ID1 (inhibitor of DNA binding 1, HLH protein) - Rat Genome Database

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Gene: ID1 (inhibitor of DNA binding 1, HLH protein) Homo sapiens
Analyze
Symbol: ID1
Name: inhibitor of DNA binding 1, HLH protein
RGD ID: 736819
HGNC Page HGNC
Description: Enables transcription regulator inhibitor activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Located in Golgi apparatus and nucleoplasm. Biomarker of primary pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHb24; class B basic helix-loop-helix protein 24; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein); DNA-binding protein inhibitor ID-1; ID; inhibitor of differentiation 1; inhibitor of dna binding 1, helix-loop-helix protein (splice variation)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2031,605,283 - 31,606,515 (+)EnsemblGRCh38hg38GRCh38
GRCh382031,605,289 - 31,606,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,193,092 - 30,194,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,656,753 - 29,657,974 (+)NCBINCBI36hg18NCBI36
Build 342029,656,752 - 29,657,974NCBI
Celera2026,949,273 - 26,950,494 (+)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2026,981,781 - 26,983,013 (+)NCBIHuRef
CHM1_12030,096,962 - 30,098,194 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-pantothenic acid  (EXP)
(S)-nicotine  (ISO)
1,4-dioxane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetamide  (ISO)
Actein  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
antimonite  (EXP)
aristolochic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
avobenzone  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (EXP)
butan-1-ol  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
candesartan  (ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
chloropicrin  (EXP)
choline  (ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
D-glucose  (ISO)
deguelin  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP)
diallyl disulfide  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (EXP)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (ISO)
ethane  (EXP)
ethanol  (EXP)
fenpyroximate  (EXP)
ferric oxide  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
furan  (ISO)
furosemide  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
geraniol  (EXP)
glucose  (ISO)
gossypol  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
icariin  (ISO)
iloprost  (EXP)
indometacin  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP,ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
menadione  (EXP)
mercury dibromide  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
ochratoxin A  (ISO)
octreotide  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
panaxydol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pasireotide  (EXP)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phlorizin  (ISO)
picoxystrobin  (EXP)
pirinixic acid  (EXP,ISO)
pomalidomide  (EXP)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (ISO)
quercetin  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resorcinol  (EXP,ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 431542  (EXP)
Securinine  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (ISO)
succimer  (EXP,ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
treprostinil  (EXP,ISO)
trichostatin A  (EXP)
triclosan  (EXP)
troglitazone  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zearalenone  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (TAS)
blood vessel endothelial cell migration  (TAS)
blood vessel morphogenesis  (TAS)
BMP signaling pathway  (ISO)
brain development  (IEA,ISO)
cell differentiation  (IBA)
cell-abiotic substrate adhesion  (IEA,ISO)
cellular response to dopamine  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (IEA,ISO)
cellular response to nerve growth factor stimulus  (IEA,ISO)
cellular response to peptide  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
circadian regulation of gene expression  (IBA)
circadian rhythm  (ISO)
collagen metabolic process  (ISO)
endothelial cell morphogenesis  (ISO)
heart development  (ISO)
lung morphogenesis  (ISO)
lung vasculature development  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (ISS)
negative regulation of dendrite morphogenesis  (IEA,ISO)
negative regulation of DNA binding  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (IDA)
negative regulation of endothelial cell differentiation  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein binding  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
negative regulation of transcription by transcription factor localization  (TAS)
negative regulation of transcription, DNA-templated  (IDA)
neuron differentiation  (IEA,ISO)
positive regulation of actin filament bundle assembly  (IEA,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
protein destabilization  (ISO)
regulation of angiogenesis  (ISO)
regulation of MAPK cascade  (ISO)
regulation of vasculature development  (IEA,ISO)
response to antibiotic  (ISO)
response to organic cyclic compound  (ISO)
transforming growth factor beta receptor signaling pathway  (TAS)

Cellular Component
centrosome  (IEA,ISO)
cytoplasm  (ISO)
Golgi apparatus  (IDA)
nucleoplasm  (IDA,TAS)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7637581   PMID:7665172   PMID:8086456   PMID:8294468   PMID:8380166   PMID:8586447   PMID:9070860   PMID:9235903   PMID:9242638   PMID:9528857   PMID:9584154   PMID:10022839  
PMID:10419887   PMID:11085505   PMID:11234019   PMID:11591653   PMID:11729207   PMID:11756408   PMID:11780052   PMID:11896613   PMID:11940648   PMID:12016143   PMID:12020803   PMID:12145280  
PMID:12203366   PMID:12296825   PMID:12477932   PMID:12547711   PMID:12576450   PMID:12718878   PMID:12719589   PMID:12787042   PMID:12823438   PMID:12881706   PMID:12947323   PMID:12949053  
PMID:14522471   PMID:14688027   PMID:14690332   PMID:14742319   PMID:14755252   PMID:15026801   PMID:15029197   PMID:15041724   PMID:15064751   PMID:15138269   PMID:15163661   PMID:15322112  
PMID:15361847   PMID:15370294   PMID:15489334   PMID:15489884   PMID:15494533   PMID:15575081   PMID:15579766   PMID:15645115   PMID:15694377   PMID:15701714   PMID:15744343   PMID:15877825  
PMID:15905202   PMID:16002046   PMID:16007194   PMID:16029118   PMID:16115231   PMID:16123120   PMID:16189525   PMID:16271072   PMID:16287090   PMID:16341674   PMID:16344560   PMID:16469432  
PMID:16506209   PMID:16525633   PMID:16552541   PMID:16556596   PMID:16682435   PMID:16894355   PMID:17072841   PMID:17102133   PMID:17145808   PMID:17202424   PMID:17426247   PMID:17537403  
PMID:17565736   PMID:17599389   PMID:17855368   PMID:17891176   PMID:17916352   PMID:18000500   PMID:18072288   PMID:18158619   PMID:18202790   PMID:18240291   PMID:18353975   PMID:18372912  
PMID:18413773   PMID:18436795   PMID:18542061   PMID:18556654   PMID:18559972   PMID:18583319   PMID:18648363   PMID:18674781   PMID:18752043   PMID:18922905   PMID:19002177   PMID:19014499  
PMID:19031736   PMID:19079342   PMID:19079362   PMID:19125693   PMID:19201527   PMID:19217708   PMID:19274049   PMID:19288008   PMID:19330020   PMID:19423615   PMID:19438642   PMID:19453261  
PMID:19491902   PMID:19515385   PMID:19551863   PMID:19567783   PMID:19571317   PMID:19643984   PMID:19644139   PMID:19710505   PMID:19766362   PMID:19843640   PMID:19906510   PMID:19926394  
PMID:19951400   PMID:20003244   PMID:20010941   PMID:20070914   PMID:20080245   PMID:20186495   PMID:20191379   PMID:20195544   PMID:20211142   PMID:20388787   PMID:20484992   PMID:20515335  
PMID:20574154   PMID:20697353   PMID:20709421   PMID:20861012   PMID:20863724   PMID:20881502   PMID:20887552   PMID:21106423   PMID:21106425   PMID:21467165   PMID:21486943   PMID:21506108  
PMID:21536374   PMID:21606196   PMID:21630092   PMID:21670698   PMID:21688151   PMID:21701587   PMID:21732357   PMID:21873635   PMID:21896993   PMID:21921026   PMID:21921784   PMID:21933340  
PMID:21955753   PMID:21988832   PMID:21993163   PMID:22076920   PMID:22139627   PMID:22226665   PMID:22278018   PMID:22301282   PMID:22354994   PMID:22379092   PMID:22393458   PMID:22480390  
PMID:22580608   PMID:22592405   PMID:22684559   PMID:22698403   PMID:22781717   PMID:22819717   PMID:23060149   PMID:23243024   PMID:23308043   PMID:23311395   PMID:23342268   PMID:23377983  
PMID:23455924   PMID:23555842   PMID:23558671   PMID:23645773   PMID:23714001   PMID:23723304   PMID:23771884   PMID:23872946   PMID:23900621   PMID:24129125   PMID:24133588   PMID:24295493  
PMID:24332369   PMID:24378760   PMID:24403496   PMID:24434151   PMID:24480377   PMID:24572994   PMID:24599583   PMID:24599933   PMID:24620998   PMID:24628854   PMID:24662327   PMID:24695670  
