Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CASP8 (caspase 8) Homo sapiens
Analyze
Symbol: CASP8
Name: caspase 8
RGD ID: 730846
Description: Exhibits several functions, including cysteine-type endopeptidase activity involved in apoptotic signaling pathway; death effector domain binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to mechanical stimulus; proteolysis; and regulation of I-kappaB kinase/NF-kappaB signaling. Localizes to CD95 death-inducing signaling complex; nucleoplasm; and ripoptosome. Implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; hepatocellular carcinoma; pancreatic cancer; and primary immunodeficiency disease. Biomarker of Alzheimer's disease and Huntington's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALPS2B; apoptotic cysteine protease; apoptotic protease Mch-5; CAP4; Casp-8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; caspase-8; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; FLJ17672; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog
Orthologs:
Mus musculus (house mouse) : Casp8 (caspase 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp8 (caspase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp8 (caspase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP8 (caspase 8)
Canis lupus familiaris (dog) : CASP8 (caspase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp8 (caspase 8)
Sus scrofa (pig) : CASP8 (caspase 8)
Chlorocebus sabaeus (African green monkey) : CASP8 (caspase 8)
Heterocephalus glaber (naked mole-rat) : Casp8 (caspase 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2201,233,443 - 201,287,711 (+)EnsemblGRCh38hg38GRCh38
GRCh382201,233,443 - 201,287,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372202,098,166 - 202,152,434 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,806,411 - 201,860,679 (+)NCBINCBI36hg18NCBI36
Build 342201,923,718 - 201,972,144NCBI
Celera2195,852,777 - 195,904,249 (+)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,949,530 - 194,000,819 (+)NCBIHuRef
CHM1_12202,104,145 - 202,158,454 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated