CASP8 Human (+)-alpha-viniferin increases activity EXP 6480464 alpha-viniferin analog results in increased activity of CASP8 protein and alpha-viniferin results in increased activity of CASP8 protein CTD PMID:16158945 CASP8 Human (+)-catechin increases activity EXP 6480464 Catechin results in increased activity of CASP8 protein CTD PMID:20206613 CASP8 Human (+)-dexrazoxane increases expression ISO Casp8 (Mus musculus) 6480464 Dexrazoxane results in increased expression of CASP8 mRNA CTD PMID:26873546 CASP8 Human (+)-Tetrandrine multiple interactions EXP 6480464 tetrandrine results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:26822499 CASP8 Human (+)-Tetrandrine increases cleavage EXP 6480464 tetrandrine results in increased cleavage of CASP8 protein CTD PMID:25266202 CASP8 Human (+)-Tetrandrine increases expression EXP 6480464 tetrandrine results in increased expression of CASP8 protein CTD PMID:31255635 CASP8 Human (-)-anisomycin increases activity EXP 6480464 Anisomycin results in increased activity of CASP8 protein CTD PMID:18241849 CASP8 Human (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CASP8 mRNA CTD PMID:22079256 CASP8 Human (-)-epigallocatechin 3-gallate multiple interactions ISO Casp8 (Mus musculus) 6480464 epigallocatechin gallate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP8 protein] CTD PMID:37286014 CASP8 Human (-)-gambogic acid multiple interactions EXP 6480464 [gambogic acid co-treated with Bortezomib] results in increased activity of CASP8 protein and [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:24291039 and PMID:24373880 CASP8 Human (1->4)-beta-D-glucan multiple interactions ISO Casp8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CASP8 mRNA CTD PMID:36331819 CASP8 Human (20S)-ginsenoside Rg3 multiple interactions EXP 6480464 ginsenoside Rg3 inhibits the reaction [cagA protein and Helicobacter pylori results in decreased cleavage of CASP8 protein] CTD PMID:26427350 CASP8 Human (R)-carnitine multiple interactions EXP 6480464 Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein] CTD PMID:32478940 CASP8 Human (R)-lipoic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA CTD PMID:23830814 CASP8 Human (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein] CTD PMID:27544635 CASP8 Human (R)-noradrenaline affects activity ISO Casp8 (Rattus norvegicus) 6480464 Norepinephrine affects the activity of CASP8 protein CTD PMID:25437044 CASP8 Human (R,R,R)-alpha-tocopherol increases cleavage EXP 6480464 alpha-Tocopherol analog results in increased cleavage of CASP8 protein CTD PMID:20686688 CASP8 Human (S)-colchicine increases expression ISO Casp8 (Rattus norvegicus) 6480464 Colchicine results in increased expression of CASP8 mRNA CTD PMID:18255150 CASP8 Human (S)-nicotine affects expression ISO Casp8 (Rattus norvegicus) 6480464 Nicotine affects the expression of CASP8 mRNA CTD PMID:20426880 CASP8 Human (Z)-3-butylidenephthalide increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 butylidenephthalide results in increased cleavage of CASP8 protein CTD PMID:16987298 CASP8 Human (Z)-3-butylidenephthalide increases cleavage EXP 6480464 butylidenephthalide results in increased cleavage of CASP8 protein CTD PMID:16987298 CASP8 Human 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expression ISO Casp8 (Rattus norvegicus) 6480464 o and p'-DDT analog results in decreased expression of CASP8 mRNA CTD PMID:22937105 CASP8 Human 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO Casp8 (Rattus norvegicus) 6480464 o and p'-DDT results in increased expression of CASP8 mRNA CTD PMID:22937105 CASP8 Human 1,2-dichloroethane increases cleavage ISO Casp8 (Mus musculus) 6480464 ethylene dichloride results in increased cleavage of CASP8 protein CTD PMID:31520740 CASP8 Human 1,2-dimethylhydrazine multiple interactions ISO Casp8 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CASP8 mRNA CTD PMID:22206623 CASP8 Human 1,3-Dinitropyrene multiple interactions ISO Casp8 (Mus musculus) 6480464 1 and 3-dinitropyrene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17240030 CASP8 Human 1,4-benzoquinone multiple interactions EXP 6480464 Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein] CTD PMID:32478940 CASP8 Human 1,4-benzoquinone increases activity EXP 6480464 quinone results in increased activity of CASP8 protein CTD PMID:32478940 CASP8 Human 1,4-dithiothreitol multiple interactions ISO Casp8 (Mus musculus) 6480464 Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] CTD PMID:11226294 CASP8 Human 1,4-naphthoquinone increases activity EXP 6480464 1 and 4-naphthoquinone results in increased activity of CASP8 protein CTD PMID:20138029 CASP8 Human 1-nitropyrene multiple interactions ISO Casp8 (Mus musculus) 6480464 1-nitropyrene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17240030 CASP8 Human 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions EXP 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15498850 CASP8 Human 17beta-estradiol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Caspase Inhibitors results in decreased activity of CASP8 protein] inhibits the reaction [Estradiol results in increased activity of CASP3 protein] more ... CTD PMID:15545282 more ... CASP8 Human 17beta-estradiol increases expression EXP 6480464 Estradiol analog results in increased expression of CASP8 mRNA and Estradiol analog results in increased expression of CASP8 protein CTD PMID:36460128 CASP8 Human 17beta-estradiol decreases activity EXP 6480464 Estradiol results in decreased activity of CASP8 protein CTD PMID:31278978 CASP8 Human 17beta-estradiol increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Estradiol results in increased cleavage of CASP8 protein CTD PMID:15545282 CASP8 Human 17beta-estradiol increases activity EXP 6480464 Estradiol results in increased activity of CASP8 protein CTD PMID:19095654 CASP8 Human 17beta-estradiol 3-benzoate increases expression ISO Casp8 (Rattus norvegicus) 6480464 estradiol 3-benzoate results in increased expression of CASP8 mRNA CTD PMID:24316378 CASP8 Human 17beta-estradiol 3-benzoate multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 estradiol 3-benzoate results in increased expression of and results in increased activity of CASP8 protein more ... CTD PMID:24316378 CASP8 Human 2,2',4,4',5,5'-hexachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:20638727 CASP8 Human 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 wortmannin inhibits the reaction [2 more ... CTD PMID:24726520 CASP8 Human 2,2',4,4',5,5'-hexachlorobiphenyl affects expression EXP 6480464 2 more ... CTD PMID:20638727 CASP8 Human 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:26808241 CASP8 Human 2,2',4,4'-Tetrabromodiphenyl ether affects expression EXP 6480464 2 more ... CTD PMID:27589474 CASP8 Human 2,2',4,4'-Tetrabromodiphenyl ether affects activity EXP 6480464 2 more ... CTD PMID:27589474 CASP8 Human 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Casp8 (Mus musculus) 6480464 2 more ... CTD PMID:25462306 CASP8 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CASP8 mRNA CTD PMID:16039398 CASP8 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Casp8 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of CASP8 mRNA CTD PMID:22666406 CASP8 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Casp8 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of CASP8 mRNA CTD PMID:21570461 CASP8 Human 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO Casp8 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased activity of CASP8 protein CTD PMID:21846477 CASP8 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Casp8 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of CASP8 mRNA CTD PMID:19520675 and PMID:33387578 CASP8 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Casp8 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of CASP8 mRNA and Tetrachlorodibenzodioxin results in increased expression of CASP8 protein CTD PMID:12167310 more ... CASP8 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Casp8 (Mus musculus) 6480464 NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CASP8 protein] and Tetrachlorodibenzodioxin results in increased cleavage of and affects the activity of CASP8 protein CTD PMID:15664267 and PMID:21846477 CASP8 Human 2,4,6-trinitrobenzenesulfonic acid decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of CASP8 protein modified form CTD PMID:30503585 CASP8 Human 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Sulfur Dioxide inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CASP8 protein modified form] CTD PMID:30503585 CASP8 Human 2,4-D multiple interactions ISO Casp8 (Mus musculus) 6480464 FAS protein promotes the reaction [2 more ... CTD PMID:36214342 CASP8 Human 2,4-D increases expression ISO Casp8 (Rattus norvegicus) 6480464 2 more ... CTD PMID:36214342 CASP8 Human 2,4-D increases expression ISO Casp8 (Mus musculus) 6480464 2 more ... CTD PMID:36214342 CASP8 Human 2,4-D multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [2 more ... CTD PMID:36085217 and PMID:36214342 CASP8 Human 2,4-dinitrotoluene affects expression ISO Casp8 (Rattus norvegicus) 6480464 2 and 4-dinitrotoluene affects the expression of CASP8 mRNA CTD PMID:21346803 CASP8 Human 2,5-hexanedione decreases expression ISO Casp8 (Mus musculus) 6480464 2 and 5-hexanedione results in decreased expression of CASP8 protein CTD PMID:33197454 CASP8 Human 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions EXP 6480464 [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:24373880 CASP8 Human 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine increases activity ISO Casp8 (Rattus norvegicus) 6480464 4-iodo-2 and 5-dimethoxyphenylisopropylamine results in increased activity of CASP8 protein CTD PMID:22983118 CASP8 Human 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Casp8 (Mus musculus) 6480464 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide more ... CTD PMID:20558151 more ... CASP8 Human 2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid multiple interactions EXP 6480464 [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein CTD PMID:18349320 CASP8 Human 2-methoxy-17beta-estradiol increases expression EXP 6480464 2-Methoxyestradiol results in increased expression of CASP8 protein modified form CTD PMID:23967052 CASP8 Human 25-hydroxycholesterol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 6-hydroxy-2 more ... CTD PMID:25845326 CASP8 Human 25-hydroxycholesterol increases activity ISO Casp8 (Rattus norvegicus) 6480464 25-hydroxycholesterol results in increased activity of CASP8 protein CTD PMID:25845326 CASP8 Human 28-deoxonimbolide increases activity EXP 6480464 28-deoxonimbolide results in increased activity of CASP8 protein CTD PMID:21381696 CASP8 Human 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Casp8 (Mus musculus) 6480464 3 more ... CTD PMID:31563530 CASP8 Human 3,3',5,5'-tetraiodothyroacetic acid increases expression EXP 6480464 tetraiodothyroacetic acid results in increased expression of CASP8 protein and tetraiodothyroacetic acid results in increased expression of CASP8 protein modified form CTD PMID:35151786 CASP8 Human 3,3',5,5'-tetraiodothyroacetic acid multiple interactions EXP 6480464 [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of CASP8 protein modified form and heteronemin promotes the reaction [tetraiodothyroacetic acid results in increased expression of CASP8 protein modified form] CTD PMID:35151786 CASP8 Human 3,4-methylenedioxymethamphetamine increases activity ISO Casp8 (Rattus norvegicus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased activity of CASP8 protein CTD PMID:22983118 and PMID:27255387 CASP8 Human 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide increases activity EXP 6480464 thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 CASP8 Human 3-chloropropane-1,2-diol increases activity EXP 6480464 alpha-Chlorohydrin results in increased activity of CASP8 protein CTD PMID:28070108 CASP8 Human 3-chloropropane-1,2-diol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP8 protein CTD PMID:34915118 CASP8 Human 3-chloropropane-1,2-diol multiple interactions EXP 6480464 alpha-Chlorohydrin results in increased expression of and results in increased cleavage of and results in increased activity of CASP8 protein and quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP8 protein] CTD PMID:27732882 CASP8 Human 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of CASP8 mRNA CTD PMID:27732882 CASP8 Human 3-hydroxybutyric acid multiple interactions ISO Casp8 (Mus musculus) 6480464 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide and E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP8 protein] CTD PMID:31332890 CASP8 Human 3-methyladenine multiple interactions EXP 6480464 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]] more ... CTD PMID:20104024 CASP8 Human 3-Nitrofluoranthene increases activity ISO Casp8 (Mus musculus) 6480464 3-nitrofluoranthene results in increased activity of CASP8 protein CTD PMID:19041363 CASP8 Human 3-nitropropanoic acid increases activity ISO Casp8 (Rattus norvegicus) 6480464 3-nitropropionic acid results in increased activity of CASP8 protein CTD PMID:15571979 CASP8 Human 3-phenylprop-2-enal increases activity EXP 6480464 cinnamaldehyde results in increased activity of CASP8 protein CTD PMID:15964311 CASP8 Human 4'-epidoxorubicin multiple interactions EXP 6480464 Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein] and Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA] CTD PMID:23867903 CASP8 Human 4,4'-sulfonyldiphenol increases activity ISO Casp8 (Rattus norvegicus) 6480464 bisphenol S results in increased activity of CASP8 protein CTD PMID:23458715 CASP8 Human 4,4'-sulfonyldiphenol increases expression ISO Casp8 (Mus musculus) 6480464 bisphenol S results in increased expression of CASP8 mRNA CTD PMID:30951980 CASP8 Human 4,5,6,7-TETRABROMOBENZOTRIAZOLE multiple interactions EXP 6480464 [4 more ... CTD PMID:16489027 CASP8 Human 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO Casp8 (Mus musculus) 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CASP8 mRNA CTD PMID:21167638 CASP8 Human 4-hydroxynon-2-enal decreases expression EXP 6480464 4-hydroxy-2-nonenal results in decreased expression of CASP8 mRNA CTD PMID:12419474 CASP8 Human 4-hydroxyphenyl retinamide multiple interactions EXP 6480464 [Fenretinide co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:17273769 CASP8 Human 4-nitro-m-cresol increases activity EXP 6480464 4-nitro-3-cresol results in increased activity of CASP8 protein CTD PMID:29307546 CASP8 Human 4-nitro-m-cresol increases activity ISO Casp8 (Mus musculus) 6480464 4-nitro-3-cresol results in increased activity of CASP8 protein CTD PMID:29307546 CASP8 Human 4-nitro-m-cresol multiple interactions EXP 6480464 CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA] more ... CTD PMID:29307546 CASP8 Human 4-nonylphenol increases cleavage ISO Casp8 (Mus musculus) 6480464 4-nonylphenol results in increased cleavage of CASP8 protein CTD PMID:22056370 CASP8 Human 4-nonylphenol increases expression ISO Casp8 (Rattus norvegicus) 6480464 4-nonylphenol results in increased expression of CASP8 mRNA CTD PMID:30228064 CASP8 Human 4-nonylphenol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 4-nonylphenol affects the reaction [bisphenol A results in increased expression of CASP8 mRNA] and bisphenol A affects the reaction [4-nonylphenol results in increased expression of CASP8 mRNA] CTD PMID:30228064 CASP8 Human 4-nonylphenol decreases expression ISO Casp8 (Rattus norvegicus) 6480464 4-nonylphenol results in decreased expression of CASP8 mRNA CTD PMID:27087316 CASP8 Human 4-phenylbutyric acid multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP8 protein] CTD PMID:31364909 CASP8 Human 5-aminolevulinic acid increases activity EXP 6480464 Aminolevulinic Acid analog results in increased activity of CASP8 protein CTD PMID:21138480 CASP8 Human 5-aminolevulinic acid multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein] CTD PMID:21138480 CASP8 Human 5-aza-2'-deoxycytidine increases cleavage EXP 6480464 Decitabine results in increased cleavage of CASP8 protein CTD PMID:18636160 CASP8 Human 