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Gene: HLA-E (major histocompatibility complex, class I, E) Homo sapiens
Symbol: HLA-E
Name: major histocompatibility complex, class I, E
Description: Exhibits beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte proliferation; and regulation of lymphocyte mediated immunity. Localizes to the MHC class I protein complex; MHC class Ib protein complex; and cell surface.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686P19218; EA1.2; EA2.1; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; HLA-6.2; lymphocyte antigen; MHC; MHC class I antigen E; MHC class Ib antigen; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; QA1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38630,489,508 - 30,494,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37630,457,183 - 30,461,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,565,250 - 30,569,077 (+)NCBINCBI36hg18NCBI36
Build 34630,565,287 - 30,568,337NCBI
Celera632,055,310 - 32,060,109 (+)NCBI
Cytogenetic Map6p22.1NCBI
HuRef630,257,312 - 30,262,111 (+)NCBIHuRef
CHM1_1630,459,288 - 30,464,087 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HLA-E
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353823
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.