibenzofuran results in decreased expression of VTN mRNACTDPMID:32109520
VTNHuman2,3-dimethoxynaphthalene-1,4-dione decreases expressionEXP 64804642,3-dimethoxy-1,4-naphthoquinone results in decreased expression of VTN mRNACTDPMID:17547211
VTNHuman2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISORGD:73695664804642,2',4,4',5-brominated diphenyl ether affects the expression of VTN mRNACTDPMID:38648751
VTNHuman2,4-dinitrotoluene affects expressionISORGD:396764804642,4-dinitrotoluene affects the expression of VTN mRNACTDPMID:21346803
VTNHuman3,4-methylenedioxymethamphetamine increases expressionISORGD:7369566480464N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of VTN mRNACTDPMID:20188158
VTNHuman3-isobutyl-1-methyl-7H-xanthine multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...CTDPMID:28628672
VTNHuman4,4'-sulfonyldiphenol increases expressionISORGD:7369566480464bisphenol S results in increased expression of VTN mRNACTDPMID:30951980
VTNHuman4,4'-sulfonyldiphenol affects expressionISORGD:7369566480464bisphenol S affects the expression of VTN mRNACTDPMID:39298647
VTNHuman4-hydroxyphenyl retinamide decreases expressionISORGD:7369566480464Fenretinide results in decreased expression of VTN mRNACTDPMID:28973697

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Biological Process
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Object Symbol
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Original Reference(s)
VTNHumancell adhesion involved_inTAS 150520179 PMID:2418831PINCPMID:2418831
VTNHumancell adhesion involved_inIEAUniProtKB-KW:KW-0130150520179 UniProtGO_REF:0000043
VTNHumancell adhesion mediated by integrin involved_inIDA 150520179 PMID:8837777BHF-UCLPMID:8837777
VTNHumancell adhesion mediated by integrin involved_inIBAPANTHER:PTN002740785|UniProtKB:P04004150520179 GO_CentralGO_REF:0000033
VTNHumancell migration involved_inIGIComplexPortal:CPX-1795150520179 PMID:22505472UniProtPMID:22505472
VTNHumancell-matrix adhesion involved_inIGIComplexPortal:CPX-1795150520179 PMID:22505472UniProtPMID:22505472
VTNHumancell-matrix adhesion acts_upstream_of_or_withinIEAUniProtKB:P29788|ensembl:ENSMUSP00000017488150520179 EnsemblGO_REF:0000107
VTNHumancell-matrix adhesion involved_inIBAMGI:98940|PANTHER:PTN002740785|UniProtKB:P04004150520179 GO_CentralGO_REF:0000033
VTNHumancell-matrix adhesion involved_inIDA 150520179 PMID:10022831BHF-UCLPMID:10022831
VTNHumanendodermal cell differentiation involved_inIDA 150520179 PMID:23154389UniProtPMID:23154389
VTNHumanextracellular matrix organization acts_upstream_of_or_withinIEAUniProtKB:P29788|ensembl:ENSMUSP00000017488150520179 EnsemblGO_REF:0000107
VTNHumanimmune response involved_inTAS 150520179 PMID:2418831PINCPMID:2418831
VTNHumanimmune response involved_inIEAInterPro:IPR020436150520179 InterProGO_REF:0000002
VTNHumanintegrin-mediated signaling pathway involved_inIMP 150520179 PMID:10022831BHF-UCLPMID:10022831
VTNHumanliver regeneration  ISORGD:39679068941 RGDPMID:10988248|REF_RGD_ID:10003090
VTNHumanliver regeneration involved_inIEAUniProtKB:Q7TQ11|ensembl:ENSRNOP00000046415150520179 EnsemblGO_REF:0000107
VTNHumannegative regulation of blood coagulation involved_inIDA 150520179 PMID:1695900BHF-UCLPMID:1695900
VTNHumannegative regulation of fibrinolysis involved_inNAS 150520179 PMID:1695900ComplexPortalPMID:1695900
VTNHumannegative regulation of proteolysis involved_inIDA 150520179 PMID:1695900BHF-UCLPMID:1695900
VTNHumanoligodendrocyte differentiation involved_inIEAUniProtKB:P29788|ensembl:ENSMUSP00000017488150520179 EnsemblGO_REF:0000107
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Cellular Component
1 to 20 of 29 rows

