VTN (vitronectin) - Rat Genome Database

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Gene: VTN (vitronectin) Canis lupus familiaris
Analyze
Symbol: VTN
Name: vitronectin
RGD ID: 12359862
Description: ENCODES a protein that exhibits collagen binding (ortholog); heparin binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); extracellular matrix organization (ortholog); liver regeneration (ortholog); PARTICIPATES IN forkhead class A signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Alveolar Bone Loss (ortholog); Churg-Strauss syndrome (ortholog); coronary artery disease (ortholog); FOUND IN basement membrane (ortholog); collagen-containing extracellular matrix (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,617,860 - 42,620,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,614,941 - 42,630,864 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,774,787 - 41,777,752 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,437,036 - 43,440,001 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,434,650 - 43,439,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,221,266 - 42,224,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,512,485 - 42,515,450 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,589,551 - 42,592,516 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
VTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,617,860 - 42,620,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,614,941 - 42,630,864 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,774,787 - 41,777,752 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,437,036 - 43,440,001 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,434,650 - 43,439,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,221,266 - 42,224,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,512,485 - 42,515,450 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,589,551 - 42,592,516 (-)NCBIUU_Cfam_GSD_1.0
VTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,367,284 - 28,370,307 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,367,284 - 28,373,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,694,305 - 26,697,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,718,425 - 23,721,500 (-)NCBINCBI36Build 36hg18NCBI36
Build 341723,718,424 - 23,721,844NCBI
Celera1723,556,056 - 23,559,131 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,902,707 - 22,905,782 (-)NCBIHuRef
CHM1_11726,757,231 - 26,760,306 (-)NCBICHM1_1
T2T-CHM13v2.01729,309,135 - 29,312,158 (-)NCBIT2T-CHM13v2.0
Vtn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,389,946 - 78,393,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,389,917 - 78,393,150 (+)EnsemblGRCm39 Ensembl
GRCm381178,499,120 - 78,502,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,499,091 - 78,502,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,312,622 - 78,315,827 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,315,481 - 78,318,519 (+)NCBIMGSCv36mm8
Celera1188,131,193 - 88,134,398 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Vtn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,892,782 - 63,895,862 (+)NCBIGRCr8
mRatBN7.21063,394,732 - 63,397,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,394,719 - 63,397,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,027,371 - 68,030,455 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,532,702 - 67,535,786 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,002,232 - 63,005,314 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,767,960 - 65,771,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,767,053 - 65,771,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,872,580 - 65,875,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,609,242 - 64,612,322 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,622,874 - 64,625,943 (+)NCBI
Celera1062,371,307 - 62,374,387 (+)NCBICelera
Cytogenetic Map10q25NCBI
Vtn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,765,193 - 4,771,019 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,765,078 - 4,768,027 (+)NCBIChiLan1.0ChiLan1.0
VTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,085,584 - 36,091,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,965,973 - 37,971,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,403,813 - 28,407,202 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,906,508 - 28,909,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,906,508 - 28,909,583 (+)Ensemblpanpan1.1panPan2
Vtn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,644,330 - 41,647,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,522,074 - 4,525,336 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,522,275 - 4,525,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,650,534 - 44,655,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,650,532 - 44,653,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,021 - 8,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,133,903 - 22,138,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,133,138 - 22,136,815 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660757,990,668 - 7,994,840 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vtn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624786966,452 - 973,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624786970,288 - 973,344 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VTN
91 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 6 6 6
Medium
Low 4 5 16 6 6 6 12 1 10 6
Below cutoff 1 7