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 [[[Decitabine co-treated with IFNG protein] results in increased expression of CASP8 protein] which co-treated with TNFSF10 protein] results in increased activity of CASP8 protein more ... CTD PMID:16607283 more ... CASP8 Human 5-aza-2'-deoxycytidine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Decitabine inhibits the reaction [Cadmium Chloride results in decreased cleavage of CASP8 protein] more ... CTD PMID:22457795 CASP8 Human 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of CASP8 mRNA and Decitabine results in increased expression of CASP8 protein CTD PMID:19214542 more ... CASP8 Human 5-aza-2'-deoxycytidine decreases methylation EXP 6480464 Decitabine results in decreased methylation of CASP8 promoter CTD PMID:19440673 CASP8 Human 5-azacytidine increases expression EXP 6480464 Azacitidine results in increased expression of CASP8 mRNA CTD PMID:18082045 CASP8 Human 5-azacytidine increases expression ISO Casp8 (Mus musculus) 6480464 Azacitidine results in increased expression of CASP8 mRNA CTD PMID:23395740 CASP8 Human 5-fluorouracil multiple interactions EXP 6480464 [Cadmium Chloride co-treated with Fluorouracil] affects the expression of CASP8 protein more ... CTD PMID:14607657 more ... CASP8 Human 5-fluorouracil increases activity ISO Casp8 (Mus musculus) 6480464 Fluorouracil results in increased activity of CASP8 protein CTD PMID:32270916 CASP8 Human 5-fluorouracil increases cleavage EXP 6480464 Fluorouracil results in increased cleavage of CASP8 protein CTD PMID:19816940 and PMID:26544897 CASP8 Human 5-fluorouracil decreases expression EXP 6480464 Fluorouracil results in decreased expression of CASP8 mRNA CTD PMID:23941782 CASP8 Human 5-fluorouracil increases expression EXP 6480464 Fluorouracil results in increased expression of CASP8 mRNA and Fluorouracil results in increased expression of CASP8 protein CTD PMID:15585135 more ... CASP8 Human 5-fluorouracil increases activity EXP 6480464 Fluorouracil results in increased activity of CASP8 protein CTD PMID:10779637 more ... CASP8 Human 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole increases cleavage EXP 6480464 Omeprazole analog results in increased cleavage of CASP8 protein CTD PMID:18336733 CASP8 Human 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine multiple interactions EXP 6480464 4-cyclohexylmethoxy-5-nitrosopyrimidine-2 and 6-diamine promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased cleavage of CASP8 protein] CTD PMID:26208482 CASP8 Human 6-bromoindirubin-3'-oxime multiple interactions EXP 6480464 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of CASP8 protein modified form] CTD PMID:28414160 CASP8 Human 6-formylpterin increases activity EXP 6480464 2-amino-4-hydroxy-6-formylpteridine results in increased activity of CASP8 protein CTD PMID:16019850 CASP8 Human 7-ketocholesterol increases activity ISO Casp8 (Rattus norvegicus) 6480464 7-ketocholesterol results in increased activity of CASP8 protein CTD PMID:25845326 CASP8 Human 7-ketocholesterol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 6-hydroxy-2 more ... CTD PMID:25845326 CASP8 Human 9'-cis-neoxanthin increases activity EXP 6480464 neoxanthin results in increased activity of CASP8 protein CTD PMID:17186379 CASP8 Human 9-cis-retinoic acid increases activity EXP 6480464 Alitretinoin results in increased activity of CASP8 protein CTD PMID:16449964 CASP8 Human 9-hydroxycanthin-6-one increases cleavage EXP 6480464 9-hydroxycanthin-6-one results in increased cleavage of CASP8 protein CTD PMID:29225138 CASP8 Human 9-Methoxycamptothecin increases activity EXP 6480464 9-methoxycamptothecin results in increased activity of CASP8 protein CTD PMID:23369935 CASP8 Human abexinostat multiple interactions EXP 6480464 Bortezomib promotes the reaction [abexinostat results in increased cleavage of CASP8 protein] CTD PMID:19417023 CASP8 Human abexinostat increases cleavage EXP 6480464 abexinostat results in increased cleavage of CASP8 protein CTD PMID:19417023 CASP8 Human ABT-737 multiple interactions EXP 6480464 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]] more ... CTD PMID:20104024 CASP8 Human ABT-737 increases cleavage EXP 6480464 ABT-737 results in increased cleavage of CASP8 protein CTD PMID:20104024 CASP8 Human acetamide increases expression ISO Casp8 (Rattus norvegicus) 6480464 acetamide results in increased expression of CASP8 mRNA CTD PMID:31881176 CASP8 Human acetylleucyl-leucyl-norleucinal multiple interactions ISO Casp8 (Mus musculus) 6480464 acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 CASP8 Human acetylsalicylic acid multiple interactions EXP 6480464 [Aspirin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein more ... CTD PMID:15481331 more ... CASP8 Human acetylsalicylic acid increases expression EXP 6480464 Aspirin results in increased expression of CASP8 mRNA CTD PMID:20457246 CASP8 Human acetylsalicylic acid increases activity EXP 6480464 Aspirin results in increased activity of CASP8 protein CTD PMID:11034327 CASP8 Human aclacinomycin A increases activity EXP 6480464 Aclarubicin results in increased activity of CASP8 protein CTD PMID:20399885 CASP8 Human acrolein affects activity EXP 6480464 Acrolein affects the activity of CASP8 protein CTD PMID:17222828 CASP8 Human acrolein multiple interactions ISO Casp8 (Mus musculus) 6480464 capsazepine inhibits the reaction [Acrolein results in increased expression of CASP8 protein] and Glutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein] CTD PMID:24376112 CASP8 Human acrolein increases expression ISO Casp8 (Mus musculus) 6480464 Acrolein results in increased expression of CASP8 protein CTD PMID:24376112 CASP8 Human acrolein increases cleavage EXP 6480464 Acrolein results in increased cleavage of CASP8 protein CTD PMID:27238871 CASP8 Human acrolein decreases activity ISO Casp8 (Mus musculus) 6480464 Acrolein results in decreased activity of CASP8 protein CTD PMID:11803030 CASP8 Human acrolein multiple interactions EXP 6480464 Acrolein inhibits the reaction [FAS protein results in increased activity of CASP8 protein] more ... CTD PMID:17222828 and PMID:27238871 CASP8 Human acrolein affects cleavage EXP 6480464 Acrolein affects the cleavage of CASP8 protein CTD PMID:17222828 CASP8 Human acrolein affects alkylation EXP 6480464 Acrolein affects the alkylation of CASP8 protein CTD PMID:17222828 CASP8 Human acrylamide increases expression ISO Casp8 (Rattus norvegicus) 6480464 Acrylamide results in increased expression of CASP8 mRNA CTD PMID:28959563 CASP8 Human acrylamide decreases expression ISO Casp8 (Mus musculus) 6480464 Acrylamide results in decreased expression of CASP8 mRNA CTD PMID:35032568 CASP8 Human actinomycin D decreases expression EXP 6480464 Dactinomycin results in decreased expression of CASP8 mRNA CTD PMID:16001973 CASP8 Human adenosine increases activity EXP 6480464 Adenosine results in increased activity of CASP8 protein CTD PMID:17303086 CASP8 Human adenosine increases activity ISO Casp8 (Rattus norvegicus) 6480464 Adenosine results in increased activity of CASP8 protein CTD PMID:16469385 CASP8 Human adenosine multiple interactions EXP 6480464 Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] CTD PMID:17303086 CASP8 Human aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CASP8 mRNA CTD PMID:27017951 more ... CASP8 Human aflatoxin B1 increases expression ISO Casp8 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of CASP8 mRNA CTD PMID:28789997 CASP8 Human aflatoxin B1 multiple interactions EXP 6480464 [Aflatoxin B1 co-treated with deoxynivalenol] promotes the reaction [Zearalenone results in increased expression of CASP8 mRNA] more ... CTD PMID:27017951 and PMID:30668976 CASP8 Human agomelatine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 agomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP8 protein] CTD PMID:36356678 CASP8 Human Ala-Gln multiple interactions EXP 6480464 alanylglutamine inhibits the reaction [tcdA protein and Clostridium difficile results in increased activity of CASP8 protein] CTD PMID:16368960 CASP8 Human alantolactone increases cleavage EXP 6480464 alantolactone results in increased cleavage of CASP8 protein CTD PMID:22721982 CASP8 Human alborixin increases activity EXP 6480464 alborixin results in increased activity of CASP8 protein CTD PMID:27378626 CASP8 Human aldehydo-D-glucose increases activity ISO Casp8 (Mus musculus) 6480464 Glucose results in increased activity of CASP8 protein CTD PMID:18973755 CASP8 Human aldehydo-D-glucose increases expression ISO Casp8 (Rattus norvegicus) 6480464 Glucose results in increased expression of CASP8 mRNA CTD PMID:38444079 CASP8 Human aldehydo-D-glucose multiple interactions EXP 6480464 [Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA and Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA] CTD PMID:33962019 CASP8 Human aldehydo-D-glucose multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Glucose co-treated with Lycopene] results in increased expression of CASP8 mRNA and Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP8] CTD PMID:18791325 and PMID:38444079 CASP8 Human aldehydo-D-glucose increases activity ISO Casp8 (Rattus norvegicus) 6480464 Glucose results in increased activity of CASP8 CTD PMID:18791325 CASP8 Human alginic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 Alginic Acid results in increased expression of and results in increased cleavage of CASP8 protein CTD PMID:35066102 CASP8 Human all-trans-acitretin increases activity EXP 6480464 Acitretin results in increased activity of CASP8 protein CTD PMID:18624760 CASP8 Human all-trans-neoxanthin increases activity EXP 6480464 neoxanthin results in increased activity of CASP8 protein CTD PMID:17186379 CASP8 Human all-trans-retinoic acid multiple interactions EXP 6480464 [Tretinoin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein more ... CTD PMID:16242776 and PMID:18098270 CASP8 Human all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of CASP8 mRNA CTD PMID:33167477 CASP8 Human all-trans-retinoic acid increases cleavage EXP 6480464 Tretinoin results in increased cleavage of CASP8 protein CTD PMID:16135400 CASP8 Human Aloe emodin increases activity EXP 6480464 aloe emodin results in increased activity of CASP8 protein CTD PMID:19928967 CASP8 Human Aloe emodin multiple interactions EXP 6480464 [Fluorouracil co-treated with aloe emodin] affects the expression of CASP8 and Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form] CTD PMID:19928967 CASP8 Human Aloe emodin increases expression EXP 6480464 aloe emodin results in increased expression of CASP8 protein modified form CTD PMID:19928967 CASP8 Human alpha-mangostin increases activity EXP 6480464 mangostin results in increased activity of CASP8 protein CTD PMID:24480042 CASP8 Human alpha-naphthoflavone increases activity ISO Casp8 (Mus musculus) 6480464 alpha-naphthoflavone results in increased activity of CASP8 protein CTD PMID:18334599 CASP8 Human alvocidib multiple interactions EXP 6480464 [alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein more ... CTD PMID:12231544 more ... CASP8 Human alvocidib increases cleavage EXP 6480464 alvocidib results in increased cleavage of CASP8 protein CTD PMID:10896673 and PMID:12589031 CASP8 Human amiloride multiple interactions EXP 6480464 Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein] and Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:15607733 and PMID:16059913 CASP8 Human amiodarone multiple interactions EXP 6480464 [TNFSF10 co-treated with Amiodarone] results in increased cleavage of CASP8 protein CTD PMID:21292685 CASP8 Human amiodarone increases expression ISO Casp8 (Rattus norvegicus) 6480464 Amiodarone results in increased expression of CASP8 protein modified form CTD PMID:21224497 CASP8 Human amlodipine multiple interactions EXP 6480464 [Amlodipine co-treated with Topotecan] results in increased activity of CASP8 protein CTD PMID:16516327 CASP8 Human amlodipine increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Amlodipine results in increased cleavage of CASP8 protein CTD PMID:33030052 CASP8 Human amlodipine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [soybean oil more ... CTD PMID:33030052 CASP8 Human ammonium chloride affects expression ISO Casp8 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of CASP8 mRNA CTD PMID:16483693 CASP8 Human ammonium chloride increases expression ISO Casp8 (Rattus norvegicus) 6480464 Ammonium Chloride results in increased expression of CASP8 protein CTD PMID:16483693 CASP8 Human ammonium chloride increases activity ISO Casp8 (Rattus norvegicus) 6480464 Ammonium Chloride results in increased activity of CASP8 protein CTD PMID:18722528 CASP8 Human amphibole asbestos increases expression EXP 6480464 Asbestos and Amphibole results in increased expression of CASP8 protein CTD PMID:20855422 CASP8 Human andrographolide multiple interactions EXP 6480464 [andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA more ... CTD PMID:19097688 and PMID:24563380 CASP8 Human andrographolide increases expression EXP 6480464 andrographolide results in increased expression of CASP8 mRNA CTD PMID:24563380 CASP8 Human andrographolide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein] CTD PMID:20946909 CASP8 Human andrographolide increases activity EXP 6480464 andrographolide results in increased activity of CASP8 protein CTD PMID:19097688 CASP8 Human anthocyanin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP8 protein] CTD PMID:28856781 CASP8 Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [6-(N more ... CTD PMID:15501958 more ... CASP8 Human antimycin A increases cleavage EXP 6480464 Antimycin A results in increased cleavage of CASP8 protein CTD PMID:32662599 CASP8 Human antimycin A multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP8 protein] CTD PMID:32662599 CASP8 Human antirheumatic drug decreases expression EXP 6480464 Antirheumatic Agents results in decreased expression of CASP8 mRNA CTD PMID:24449571 CASP8 Human apigenin increases cleavage EXP 6480464 Apigenin results in increased cleavage of CASP8 protein CTD PMID:15486995 CASP8 Human apigenin multiple interactions EXP 6480464 [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein CTD PMID:29247770 CASP8 Human apigenin increases activity ISO Casp8 (Rattus norvegicus) 6480464 Apigenin results in increased activity of CASP8 protein CTD PMID:24144774 CASP8 Human apigenin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein] more ... CTD PMID:24144774 and PMID:30152906 CASP8 Human arachidonic acid increases activity EXP 6480464 Arachidonic Acid results in increased activity of CASP8 protein CTD PMID:19720122 CASP8 Human arachidonic acid multiple interactions EXP 6480464 FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein] CTD PMID:19720122 CASP8 Human arecoline increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Arecoline results in increased cleavage of CASP8 protein CTD PMID:33929070 CASP8 Human arjunolic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein] CTD PMID:21420465 CASP8 Human Aroclor 1254 decreases expression ISO Casp8 (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CASP8 mRNA CTD PMID:23650126 CASP8 Human arsane affects methylation EXP 6480464 Arsenic affects the methylation of CASP8 gene CTD PMID:25304211 CASP8 Human arsane multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP8 protein and ATF3 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP8 protein] CTD PMID:33921748 CASP8 Human arsane increases expression EXP 6480464 Arsenic results in increased expression of CASP8 mRNA CTD PMID:27838757 CASP8 Human arsenic atom affects methylation EXP 6480464 Arsenic affects the methylation of CASP8 gene CTD PMID:25304211 CASP8 Human arsenic atom multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP8 protein and ATF3 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP8 protein] CTD PMID:33921748 CASP8 Human arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of CASP8 mRNA CTD PMID:27838757 CASP8 Human arsenous acid multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of CASP8 mRNA more ... CTD PMID:16174796 more ... CASP8 Human arsenous acid increases cleavage EXP 6480464 Arsenic Trioxide results in increased cleavage of CASP8 protein CTD