  
Object Symbol
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Evidence
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Reference
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Source
Original Reference(s)
VTNHumanalphav-beta3 integrin-vitronectin complex part_ofTAS 150520179 PMID:19267251BHF-UCLPMID:19267251
VTNHumanbasement membrane  ISORGD:39679068941 RGDPMID:11728964|REF_RGD_ID:10003096
VTNHumanbasement membrane located_inIEAUniProtKB:Q7TQ11|ensembl:ENSRNOP00000046415150520179 EnsemblGO_REF:0000107
VTNHumanblood microparticle located_inHDA 150520179 PMID:22516433UniProtPMID:22516433
VTNHumancollagen-containing extracellular matrix located_inHDA 150520179 PMID:20551380, PMID:25037231, PMID:27559042, PMID:28327460, PMID:28675934BHF-UCLPMID:20551380|PMID:25037231|PMID:27559042|PMID:28327460|PMID:28675934
VTNHumancollagen-containing extracellular matrix is_active_inIBAPANTHER:PTN000531402|RGD:3967150520179 GO_CentralGO_REF:0000033
VTNHumancollagen-containing extracellular matrix located_inIDA 150520179 PMID:1632457BHF-UCLPMID:1632457
VTNHumancollagen-containing extracellular matrix  ISORGD:39679068941 RGDPMID:2426279|REF_RGD_ID:10003088
VTNHumancollagen-containing extracellular matrix located_inISSUniProtKB:P48819150520179 PMID:22261194BHF-UCLPMID:22261194
VTNHumanendoplasmic reticulum located_inIDA 150520179 HPAGO_REF:0000052
VTNHumanextracellular exosome located_inHDA 150520179 PMID:19199708, PMID:23533145UniProtPMID:19199708|PMID:23533145
VTNHumanextracellular matrix located_inIEAUniProtKB:P29788|ensembl:ENSMUSP00000017488150520179 EnsemblGO_REF:0000107
VTNHumanextracellular region located_inHDA 150520179 PMID:27068509BHF-UCLPMID:27068509
VTNHumanextracellular region located_inIEAUniProtKB-SubCell:SL-0112|UniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
VTNHumanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
VTNHumanextracellular region located_inNAS 150520179 PMID:14718574UniProtPMID:14718574
VTNHumanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-216076|Reactome:R-HSA-2161282|Reactome:R-HSA-2396079|Reactome:R-HSA-2396370|Reactome:R-HSA-2426471|Reactome:R-HSA-2530429|Reactome:R-HSA-2530453|Reactome:R-HSA-2731122|Reactome:R-NUL-2465871
VTNHumanextracellular space located_inIEAUniProtKB:Q7TQ11|ensembl:ENSRNOP00000046415150520179 EnsemblGO_REF:0000107
VTNHumanextracellular space is_active_inIBAMGI:1891344|PANTHER:PTN000531402|RGD:3967|UniProtKB:P04004150520179 GO_CentralGO_REF:0000033
VTNHumanextracellular space located_inHDA 150520179 PMID:16502470UniProtPMID:16502470
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Molecular Function
1 to 20 of 27 rows

