CASP8 (caspase 8) - Rat Genome Database

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Gene: CASP8 (caspase 8) Homo sapiens
Symbol: CASP8
Name: caspase 8
RGD ID: 730846
Description: Enables several functions, including cysteine-type endopeptidase activity involved in apoptotic signaling pathway; death effector domain binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to mechanical stimulus; proteolysis; and regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytosol and nucleoplasm. Part of CD95 death-inducing signaling complex and ripoptosome. Implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Biomarker of Alzheimer's disease; Huntington's disease; and autoimmune disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALPS2B; apoptotic cysteine protease; apoptotic protease Mch-5; CAP4; Casp-8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; caspase-8; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; FLJ17672; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2201,233,443 - 201,287,711 (+)EnsemblGRCh38hg38GRCh38
GRCh382201,233,443 - 201,287,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372202,098,166 - 202,152,434 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,806,411 - 201,860,679 (+)NCBINCBI36hg18NCBI36
Build 342201,923,718 - 201,972,144NCBI
Celera2195,852,777 - 195,904,249 (+)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,949,530 - 194,000,819 (+)NCBIHuRef
CHM1_12202,104,145 - 202,158,454 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (EXP)
adenocarcinoma  (EXP)
Alcohol-Related Disorders  (ISO)
allergic contact dermatitis  (EXP)
Alzheimer's disease  (IEP,ISO)
atopic dermatitis  (ISS)
autoimmune disease  (IEP)
autoimmune lymphoproliferative syndrome  (EXP)
autoimmune lymphoproliferative syndrome type 2B  (IAGP)
bacterial infectious disease  (ISO)
Brain Contusion  (ISO)
Brain Injuries  (ISO)
breast cancer  (IAGP)
Breast Neoplasms  (EXP)
Bronchopulmonary Dysplasia  (ISO)
Cerebral Hemorrhage  (EXP,ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colorectal Neoplasms  (EXP)
contact dermatitis  (EXP)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (EXP)
Esophageal Neoplasms  (EXP)
esophagus adenocarcinoma  (IAGP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Prostate Cancer  (EXP)
head and neck squamous cell carcinoma  (EXP)
heart disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (IAGP,ISO)
Huntington's disease  (IEP)
hyperglycemia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (IAGP,IEA)
Lung Neoplasms  (EXP,IAGP)
lung non-small cell carcinoma  (EXP)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (EXP)
mitochondrial metabolism disease  (EXP)
Myocardial Reperfusion Injury  (EXP,ISO)
nephritis  (ISO)
Neurodevelopmental Disorders  (IAGP)
Osteoarthritis, Experimental  (ISO)
pancreatic cancer  (IAGP)
papillomavirus infectious disease  (EXP)
pre-malignant neoplasm  (ISO)
primary immunodeficiency disease  (IAGP)
Pulmonary Arterial Hypertension  (IAGP)
Radiation Injuries, Experimental  (ISO)
Reperfusion Injury  (EXP)
retinal detachment  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (EXP)
status epilepticus  (EXP,ISO)
Stomach Neoplasms  (EXP)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (EXP,ISO)
Uterine Cervical Neoplasms  (EXP)
Viral Myocarditis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (EXP)
(+)-catechin  (EXP)
(+)-dexrazoxane  (ISO)
(+)-Tetrandrine  (EXP)
(-)-anisomycin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-gambogic acid  (EXP)
(20S)-ginsenoside Rg3  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-benzoquinone  (EXP)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-methoxy-17beta-estradiol  (EXP)
25-hydroxycholesterol  (ISO)
28-deoxonimbolide  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (EXP)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitro-m-cresol  (EXP,ISO)
4-nonylphenol  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (EXP)
6-bromoindirubin-3'-oxime  (EXP)
6-formylpterin  (EXP)
7-ketocholesterol  (ISO)
9'-cis-neoxanthin  (EXP)
9-cis-retinoic acid  (EXP)
9-hydroxycanthin-6-one  (EXP)
ABT-737  (EXP)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP)
aclacinomycin A  (EXP)
acrolein  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
adenosine  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Ala-Gln  (EXP)
alantolactone  (EXP)
alborixin  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-acitretin  (EXP)
all-trans-neoxanthin  (EXP)
all-trans-retinoic acid  (EXP)
Aloe emodin  (EXP)
alpha-mangostin  (EXP)
alpha-naphthoflavone  (ISO)
alvocidib  (EXP)
amiloride  (EXP)
amiodarone  (EXP,ISO)
amlodipine  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
andrographolide  (EXP,ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP,ISO)
arachidonic acid  (EXP)
arjunolic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
asarone  (EXP)
atorvastatin calcium  (EXP,ISO)
auranofin  (EXP)
azadirachtin A  (EXP)
azadiradione  (EXP)
bafilomycin A1  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (EXP)
bathocuproine disulfonic acid  (EXP)
beauvericin  (EXP)
belinostat  (EXP)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[e]pyrene  (EXP,ISO)
benzophenanthridine  (EXP)
berberine  (EXP)
beta-hexachlorocyclohexane  (ISO)
betulin  (EXP)
betulinic acid  (EXP)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