PMID:18491231 more ... CASP8 Human arsenous acid increases activity ISO Casp8 (Mus musculus) 6480464 Arsenic Trioxide results in increased activity of CASP8 protein CTD PMID:21565247 and PMID:25410152 CASP8 Human arsenous acid increases activity EXP 6480464 Arsenic Trioxide results in increased activity of CASP8 protein CTD PMID:10721769 more ... CASP8 Human arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CASP8 mRNA more ... CTD PMID:20953137 more ... CASP8 Human arsenous acid multiple interactions ISO Casp8 (Mus musculus) 6480464 Arsenic Trioxide promotes the reaction [Drugs and Chinese Herbal results in increased cleavage of CASP8 protein] CTD PMID:28587418 CASP8 Human arsenous acid affects activity EXP 6480464 Arsenic Trioxide affects the activity of CASP8 protein CTD PMID:16010437 CASP8 Human asarone increases activity EXP 6480464 asarone results in increased activity of CASP8 protein CTD PMID:29174417 CASP8 Human atorvastatin calcium multiple interactions EXP 6480464 [Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP8 protein CTD PMID:18172863 CASP8 Human atorvastatin calcium multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein] and [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein] CTD PMID:20946910 CASP8 Human atorvastatin calcium increases activity EXP 6480464 Atorvastatin results in increased activity of CASP8 protein CTD PMID:15705602 CASP8 Human atrazine multiple interactions ISO Casp8 (Mus musculus) 6480464 Melatonin inhibits the reaction [Atrazine results in increased cleavage of CASP8 protein] CTD PMID:25259610 CASP8 Human atrazine increases cleavage ISO Casp8 (Mus musculus) 6480464 Atrazine results in increased cleavage of CASP8 protein CTD PMID:25259610 CASP8 Human auranofin multiple interactions EXP 6480464 Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein CTD PMID:20542334 CASP8 Human Auriculasin multiple interactions EXP 6480464 [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein and TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein] CTD PMID:30817944 CASP8 Human azadirachtin A increases expression EXP 6480464 azadirachtin results in increased expression of CASP8 protein CTD PMID:20429769 CASP8 Human azadiradione increases activity EXP 6480464 azadiradione results in increased activity of CASP8 protein CTD PMID:21381696 CASP8 Human bafilomycin A1 multiple interactions ISO Casp8 (Mus musculus) 6480464 bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 CASP8 Human bafilomycin A1 multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein] CTD PMID:28378122 CASP8 Human baicalein multiple interactions ISO Casp8 (Mus musculus) 6480464 baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form] CTD PMID:20850421 CASP8 Human BAPTA multiple interactions ISO Casp8 (Mus musculus) 6480464 1 more ... CTD PMID:29111403 CASP8 Human Bardoxolone methyl decreases expression EXP 6480464 bardoxolone methyl results in decreased expression of CASP8 protein CTD PMID:25246272 CASP8 Human bathocuproine disulfonic acid multiple interactions EXP 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA] and bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]] CTD PMID:15477007 CASP8 Human beauvericin increases expression EXP 6480464 beauvericin results in increased expression of CASP8 mRNA CTD PMID:29203277 CASP8 Human belinostat increases expression EXP 6480464 belinostat results in increased expression of CASP8 mRNA CTD PMID:26272509 CASP8 Human belinostat multiple interactions EXP 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA CTD PMID:27188386 CASP8 Human bellidifolin increases expression EXP 6480464 bellidifolin results in increased expression of CASP8 protein CTD PMID:33299414 CASP8 Human benzalkonium chloride decreases expression EXP 6480464 Benzalkonium Compounds results in decreased expression of CASP8 mRNA CTD PMID:28236482 CASP8 Human benzene increases expression ISO Casp8 (Rattus norvegicus) 6480464 Benzene results in increased expression of CASP8 protein CTD PMID:17171516 CASP8 Human benzene-1,2,4-triol increases activity EXP 6480464 hydroxyhydroquinone results in increased activity of CASP8 protein CTD PMID:23776099 CASP8 Human benzo[a]pyrene increases cleavage EXP 6480464 Benzo(a)pyrene results in increased cleavage of CASP8 protein CTD PMID:16041517 CASP8 Human benzo[a]pyrene increases methylation EXP 6480464 Benzo(a)pyrene results in increased methylation of CASP8 promoter CTD PMID:27901495 CASP8 Human benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of CASP8 5' UTR CTD PMID:27901495 CASP8 Human benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CASP8 mRNA CTD PMID:24239969 CASP8 Human benzo[a]pyrene increases expression ISO Casp8 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of CASP8 mRNA CTD PMID:22228805 CASP8 Human benzo[a]pyrene increases activity ISO Casp8 (Rattus norvegicus) 6480464 Benzo(a)pyrene results in increased activity of CASP8 protein CTD PMID:22051199 CASP8 Human benzo[a]pyrene multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP8 protein] CTD PMID:22051199 CASP8 Human benzo[a]pyrene decreases expression ISO Casp8 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of CASP8 mRNA CTD PMID:19770486 CASP8 Human benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein more ... CTD PMID:16041517 and PMID:22951985 CASP8 Human benzo[a]pyrene diol epoxide I increases cleavage EXP 6480464 7 more ... CTD PMID:21983885 CASP8 Human benzo[e]pyrene increases activity EXP 6480464 benzo(e)pyrene results in increased activity of CASP8 protein CTD PMID:18586875 CASP8 Human benzo[e]pyrene increases activity ISO Casp8 (Rattus norvegicus) 6480464 benzo(e)pyrene results in increased activity of CASP8 protein CTD PMID:19899995 CASP8 Human benzophenanthridine increases activity EXP 6480464 Benzophenanthridines analog results in increased activity of CASP8 protein CTD PMID:23117580 CASP8 Human berberine increases activity EXP 6480464 Berberine results in increased activity of CASP8 protein CTD PMID:20656010 CASP8 Human beta-hexachlorocyclohexane increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 beta-hexachlorocyclohexane results in increased cleavage of CASP8 protein CTD PMID:19760616 CASP8 Human Beta-Solamarine multiple interactions EXP 6480464 beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP8 protein] CTD PMID:17619073 CASP8 Human Beta-Solamarine increases activity EXP 6480464 beta-solamarine results in increased activity of CASP8 protein CTD PMID:17619073 CASP8 Human betulin increases cleavage EXP 6480464 betulin results in increased cleavage of CASP8 protein CTD PMID:32190974 CASP8 Human betulinic acid increases activity EXP 6480464 Betulinic Acid results in increased activity of CASP8 protein CTD PMID:26772157 and PMID:29454615 CASP8 Human BI-2536 increases activity EXP 6480464 BI 2536 results in increased activity of CASP8 protein CTD PMID:24403256 CASP8 Human bifenthrin increases activity ISO Casp8 (Mus musculus) 6480464 bifenthrin results in increased activity of CASP8 protein CTD PMID:26071804 CASP8 Human bifenthrin decreases expression ISO Casp8 (Mus musculus) 6480464 bifenthrin results in decreased expression of CASP8 mRNA CTD PMID:26071804 CASP8 Human bis(2-chloroethyl) sulfide multiple interactions EXP 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Mustard Gas results in increased activity of CASP8 protein] more ... CTD PMID:12482751 more ... CASP8 Human bis(2-chloroethyl) sulfide increases activity EXP 6480464 Mustard Gas results in increased activity of CASP8 protein CTD PMID:16738803 and PMID:20226831 CASP8 Human bis(2-chloroethyl) sulfide increases expression ISO Casp8 (Mus musculus) 6480464 Mustard Gas results in increased expression of CASP8 mRNA CTD PMID:18955075 CASP8 Human bis(2-ethylhexyl) phthalate increases activity EXP 6480464 Diethylhexyl Phthalate results in increased activity of CASP8 protein CTD PMID:22155658 CASP8 Human bis(2-ethylhexyl) phthalate decreases expression ISO Casp8 (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of CASP8 mRNA CTD PMID:31211961 CASP8 Human bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of CASP8 mRNA CTD PMID:31163220 CASP8 Human bis(2-ethylhexyl) phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein more ... CTD PMID:28013214 more ... CASP8 Human bis(2-ethylhexyl) phthalate increases expression ISO Casp8 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of CASP8 mRNA CTD PMID:25701202 and PMID:37975621 CASP8 Human bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CASP8 protein CTD PMID:21277958 CASP8 Human bisphenol A multiple interactions ISO Casp8 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein and [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of CASP8 protein CTD PMID:35739755 and PMID:37364641 CASP8 Human bisphenol A multiple interactions EXP 6480464 bisphenol A results in decreased expression of and results in increased cleavage of CASP8 protein CTD PMID:38372072 CASP8 Human bisphenol A increases activity EXP 6480464 bisphenol A results in increased activity of CASP8 protein CTD PMID:30036487 and PMID:30841469 CASP8 Human bisphenol A increases activity ISO Casp8 (Mus musculus) 6480464 bisphenol A results in increased activity of CASP8 protein CTD PMID:31387175 CASP8 Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CASP8 mRNA and bisphenol A results in increased expression of CASP8 protein CTD PMID:29275510 more ... CASP8 Human bisphenol A increases expression ISO Casp8 (Rattus norvegicus) 6480464 bisphenol A analog results in increased expression of CASP8 mRNA and bisphenol A results in increased expression of CASP8 mRNA CTD PMID:27539358 more ... CASP8 Human bisphenol A decreases expression ISO Casp8 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of CASP8 mRNA CTD PMID:25181051 CASP8 Human bisphenol A increases expression ISO Casp8 (Mus musculus) 6480464 bisphenol A results in increased expression of CASP8 mRNA and bisphenol A results in increased expression of CASP8 protein CTD PMID:23900028 more ... CASP8 Human bisphenol A multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 4-nonylphenol affects the reaction [bisphenol A results in increased expression of CASP8 mRNA] more ... CTD PMID:25454643 more ... CASP8 Human bisphenol A increases activity ISO Casp8 (Rattus norvegicus) 6480464 bisphenol A results in increased activity of CASP8 protein CTD PMID:25454643 CASP8 Human bisphenol A affects expression ISO Casp8 (Mus musculus) 6480464 bisphenol A affects the expression of CASP8 mRNA CTD PMID:26049153 and PMID:26746108 CASP8 Human Bisphenol A glycidylmethacrylate multiple interactions ISO Casp8 (Mus musculus) 6480464 wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein] CTD PMID:26756871 CASP8 Human Bisphenol A glycidylmethacrylate increases activity ISO Casp8 (Mus musculus) 6480464 Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein CTD PMID:26756871 CASP8 Human bisphenol F increases expression ISO Casp8 (Mus musculus) 6480464 bisphenol F results in increased expression of CASP8 mRNA CTD PMID:30951980 and PMID:31453682 CASP8 Human bisphenol F increases activity EXP 6480464 bisphenol F results in increased activity of CASP8 protein CTD PMID:33916708 CASP8 Human bleomycin A2 multiple interactions EXP 6480464 [Polyphenols co-treated with Bleomycin] results in increased expression of CASP8 mRNA and [Tea co-treated with Bleomycin] results in increased expression of CASP8 mRNA CTD PMID:26800624 CASP8 Human borrelidin increases activity EXP 6480464 borrelidin results in increased activity of CASP8 protein CTD PMID:14563161 CASP8 Human bortezomib multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of CASP8 mRNA more ... CTD PMID:12393500 more ... CASP8 Human bortezomib increases cleavage EXP 6480464 Bortezomib results in increased cleavage of CASP8 protein CTD PMID:12393500 more ... CASP8 Human Brevetoxin B increases activity EXP 6480464 brevetoxin 2 results in increased activity of CASP8 protein CTD PMID:19536525 CASP8 Human bromoacetate decreases expression EXP 6480464 bromoacetate results in decreased expression of CASP8 mRNA CTD PMID:19753638 CASP8 Human bromoacetate increases expression EXP 6480464 bromoacetate results in increased expression of CASP8 mRNA CTD PMID:19753638 CASP8 Human Brusatol increases cleavage EXP 6480464 brusatol results in increased cleavage of CASP8 protein CTD PMID:33465425 CASP8 Human bupropion increases activity EXP 6480464 Bupropion results in increased activity of CASP8 protein CTD PMID:21354251 CASP8 Human busulfan increases activity EXP 6480464 Busulfan results in increased activity of CASP8 protein CTD PMID:18339423 CASP8 Human busulfan multiple interactions EXP 6480464 [decitabine co-treated with Busulfan] results in increased activity of CASP8 protein and pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein] CTD PMID:19732952 CASP8 Human butein increases activity EXP 6480464 butein results in increased activity of CASP8 protein CTD PMID:35130734 CASP8 Human Butylbenzyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein more ... CTD PMID:28013214 more ... CASP8 Human Butylparaben increases expression EXP 6480464 butylparaben results in increased expression of CASP8 protein CTD PMID:24481588 CASP8 Human cadmium atom multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 agomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP8 protein] and Cadmium inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:16263807 and PMID:36356678 CASP8 Human cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of CASP8 mRNA CTD PMID:27687512 CASP8 Human cadmium atom increases cleavage ISO Casp8 (Mus musculus) 6480464 Cadmium results in increased cleavage of CASP8 protein CTD PMID:29111403 CASP8 Human cadmium atom multiple interactions ISO Casp8 (Mus musculus) 6480464 1 more ... CTD PMID:29111403 CASP8 Human cadmium dichloride multiple interactions ISO Casp8 (Mus musculus) 6480464 [Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased activity of CASP8 protein more ... CTD PMID:16421179 more ... CASP8 Human cadmium dichloride decreases expression ISO Casp8 (Mus musculus) 6480464 Cadmium Chloride results in decreased expression of CASP8 protein CTD PMID:35844137 CASP8 Human cadmium dichloride decreases response to substance EXP 6480464 CASP8 results in decreased susceptibility to Cadmium Chloride CTD PMID:25448810 CASP8 Human cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of CASP8 promoter CTD PMID:25448810 CASP8 Human cadmium dichloride increases activity EXP 6480464 Cadmium Chloride results in increased activity of CASP8 protein CTD PMID:21697648 and PMID:23485651 CASP8 Human cadmium dichloride increases activity ISO Casp8 (Mus musculus) 6480464 Cadmium Chloride results in increased activity of CASP8 protein CTD PMID:16421179 and PMID:21252392 CASP8 Human cadmium dichloride decreases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased cleavage of CASP8 protein CTD PMID:22457795 CASP8 Human cadmium dichloride decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of CASP8 protein CTD PMID:22457795 CASP8 Human cadmium dichloride increases methylation ISO Casp8 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased methylation of CASP8 promoter CTD PMID:22457795 CASP8 Human cadmium dichloride multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 agomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP8 protein] more ... CTD PMID:16263807 more ... CASP8 Human cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride co-treated with Fluorouracil] affects the expression of CASP8 protein more ... CTD PMID:23941782 more ... CASP8 Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of CASP8 mRNA CTD PMID:19426795 more ... CASP8 Human cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of CASP8 mRNA and Cadmium Chloride results in increased expression of CASP8 protein CTD PMID:12160620 more ... CASP8 Human cadmium dichloride increases expression ISO Casp8 (Mus musculus) 6480464 Cadmium Chloride results in increased expression of CASP8 protein CTD PMID:21420465 and PMID:28342888 CASP8 Human cadmium sulfide decreases expression EXP 6480464 cadmium sulfide results in decreased expression of CASP8 mRNA CTD PMID:27866839 CASP8 Human caffeine increases phosphorylation EXP 6480464 Caffeine results in increased