  
Object Symbol
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Reference
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Original Reference(s)
VTNHumancollagen binding  ISORGD:39679068941 RGDPMID:10988248|REF_RGD_ID:10003090
VTNHumancollagen binding enablesIEAUniProtKB:Q7TQ11|ensembl:ENSRNOP00000046415150520179 EnsemblGO_REF:0000107
VTNHumanextracellular matrix binding enablesIEAUniProtKB:P29788|ensembl:ENSMUSP00000017488150520179 EnsemblGO_REF:0000107
VTNHumanextracellular matrix binding enablesIBAMGI:98940|PANTHER:PTN002740785150520179 GO_CentralGO_REF:0000033
VTNHumanextracellular matrix structural constituent enablesRCA 150520179 PMID:20551380, PMID:25037231, PMID:27559042, PMID:28327460, PMID:28675934BHF-UCLPMID:20551380|PMID:25037231|PMID:27559042|PMID:28327460|PMID:28675934
VTNHumanextracellular matrix structural constituent enablesISSUniProtKB:P48819150520179 BHF-UCLGO_REF:0000024
VTNHumanheparin binding  ISORGD:39679068941 RGDPMID:8804356|REF_RGD_ID:10040982
VTNHumanheparin binding enablesIEAUniProtKB-KW:KW-0358150520179 UniProtGO_REF:0000043
VTNHumanheparin binding enablesIEAUniProtKB:Q7TQ11|ensembl:ENSRNOP00000046415150520179 EnsemblGO_REF:0000107
VTNHumanidentical protein binding  ISORGD:39679068941 RGDPMID:17369286|REF_RGD_ID:10003099
VTNHumanidentical protein binding enablesIEAUniProtKB:Q7TQ11|ensembl:ENSRNOP00000046415150520179 EnsemblGO_REF:0000107
VTNHumanintegrin binding enablesIPIUniProtKB:P05106150520179 PMID:8837777BHF-UCLPMID:8837777
VTNHumanintegrin binding enablesIBAPANTHER:PTN002740785|UniProtKB:P04004150520179 GO_CentralGO_REF:0000033
VTNHumanintegrin binding enablesIDA 150520179 PMID:22505472UniProtPMID:22505472
VTNHumanpolysaccharide binding enablesIEAInterPro:IPR020436150520179 InterProGO_REF:0000002
VTNHumanprotein binding enablesIPIUniProtKB:Q07021150520179 PMID:28514442, PMID:33961781, PMID:8900153IntActPMID:28514442|PMID:33961781|PMID:8900153
VTNHumanprotein binding enablesIPIUniProtKB:P75167|UniProtKB:P75358|UniProtKB:P75390|UniProtKB:P75391|UniProtKB:P75392|UniProtKB:P75611|UniProtKB:P78007|UniProtKB:P78031150520179 PMID:27616280AgBasePMID:27616280
VTNHumanprotein binding enablesIPIUniProtKB:A0A024A2C9150520179 PMID:26538390IntActPMID:26538390
VTNHumanprotein binding enablesIPIUniProtKB:Q4KTX9150520179 PMID:24664511IntActPMID:24664511
VTNHumanprotein binding enablesIPIUniProtKB:A0A024A2C9|UniProtKB:A4NBN9150520179 PMID:26538390AgBasePMID:26538390
1 to 20 of 27 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VTNHumancell-extracellular matrix signaling pathway  IEA 6907045 KEGGhsa:04512

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
VTNHumanforkhead class A signaling pathway  EXP 6484113 PIDPID:200226
VTNHumanvascular endothelial growth factor signaling pathway   EXP 6484113 PIDPID:200188

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#
Reference Title
Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Cai XW, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):867-76.
3. Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy. Casaroli Marano RP, etal., Exp Eye Res. 1995 Jan;60(1):5-17.
4. Evaluation of fibronectin, vitronectin, and leptin levels in coronary artery disease: impacts on thrombosis and thrombolysis. Ekmekci H, etal., Clin Appl Thromb Hemost. 2005 Jan;11(1):63-70.
5. Plasma vitronectin levels in patients with coronary atherosclerosis are increased and correlate with extent of disease. Ekmekci H, etal., J Thromb Thrombolysis. 2002 Dec;14(3):221-5.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. Modification of vitronectin by advanced glycation alters functional properties in vitro and in the diabetic retina. Hammes HP, etal., Lab Invest. 1996 Sep;75(3):325-38.
8. Vitronectin- and fibronectin-containing immune complexes in primary systemic vasculitis. Maehnss K, etal., J Autoimmun. 2002 May;18(3):239-50.
9. Reactive glial cells express a vitronectin-like protein in the hippocampus of epileptic rats. Niquet J, etal., Glia. 1996 Apr;16(4):359-67.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Anti-vitronectin antibodies enhance anti-Thy-1-induced proteinuria in PVG/c, but not in Wistar rats. Van Dixhoorn MG, etal., J Am Soc Nephrol. 1998 Jun;9(6):994-1007.
14. Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin. Wu YP, etal., Blood. 2004 Aug 15;104(4):1034-41. Epub 2004 Apr 6.
15. Alterations of vitronectin and its receptor alpha(v) integrin in the rat renal glomerular wall during diabetes. Yoon S, etal., Am J Kidney Dis. 2001 Dec;38(6):1298-306.
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1 to 10 of 21 rows
PMID:631332   PMID:1372588   PMID:1377736   PMID:1632457   PMID:1694173   PMID:1695900   PMID:1696913   PMID:1698787   PMID:1704366   PMID:1706595   PMID:1709100   PMID:2414098  
PMID:2418831   PMID:2433863   PMID:2447940   PMID:2448300   PMID:2454751   PMID:2475499   PMID:2479556   PMID:3004934   PMID:6210287   PMID:7490129   PMID:7518183   PMID:7522053  
PMID:7522689   PMID:7545318   PMID:7559467   PMID:7682219   PMID:7690138   PMID:8120056   PMID:8567871   PMID:8626514   PMID:8663085   PMID:8830783   PMID:8837777   PMID:8900153  
PMID:8920805   PMID:9030777   PMID:9065424   PMID:9151113   PMID:9443892   PMID:9718986   PMID:9733784   PMID:10022831   PMID:10329419   PMID:10342887   PMID:10586957   PMID:10722842  
PMID:10835423   PMID:10887113   PMID:11113116   PMID:11156415   PMID:11419941   PMID:11437656   PMID:11744726   PMID:11751588   PMID:11756447   PMID:11785953   PMID:11796716   PMID:11796824  
PMID:11864711   PMID:12019263   PMID:12071840   PMID:12091360   PMID:12437099   PMID:12477932   PMID:12565847   PMID:12757937   PMID:12808446   PMID:12810534   PMID:14586734   PMID:14681059  
PMID:14718574   PMID:14760718   PMID:15123712   PMID:15123885   PMID:15140223   PMID:15489334   PMID:15641781   PMID:15717924   PMID:15777802   PMID:15799029   PMID:15843372   PMID:15905170  
PMID:15914035   PMID:16195248   PMID:16237761   PMID:16335952   PMID:16502470   PMID:16785539   PMID:16807684   PMID:16815299   PMID:17081983   PMID:17344041   PMID:17766387   PMID:18174166  
PMID:18200066   PMID:18340378   PMID:18362146   PMID:18376415   PMID:18516040   PMID:18624398   PMID:18658131   PMID:18781095   PMID:18842294   PMID:19118218   PMID:19162023   PMID:19193026  
PMID:19199708   PMID:19267251   PMID:19288063   PMID:19408099   PMID:19635912   PMID:19657137   PMID:19730683   PMID:19893454   PMID:19913121   PMID:19998373   PMID:20031688   PMID:20066177  
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VTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,367,284 - 28,370,307 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,367,284 - 28,373,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,694,305 - 26,697,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,718,425 - 23,721,500 (-)NCBINCBI36Build 36hg18NCBI36
Build 341723,718,424 - 23,721,844NCBI
Celera1723,556,056 - 23,559,131 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,902,707 - 22,905,782 (-)NCBIHuRef
CHM1_11726,757,231 - 26,760,306 (-)NCBICHM1_1
T2T-CHM13v2.01729,309,135 - 29,312,158 (-)NCBIT2T-CHM13v2.0
Vtn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,389,946 - 78,393,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,389,917 - 78,393,150 (+)EnsemblGRCm39 Ensembl
GRCm381178,499,120 - 78,502,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,499,091 - 78,502,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,312,622 - 78,315,827 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,315,481 - 78,318,519 (+)NCBIMGSCv36mm8
Celera1188,131,193 - 88,134,398 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Vtn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,892,782 - 63,895,862 (+)NCBIGRCr8
mRatBN7.21063,394,732 - 63,397,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,394,719 - 63,397,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,027,371 - 68,030,455 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,532,702 - 67,535,786 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,002,232 - 63,005,314 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,767,960 - 65,771,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,767,053 - 65,771,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,872,580 - 65,875,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,609,242 - 64,612,322 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,622,874 - 64,625,943 (+)NCBI
Celera1062,371,307 - 62,374,387 (+)NCBICelera
Cytogenetic Map10q25NCBI
Vtn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,765,193 - 4,771,019 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,765,078 - 4,768,027 (+)NCBIChiLan1.0ChiLan1.0
VTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,085,584 - 36,091,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,965,973 - 37,971,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,403,813 - 28,407,202 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,906,508 - 28,909,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,906,508 - 28,909,583 (+)Ensemblpanpan1.1panPan2
VTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,617,860 - 42,620,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,614,941 - 42,630,864 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,774,787 - 41,777,752 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,437,036 - 43,440,001 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,434,650 - 43,439,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,221,266 - 42,224,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,512,485 - 42,515,450 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,589,551 - 42,592,516 (-)NCBIUU_Cfam_GSD_1.0
Vtn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,644,330 - 41,647,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,522,074 - 4,525,336 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,522,275 - 4,525,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,650,534 - 44,655,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,650,532 - 44,653,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,021 - 8,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,133,903 - 22,138,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,133,138 - 22,136,815 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660757,990,668 - 7,994,840 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vtn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624786966,452 - 973,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624786970,288 - 973,344 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in VTN
73 total Variants