Sequence


RefSeq Acc Id: ENSCAFT00000029633   ⟹   ENSCAFP00000027540
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,614,941 - 42,616,348 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000029640   ⟹   ENSCAFP00000027547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,617,860 - 42,630,864 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000064386   ⟹   ENSCAFP00000050199
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,617,860 - 42,620,751 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090328   ⟹   ENSCAFP00000066346
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,614,941 - 42,620,693 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845012746   ⟹   ENSCAFP00845009941
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,434,650 - 43,439,929 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845012787   ⟹   ENSCAFP00845009971
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,434,650 - 43,435,524 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845012802   ⟹   ENSCAFP00845009983
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,437,039 - 43,439,934 (-)Ensembl
RefSeq Acc Id: XM_038486389   ⟹   XP_038342317
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1942,221,266 - 42,224,231 (-)NCBI
RefSeq Acc Id: XM_038548227   ⟹   XP_038404155
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0942,589,551 - 42,592,516 (-)NCBI
RefSeq Acc Id: XM_038612192   ⟹   XP_038468120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0942,512,485 - 42,515,450 (-)NCBI
RefSeq Acc Id: XM_038677450   ⟹   XP_038533378
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0943,437,036 - 43,440,001 (-)NCBI
RefSeq Acc Id: XM_848947   ⟹   XP_854040
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1942,617,860 - 42,620,825 (-)NCBI
Dog10K_Boxer_Tasha941,774,787 - 41,777,752 (-)NCBI
Sequence:
RefSeq Acc Id: XP_854040   ⟸   XM_848947
- UniProtKB: A0A8C0KGK5 (UniProtKB/TrEMBL),   A0A8C0T6T8 (UniProtKB/TrEMBL),   A0A8I3N025 (UniProtKB/TrEMBL),   A0A8C0NBU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000050199   ⟸   ENSCAFT00000064386
RefSeq Acc Id: ENSCAFP00000027547   ⟸   ENSCAFT00000029640
RefSeq Acc Id: ENSCAFP00000027540   ⟸   ENSCAFT00000029633
RefSeq Acc Id: ENSCAFP00000066346   ⟸   ENSCAFT00000090328
RefSeq Acc Id: XP_038342317   ⟸   XM_038486389
RefSeq Acc Id: XP_038468120   ⟸   XM_038612192
RefSeq Acc Id: XP_038533378   ⟸   XM_038677450
- UniProtKB: A0A8C0KGK5 (UniProtKB/TrEMBL),   A0A8C0T6T8 (UniProtKB/TrEMBL),   A0A8I3N025 (UniProtKB/TrEMBL),   A0A8C0NBU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404155   ⟸   XM_038548227
- UniProtKB: A0A8C0KGK5 (UniProtKB/TrEMBL),   A0A8C0NBU9 (UniProtKB/TrEMBL),   A0A8C0T6T8 (UniProtKB/TrEMBL),   A0A8I3N025 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845009971   ⟸   ENSCAFT00845012787
RefSeq Acc Id: ENSCAFP00845009983   ⟸   ENSCAFT00845012802
RefSeq Acc Id: ENSCAFP00845009941   ⟸   ENSCAFT00845012746
Protein Domains
Homeobox   SMB

Promoters
RGD ID:13684672
Promoter ID:EPDNEW_C2740
Type:initiation region
Name:VTN_1
Description:vitronectin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1942,620,732 - 42,620,792EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018672 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013731 UniProtKB/TrEMBL
  ENSCAFG00040020222 UniProtKB/TrEMBL
  ENSCAFG00845007195 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029640.5 UniProtKB/TrEMBL
  ENSCAFT00030025413.1 UniProtKB/TrEMBL
  ENSCAFT00040037412.1 UniProtKB/TrEMBL
  ENSCAFT00845012746.1 UniProtKB/TrEMBL
  ENSCAFT00845012802 ENTREZGENE
  ENSCAFT00845012802.1 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  4.10.410.20 UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Somatomedin_B-like_dom_sf UniProtKB/TrEMBL
  Somatomedin_B_chordata UniProtKB/TrEMBL
  Somatomedin_B_dom UniProtKB/TrEMBL
KEGG Report cfa:480621 UniProtKB/TrEMBL
NCBI Gene VTN ENTREZGENE
PANTHER HEMOPEXIN DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  VITRONECTIN UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/TrEMBL
  Homeodomain UniProtKB/TrEMBL
  Somatomedin_B UniProtKB/TrEMBL
PRINTS SOMATOMEDINB UniProtKB/TrEMBL
PROSITE HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  SMB_1 UniProtKB/TrEMBL
  SMB_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
  SM00120 UniProtKB/TrEMBL
  SM00201 UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
  SSF50923 UniProtKB/TrEMBL
  SSF90188 UniProtKB/TrEMBL
UniProt A0A8C0KGK5 ENTREZGENE
  A0A8C0NBU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T6T8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N025 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N567_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:97230 ENTREZGENE