PMID:24804700   PMID:24861919   PMID:24948111   PMID:24952347   PMID:24970809   PMID:25010525   PMID:25028095   PMID:25031707   PMID:25323535   PMID:25344919   PMID:25449776   PMID:25496992  
PMID:25514034   PMID:25549282   PMID:25609649   PMID:25623217   PMID:25778840   PMID:25814554   PMID:25924227   PMID:25938540   PMID:26072160   PMID:26191235   PMID:26475334   PMID:26496610  
PMID:26577912   PMID:26735018   PMID:26797271   PMID:26858249   PMID:27044543   PMID:27087608   PMID:27466488   PMID:27477274   PMID:27546618   PMID:27610466   PMID:27633352   PMID:27978873  
PMID:28270523   PMID:28510612   PMID:28514442   PMID:28549790   PMID:29039489   PMID:29079782   PMID:29159326   PMID:29208670   PMID:29508175   PMID:29748374   PMID:29956775   PMID:30066902  
PMID:30154433   PMID:30260001   PMID:30535485   PMID:30563891   PMID:30584986   PMID:30626729   PMID:30887652   PMID:31292163   PMID:31391242   PMID:31545447   PMID:31582374   PMID:31646712  
PMID:31916318   PMID:31953577   PMID:32004572   PMID:32296183   PMID:32305567   PMID:32361395   PMID:32376787   PMID:32594826   PMID:32705157   PMID:32814053   PMID:33178820   PMID:33390793  
PMID:33961781   PMID:33990575  


Genomics

Comparative Map Data
ID1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2031,605,283 - 31,606,515 (+)EnsemblGRCh38hg38GRCh38
GRCh382031,605,289 - 31,606,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,193,092 - 30,194,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,656,753 - 29,657,974 (+)NCBINCBI36hg18NCBI36
Build 342029,656,752 - 29,657,974NCBI
Celera2026,949,273 - 26,950,494 (+)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2026,981,781 - 26,983,013 (+)NCBIHuRef
CHM1_12030,096,962 - 30,098,194 (+)NCBICHM1_1
Id1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,578,171 - 152,579,330 (+)NCBIGRCm39mm39
GRCm39 Ensembl2152,578,171 - 152,579,330 (+)Ensembl
GRCm382152,736,251 - 152,737,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,736,251 - 152,737,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,562,010 - 152,563,146 (+)NCBIGRCm37mm9NCBIm37
MGSCv362152,427,715 - 152,428,851 (+)NCBImm8
Celera2158,552,315 - 158,553,451 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Id1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,210,666 - 141,212,420 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3141,211,267 - 141,212,419 (+)Ensembl
Rnor_6.03148,214,623 - 148,216,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,215,540 - 148,216,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,619,728 - 154,621,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,086,162 - 143,087,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13142,991,791 - 142,992,906 (+)NCBI
Celera3139,960,608 - 139,961,735 (+)NCBICelera
Cytogenetic Map3q41NCBI
Id1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,337,757 - 29,339,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,337,969 - 29,339,178 (-)NCBIChiLan1.0ChiLan1.0
ID1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12028,535,470 - 28,536,726 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2028,535,582 - 28,536,311 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02027,895,177 - 27,896,414 (+)NCBIMhudiblu_PPA_v0panPan3
ID1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,094,339 - 21,096,276 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,094,755 - 21,096,276 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,741,568 - 20,743,501 (+)NCBI
ROS_Cfam_1.02421,780,949 - 21,782,885 (+)NCBI
UMICH_Zoey_3.12421,059,018 - 21,060,951 (+)NCBI
UNSW_CanFamBas_1.02421,163,982 - 21,165,918 (+)NCBI
UU_Cfam_GSD_1.02421,594,218 - 21,596,151 (+)NCBI
Id1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,179,346 - 170,180,525 (+)NCBI
SpeTri2.0NW_00493648518,610,721 - 18,611,889 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ID1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,315,964 - 35,317,744 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,316,518 - 35,317,742 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,187,160 - 40,188,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247994
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,008,660 - 36,009,880 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl236,008,636 - 36,010,017 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605090,944,637 - 90,945,863 (-)NCBIVero_WHO_p1.0