phosphorylation of CASP8 protein CTD PMID:35688186 CASP8 Human Calcimycin increases activity EXP 6480464 Calcimycin results in increased activity of CASP8 protein CTD PMID:25410152 CASP8 Human Calcimycin increases activity ISO Casp8 (Mus musculus) 6480464 Calcimycin results in increased activity of CASP8 protein CTD PMID:25410152 CASP8 Human calcitriol multiple interactions EXP 6480464 [Calcitriol co-treated with Gemcitabine] results in increased expression of CASP8 protein CTD PMID:20699664 CASP8 Human calcitriol affects expression ISO Casp8 (Mus musculus) 6480464 Calcitriol affects the expression of CASP8 mRNA CTD PMID:15138306 CASP8 Human Calpeptin multiple interactions ISO Casp8 (Mus musculus) 6480464 calpeptin inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 CASP8 Human camptothecin multiple interactions EXP 6480464 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2 more ... CTD PMID:15475000 more ... CASP8 Human camptothecin decreases expression EXP 6480464 Camptothecin results in decreased expression of CASP8 mRNA CTD PMID:30581319 CASP8 Human camptothecin increases expression EXP 6480464 Camptothecin results in increased expression of CASP8 protein CTD PMID:30885713 CASP8 Human camptothecin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP8 protein] CTD PMID:19497415 CASP8 Human camptothecin increases activity EXP 6480464 Camptothecin results in increased activity of CASP8 protein CTD PMID:15475000 and PMID:34635930 CASP8 Human camptothecin affects cleavage EXP 6480464 Camptothecin affects the cleavage of CASP8 protein CTD PMID:10896673 CASP8 Human cannabidiol decreases expression ISO Casp8 (Mus musculus) 6480464 Cannabidiol results in decreased expression of CASP8 mRNA CTD PMID:33019509 CASP8 Human cannabidiol increases cleavage EXP 6480464 Cannabidiol results in increased cleavage of CASP8 protein CTD PMID:31699976 CASP8 Human cannabidiol decreases expression EXP 6480464 Cannabidiol results in decreased expression of CASP8 mRNA CTD PMID:27932991 and PMID:31801206 CASP8 Human cannabidiol multiple interactions EXP 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of CASP8 mRNA CTD PMID:30096889 CASP8 Human cannabigerol decreases expression ISO Casp8 (Mus musculus) 6480464 cannabigerol results in decreased expression of CASP8 mRNA CTD PMID:33019509 CASP8 Human cantharidic acid multiple interactions EXP 6480464 SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP8 protein] CTD PMID:29159945 and PMID:31916385 CASP8 Human cantharidic acid increases cleavage EXP 6480464 cantharidic acid results in increased cleavage of CASP8 protein CTD PMID:29159945 more ... CASP8 Human cantharidin multiple interactions EXP 6480464 Cantharidin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:27113412 CASP8 Human capsaicin multiple interactions EXP 6480464 [Capsaicin co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein more ... CTD PMID:19846903 more ... CASP8 Human capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of CASP8 mRNA CTD PMID:19502594 CASP8 Human capsaicin increases activity EXP 6480464 Capsaicin results in increased activity of CASP8 protein CTD PMID:19502594 CASP8 Human capsaicin decreases expression EXP 6480464 Capsaicin results in decreased expression of CASP8 protein CTD PMID:19846903 CASP8 Human capsazepine multiple interactions ISO Casp8 (Mus musculus) 6480464 capsazepine inhibits the reaction [Acrolein results in increased expression of CASP8 protein] CTD PMID:24376112 CASP8 Human carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of CASP8 mRNA CTD PMID:24752500 CASP8 Human carbon atom multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA CTD PMID:31268311 CASP8 Human carbon monoxide increases activity ISO Casp8 (Rattus norvegicus) 6480464 Carbon Monoxide results in increased activity of CASP8 protein CTD PMID:25562542 CASP8 Human carbon monoxide multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA CTD PMID:31268311 CASP8 Human carbon nanotube increases expression EXP 6480464 Nanotubes more ... CTD PMID:23634900 and PMID:32493873 CASP8 Human carbon nanotube increases expression ISO Casp8 (Rattus norvegicus) 6480464 Nanotubes and Carbon results in increased expression of CASP8 mRNA CTD PMID:30605223 CASP8 Human carbon nanotube increases activity ISO Casp8 (Rattus norvegicus) 6480464 Nanotubes and Carbon analog results in increased activity of CASP8 protein CTD PMID:19827037 CASP8 Human carbon nanotube increases expression ISO Casp8 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 CASP8 Human carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases expression EXP 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CASP8 mRNA CTD PMID:16039398 CASP8 Human carnosic acid increases cleavage EXP 6480464 salvin results in increased cleavage of CASP8 protein CTD PMID:28918123 CASP8 Human carnosic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein] CTD PMID:29854073 CASP8 Human carnosic acid multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein] CTD PMID:28918123 CASP8 Human carnosine multiple interactions ISO Casp8 (Mus musculus) 6480464 Carnosine inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein] CTD PMID:29191451 CASP8 Human casticin multiple interactions EXP 6480464 casticin results in increased cleavage of and results in increased activity of CASP8 protein and casticin results in increased expression of and results in increased activity of CASP8 protein CTD PMID:27862857 and PMID:29098808 CASP8 Human catechol increases activity EXP 6480464 catechol results in increased activity of CASP8 protein CTD PMID:23776099 CASP8 Human celastrol increases cleavage EXP 6480464 celastrol results in increased cleavage of CASP8 protein CTD PMID:21466843 CASP8 Human celastrol decreases expression EXP 6480464 celastrol results in decreased expression of CASP8 mRNA CTD PMID:27374097 CASP8 Human celecoxib increases activity EXP 6480464 Celecoxib analog results in increased activity of CASP8 protein and Celecoxib results in increased activity of CASP8 protein CTD PMID:12824303 and PMID:15499625 CASP8 Human celecoxib increases cleavage EXP 6480464 Celecoxib results in increased cleavage of CASP8 protein CTD PMID:20104024 CASP8 Human celecoxib multiple interactions EXP 6480464 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]] more ... CTD PMID:15197583 more ... CASP8 Human cerivastatin increases activity EXP 6480464 cerivastatin results in increased activity of CASP8 protein CTD PMID:15705602 CASP8 Human ceruletide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Ceruletide results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16339139 CASP8 Human chalcone increases cleavage EXP 6480464 Chalcone results in increased cleavage of CASP8 protein CTD PMID:20620131 CASP8 Human chalcone multiple interactions EXP 6480464 MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein] CTD PMID:20620131 CASP8 Human chalcones multiple interactions EXP 6480464 BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein] and Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:30576621 CASP8 Human chalcones increases expression EXP 6480464 Chalcones analog results in increased expression of CASP8 mRNA CTD PMID:32856275 CASP8 Human chlorambucil increases activity EXP 6480464 Chlorambucil results in increased activity of CASP8 protein CTD PMID:11675354 CASP8 Human chloroacetaldehyde decreases activity EXP 6480464 chloroacetaldehyde results in decreased activity of CASP8 protein CTD PMID:17035713 CASP8 Human chlorogenic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein] CTD PMID:28623112 CASP8 Human chloroquine increases cleavage EXP 6480464 Chloroquine results in increased cleavage of CASP8 protein CTD PMID:27692344 and PMID:28906492 CASP8 Human chloroquine multiple interactions EXP 6480464 Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP8 protein] CTD PMID:28906492 CASP8 Human chloroquine multiple interactions ISO Casp8 (Mus musculus) 6480464 Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 CASP8 Human chlorothalonil increases expression EXP 6480464 tetrachloroisophthalonitrile results in increased expression of CASP8 mRNA CTD PMID:34549778 CASP8 Human chlorpyrifos decreases expression ISO Casp8 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of CASP8 mRNA CTD PMID:32715474 CASP8 Human chlorpyrifos increases expression ISO Casp8 (Rattus norvegicus) 6480464 Chlorpyrifos results in increased expression of CASP8 protein CTD PMID:30990955 CASP8 Human chlorpyrifos multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Chlorpyrifos results in increased expression of CASP8 protein] CTD PMID:30990955 CASP8 Human chlorpyrifos multiple interactions EXP 6480464 [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 mRNA and [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 protein CTD PMID:32800223 CASP8 Human cholesterol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 6-hydroxy-2 more ... CTD PMID:19477266 and PMID:20946910 CASP8 Human cholesterol increases expression ISO Casp8 (Rattus norvegicus) 6480464 Cholesterol analog results in increased expression of CASP8 mRNA and Cholesterol results in increased expression of CASP8 protein CTD PMID:19477266 and PMID:20946910 CASP8 Human cholesterol increases activity ISO Casp8 (Rattus norvegicus) 6480464 Cholesterol analog results in increased activity of CASP8 protein CTD PMID:19477266 CASP8 Human choline multiple interactions ISO Casp8 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CASP8 gene CTD PMID:20938992 CASP8 Human chromium atom increases expression ISO Casp8 (Rattus norvegicus) 6480464 Chromium results in increased expression of CASP8 mRNA CTD PMID:17692352 CASP8 Human chromium(3+) trichloride multiple interactions EXP 6480464 chromic chloride results in increased expression of and results in increased activity of CASP8 protein CTD PMID:14741615 CASP8 Human chromium(6+) increases expression EXP 6480464 chromium hexavalent ion results in increased expression of CASP8 mRNA CTD PMID:27793765 CASP8 Human chromone increases expression EXP 6480464 4-chromone analog results in increased expression of CASP8 protein modified form CTD PMID:30256521 CASP8 Human chromone multiple interactions EXP 6480464 benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP8 protein modified form] CTD PMID:30256521 CASP8 Human chrysazin multiple interactions EXP 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein] and danthron results in increased activity of and results in increased expression of CASP8 protein CTD PMID:21126053 CASP8 Human chrysazin increases expression EXP 6480464 danthron results in increased expression of CASP8 mRNA CTD PMID:21126053 CASP8 Human chrysin multiple interactions EXP 6480464 [Cisplatin co-treated with chrysin] results in increased cleavage of CASP8 protein more ... CTD PMID:20457140 more ... CASP8 Human chrysin increases cleavage EXP 6480464 chrysin results in increased cleavage of CASP8 protein CTD PMID:25770930 CASP8 Human ciglitazone multiple interactions EXP 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]] more ... CTD PMID:21067863 CASP8 Human ciglitazone increases activity EXP 6480464 ciglitazone results in increased activity of CASP8 protein CTD PMID:21067863 CASP8 Human cilostazol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein] CTD PMID:18311796 CASP8 Human cimetidine increases activity EXP 6480464 Cimetidine results in increased activity of CASP8 protein CTD PMID:17273750 and PMID:20127008 CASP8 Human Cinobufotalin increases cleavage EXP 6480464 cinobufotalin results in increased cleavage of CASP8 protein CTD PMID:22898211 CASP8 Human ciprofloxacin increases activity EXP 6480464 Ciprofloxacin results in increased activity of CASP8 protein CTD PMID:11875713 CASP8 Human cisplatin multiple interactions EXP 6480464 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP8 protein]] more ... CTD PMID:16803524 more ... CASP8 Human cisplatin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 tranilast inhibits the reaction [Cisplatin results in increased expression of CASP8 protein] CTD PMID:34047436 CASP8 Human cisplatin increases expression ISO Casp8 (Mus musculus) 6480464 Cisplatin results in increased expression of CASP8 mRNA CTD PMID:26546572 CASP8 Human cisplatin multiple interactions ISO Casp8 (Mus musculus) 6480464 4-methyl-N1-(3-phenylpropyl)benzene-1 more ... CTD PMID:26546572 and PMID:29191451 CASP8 Human cisplatin increases activity EXP 6480464 Cisplatin results in increased activity of CASP8 protein CTD PMID:16009487 more ... CASP8 Human cisplatin increases cleavage ISO Casp8 (Mus musculus) 6480464 Cisplatin results in increased cleavage of CASP8 protein CTD PMID:29191451 CASP8 Human cisplatin increases cleavage EXP 6480464 Cisplatin results in increased cleavage of CASP8 protein CTD PMID:17021654 more ... CASP8 Human cisplatin increases expression ISO Casp8 (Rattus norvegicus) 6480464 Cisplatin results in increased expression of CASP8 protein CTD PMID:21525749 and PMID:34047436 CASP8 Human cisplatin increases activity ISO Casp8 (Mus musculus) 6480464 Cisplatin results in increased activity of CASP8 protein CTD PMID:21526214 CASP8 Human cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of CASP8 mRNA and Cisplatin results in increased expression of CASP8 protein CTD PMID:16803524 more ... CASP8 Human cisplatin decreases response to substance EXP 6480464 CASP8 protein mutant form results in decreased susceptibility to Cisplatin CTD PMID:21801448 CASP8 Human cladribine multiple interactions EXP 6480464 [Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein more ... CTD PMID:12948851 more ... CASP8 Human cladribine increases activity EXP 6480464 Cladribine results in increased activity of CASP8 protein CTD PMID:11672427 more ... CASP8 Human cladribine increases cleavage EXP 6480464 Cladribine results in increased cleavage of CASP8 protein CTD PMID:15516989 CASP8 Human clavulone II multiple interactions EXP 6480464 clavulone II results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15920677 CASP8 Human clofibrate increases expression ISO Casp8 (Mus musculus) 6480464 Clofibrate results in increased expression of CASP8 mRNA CTD PMID:23811191 CASP8 Human clomipramine increases activity ISO Casp8 (Mus musculus) 6480464 Clomipramine results in increased activity of CASP8 protein CTD PMID:28482088 CASP8 Human clonidine increases activity EXP 6480464 Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 CASP8 Human clonidine (amino form) increases activity EXP 6480464 Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 CASP8 Human clonidine (imino form) increases activity EXP 6480464 Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 CASP8 Human clotrimazole multiple interactions ISO Casp8 (Mus musculus) 6480464 [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein] and Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP8 protein] CTD PMID:22033380 CASP8 Human cobalt dichloride increases activity EXP 6480464 cobaltous chloride results in increased activity of CASP8 protein CTD PMID:16374551 CASP8 Human cobalt dichloride affects activity ISO Casp8 (Mus musculus) 6480464 cobaltous chloride affects the activity of CASP8 protein CTD PMID:23684559 CASP8 Human cocaine affects expression ISO Casp8 (Mus musculus) 6480464 Cocaine affects the expression of CASP8 mRNA CTD PMID:15681117 CASP8 Human cocaine increases activity ISO Casp8 (Rattus norvegicus) 6480464 Cocaine results in increased activity of CASP8 protein CTD PMID:11392460 and PMID:18974856 CASP8 Human coenzyme Q10 multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein] CTD PMID:27087047 CASP8 Human colistin increases cleavage ISO Casp8 (Mus musculus) 6480464 Colistin results in increased cleavage of CASP8 protein CTD PMID:34560125 CASP8 Human conjugated linoleic acid increases expression ISO Casp8 (Mus musculus) 6480464 Linoleic Acids and Conjugated results in increased expression of CASP8 protein CTD PMID:20155912 CASP8 Human copper atom multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein and [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein CTD PMID:22276220 CASP8 Human copper atom multiple interactions ISO Casp8 (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP8 mRNA and [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP8 protein