Vtn (vitronectin) - Rat Genome Database

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Gene: Vtn (vitronectin) Mus musculus
Analyze
Symbol: Vtn
Name: vitronectin
RGD ID: 736956
MGI Page MGI
Description: Enables extracellular matrix binding activity. Involved in oligodendrocyte differentiation. Acts upstream of or within cell-matrix adhesion; extracellular matrix organization; and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and retina. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI256434; S-protein; serum-spreading factor; Vn
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,389,946 - 78,393,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,389,917 - 78,393,150 (+)EnsemblGRCm39 Ensembl
GRCm381178,499,120 - 78,502,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,499,091 - 78,502,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,312,622 - 78,315,827 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,315,481 - 78,318,519 (+)NCBIMGSCv36mm8
Celera1188,131,193 - 88,134,398 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
dexamethasone  (ISO)
diazepam  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
furan  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lipopolysaccharide  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP)
nicotinic acid  (ISO)
nitrofen  (ISO)
nitroglycerin  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
pioglitazone  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
telmisartan  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trametinib  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Cai XW, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):867-76.
3. Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy. Casaroli Marano RP, etal., Exp Eye Res. 1995 Jan;60(1):5-17.
4. Evaluation of fibronectin, vitronectin, and leptin levels in coronary artery disease: impacts on thrombosis and thrombolysis. Ekmekci H, etal., Clin Appl Thromb Hemost. 2005 Jan;11(1):63-70.
5. Plasma vitronectin levels in patients with coronary atherosclerosis are increased and correlate with extent of disease. Ekmekci H, etal., J Thromb Thrombolysis. 2002 Dec;14(3):221-5.
6. Modification of vitronectin by advanced glycation alters functional properties in vitro and in the diabetic retina. Hammes HP, etal., Lab Invest. 1996 Sep;75(3):325-38.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Vitronectin- and fibronectin-containing immune complexes in primary systemic vasculitis. Maehnss K, etal., J Autoimmun. 2002 May;18(3):239-50.
9. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Reactive glial cells express a vitronectin-like protein in the hippocampus of epileptic rats. Niquet J, etal., Glia. 1996 Apr;16(4):359-67.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Anti-vitronectin antibodies enhance anti-Thy-1-induced proteinuria in PVG/c, but not in Wistar rats. Van Dixhoorn MG, etal., J Am Soc Nephrol. 1998 Jun;9(6):994-1007.
19. Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin. Wu YP, etal., Blood. 2004 Aug 15;104(4):1034-41. Epub 2004 Apr 6.
20. Alterations of vitronectin and its receptor alpha(v) integrin in the rat renal glomerular wall during diabetes. Yoon S, etal., Am J Kidney Dis. 2001 Dec;38(6):1298-306.
Additional References at PubMed
PMID:47885   PMID:1372829   PMID:1695900   PMID:1698787   PMID:1719529   PMID:2412864   PMID:2418831   PMID:6191326   PMID:7490093   PMID:7505250   PMID:7519600   PMID:7544171  
PMID:7937138   PMID:8618914   PMID:8621404   PMID:8681037   PMID:8889548   PMID:9417058   PMID:9525990   PMID:9614184   PMID:9639027   PMID:10349636   PMID:10780854   PMID:11042159  
PMID:11076861   PMID:11083866   PMID:11130978   PMID:11386760   PMID:12067901   PMID:12393886   PMID:12477932   PMID:12482822   PMID:12562917   PMID:12603314   PMID:14660441   PMID:15226823  
PMID:15308506   PMID:15489334   PMID:15687502   PMID:15728191   PMID:15733060   PMID:16141072   PMID:16141073   PMID:16194205   PMID:16479252   PMID:16518820   PMID:16782087   PMID:16893423  
PMID:17330941   PMID:17504807   PMID:17548654   PMID:17888748   PMID:17936262   PMID:17982099   PMID:18084301   PMID:18255021   PMID:18287559   PMID:18757743   PMID:19574558   PMID:19633172  
PMID:19760599   PMID:19811533   PMID:20164359   PMID:20460368   PMID:20492459   PMID:20944625   PMID:21267068   PMID:21270094   PMID:21282332   PMID:21335239   PMID:21571686   PMID:21734232  
PMID:21764994   PMID:21862448   PMID:21873635   PMID:22008794   PMID:22159717   PMID:22281987   PMID:22606350   PMID:23019340   PMID:23041440   PMID:23155445   PMID:23345331   PMID:24509439  
PMID:24603119   PMID:25355214   PMID:25799354   PMID:26640242   PMID:26648042   PMID:26951610   PMID:27106291   PMID:27798934   PMID:28071719   PMID:28218242   PMID:28378742   PMID:29028290  
PMID:29222114   PMID:29555813   PMID:29618843   PMID:29661186   PMID:29891551   PMID:30408465   PMID:30937689   PMID:31678139   PMID:32312218   PMID:32857879   PMID:34321999   PMID:34474245  
PMID:35294899   PMID:35531929  