Id1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624741897,038 - 898,249 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
PMC156147P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,193,391 - 30,193,470UniSTSGRCh37
Build 362029,657,052 - 29,657,131RGDNCBI36
Celera2026,949,572 - 26,949,651RGD
HuRef2026,982,086 - 26,982,165UniSTS
PMC22262P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,193,580 - 30,193,964UniSTSGRCh37
Build 362029,657,241 - 29,657,625RGDNCBI36
Celera2026,949,761 - 26,950,145RGD
Cytogenetic Map20q11UniSTS
HuRef2026,982,275 - 26,982,659UniSTS
WI-9304  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,194,178 - 30,194,288UniSTSGRCh37
Build 362029,657,839 - 29,657,949RGDNCBI36
Celera2026,950,359 - 26,950,469RGD
Cytogenetic Map20q11UniSTS
HuRef2026,982,873 - 26,982,983UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR29B1hsa-miR-29b-3pOncomiRDBexternal_infoNANA22249264
MIR100hsa-miR-100-5pMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)19396866
MIR520Hhsa-miR-520hMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)19435428
MIR381hsa-miR-381-3pOncomiRDBexternal_infoNANA22592211
MIR29B2hsa-miR-29b-3pOncomiRDBexternal_infoNANA22249264

Predicted Target Of
Summary Value
Count of predictions:534
Count of miRNA genes:299
Interacting mature miRNAs:313
Transcripts:ENST00000376105, ENST00000376112
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 13 6 27 6 7 9 1 14 38 40 4 2
Medium 2406 2241 1663 583 616 427 4102 1983 3662 379 1394 1561 171 1 1193 2579 5 2
Low 20 673 36 35 952 31 246 211 72 26 28 11 4 7 207 1
Below cutoff 70 243 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_181353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI304595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL110115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG546814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI768231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM856018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA839689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000376105   ⟹   ENSP00000365273
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2031,605,283 - 31,606,515 (+)Ensembl
RefSeq Acc Id: ENST00000376112   ⟹   ENSP00000365280
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2031,605,289 - 31,606,510 (+)Ensembl
RefSeq Acc Id: NM_002165   ⟹   NP_002156
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382031,605,289 - 31,606,510 (+)NCBI
GRCh372030,193,086 - 30,194,318 (+)NCBI
Build 362029,656,753 - 29,657,974 (+)NCBI Archive
HuRef2026,981,781 - 26,983,013 (+)NCBI
CHM1_12030,096,962 - 30,098,194 (+)NCBI
Sequence:
RefSeq Acc Id: NM_181353   ⟹   NP_851998
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382031,605,289 - 31,606,510 (+)NCBI
GRCh372030,193,086 - 30,194,318 (+)NCBI
Build 362029,656,753 - 29,657,974 (+)NCBI Archive
HuRef2026,981,781 - 26,983,013 (+)NCBI
CHM1_12030,096,962 - 30,098,194 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_851998   ⟸   NM_181353
- Peptide Label: isoform b
- UniProtKB: P41134 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_002156   ⟸   NM_002165
- Peptide Label: isoform a
- UniProtKB: P41134 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000365273   ⟸   ENST00000376105
RefSeq Acc Id: ENSP00000365280   ⟸   ENST00000376112
Protein Domains
bHLH

Promoters
RGD ID:6798812
Promoter ID:HG_KWN:38986
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:OTTHUMT00000078550,   OTTHUMT00000078551
Position:
Human AssemblyChrPosition (strand)Source
Build 362029,656,466 - 29,656,966 (+)MPROMDB
RGD ID:13206605
Promoter ID:EPDNEW_H26883
Type:multiple initiation site
Name:ID1_1
Description:inhibitor of DNA binding 1, HLH protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26882  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382031,605,289 - 31,605,349EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q11.21(chr20:31289875-32302312)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052792]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052792]|See cases [RCV000052792] Chr20:31289875..32302312 [GRCh38]
Chr20:29877678..30890115 [GRCh37]
Chr20:29341339..30353776 [NCBI36]
Chr20:20q11.21
uncertain significance
GRCh38/hg38 20p12.2-q12(chr20:9811433-39316956)x3 copy number gain See cases [RCV000052999] Chr20:9811433..39316956 [GRCh38]
Chr20:9792081..37945599 [GRCh37]
Chr20:9740081..37379013 [NCBI36]
Chr20:20p12.2-q12