CTD PMID:31491480 CASP8 Human copper atom increases expression ISO Casp8 (Rattus norvegicus) 6480464 Copper deficiency results in increased expression of CASP8 mRNA and Copper results in increased expression of CASP8 protein CTD PMID:17418555 and PMID:30556269 CASP8 Human copper atom increases expression ISO Casp8 (Mus musculus) 6480464 Copper analog results in increased expression of CASP8 protein CTD PMID:22000994 CASP8 Human copper atom multiple interactions EXP 6480464 [Ditiocarb binds to Copper] which results in increased activity of CASP8 protein and [Thiosemicarbazones binds to Copper] which results in decreased activity of CASP8 protein CTD PMID:20931265 and PMID:22951949 CASP8 Human copper(0) multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein and [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein CTD PMID:22276220 CASP8 Human copper(0) multiple interactions ISO Casp8 (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP8 mRNA and [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP8 protein CTD PMID:31491480 CASP8 Human copper(0) increases expression ISO Casp8 (Rattus norvegicus) 6480464 Copper deficiency results in increased expression of CASP8 mRNA and Copper results in increased expression of CASP8 protein CTD PMID:17418555 and PMID:30556269 CASP8 Human copper(0) increases expression ISO Casp8 (Mus musculus) 6480464 Copper analog results in increased expression of CASP8 protein CTD PMID:22000994 CASP8 Human copper(0) multiple interactions EXP 6480464 [Ditiocarb binds to Copper] which results in increased activity of CASP8 protein and [Thiosemicarbazones binds to Copper] which results in decreased activity of CASP8 protein CTD PMID:20931265 and PMID:22951949 CASP8 Human copper(II) chloride increases expression ISO Casp8 (Mus musculus) 6480464 cupric chloride results in increased expression of CASP8 protein CTD PMID:23313662 CASP8 Human copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of CASP8 mRNA CTD PMID:19549813 CASP8 Human copper(II) sulfate multiple interactions ISO Casp8 (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP8 mRNA and [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP8 protein CTD PMID:31491480 CASP8 Human copper(II) sulfate multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein] more ... CTD PMID:20946909 and PMID:33127410 CASP8 Human cordycepin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein] CTD PMID:21310227 CASP8 Human cordycepin increases expression EXP 6480464 cordycepin results in increased expression of CASP8 protein CTD PMID:23941773 CASP8 Human cordycepin increases activity EXP 6480464 cordycepin results in increased activity of CASP8 protein CTD PMID:21310227 CASP8 Human corticosterone increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Corticosterone results in increased cleavage of CASP8 protein CTD PMID:29625166 CASP8 Human corticosterone multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Estradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein] more ... CTD PMID:29625166 CASP8 Human coumarin increases expression EXP 6480464 coumarin analog results in increased expression of CASP8 mRNA CTD PMID:32578917 CASP8 Human crizotinib increases cleavage EXP 6480464 Crizotinib results in increased cleavage of CASP8 protein CTD PMID:31706006 CASP8 Human crocidolite asbestos multiple interactions EXP 6480464 Asbestos more ... CTD PMID:22608188 CASP8 Human crocidolite asbestos increases expression EXP 6480464 Asbestos more ... CTD PMID:23634900 CASP8 Human crocidolite asbestos increases activity EXP 6480464 Asbestos and Crocidolite results in increased activity of CASP8 protein CTD PMID:22608188 CASP8 Human crocin-1 increases activity EXP 6480464 crocin results in increased activity of CASP8 protein CTD PMID:32886819 CASP8 Human cucurbitacin I increases cleavage EXP 6480464 cucurbitacin I results in increased cleavage of CASP8 protein CTD PMID:24858077 CASP8 Human curcumin increases activity EXP 6480464 Curcumin results in increased activity of CASP8 protein CTD PMID:17096185 CASP8 Human curcumin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP8 mRNA] more ... CTD PMID:23267840 more ... CASP8 Human curcumin increases cleavage EXP 6480464 Curcumin results in increased cleavage of CASP8 protein CTD PMID:14555224 and PMID:22523229 CASP8 Human curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of CASP8 mRNA and Curcumin results in decreased expression of CASP8 protein CTD PMID:17148446 and PMID:33582110 CASP8 Human curcumin multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein more ... CTD PMID:16173963 more ... CASP8 Human cyanocob(III)alamin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA]] and Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA] CTD PMID:23935743 CASP8 Human cyclizine increases activity ISO Casp8 (Mus musculus) 6480464 Cyclizine results in increased activity of CASP8 protein CTD PMID:38314619 CASP8 Human cycloheximide multiple interactions EXP 6480464 [Cycloheximide co-treated with TNF] results in increased cleavage of and results in increased activity of CASP8 protein more ... CTD PMID:12760867 more ... CASP8 Human cycloheximide increases activity EXP 6480464 Cycloheximide results in increased activity of CASP8 protein CTD PMID:15924153 CASP8 Human cyclophosphamide multiple interactions EXP 6480464 [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Cyclophosphamide metabolite more ... CTD PMID:17898787 and PMID:22010212 CASP8 Human cyclophosphamide increases response to substance EXP 6480464 CASP8 protein results in increased susceptibility to Cyclophosphamide metabolite CTD PMID:22010212 CASP8 Human cyclosporin A multiple interactions EXP 6480464 Cyclosporine inhibits the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:15548389 CASP8 Human cyclosporin A multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Cyclosporine inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein] CTD PMID:15799720 CASP8 Human cylindrospermopsin increases expression EXP 6480464 cylindrospermopsin results in increased expression of CASP8 mRNA CTD PMID:23726867 CASP8 Human cytarabine multiple interactions EXP 6480464 [Cytarabine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein more ... CTD PMID:12780785 more ... CASP8 Human D-glucitol increases activity ISO Casp8 (Rattus norvegicus) 6480464 Sorbitol results in increased activity of CASP8 protein CTD PMID:20609311 CASP8 Human D-glucitol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]] and Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein] CTD PMID:20609311 CASP8 Human D-gluconic acid multiple interactions EXP 6480464 [gluconic acid co-treated with Zinc Sulfate] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA] CTD PMID:27017951 CASP8 Human D-glucose increases activity ISO Casp8 (Mus musculus) 6480464 Glucose results in increased activity of CASP8 protein CTD PMID:18973755 CASP8 Human D-glucose increases expression ISO Casp8 (Rattus norvegicus) 6480464 Glucose results in increased expression of CASP8 mRNA CTD PMID:38444079 CASP8 Human D-glucose multiple interactions EXP 6480464 [Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA and Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA] CTD PMID:33962019 CASP8 Human D-glucose multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Glucose co-treated with Lycopene] results in increased expression of CASP8 mRNA and Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP8] CTD PMID:18791325 and PMID:38444079 CASP8 Human D-glucose increases activity ISO Casp8 (Rattus norvegicus) 6480464 Glucose results in increased activity of CASP8 CTD PMID:18791325 CASP8 Human dacarbazine multiple interactions EXP 6480464 Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein and TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 CASP8 Human daunorubicin multiple interactions EXP 6480464 [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:12780785 CASP8 Human DDE increases activity EXP 6480464 Dichlorodiphenyl Dichloroethylene results in increased activity of CASP8 protein CTD PMID:19545618 CASP8 Human DDE increases activity ISO Casp8 (Rattus norvegicus) 6480464 Dichlorodiphenyl Dichloroethylene results in increased activity of CASP8 protein CTD PMID:24576310 CASP8 Human DDE increases expression ISO Casp8 (Rattus norvegicus) 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of CASP8 mRNA CTD PMID:19644561 more ... CASP8 Human DDE decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of CASP8 protein CTD PMID:20025943 CASP8 Human deguelin multiple interactions EXP 6480464 [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein CTD PMID:25242579 CASP8 Human delphinidin multiple interactions EXP 6480464 [delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP8 protein and delphinidin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:25954945 and PMID:30125548 CASP8 Human delphinidin increases expression EXP 6480464 delphinidin results in increased expression of CASP8 protein CTD PMID:33955636 CASP8 Human demethoxycurcumin decreases expression EXP 6480464 demethoxycurcumin results in decreased expression of CASP8 mRNA CTD PMID:33582110 CASP8 Human demethoxyfumitremorgin C increases activity EXP 6480464 demethoxyfumitremorgin C results in increased activity of CASP8 protein CTD PMID:28359723 CASP8 Human deoxynivalenol increases expression EXP 6480464 deoxynivalenol results in increased expression of CASP8 mRNA CTD PMID:22846391 and PMID:30668976 CASP8 Human deoxynivalenol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of CASP8 mRNA] CTD PMID:34673182 CASP8 Human deoxynivalenol increases expression ISO Casp8 (Rattus norvegicus) 6480464 deoxynivalenol results in increased expression of CASP8 mRNA CTD PMID:34673182 CASP8 Human deoxynivalenol multiple interactions EXP 6480464 [Aflatoxin B1 co-treated with deoxynivalenol] promotes the reaction [Zearalenone results in increased expression of CASP8 mRNA] more ... CTD PMID:30668976 CASP8 Human deoxynivalenol multiple interactions ISO Casp8 (Mus musculus) 6480464 deoxynivalenol results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:22491426 CASP8 Human desferrioxamine B increases activity EXP 6480464 Deferoxamine results in increased activity of CASP8 protein CTD PMID:16374551 CASP8 Human desferrioxamine B multiple interactions EXP 6480464 [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP8 mRNA more ... CTD PMID:16374551 more ... CASP8 Human Destruxin B decreases expression EXP 6480464 destruxin B results in decreased expression of CASP8 protein CTD PMID:23751424 CASP8 Human Destruxin B increases activity EXP 6480464 destruxin B results in increased activity of CASP8 protein CTD PMID:23751424 CASP8 Human dexamethasone multiple interactions EXP 6480464 [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein more ... CTD PMID:17070682 more ... CASP8 Human dexamethasone increases response to substance EXP 6480464 CASP8 protein results in increased susceptibility to Dexamethasone CTD PMID:22010212 CASP8 Human dexamethasone multiple interactions ISO Casp8 (Mus musculus) 6480464 [benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA] more ... CTD PMID:11399061 and PMID:20671745 CASP8 Human dexamethasone multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Dexamethasone inhibits the reaction [TGFB1 protein results in increased activity of CASP8 protein] CTD PMID:15388240 CASP8 Human dexamethasone increases activity ISO Casp8 (Mus musculus) 6480464 Dexamethasone results in increased activity of CASP8 protein CTD PMID:11399061 CASP8 Human dexamethasone increases activity EXP 6480464 Dexamethasone results in increased activity of CASP8 protein CTD PMID:15576458 CASP8 Human dexmedetomidine increases activity EXP 6480464 Dexmedetomidine results in increased activity of CASP8 protein CTD PMID:18724006 CASP8 Human dextran sulfate decreases expression ISO Casp8 (Mus musculus) 6480464 Dextran Sulfate results in decreased expression of CASP8 protein CTD PMID:29496522 CASP8 Human dextran sulfate multiple interactions ISO Casp8 (Mus musculus) 6480464 dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in decreased expression of CASP8 protein] CTD PMID:29496522 CASP8 Human Di-n-hexyl phthalate increases expression EXP 6480464 di-n-hexyl phthalate results in increased expression of CASP8 mRNA CTD PMID:33043605 CASP8 Human Di-n-octyl phthalate decreases expression ISO Casp8 (Mus musculus) 6480464 di-n-octyl phthalate results in decreased expression of CASP8 protein CTD PMID:29128616 CASP8 Human Di-n-octyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein and [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of CASP8 protein CTD PMID:35739755 and PMID:37364641 CASP8 Human diallyl disulfide increases cleavage EXP 6480464 diallyl disulfide results in increased cleavage of CASP8 protein CTD PMID:30677442 CASP8 Human diallyl disulfide multiple interactions EXP 6480464 diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein] CTD PMID:30677442 CASP8 Human diallyl trisulfide multiple interactions EXP 6480464 [diallyl trisulfide results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP8 protein and Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP8 protein] CTD PMID:22578287 and PMID:28571773 CASP8 Human diallyl trisulfide increases activity EXP 6480464 diallyl trisulfide results in increased activity of CASP8 protein CTD PMID:22595511 CASP8 Human diallyl trisulfide increases cleavage EXP 6480464 diallyl trisulfide results in increased cleavage of CASP8 protein CTD PMID:22578287 CASP8 Human diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CASP8 mRNA more ... CTD PMID:20953137 more ... CASP8 Human diarsenic trioxide increases activity ISO Casp8 (Mus musculus) 6480464 Arsenic Trioxide results in increased activity of CASP8 protein CTD PMID:21565247 and PMID:25410152 CASP8 Human diarsenic trioxide increases activity EXP 6480464 Arsenic Trioxide results in increased activity of CASP8 protein CTD PMID:10721769 more ... CASP8 Human diarsenic trioxide multiple interactions ISO Casp8 (Mus musculus) 6480464 Arsenic Trioxide promotes the reaction [Drugs and Chinese Herbal results in increased cleavage of CASP8 protein] CTD PMID:28587418 CASP8 Human diarsenic trioxide multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of CASP8 mRNA more ... CTD PMID:16174796 more ... CASP8 Human diarsenic trioxide increases cleavage EXP 6480464 Arsenic Trioxide results in increased cleavage of CASP8 protein CTD PMID:18491231 more ... CASP8 Human diarsenic trioxide affects activity EXP 6480464 Arsenic Trioxide affects the activity of CASP8 protein CTD PMID:16010437 CASP8 Human diazinon affects expression ISO Casp8 (Rattus norvegicus) 6480464 Diazinon affects the expression of CASP8 mRNA CTD PMID:22546817 CASP8 Human diazinon multiple interactions EXP 6480464 Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA] and Selenium analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA] CTD PMID:27920530 CASP8 Human diazinon increases expression EXP 6480464 Diazinon results in increased expression of CASP8 mRNA CTD PMID:27920530 CASP8 Human dibenziodolium multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein] CTD PMID:15799720 CASP8 Human dibenziodolium multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP8 protein] CTD PMID:33577942 CASP8 Human dibenziodolium increases activity EXP 6480464 diphenyleneiodonium results in increased activity of CASP8 protein CTD PMID:33577942 CASP8 Human Dibutyl phosphate affects expression EXP 6480464 di-n-butylphosphoric acid affects the expression of CASP8 mRNA CTD PMID:37042841 CASP8 Human dibutyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein more ... CTD PMID:28013214 more ... CASP8 Human dibutyl phthalate increases expression ISO Casp8 (Mus musculus) 6480464 Dibutyl Phthalate results in increased expression of CASP8 protein CTD PMID:31712109 CASP8 Human dichloroacetic acid increases expression ISO Casp8 (Mus musculus) 6480464 Dichloroacetic Acid results in increased expression of CASP8 mRNA CTD PMID:28962523 CASP8 Human diclofenac increases activity ISO Casp8 (Rattus norvegicus) 6480464 Diclofenac results in increased activity of CASP8 protein CTD PMID:14609740 CASP8 Human diclofenac affects expression EXP 6480464 Diclofenac affects the expression