Predicted Target Of
Summary Value
Count of predictions:959
Count of miRNA genes:608
Interacting mature miRNAs:691
Transcripts:ENST00000226218, ENST00000539746, ENST00000542029
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 1376 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
407169093GWAS818069_Hblood protein measurement QTL GWAS818069 (human)2e-68blood protein measurement172836784028367841Human
596968343GWAS1087862_Hleukocyte immunoglobulin-like receptor subfamily B member 3 measurement QTL GWAS1087862 (human)2e-79blood protein measurement172836784028367841Human
407208002GWAS856978_Hcholine/ethanolamine kinase measurement QTL GWAS856978 (human)7e-42choline/ethanolamine kinase measurement172836784028367841Human
406984773GWAS633749_Hlow density lipoprotein cholesterol measurement QTL GWAS633749 (human)4e-08low density lipoprotein cholesterol measurement172836784028367841Human
596968349GWAS1087868_Hcentromere protein W measurement QTL GWAS1087868 (human)4e-70blood protein measurement172836784028367841Human
407023691GWAS672667_Hblood protein measurement QTL GWAS672667 (human)2e-26blood protein measurement172836784028367841Human
407101514GWAS750490_Hmucin-1 measurement QTL GWAS750490 (human)5e-80mucin-1 measurement172836784028367841Human
596968348GWAS1087867_Hcomplement factor D measurement QTL GWAS1087867 (human)7e-16blood protein measurement172836784028367841Human
407062601GWAS711577_Hblood protein measurement QTL GWAS711577 (human)3e-42blood protein measurement172836784028367841Human
407062600GWAS711576_Hblood protein measurement QTL GWAS711576 (human)2e-42DnaJ homolog subfamily B member 9 measurement172836784028367841Human

1 to 10 of 1376 rows
RH11584  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371726,694,315 - 26,694,774UniSTSGRCh37
Build 361723,718,442 - 23,718,901RGDNCBI36
Celera1723,556,073 - 23,556,532RGD
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map17q11UniSTS
HuRef1722,902,724 - 22,903,183UniSTS
RH12566  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371726,698,119 - 26,698,266UniSTSGRCh37
Build 361723,722,246 - 23,722,393RGDNCBI36
Celera1723,559,877 - 23,560,024RGD
Cytogenetic Map17q11UniSTS
HuRef1722,906,528 - 22,906,675UniSTS
RH39314  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371726,698,039 - 26,698,202UniSTSGRCh37
Build 361723,722,166 - 23,722,329RGDNCBI36
Celera1723,559,797 - 23,559,960RGD
Cytogenetic Map17q11UniSTS
HuRef1722,906,448 - 22,906,611UniSTS
G44355  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371726,694,756 - 26,695,005UniSTSGRCh37
Build 361723,718,883 - 23,719,132RGDNCBI36
Celera1723,556,514 - 23,556,763RGD
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map17q11UniSTS
HuRef1722,903,165 - 22,903,414UniSTS
GDB:186726  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371726,694,695 - 26,695,224UniSTSGRCh37
Build 361723,718,822 - 23,719,351RGDNCBI36
Celera1723,556,453 - 23,556,982RGD
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map17q11UniSTS
HuRef1722,903,104 - 22,903,633UniSTS
VTN  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371726,695,897 - 26,696,418UniSTSGRCh37
Build 361723,720,024 - 23,720,545RGDNCBI36
Celera1723,557,655 - 23,558,176RGD
HuRef1722,904,306 - 22,904,827UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2397 2780 2238 4933 1717 2325 3 621 1805 462 2258 7079 6306 48 3709 822 1703 1596 170



Ensembl Acc Id: ENST00000226218   ⟹   ENSP00000226218
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1728,367,284 - 28,370,307 (-)Ensembl
Ensembl Acc Id: ENST00000539746
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1728,367,868 - 28,368,937 (-)Ensembl
Ensembl Acc Id: ENST00000542029   ⟹   ENSP00000440439
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1728,369,682 - 28,373,091 (-)Ensembl
RefSeq Acc Id: NM_000638   ⟹   NP_000629
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,367,284 - 28,370,307 (-)NCBI
GRCh371726,694,298 - 26,697,373 (-)ENTREZGENE
Build 361723,718,425 - 23,721,500 (-)NCBI Archive
HuRef1722,902,707 - 22,905,782 (-)ENTREZGENE
CHM1_11726,757,231 - 26,760,306 (-)NCBI
T2T-CHM13v2.01729,309,135 - 29,312,158 (-)NCBI
Sequence:
RefSeq Acc Id: NP_000629   ⟸   NM_000638
- Peptide Label: precursor
- UniProtKB: P01141 (UniProtKB/Swiss-Prot),   B2R7G0 (UniProtKB/Swiss-Prot),   Q9BSH7 (UniProtKB/Swiss-Prot),   P04004 (UniProtKB/Swiss-Prot),   D9ZGG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000440439   ⟸   ENST00000542029
Ensembl Acc Id: ENSP00000226218   ⟸   ENST00000226218
SMB

Name Modeler Protein Id AA Range Protein Structure
AF-P04004-F1-model_v2 AlphaFold P04004 1-478 view protein structure

RGD ID:6794730
Promoter ID:HG_KWN:25543
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:OTTHUMT00000255680
Position:
Human AssemblyChrPosition (strand)Source
Build 361723,722,571 - 23,723,071 (-)MPROMDB
RGD ID:7234351
Promoter ID:EPDNEW_H22921
Type:initiation region
Name:VTN_1
Description:vitronectin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,370,268 - 28,370,328EPDNEW


1 to 40 of 44 rows
Database
Acc Id
Source(s)
COSMIC VTN COSMIC
Ensembl Genes ENSG00000109072 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000226218 ENTREZGENE
  ENST00000226218.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot
  4.10.410.20 UniProtKB/Swiss-Prot
GTEx ENSG00000109072 GTEx
HGNC ID HGNC:12724 ENTREZGENE
Human Proteome Map VTN Human Proteome Map
InterPro Heme_transport/Cell_adhesion UniProtKB/Swiss-Prot
  Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  Somatomedin_B-like_dom_sf UniProtKB/Swiss-Prot
  Somatomedin_B_chordata UniProtKB/Swiss-Prot
  Somatomedin_B_dom UniProtKB/Swiss-Prot
KEGG Report hsa:7448 UniProtKB/Swiss-Prot
NCBI Gene 7448 ENTREZGENE
OMIM 193190 OMIM
PANTHER HEMOPEXIN DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  VITRONECTIN UniProtKB/Swiss-Prot
Pfam Hemopexin UniProtKB/Swiss-Prot
  Somatomedin_B UniProtKB/Swiss-Prot
PharmGKB PA37335 PharmGKB
PRINTS SOMATOMEDINB UniProtKB/Swiss-Prot
PROSITE HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  SMB_1 UniProtKB/Swiss-Prot
  SMB_2 UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot
  SM00201 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50923 UniProtKB/Swiss-Prot
  SSF90188 UniProtKB/Swiss-Prot
UniProt B2R7G0 ENTREZGENE
  D9ZGG2 ENTREZGENE, UniProtKB/TrEMBL
  F5GX75_HUMAN UniProtKB/TrEMBL
  P01141 ENTREZGENE
  P04004 ENTREZGENE
  Q9BSH7 ENTREZGENE
1 to 40 of 44 rows