pathogenic
GRCh38/hg38 20q11.21(chr20:31254983-32575288)x3 copy number gain See cases [RCV000134504] Chr20:31254983..32575288 [GRCh38]
Chr20:29842786..31163090 [GRCh37]
Chr20:29306447..30626751 [NCBI36]
Chr20:20q11.21
pathogenic
GRCh38/hg38 20q11.21(chr20:31254983-33473080)x3 copy number gain See cases [RCV000135358] Chr20:31254983..33473080 [GRCh38]
Chr20:29842786..32060886 [GRCh37]
Chr20:29306447..31524547 [NCBI36]
Chr20:20q11.21
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q11.21(chr20:31245583-32017285)x4 copy number gain See cases [RCV000138183] Chr20:31245583..32017285 [GRCh38]
Chr20:29833386..30605088 [GRCh37]
Chr20:29297047..30068749 [NCBI36]
Chr20:20q11.21
likely pathogenic
GRCh38/hg38 20q11.21(chr20:31254983-31660401)x3 copy number gain See cases [RCV000141034] Chr20:31254983..31660401 [GRCh38]
Chr20:29842786..30248204 [GRCh37]
Chr20:29306447..29711865 [NCBI36]
Chr20:20q11.21
uncertain significance
GRCh37/hg19 20p12.1-q11.21(chr20:17705775-31600738)x3 copy number gain See cases [RCV000240436] Chr20:17705775..31600738 [GRCh37]
Chr20:20p12.1-q11.21
pathogenic
GRCh37/hg19 20q11.21(chr20:29877878-30231917)x3 copy number gain See cases [RCV000448484] Chr20:29877878..30231917 [GRCh37]
Chr20:20q11.21
likely benign
GRCh37/hg19 20p11.21-q11.21(chr20:24162775-31820857)x3 copy number gain See cases [RCV000448977] Chr20:24162775..31820857 [GRCh37]
Chr20:20p11.21-q11.21
likely pathogenic
GRCh37/hg19 20q11.21(chr20:29833535-30599771)x3 copy number gain See cases [RCV000511585] Chr20:29833535..30599771 [GRCh37]
Chr20:20q11.21
uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20q11.21(chr20:29425357-30226690)x3 copy number gain See cases [RCV000515558] Chr20:29425357..30226690 [GRCh37]
Chr20:20q11.21
uncertain significance
GRCh37/hg19 20p11.21-q11.21(chr20:24876569-30494851)x3 copy number gain See cases [RCV000512500] Chr20:24876569..30494851 [GRCh37]
Chr20:20p11.21-q11.21
uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
Single allele duplication not provided [RCV000677978] Chr20:17705775..31600738 [GRCh37]
Chr20:20p12.1-q11.21
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20q11.21-11.23(chr20:29833608-35087952)x3 copy number gain not provided [RCV000849735] Chr20:29833608..35087952 [GRCh37]
Chr20:20q11.21-11.23
pathogenic
GRCh37/hg19 20q11.21(chr20:29835457-30232565)x3 copy number gain not provided [RCV000849469] Chr20:29835457..30232565 [GRCh37]
Chr20:20q11.21
uncertain significance
GRCh37/hg19 20q11.21(chr20:29651839-30195919)x3 copy number gain not provided [RCV001007089] Chr20:29651839..30195919 [GRCh37]
Chr20:20q11.21
likely benign
GRCh37/hg19 20p11.23-q11.21(chr20:19750804-30479077)x3 copy number gain not provided [RCV001258738] Chr20:19750804..30479077 [GRCh37]
Chr20:20p11.23-q11.21
likely pathogenic
GRCh37/hg19 20q11.21(chr20:29833534-30494851)x3 copy number gain not provided [RCV001258905] Chr20:29833534..30494851 [GRCh37]
Chr20:20q11.21
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5360 AgrOrtholog
COSMIC ID1 COSMIC
Ensembl Genes ENSG00000125968 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000365273 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000365280 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000376105 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000376112 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
GTEx ENSG00000125968 GTEx
HGNC ID HGNC:5360 ENTREZGENE
Human Proteome Map ID1 Human Proteome Map
InterPro bHLH_dom UniProtKB/Swiss-Prot
  DNA-bd_prot-inh UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report hsa:3397 UniProtKB/Swiss-Prot
NCBI Gene 3397 ENTREZGENE
OMIM 600349 OMIM
PANTHER PTHR11723 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PharmGKB PA29608 PharmGKB
PROSITE BHLH UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt ID1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8K537 UniProtKB/Swiss-Prot
  E1P5L4 UniProtKB/Swiss-Prot
  O00651 UniProtKB/Swiss-Prot
  O00652 UniProtKB/Swiss-Prot
  Q16371 UniProtKB/Swiss-Prot
  Q16377 UniProtKB/Swiss-Prot
  Q5TE66 UniProtKB/Swiss-Prot
  Q5TE67 UniProtKB/Swiss-Prot
  Q969Z7 UniProtKB/Swiss-Prot
  Q9H0Z5 UniProtKB/Swiss-Prot
  Q9H109 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 ID1  inhibitor of DNA binding 1, HLH protein  ID1  inhibitor of DNA binding 1, dominant negative helix-loop-helix protein  Symbol and/or name change 5135510 APPROVED