Genomics

Comparative Map Data
Vtn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,389,946 - 78,393,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,389,917 - 78,393,150 (+)EnsemblGRCm39 Ensembl
GRCm381178,499,120 - 78,502,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,499,091 - 78,502,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,312,622 - 78,315,827 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,315,481 - 78,318,519 (+)NCBIMGSCv36mm8
Celera1188,131,193 - 88,134,398 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
VTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,367,284 - 28,370,307 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,367,284 - 28,373,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,694,305 - 26,697,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,718,425 - 23,721,500 (-)NCBINCBI36Build 36hg18NCBI36
Build 341723,718,424 - 23,721,844NCBI
Celera1723,556,056 - 23,559,131 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,902,707 - 22,905,782 (-)NCBIHuRef
CHM1_11726,757,231 - 26,760,306 (-)NCBICHM1_1
T2T-CHM13v2.01729,309,135 - 29,312,158 (-)NCBIT2T-CHM13v2.0
Vtn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,892,782 - 63,895,862 (+)NCBIGRCr8
mRatBN7.21063,394,732 - 63,397,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,394,719 - 63,397,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,027,371 - 68,030,455 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,532,702 - 67,535,786 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,002,232 - 63,005,314 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,767,960 - 65,771,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,767,053 - 65,771,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,872,580 - 65,875,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,609,242 - 64,612,322 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,622,874 - 64,625,943 (+)NCBI
Celera1062,371,307 - 62,374,387 (+)NCBICelera
Cytogenetic Map10q25NCBI
Vtn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,765,193 - 4,771,019 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,765,078 - 4,768,027 (+)NCBIChiLan1.0ChiLan1.0
VTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,085,584 - 36,091,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,965,973 - 37,971,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,403,813 - 28,407,202 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,906,508 - 28,909,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,906,508 - 28,909,583 (+)Ensemblpanpan1.1panPan2
VTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,617,860 - 42,620,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,614,941 - 42,630,864 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,774,787 - 41,777,752 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,437,036 - 43,440,001 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,434,650 - 43,439,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,221,266 - 42,224,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,512,485 - 42,515,450 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,589,551 - 42,592,516 (-)NCBIUU_Cfam_GSD_1.0
Vtn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,644,330 - 41,647,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,522,074 - 4,525,336 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,522,275 - 4,525,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,650,534 - 44,655,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,650,532 - 44,653,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,021 - 8,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,133,903 - 22,138,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,133,138 - 22,136,815 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660757,990,668 - 7,994,840 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vtn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624786966,452 - 973,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624786970,288 - 973,344 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vtn
109 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:715
Count of miRNA genes:414
Interacting mature miRNAs:483
Transcripts:ENSMUST00000017488, ENSMUST00000128479, ENSMUST00000146997, ENSMUST00000153628
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117373754182069425Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
4141365Ltxs3_mlethal factor toxin susceptibility 3 (mouse)Not determined117757387380746358Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse

Markers in Region
AI256434  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381178,502,179 - 78,502,299UniSTSGRCm38
MGSCv371178,315,681 - 78,315,801UniSTSGRCm37
Celera1188,134,252 - 88,134,372UniSTS
Cytogenetic Map11B5UniSTS
cM Map1145.0UniSTS
cM Map1145.09UniSTS
Whitehead/MRC_RH11997.6UniSTS
D11Seg34  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381178,497,568 - 78,497,690UniSTSGRCm38
MGSCv371178,311,070 - 78,311,192UniSTSGRCm37
Celera1188,129,641 - 88,129,763UniSTS
Cytogenetic Map11B5UniSTS
cM Map1145.09UniSTS
D11Seg35  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381178,500,718 - 78,500,819UniSTSGRCm38
MGSCv371178,314,220 - 78,314,321UniSTSGRCm37
Celera1188,132,791 - 88,132,892UniSTS
Cytogenetic Map11B5UniSTS
cM Map1145.1UniSTS
cM Map1145.09UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000017488   ⟹   ENSMUSP00000017488
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,389,946 - 78,393,150 (+)Ensembl
GRCm38.p6 Ensembl1178,499,120 - 78,502,324 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128479
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,389,917 - 78,391,411 (+)Ensembl
GRCm38.p6 Ensembl1178,499,091 - 78,500,585 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,389,998 - 78,391,070 (+)Ensembl
GRCm38.p6 Ensembl1178,499,172 - 78,500,244 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153628
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,391,432 - 78,393,048 (+)Ensembl
GRCm38.p6 Ensembl1178,500,606 - 78,502,222 (+)Ensembl
RefSeq Acc Id: NM_011707   ⟹   NP_035837
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391178,389,946 - 78,393,151 (+)NCBI
GRCm381178,499,120 - 78,502,325 (+)ENTREZGENE
MGSCv371178,312,622 - 78,315,827 (+)RGD
Celera1188,131,193 - 88,134,398 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035837   ⟸   NM_011707
- Peptide Label: precursor
- UniProtKB: Q91X32 (UniProtKB/Swiss-Prot),   Q8VII4 (UniProtKB/Swiss-Prot),   Q5SYG4 (UniProtKB/Swiss-Prot),   Q9D080 (UniProtKB/Swiss-Prot),   P29788 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000017488   ⟸   ENSMUST00000017488
Protein Domains
SMB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29788-F1-model_v2 AlphaFold P29788 1-478 view protein structure

Promoters
RGD ID:6822451
Promoter ID:MM_KWN:8717
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver
Transcripts:NM_011707,   OTTMUST00000000459,   OTTMUST00000000460
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361178,312,444 - 78,312,944 (+)MPROMDB
RGD ID:6822453
Promoter ID:MM_KWN:8718
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung,   Spleen
Transcripts:OTTMUST00000000461
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361178,313,276 - 78,314,347 (+)MPROMDB
RGD ID:8675728
Promoter ID:EPDNEW_M15895
Type:initiation region
Name:Vtn_2
Description:Mus musculus vitronectin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15896  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381178,499,094 - 78,499,154EPDNEW
RGD ID:8675730
Promoter ID:EPDNEW_M15896
Type:initiation region
Name:Vtn_1
Description:Mus musculus vitronectin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15895  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381178,499,266 - 78,499,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98940 AgrOrtholog
Ensembl Genes ENSMUSG00000017344 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000017488 ENTREZGENE
  ENSMUST00000017488.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot
  4.10.410.20 UniProtKB/Swiss-Prot
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  Somatomedin_B-like_dom_sf UniProtKB/Swiss-Prot
  Somatomedin_B_chordata UniProtKB/Swiss-Prot
  Somatomedin_B_dom UniProtKB/Swiss-Prot
KEGG Report mmu:22370 UniProtKB/Swiss-Prot
MGD MGI:98940 ENTREZGENE
NCBI Gene 22370 ENTREZGENE
PANTHER HEMOPEXIN DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  VITRONECTIN UniProtKB/Swiss-Prot
Pfam Hemopexin UniProtKB/Swiss-Prot
  Somatomedin_B UniProtKB/Swiss-Prot
PhenoGen Vtn PhenoGen
PRINTS SOMATOMEDINB UniProtKB/Swiss-Prot
PROSITE HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  SMB_1 UniProtKB/Swiss-Prot
  SMB_2 UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot
  SM00201 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50923 UniProtKB/Swiss-Prot
  SSF90188 UniProtKB/Swiss-Prot
UniProt P29788 ENTREZGENE
  Q5SYG4 ENTREZGENE
  Q8VII4 ENTREZGENE
  Q91X32 ENTREZGENE
  Q9D080 ENTREZGENE
  VTNC_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q5SYG4 UniProtKB/Swiss-Prot
  Q8VII4 UniProtKB/Swiss-Prot
  Q91X32 UniProtKB/Swiss-Prot
  Q9D080 UniProtKB/Swiss-Prot