of CASP8 mRNA CTD PMID:24752500 CASP8 Human diclofenac increases activity EXP 6480464 Diclofenac results in increased activity of CASP8 protein CTD PMID:27313093 CASP8 Human diclofenac multiple interactions EXP 6480464 [Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein more ... CTD PMID:20237495 and PMID:27313093 CASP8 Human dieckol increases activity EXP 6480464 dieckol results in increased activity of CASP8 protein CTD PMID:31291034 CASP8 Human dieldrin affects expression ISO Casp8 (Rattus norvegicus) 6480464 Dieldrin affects the expression of CASP8 mRNA CTD PMID:22546817 CASP8 Human diepoxybutane increases expression EXP 6480464 diepoxybutane results in increased expression of CASP8 mRNA CTD PMID:29792945 CASP8 Human diethyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein more ... CTD PMID:28013214 more ... CASP8 Human diethyldithiocarbamic acid multiple interactions EXP 6480464 [Ditiocarb binds to Copper] which results in increased activity of CASP8 protein CTD PMID:22951949 CASP8 Human diethylstilbestrol increases expression ISO Casp8 (Mus musculus) 6480464 Diethylstilbestrol results in increased expression of CASP8 mRNA CTD PMID:15545218 CASP8 Human diethylstilbestrol increases expression ISO Casp8 (Rattus norvegicus) 6480464 Diethylstilbestrol results in increased expression of CASP8 mRNA CTD PMID:21658437 CASP8 Human digitoxin increases cleavage EXP 6480464 Digitoxin analog results in increased cleavage of CASP8 protein and Digitoxin results in increased cleavage of CASP8 protein CTD PMID:22037315 and PMID:34717917 CASP8 Human digitoxin multiple interactions EXP 6480464 Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein] more ... CTD PMID:34717917 CASP8 Human Dihydrotanshinone I multiple interactions ISO Casp8 (Mus musculus) 6480464 dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in decreased expression of CASP8 protein] and dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in decreased expression of CASP8 protein] CTD PMID:29496522 CASP8 Human diisobutyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CASP8 mRNA CTD PMID:28013214 CASP8 Human Diisodecyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein and [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of CASP8 protein CTD PMID:35739755 and PMID:37364641 CASP8 Human diisononyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein more ... CTD PMID:28013214 more ... CASP8 Human Dimethyl phthalate increases expression ISO Casp8 (Rattus norvegicus) 6480464 dimethyl phthalate results in increased expression of CASP8 mRNA CTD PMID:35598668 CASP8 Human dimethylarsinic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [CASP8 protein results in increased susceptibility to Cacodylic Acid] CTD PMID:15276415 CASP8 Human dimethylarsinic acid increases response to substance ISO Casp8 (Rattus norvegicus) 6480464 CASP8 protein results in increased susceptibility to Cacodylic Acid CTD PMID:15276415 CASP8 Human dioscin increases activity EXP 6480464 dioscin results in increased activity of CASP8 protein CTD PMID:22334414 CASP8 Human dioscin decreases expression EXP 6480464 dioscin results in decreased expression of CASP8 mRNA CTD PMID:33359023 CASP8 Human dioscin multiple interactions EXP 6480464 dioscin results in decreased expression of and results in increased cleavage of CASP8 protein CTD PMID:33359023 CASP8 Human dioscin increases expression EXP 6480464 dioscin results in increased expression of CASP8 mRNA and dioscin results in increased expression of CASP8 protein CTD PMID:29990575 CASP8 Human dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of CASP8 mRNA CTD PMID:23452621 CASP8 Human dioxygen multiple interactions EXP 6480464 3 more ... CTD PMID:23452621 CASP8 Human dipyridamole multiple interactions EXP 6480464 Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] CTD PMID:17303086 CASP8 Human diquat multiple interactions ISO Casp8 (Mus musculus) 6480464 [Antioxidants results in decreased susceptibility to Diquat] which results in decreased expression of CASP8 mRNA CTD PMID:32536062 CASP8 Human disodium selenite increases expression ISO Casp8 (Mus musculus) 6480464 Sodium Selenite results in increased expression of CASP8 mRNA CTD PMID:19363675 CASP8 Human disodium selenite increases cleavage EXP 6480464 Sodium Selenite results in increased cleavage of CASP8 protein CTD PMID:34520753 CASP8 Human disodium selenite decreases activity ISO Casp8 (Rattus norvegicus) 6480464 Sodium Selenite results in decreased activity of CASP8 protein CTD PMID:18209489 CASP8 Human docebenone multiple interactions ISO Casp8 (Mus musculus) 6480464 2 more ... CTD PMID:25432964 CASP8 Human donepezil hydrochloride increases activity EXP 6480464 Donepezil results in increased activity of CASP8 protein CTD PMID:20522977 CASP8 Human dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 CASP8 Human doxorubicin multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein] more ... CTD PMID:15812552 more ... CASP8 Human doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of CASP8 mRNA CTD PMID:30581319 CASP8 Human doxorubicin increases expression ISO Casp8 (Rattus norvegicus) 6480464 Doxorubicin results in increased expression of CASP8 protein CTD PMID:27087047 CASP8 Human doxorubicin increases response to substance EXP 6480464 CASP8 protein results in increased susceptibility to Doxorubicin CTD PMID:22010212 CASP8 Human doxorubicin increases activity EXP 6480464 Doxorubicin results in increased activity of CASP8 protein CTD PMID:15868924 more ... CASP8 Human doxorubicin increases expression ISO Casp8 (Mus musculus) 6480464 Doxorubicin results in increased expression of CASP8 mRNA and Doxorubicin results in increased expression of CASP8 protein CTD PMID:26873546 and PMID:32289291 CASP8 Human doxorubicin increases activity ISO Casp8 (Rattus norvegicus) 6480464 Doxorubicin results in increased activity of CASP8 protein CTD PMID:15799720 more ... CASP8 Human doxorubicin increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Doxorubicin results in increased cleavage of CASP8 protein CTD PMID:12107157 more ... CASP8 Human doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of CASP8 mRNA and Doxorubicin results in increased expression of CASP8 protein CTD PMID:16001973 and PMID:25339540 CASP8 Human doxorubicin increases cleavage EXP 6480464 Doxorubicin analog results in increased cleavage of CASP8 protein and Doxorubicin results in increased cleavage of CASP8 protein CTD PMID:15981920 more ... CASP8 Human doxorubicin affects expression EXP 6480464 Doxorubicin affects the expression of CASP8 mRNA CTD PMID:16705698 CASP8 Human doxorubicin affects activity EXP 6480464 Doxorubicin affects the activity of CASP8 protein CTD PMID:15870702 CASP8 Human doxorubicin multiple interactions ISO Casp8 (Mus musculus) 6480464 [zoledronic acid co-treated with Doxorubicin] results in increased activity of CASP8 protein CTD PMID:19789217 CASP8 Human doxorubicin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 1 more ... CTD PMID:15799720 more ... CASP8 Human doxorubicin increases activity ISO Casp8 (Mus musculus) 6480464 Doxorubicin results in increased activity of CASP8 protein CTD PMID:16018998 CASP8 Human Echimidine multiple interactions EXP 6480464 echimidine results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:29458164 CASP8 Human Echinocystic acid increases activity EXP 6480464 echinocystic acid analog results in increased activity of CASP8 protein CTD PMID:15863893 CASP8 Human eckol multiple interactions EXP 6480464 [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein CTD PMID:21514314 CASP8 Human edaravone decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Edaravone results in decreased expression of CASP8 protein CTD PMID:17967739 CASP8 Human elemental carbon multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA CTD PMID:31268311 CASP8 Human elemental selenium multiple interactions EXP 6480464 [Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein] more ... CTD PMID:17970047 and PMID:27920530 CASP8 Human elemental selenium increases activity EXP 6480464 Selenium results in increased activity of CASP8 protein CTD PMID:12432279 CASP8 Human elemental selenium decreases expression EXP 6480464 Selenium results in decreased expression of CASP8 mRNA CTD PMID:19244175 CASP8 Human ellipticine multiple interactions EXP 6480464 ellipticine results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21843585 CASP8 Human emodin multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein] more ... CTD PMID:27032576 CASP8 Human emodin increases activity EXP 6480464 Emodin results in increased activity of CASP8 protein CTD PMID:27032576 CASP8 Human endosulfan multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Endosulfan results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:30796443 CASP8 Human entinostat increases expression EXP 6480464 entinostat results in increased expression of CASP8 mRNA CTD PMID:26272509 CASP8 Human entinostat multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA CTD PMID:27188386 CASP8 Human enzalutamide decreases expression EXP 6480464 enzalutamide results in decreased expression of CASP8 protein CTD PMID:32805266 CASP8 Human epichlorohydrin increases expression EXP 6480464 Epichlorohydrin results in increased expression of CASP8 mRNA CTD PMID:29792945 CASP8 Human epoxiconazole decreases expression ISO Casp8 (Mus musculus) 6480464 epoxiconazole results in decreased expression of CASP8 mRNA CTD PMID:35436446 CASP8 Human esculetin multiple interactions EXP 6480464 [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16051289 CASP8 Human etacrynic acid multiple interactions EXP 6480464 [arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP8 protein CTD PMID:23082001 CASP8 Human etacrynic acid increases cleavage EXP 6480464 Ethacrynic Acid results in increased cleavage of CASP8 protein CTD PMID:23082001 CASP8 Human ethanol increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Ethanol results in increased cleavage of CASP8 protein CTD PMID:25859307 and PMID:29085585 CASP8 Human ethanol multiple interactions ISO Casp8 (Mus musculus) 6480464 sodium propionate inhibits the reaction [Ethanol results in increased expression of CASP8 mRNA] CTD PMID:35639301 CASP8 Human ethanol increases expression ISO Casp8 (Rattus norvegicus) 6480464 Ethanol results in increased expression of CASP8 mRNA CTD PMID:36085217 CASP8 Human ethanol increases activity ISO Casp8 (Rattus norvegicus) 6480464 Ethanol results in increased activity of CASP8 protein CTD PMID:25289771 CASP8 Human ethanol increases expression ISO Casp8 (Mus musculus) 6480464 Ethanol results in increased expression of CASP8 mRNA and Ethanol results in increased expression of CASP8 protein CTD PMID:19429258 and PMID:35639301 CASP8 Human ethanol multiple interactions EXP 6480464 ALDH2 protein inhibits the reaction [Ethanol results in increased expression of CASP8 protein] CTD PMID:19429258 CASP8 Human ethanol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [2 more ... CTD PMID:25289771 more ... CASP8 Human ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 [1 more ... CTD PMID:29111403 CASP8 Human etoposide multiple interactions EXP 6480464 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2 more ... CTD PMID:15475000 more ... CASP8 Human etoposide increases response to substance EXP 6480464 CASP8 protein results in increased susceptibility to Etoposide CTD PMID:22010212 CASP8 Human etoposide increases cleavage EXP 6480464 Etoposide results in increased cleavage of CASP8 protein CTD PMID:21801448 CASP8 Human etoposide increases activity EXP 6480464 Etoposide results in increased activity of CASP8 protein CTD PMID:15475000 CASP8 Human etoposide decreases response to substance EXP 6480464 CASP8 protein mutant form results in decreased susceptibility to Etoposide CTD PMID:21801448 CASP8 Human fangchinoline increases cleavage EXP 6480464 fangchinoline results in increased cleavage of CASP8 protein CTD PMID:28754437 CASP8 Human fenbendazole increases expression EXP 6480464 Fenbendazole analog results in increased expression of CASP8 mRNA and Fenbendazole results in increased expression of CASP8 mRNA CTD PMID:35569513 CASP8 Human fenpropathrin increases expression ISO Casp8 (Rattus norvegicus) 6480464 fenpropathrin results in increased expression of CASP8 mRNA CTD PMID:38369055 CASP8 Human fenpropathrin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP8 mRNA] CTD PMID:38369055 CASP8 Human fingolimod hydrochloride increases cleavage EXP 6480464 Fingolimod Hydrochloride results in increased cleavage of CASP8 protein CTD PMID:25939952 CASP8 Human fingolimod hydrochloride multiple interactions EXP 6480464 SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein] CTD PMID:25939952 CASP8 Human fisetin multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP8 protein] more ... CTD PMID:21216935 and PMID:21964635 CASP8 Human fisetin increases activity EXP 6480464 fisetin results in increased activity of CASP8 protein CTD PMID:21964635 and PMID:28181380 CASP8 Human flavanone multiple interactions EXP 6480464 [benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to flavanone and flavanone results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:22056764 CASP8 Human flavones increases activity EXP 6480464 Flavones analog results in increased activity of CASP8 protein CTD PMID:20674374 CASP8 Human flavonols multiple interactions EXP 6480464 Flavonols results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:28235426 CASP8 Human fluoxetine increases activity ISO Casp8 (Mus musculus) 6480464 Fluoxetine results in increased activity of CASP8 protein CTD PMID:28482088 CASP8 Human fluticasone multiple interactions EXP 6480464 [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein CTD PMID:15536434 CASP8 Human fluvastatin increases activity EXP 6480464 fluvastatin results in increased activity of CASP8 protein CTD PMID:24964743 CASP8 Human fluvastatin multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [fluvastatin results in increased activity of CASP8 protein] CTD PMID:24964743 CASP8 Human folic acid affects expression EXP 6480464 Folic Acid affects the expression of CASP8 mRNA CTD PMID:16361273 CASP8 Human folic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Folic Acid inhibits the reaction [Dietary Fats results in increased expression of CASP8 mRNA] and Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA]] CTD PMID:23935743 CASP8 Human folic acid multiple interactions EXP 6480464 Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 mRNA] more ... CTD PMID:29250709 and PMID:30581319 CASP8 Human folic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 CASP8 Human formaldehyde increases expression ISO Casp8 (Rattus norvegicus) 6480464 Formaldehyde results in increased expression of CASP8 mRNA CTD PMID:20448356 CASP8 Human formaldehyde increases activity ISO Casp8 (Rattus norvegicus) 6480464 Formaldehyde results in increased activity of CASP8 protein CTD PMID:20448356 CASP8 Human formononetin increases activity EXP 6480464 formononetin results in increased activity of CASP8 protein CTD PMID:23867903 CASP8 Human formononetin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA] more ... CTD PMID:23867903 CASP8 Human formononetin increases expression EXP 6480464 formononetin results in increased expression of CASP8 mRNA CTD PMID:23867903 CASP8 Human fructose multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Plant Extracts inhibits the reaction [Fructose results in decreased cleavage of CASP8 protein] CTD PMID:33475235 CASP8 Human fructose decreases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Fructose results in decreased cleavage of CASP8 protein CTD PMID:33475235 CASP8 Human furan increases expression ISO Casp8 (Rattus norvegicus) 6480464 furan results in increased expression of CASP8 mRNA CTD PMID:27387713 CASP8 Human furosemide affects expression ISO Casp8 (Rattus norvegicus) 6480464 Furosemide affects the expression of CASP8 mRNA CTD PMID:17497460 CASP8 Human Fusarenone X increases expression ISO Casp8 (Mus musculus) 6480464 fusarenon-X results in increased expression of CASP8 mRNA CTD PMID:24983900 CASP8 Human gallic acid increases expression EXP 6480464 Gallic Acid results in increased expression