borrelidin  (EXP)
bortezomib  (EXP)
Brevetoxin B  (EXP)
Brusatol  (EXP)
bupropion  (EXP)
busulfan  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (EXP)
Calcimycin  (EXP,ISO)
calcitriol  (EXP,ISO)
Calpeptin  (ISO)
camptothecin  (EXP,ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidic acid  (EXP)
cantharidin  (EXP)
capsaicin  (EXP)
capsazepine  (ISO)
carbamazepine  (EXP)
carbon atom  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
casticin  (EXP)
catechol  (EXP)
celastrol  (EXP)
celecoxib  (EXP)
cerivastatin  (EXP)
ceruletide  (ISO)
chalcone  (EXP)
chalcones  (EXP)
chlorambucil  (EXP)
chloroacetaldehyde  (EXP)
chlorogenic acid  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(3+) trichloride  (EXP)
chromium(6+)  (EXP)
chromone  (EXP)
chrysazin  (EXP)
chrysin  (EXP)
ciglitazone  (EXP)
cilostazol  (ISO)
cimetidine  (EXP)
Cinobufotalin  (EXP)
ciprofloxacin  (EXP)
cisplatin  (EXP,ISO)
cladribine  (EXP)
clavulone II  (EXP)
clofibrate  (ISO)
clomipramine  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clotrimazole  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP)
corticosterone  (ISO)
coumarin  (EXP)
crizotinib  (EXP)
crocidolite asbestos  (EXP)
crocin-1  (EXP)
cucurbitacin I  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cytarabine  (EXP)
D-glucitol  (ISO)
D-gluconic acid  (EXP)
D-glucose  (ISO)
dacarbazine  (EXP)
daunorubicin  (EXP)
Deguelin  (EXP)
delphinidin  (EXP)
demethoxycurcumin  (EXP)
demethoxyfumitremorgin C  (EXP)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dieckol  (EXP)
dieldrin  (ISO)
diepoxybutane  (EXP)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (EXP)
Dihydrotanshinone I  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (EXP)
dioxygen  (EXP)
dipyridamole  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
docebenone  (ISO)
donepezil hydrochloride  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
Echimidine  (EXP)
Echinocystic acid  (EXP)
eckol  (EXP)
edaravone  (ISO)
elemental carbon  (EXP)
elemental selenium  (EXP)
ellipticine  (EXP)
emodin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
enzalutamide  (EXP)
epichlorohydrin  (EXP)
esculetin  (EXP)
etacrynic acid  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (EXP)
fangchinoline  (EXP)
fingolimod hydrochloride  (EXP)
fisetin  (EXP)
flavanone  (EXP)
flavones  (EXP)
flavonols  (EXP)
fluoxetine  (ISO)
fluticasone  (EXP)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (EXP)
furan  (ISO)
furosemide  (ISO)
Fusarenone X  (ISO)
gallic acid  (EXP)
gallium atom  (EXP)
gardenin B  (EXP)
gedunin  (EXP)
gefitinib  (EXP)
gemcitabine  (EXP)
genistein  (EXP)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
geraniol  (EXP,ISO)
gibberellin A3  (ISO)
gingerol  (EXP,ISO)
glabridin  (EXP)
glucose  (ISO)
glutaraldehyde  (EXP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
Grifolin  (EXP)
guggulsterone  (EXP)
helenalin  (EXP)
Heliotrine  (EXP)
hexachlorobenzene  (ISO)
homocysteine  (EXP)
Honokiol  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hyperforin  (EXP)
icariside II  (EXP)
idelalisib  (EXP)
Ilimaquinone  (EXP)
imipramine  (ISO)
indirubin-3'-monoxime  (EXP)
indometacin  (EXP,ISO)
ionomycin  (EXP)
irinotecan  (EXP)
iron(III) nitrilotriacetate  (ISO)
isoflavones  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
juglone  (EXP)
kojic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
Licochalcone A  (EXP)
linalool  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (EXP)
lonafarnib  (EXP)
lonidamine  (EXP)
Loratadine  (EXP)
losartan  (ISO)
lovastatin  (EXP,ISO)
lupeol  (EXP)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (ISO)
LY294002  (EXP)
lycopene  (EXP,ISO)
magnesium oxide  (EXP)
malathion  (ISO)
mancozeb  (EXP)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
masoprocol  (EXP,ISO)
MeIQx  (EXP)
melatonin  (EXP,ISO)
melittin  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
metformin  (EXP)
methotrexate  (EXP)
methoxsalen  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (EXP)
metiram  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP)
minocycline  (ISO)
mitomycin C  (EXP)
mitoxantrone  (EXP)
molybdenum atom  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (EXP,ISO)
myricetin  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nelfinavir  (EXP)
neohesperidin dihydrochalcone  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
Niflumic acid  (EXP)
nimesulide  (EXP)
nimustine  (EXP)
nitric oxide  (EXP,ISO)
nitroprusside  (EXP,ISO)
nobiletin  (EXP)
nocodazole  (EXP)
Nodularin  (EXP,ISO)
norfloxacin  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP)
Nutlin-3  (EXP)
nystatin  (EXP)
Obacunone  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (EXP)
okadaic acid  (EXP)
olaparib  (EXP)
oleandrin  (EXP)
oleanolic acid  (EXP)
omeprazole  (EXP)
omethoate  (EXP)
orlistat  (EXP,ISO)
oroxylin A  (EXP)
osthole  (EXP)
ouabain  (EXP)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (EXP)
p-cresol  (EXP)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP,ISO)
Panduratin A  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
Parthenin  (EXP)
parthenolide  (EXP)
patulin  (EXP)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (EXP)
pepstatin A  (ISO)
perfluorononanoic acid  (ISO)
perifosine  (EXP)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenol  (EXP)
phenylephrine  (EXP)</