of CASP8 protein CTD PMID:22245431 CASP8 Human gallium atom increases activity EXP 6480464 Gallium results in increased activity of CASP8 protein CTD PMID:21194614 CASP8 Human gardenin B multiple interactions EXP 6480464 gardenin B results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:27423764 CASP8 Human gedunin increases activity EXP 6480464 gedunin results in increased activity of CASP8 protein CTD PMID:21381696 CASP8 Human gefitinib increases cleavage EXP 6480464 Gefitinib results in increased cleavage of CASP8 protein CTD PMID:31168030 CASP8 Human gemcitabine increases activity EXP 6480464 Gemcitabine results in increased activity of CASP8 protein CTD PMID:12479703 and PMID:17159604 CASP8 Human gemcitabine multiple interactions EXP 6480464 [Calcitriol co-treated with Gemcitabine] results in increased expression of CASP8 protein more ... CTD PMID:17671697 more ... CASP8 Human gemcitabine increases cleavage EXP 6480464 Gemcitabine results in increased cleavage of CASP8 protein CTD PMID:14750167 CASP8 Human genistein multiple interactions EXP 6480464 [Genistein co-treated with TNFSF10 protein] results in increased activity of CASP8 protein more ... CTD PMID:18546268 more ... CASP8 Human gentamycin increases activity ISO Casp8 (Rattus norvegicus) 6480464 Gentamicins results in increased activity of CASP8 protein CTD PMID:17132701 CASP8 Human gentamycin increases expression ISO Casp8 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of CASP8 mRNA CTD PMID:33387578 CASP8 Human gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of CASP8 mRNA CTD PMID:29992668 CASP8 Human gentamycin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP8 protein] more ... CTD PMID:17132701 CASP8 Human Gentiopicrin multiple interactions ISO Casp8 (Mus musculus) 6480464 gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein] and gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form] CTD PMID:20558151 CASP8 Human geraniol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein] and geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA] CTD PMID:21907755 CASP8 Human geraniol increases expression EXP 6480464 geraniol results in increased expression of CASP8 mRNA and geraniol results in increased expression of CASP8 protein CTD PMID:30506710 CASP8 Human gibberellin A3 decreases methylation ISO Casp8 (Rattus norvegicus) 6480464 gibberellic acid results in decreased methylation of CASP8 gene and gibberellic acid results in decreased methylation of CASP8 promoter CTD PMID:31733319 CASP8 Human gibberellin A3 increases expression ISO Casp8 (Rattus norvegicus) 6480464 gibberellic acid results in increased expression of CASP8 mRNA and gibberellic acid results in increased expression of CASP8 protein CTD PMID:31733319 CASP8 Human gingerol multiple interactions EXP 6480464 [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein and Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein] CTD PMID:25034532 CASP8 Human gingerol increases cleavage EXP 6480464 gingerol results in increased cleavage of CASP8 protein CTD PMID:28249781 CASP8 Human gingerol affects activity ISO Casp8 (Mus musculus) 6480464 gingerol affects the activity of CASP8 protein CTD PMID:17454143 CASP8 Human glabridin increases cleavage EXP 6480464 glabridin results in increased cleavage of CASP8 protein CTD PMID:29663662 CASP8 Human glucose increases activity ISO Casp8 (Mus musculus) 6480464 Glucose results in increased activity of CASP8 protein CTD PMID:18973755 CASP8 Human glucose increases expression ISO Casp8 (Rattus norvegicus) 6480464 Glucose results in increased expression of CASP8 mRNA CTD PMID:38444079 CASP8 Human glucose multiple interactions EXP 6480464 [Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA and Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA] CTD PMID:33962019 CASP8 Human glucose multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Glucose co-treated with Lycopene] results in increased expression of CASP8 mRNA and Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP8] CTD PMID:18791325 and PMID:38444079 CASP8 Human glucose increases activity ISO Casp8 (Rattus norvegicus) 6480464 Glucose results in increased activity of CASP8 CTD PMID:18791325 CASP8 Human glutaraldehyde decreases expression EXP 6480464 Glutaral results in decreased expression of CASP8 mRNA CTD PMID:28236482 CASP8 Human glutathione multiple interactions ISO Casp8 (Mus musculus) 6480464 Glutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein] CTD PMID:24376112 CASP8 Human glutathione multiple interactions EXP 6480464 Glutathione inhibits the reaction [1 more ... CTD PMID:24515801 CASP8 Human glycochenodeoxycholic acid increases activity ISO Casp8 (Rattus norvegicus) 6480464 Glycochenodeoxycholic Acid results in increased activity of CASP8 protein CTD PMID:12873810 and PMID:15767249 CASP8 Human glycochenodeoxycholic acid increases cleavage ISO Casp8 (Mus musculus) 6480464 Glycochenodeoxycholic Acid results in increased cleavage of CASP8 protein CTD PMID:25125499 CASP8 Human glycyrrhizinic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP8 protein] CTD PMID:22051199 CASP8 Human glycyrrhizinic acid increases activity EXP 6480464 Glycyrrhizic Acid results in increased activity of CASP8 protein CTD PMID:35844403 CASP8 Human glycyrrhizinic acid multiple interactions EXP 6480464 [Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP8 mRNA CTD PMID:37659683 CASP8 Human glyphosate multiple interactions EXP 6480464 [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 mRNA and [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 protein CTD PMID:32800223 CASP8 Human glyphosate decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Glyphosate results in decreased expression of CASP8 mRNA CTD PMID:38314887 CASP8 Human gold atom increases expression EXP 6480464 Gold results in increased expression of CASP8 mRNA CTD PMID:22178767 CASP8 Human gold atom decreases expression EXP 6480464 Gold analog results in decreased expression of CASP8 mRNA CTD PMID:36057382 CASP8 Human gold(0) increases expression EXP 6480464 Gold results in increased expression of CASP8 mRNA CTD PMID:22178767 CASP8 Human gold(0) decreases expression EXP 6480464 Gold analog results in decreased expression of CASP8 mRNA CTD PMID:36057382 CASP8 Human Grifolin increases activity EXP 6480464 grifolin results in increased activity of CASP8 protein CTD PMID:15949805 CASP8 Human guggulsterone increases activity EXP 6480464 pregna-4 more ... CTD PMID:17475222 CASP8 Human helenalin multiple interactions EXP 6480464 helenalin inhibits the reaction [CD 437 results in increased activity of CASP8 protein] CTD PMID:16024638 CASP8 Human Heliotrine increases cleavage EXP 6480464 heliotrine results in increased cleavage of CASP8 protein CTD PMID:29458164 CASP8 Human hexachlorobenzene increases activity ISO Casp8 (Rattus norvegicus) 6480464 Hexachlorobenzene results in increased activity of CASP8 protein CTD PMID:21787832 and PMID:23708402 CASP8 Human homocysteine multiple interactions EXP 6480464 Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 mRNA] and Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 protein] CTD PMID:29250709 CASP8 Human homocysteine affects expression EXP 6480464 Homocysteine affects the expression of CASP8 mRNA and Homocysteine affects the expression of CASP8 protein CTD PMID:29250709 CASP8 Human Honokiol increases activity EXP 6480464 honokiol results in increased activity of CASP8 protein CTD PMID:15802533 CASP8 Human hyaluronic acid multiple interactions EXP 6480464 [Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein CTD PMID:20237495 CASP8 Human hydrogen peroxide increases activity ISO Casp8 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in increased activity of CASP8 protein CTD PMID:15799720 more ... CASP8 Human hydrogen peroxide increases expression ISO Casp8 (Mus musculus) 6480464 Hydrogen Peroxide results in increased expression of CASP8 mRNA CTD PMID:31696622 CASP8 Human hydrogen peroxide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 1 more ... CTD PMID:15799720 more ... CASP8 Human hydrogen peroxide increases expression ISO Casp8 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in increased expression of CASP8 protein CTD PMID:20946910 and PMID:27525270 CASP8 Human hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of CASP8 protein CTD PMID:21179406 CASP8 Human hydrogen peroxide multiple interactions EXP 6480464 Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein] CTD PMID:21431366 CASP8 Human hydrogen peroxide increases activity EXP 6480464 Hydrogen Peroxide results in increased activity of CASP8 protein CTD PMID:21431366 CASP8 Human hydroquinone multiple interactions EXP 6480464 FADD protein affects the reaction [hydroquinone results in increased cleavage of CASP8 protein] more ... CTD PMID:15777082 and PMID:23288922 CASP8 Human hydroquinone increases cleavage EXP 6480464 hydroquinone results in increased cleavage of CASP8 protein CTD PMID:23288922 CASP8 Human hydroquinone increases expression ISO Casp8 (Mus musculus) 6480464 hydroquinone results in increased expression of CASP8 protein CTD PMID:27606422 CASP8 Human hydroquinone increases activity EXP 6480464 hydroquinone results in increased activity of CASP8 protein CTD PMID:23776099 CASP8 Human hydroquinone O-beta-D-glucopyranoside decreases expression EXP 6480464 Arbutin results in decreased expression of CASP8 mRNA CTD PMID:17103032 CASP8 Human hydroxyurea increases expression ISO Casp8 (Mus musculus) 6480464 Hydroxyurea results in increased expression of CASP8 protein CTD PMID:26399158 CASP8 Human hyperforin increases cleavage EXP 6480464 hyperforin results in increased cleavage of CASP8 protein CTD PMID:32485087 CASP8 Human icariside II increases activity EXP 6480464 baohuoside I results in increased activity of CASP8 protein CTD PMID:19289254 CASP8 Human idelalisib multiple interactions EXP 6480464 [TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein more ... CTD PMID:31445927 CASP8 Human Ilimaquinone increases cleavage EXP 6480464 ilimaquinone results in increased cleavage of CASP8 protein CTD PMID:24930757 CASP8 Human imipramine multiple interactions ISO Casp8 (Mus musculus) 6480464 Imipramine inhibits the reaction [lead acetate results in increased activity of CASP8 protein] CTD PMID:22033380 CASP8 Human indirubin-3'-monoxime multiple interactions EXP 6480464 [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CASP8 mRNA CTD PMID:18958680 CASP8 Human indometacin multiple interactions EXP 6480464 [Indomethacin results in increased activity of CASP8 protein] which results in increased susceptibility to Doxorubicin more ... CTD PMID:15265368 and PMID:15812552 CASP8 Human indometacin decreases activity ISO Casp8 (Rattus norvegicus) 6480464 Indomethacin results in decreased activity of CASP8 protein CTD PMID:19615346 CASP8 Human ionomycin multiple interactions EXP 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA] more ... CTD PMID:12165276 and PMID:15477007 CASP8 Human irinotecan increases activity EXP 6480464 Irinotecan results in increased activity of CASP8 protein CTD PMID:16432164 CASP8 Human irinotecan multiple interactions EXP 6480464 Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP8 protein] more ... CTD PMID:16432164 and PMID:18182997 CASP8 Human iron dichloride increases expression EXP 6480464 ferrous chloride results in increased expression of CASP8 mRNA CTD PMID:35984750 CASP8 Human iron(III) nitrilotriacetate multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein more ... CTD PMID:21907755 CASP8 Human isoflavones increases expression ISO Casp8 (Rattus norvegicus) 6480464 Isoflavones results in increased expression of CASP8 mRNA CTD PMID:25035168 CASP8 Human isoflurane multiple interactions ISO Casp8 (Mus musculus) 6480464 resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP8 protein] CTD PMID:23922164 CASP8 Human isoflurane increases activity ISO Casp8 (Mus musculus) 6480464 Isoflurane results in increased activity of CASP8 protein CTD PMID:23922164 CASP8 Human isoliquiritigenin increases activity EXP 6480464 isoliquiritigenin results in increased activity of CASP8 protein CTD PMID:16158945 CASP8 Human isoprenaline increases expression ISO Casp8 (Rattus norvegicus) 6480464 Isoproterenol results in increased expression of CASP8 mRNA and Isoproterenol results in increased expression of CASP8 protein CTD PMID:25794854 more ... CASP8 Human isoprenaline multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein] more ... CTD PMID:25794854 more ... CASP8 Human isotretinoin increases cleavage EXP 6480464 Isotretinoin results in increased cleavage of CASP8 protein CTD PMID:16135400 CASP8 Human isotretinoin increases expression ISO Casp8 (Mus musculus) 6480464 Isotretinoin results in increased expression of CASP8 protein CTD PMID:27606422 CASP8 Human ivermectin decreases expression EXP 6480464 Ivermectin results in decreased expression of CASP8 protein CTD PMID:32959892 CASP8 Human juglone increases activity EXP 6480464 juglone results in increased activity of CASP8 protein CTD PMID:20138029 CASP8 Human kojic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA CTD PMID:18544905 CASP8 Human L-1,4-dithiothreitol multiple interactions ISO Casp8 (Mus musculus) 6480464 Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] CTD PMID:11226294 CASP8 Human L-ascorbic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Ascorbic Acid co-treated with INS1 protein] results in increased expression of CASP8 mRNA and [Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA CTD PMID:18544905 and PMID:20400526 CASP8 Human L-ascorbic acid increases expression EXP 6480464 Ascorbic Acid results in increased expression of CASP8 mRNA CTD PMID:30597948 CASP8 Human L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein] CTD PMID:23711929 CASP8 Human L-methionine multiple interactions ISO Casp8 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CASP8 gene CTD PMID:20938992 CASP8 Human lactacystin multiple interactions ISO Casp8 (Mus musculus) 6480464 lactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] CTD PMID:20671745 CASP8 Human lead diacetate multiple interactions ISO Casp8 (Mus musculus) 6480464 1 more ... CTD PMID:22033380 CASP8 Human lead diacetate increases activity ISO Casp8 (Mus musculus) 6480464 lead acetate results in increased activity of CASP8 protein CTD PMID:22033380 CASP8 Human Licochalcone A multiple interactions EXP 6480464 SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP8 protein] CTD PMID:30983163 CASP8 Human Licochalcone A increases expression EXP 6480464 licochalcone A results in increased expression of CASP8 mRNA CTD PMID:30055311 CASP8 Human Licochalcone A increases cleavage EXP 6480464 licochalcone A results in increased cleavage of CASP8 protein CTD PMID:30983163 CASP8 Human Licochalcone B increases cleavage EXP 6480464 licochalcone B results in increased cleavage of CASP8 protein CTD PMID:35948134 CASP8 Human Licochalcone B multiple interactions EXP 6480464 TNFRSF10B protein promotes the reaction [licochalcone B results in increased cleavage of CASP8 protein] CTD PMID:35948134 CASP8 Human Liensinine multiple interactions ISO Casp8 (Mus musculus) 6480464 liensinine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP8 protein] CTD PMID:38692452 CASP8 Human linalool increases expression EXP 6480464 linalool results in increased expression of CASP8 mRNA CTD PMID:26703569 CASP8 Human lipoic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA CTD PMID:23830814 CASP8 Human lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein] CTD PMID:27544635 CASP8 Human lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of CASP8 protein CTD PMID:21844306 CASP8 Human lipopolysaccharide decreases expression ISO Casp8 (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of CASP8 mRNA and Lipopolysaccharides results in decreased expression of CASP8 protein CTD PMID:35833596 CASP8 Human lipopolysaccharide increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Lipopolysaccharides results in increased cleavage of CASP8 protein CTD PMID:31486215 CASP8 Human lipopolysaccharide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Honghua extract more ... CTD PMID:31486215 CASP8 Human lipopolysaccharide increases cleavage ISO Casp8 (Mus musculus) 6480464 Lipopolysaccharides results in increased cleavage of CASP8 protein CTD PMID:30776389 and PMID:38692452 CASP8 Human lipopolysaccharide increases activity ISO Casp8 (Mus musculus) 6480464 Lipopolysaccharides results in increased activity of CASP8 protein CTD PMID:23170834 CASP8 Human lipopolysaccharide increases expression ISO Casp8 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of CASP8 mRNA CTD PMID:23107598 CASP8 Human lipopolysaccharide multiple interactions ISO Casp8 (Mus musculus) 6480464 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP8 protein] more ... CTD PMID:20558151 more ... CASP8 Human Lipstatin multiple interactions EXP 6480464 lipstatin analog results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:20577697 CASP8 Human lithium atom multiple interactions EXP 6480464 Lithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein] and Lithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein] CTD PMID:15475000 CASP8 Human lithium hydride multiple interactions EXP 6480464 Lithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein] and Lithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein] CTD PMID:15475000 CASP8 Human lithocholic acid multiple interactions EXP 6480464 [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein more ... CTD PMID:19054763 CASP8 Human lonafarnib multiple interactions EXP 6480464 [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP8 protein CTD PMID:16118318 CASP8 Human lonidamine multiple interactions EXP 6480464 [arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein and BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:21889928 CASP8 Human loratadine increases cleavage EXP 6480464 Loratadine results in increased cleavage of CASP8 protein CTD PMID:20570632 CASP8 Human losartan decreases activity ISO Casp8 (Rattus norvegicus) 6480464 Losartan results in decreased activity of CASP8 protein CTD PMID:23875703 CASP8 Human lovastatin increases activity EXP 6480464 Lovastatin results in increased activity of CASP8 protein CTD PMID:15705602 CASP8 Human lovastatin increases activity ISO Casp8 (Mus musculus) 6480464 Lovastatin results in increased activity of CASP8 protein CTD PMID:15180944 CASP8 Human lupeol increases expression EXP 6480464 lupeol results in increased expression of CASP8 mRNA and lupeol results in increased expression of CASP8 protein CTD PMID:30506710 CASP8 Human Lupiwighteone increases cleavage EXP 6480464 lupiwighteone results in increased cleavage of CASP8 protein CTD PMID:31604113 CASP8 Human luteolin multiple interactions EXP 6480464 [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein more ... CTD PMID:15334063 more ... CASP8 Human luteolin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein] CTD PMID:27525270 CASP8 Human Luteolin 7-methyl ether multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP8 protein] and hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP8 protein] CTD PMID:24144774 CASP8 Human Luteolin 7-methyl ether increases activity ISO Casp8 (Rattus norvegicus) 6480464 hydroxygenkwanin results in increased activity of CASP8 protein CTD PMID:24144774 CASP8 Human luteolin 7-O-beta-D-glucoside increases cleavage EXP 6480464 luteolin-7-glucoside results in increased cleavage of CASP8 protein CTD PMID:34165247 CASP8 Human LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein] more ... CTD PMID:15850772 more ... CASP8 Human LY294002 multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [soybean oil and phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP8 protein]] CTD PMID:33030052 CASP8 Human LY294002 increases activity EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein CTD PMID:15942663 CASP8 Human lycopene multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Glucose co-treated with Lycopene] results in increased expression of CASP8 mRNA more ... CTD PMID:16030430 and PMID:38444079 CASP8 Human lycopene decreases expression EXP 6480464 lycopene results in decreased expression of CASP8 mRNA CTD PMID:16886892 CASP8 Human Maduramicin increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 maduramicin results in increased cleavage of CASP8 protein CTD PMID:29047155 CASP8 Human magnesium oxide multiple interactions EXP 6480464 Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA] CTD PMID:27920530 CASP8 Human malathion increases activity ISO Casp8 (Mus musculus) 6480464 Malathion results in increased activity of CASP8 protein CTD PMID:12505448 CASP8 Human mancozeb increases activity EXP 6480464 mancozeb results in increased activity of CASP8 protein CTD PMID:22824503 CASP8 Human maneb increases activity EXP 6480464 Maneb results in increased activity of CASP8 protein CTD PMID:22824503 CASP8 Human manganese atom increases activity ISO Casp8 (Rattus norvegicus) 6480464 Manganese results in increased activity of CASP8 protein CTD PMID:31161640 CASP8 Human manganese atom multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein] CTD PMID:31161640 CASP8 Human manganese(0) multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein] CTD PMID:31161640 CASP8 Human manganese(0) increases activity ISO Casp8 (Rattus norvegicus) 6480464 Manganese results in increased activity of CASP8 protein CTD PMID:31161640 CASP8 Human manganese(II) chloride increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 manganese chloride results in increased cleavage of CASP8 protein CTD PMID:21704098 and PMID:28378122 CASP8 Human manganese(II) chloride multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein] more ... CTD PMID:28378122 CASP8 Human mangiferin increases expression EXP 6480464 mangiferin results in increased expression of CASP8 protein CTD PMID:32420661 CASP8 Human mangiferin multiple interactions EXP 6480464 mangiferin inhibits the reaction [aluminum maltolate results in increased activity of CASP8 protein] CTD PMID:37455591 CASP8 Human masoprocol multiple interactions EXP 6480464 [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17645780 CASP8 Human masoprocol multiple interactions ISO Casp8 (Mus musculus) 6480464 Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein] CTD PMID:10203695 CASP8 Human masoprocol increases expression EXP 6480464 Masoprocol results in increased expression of CASP8 protein CTD PMID:17645780 CASP8 Human MeIQx decreases expression EXP 6480464 2-amino-3 more ... CTD PMID:20816883 CASP8 Human melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA] and Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein] CTD PMID:21431366 and PMID:33962019 CASP8 Human melatonin multiple interactions ISO Casp8 (Mus musculus) 6480464 Melatonin inhibits the reaction [Atrazine results in increased cleavage of CASP8 protein] and Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 protein] CTD PMID:25259610 and PMID:35844137 CASP8 Human melatonin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein] CTD PMID:25454643 CASP8 Human melittin increases expression EXP 6480464 Melitten results in increased expression of CASP8 protein modified form CTD PMID:22027265 CASP8 Human mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of CASP8 mRNA CTD PMID:26272509 CASP8 Human mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA CTD PMID:27188386 CASP8 Human mercury dichloride multiple interactions ISO Casp8 (Mus musculus) 6480464 [Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased activity of CASP8 protein CTD PMID:16421179 CASP8 Human mercury dichloride increases activity ISO Casp8 (Mus musculus) 6480464 Mercuric Chloride results in increased activity of CASP8 protein CTD PMID:16421179 CASP8 Human metformin decreases activity EXP 6480464 Metformin results in decreased activity of CASP8 protein CTD PMID:15531508 CASP8 Human metformin multiple interactions EXP 6480464 [Paclitaxel co-treated with Metformin] results in increased expression of CASP8 mRNA CTD PMID:29309887 CASP8 Human methotrexate multiple interactions EXP 6480464 [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Antineoplastic Agents more ... CTD PMID:17637740 more ... CASP8 Human methotrexate increases expression ISO Casp8 (Rattus norvegicus) 6480464 Methotrexate results in increased expression of CASP8 protein CTD PMID:36482745 CASP8 Human methotrexate multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 ramelteon inhibits the reaction [Methotrexate results in increased expression of CASP8 protein] CTD PMID:36482745 CASP8 Human methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of CASP8 mRNA and Methotrexate results in increased expression of CASP8 protein CTD PMID:17400583 more ... CASP8 Human methoxsalen decreases expression EXP 6480464 Methoxsalen results in decreased expression of CASP8 protein CTD PMID:22796345 CASP8 Human methoxychlor increases activity ISO Casp8 (Mus musculus) 6480464 Methoxychlor results in increased activity of CASP8 protein CTD PMID:20568958 CASP8 Human methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of CASP8 mRNA CTD PMID:28001369 CASP8 Human Methylone increases activity ISO Casp8 (Rattus norvegicus) 6480464 methylone results in increased activity of CASP8 protein CTD PMID:27255387 CASP8 Human methylphenidate increases expression ISO Casp8 (Rattus norvegicus) 6480464 Methylphenidate results in increased expression of CASP8 mRNA CTD PMID:32746681 CASP8 Human methylseleninic acid multiple interactions EXP 6480464 [2 more ... CTD PMID:18444175 and PMID:18790785 CASP8 Human methylseleninic acid increases cleavage EXP 6480464 [methylselenic acid results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein and methylselenic acid results in increased cleavage of CASP8 protein CTD PMID:18790785 CASP8 Human metiram multiple interactions EXP 6480464 [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 mRNA and [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 protein CTD PMID:32800223 CASP8 Human mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Fluvastatin results in increased activity of CASP8 protein] CTD PMID:24964743 CASP8 Human microcystin-LR increases expression ISO Casp8 (Mus musculus) 6480464 cyanoginosin LR results in increased expression of CASP8 mRNA and cyanoginosin LR results in increased expression of CASP8 protein CTD PMID:23454832 and PMID:23891578 CASP8 Human mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]] and Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]] CTD PMID:12645856 and PMID:17070682 CASP8 Human minocycline multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein] more ... CTD PMID:12930891 more ... CASP8 Human minocycline decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Minocycline results in decreased expression of CASP8 mRNA CTD PMID:14998631 CASP8 Human mitomycin C multiple interactions EXP 6480464 Mitomycin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:12181741 CASP8 Human mitomycin C increases activity EXP 6480464 Mitomycin results in increased activity of CASP8 protein CTD PMID:10960761 more ... CASP8 Human mitomycin C increases cleavage EXP 6480464 Mitomycin results in increased cleavage of CASP8 protein CTD PMID:16019139 and PMID:17021654 CASP8 Human mitoxantrone increases activity EXP 6480464 Mitoxantrone results in increased activity of CASP8 protein CTD PMID:12948851 CASP8 Human mitoxantrone increases activity ISO Casp8 (Mus musculus) 6480464 Mitoxantrone results in increased activity of CASP8 protein CTD PMID:32894303 CASP8 Human ML-7 multiple interactions EXP 6480464 [ML 7 co-treated with quinocetone] results in increased cleavage of CASP8 protein and ML 7 results in increased susceptibility to [quinocetone results in increased cleavage of CASP8 protein] CTD PMID:26446980 CASP8 Human molybdenum atom increases activity EXP 6480464 Molybdenum analog results in increased activity of CASP8 protein CTD PMID:26391003 CASP8 Human mono(2-ethylhexyl) phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [FASL protein modified form affects the susceptibility to mono-(2-ethylhexyl)phthalate] which results in increased cleavage of CASP8 protein more ... CTD PMID:12490136 more ... CASP8 Human mono(2-ethylhexyl) phthalate increases expression ISO Casp8 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of CASP8 protein CTD PMID:37286014 CASP8 Human mono(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CASP8 mRNA CTD PMID:35861251 CASP8 Human monobenzyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CASP8 mRNA CTD PMID:31884101 CASP8 Human monobenzyl phthalate multiple interactions EXP 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CASP8 mRNA CTD PMID:35861251 CASP8 Human Monobutylphthalate multiple interactions EXP 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CASP8 mRNA CTD PMID:35861251 CASP8 Human monoethyl phthalate multiple interactions ISO Casp8 (Mus musculus) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CASP8 mRNA CTD PMID:31884101 CASP8 Human monoethyl phthalate multiple interactions EXP 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CASP8 mRNA CTD PMID:35861251 CASP8 Human morphine multiple interactions EXP 6480464 ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form] CTD PMID:19239323 CASP8 Human morphine increases activity ISO Casp8 (Mus musculus) 6480464 Morphine results in increased activity of CASP8 protein CTD PMID:11590188 CASP8 Human morphine increases activity EXP 6480464 Morphine results in increased activity of CASP8 protein CTD PMID:19070643 CASP8 Human morphine decreases expression EXP 6480464 Morphine results in decreased expression of CASP8 protein alternative form CTD PMID:19239323 CASP8 Human myricetin decreases expression EXP 6480464 myricetin results in decreased expression of CASP8 protein CTD PMID:29698783 CASP8 Human N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine increases activity EXP 6480464 N more ... CTD PMID:17979179 CASP8 Human N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide multiple interactions EXP 6480464 N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide affects the localization of and results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15520213 CASP8 Human N-(p-amylcinnamoyl)anthranilic acid multiple interactions EXP 6480464 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP8 protein]] CTD PMID:35395232 CASP8 Human N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [[cholix toxin more ... CTD PMID:16169029 more ... CASP8 Human N-acetyl-L-cysteine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein] more ... CTD PMID:18791325 more ... CASP8 Human N-acetyl-L-cysteine multiple interactions EXP 127284846 N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP8 protein in the stomach) RGD CASP8 Human N-acetyl-L-cysteine multiple interactions ISO Casp8 (Mus musculus) 6480464 [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 mRNA]] more ... CTD PMID:20184945 more ... CASP8 Human N-Acetyl-S-(1,2-dichlorovinyl)-cysteine affects expression EXP 6480464 S-1 and 2-dichlorovinyl-N-acetylcysteine affects the expression of CASP8 mRNA CTD PMID:16844155 CASP8 Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15498850 CASP8 Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases activity ISO Casp8 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP8 protein CTD PMID:20100472 and PMID:20449726 CASP8 Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO Casp8 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] more ... CTD PMID:15914627 and PMID:20671745 CASP8 Human N-methyl-4-phenylpyridinium increases activity ISO Casp8 (Rattus norvegicus) 6480464 1-Methyl-4-phenylpyridinium results in increased activity of CASP8 protein CTD PMID:33127410 CASP8 Human N-methyl-4-phenylpyridinium multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Copper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP8 protein] CTD PMID:33127410 CASP8 Human N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein more ... CTD PMID:16030430 CASP8 Human N-methyl-N-nitrosourea multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP8 protein and [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP8 mRNA CTD PMID:20732338 and PMID:22465879 CASP8 Human N-methyl-N-nitrosourea increases expression ISO Casp8 (Rattus norvegicus) 6480464 Methylnitrosourea results in increased expression of CASP8 mRNA CTD PMID:28688903 CASP8 Human N-nitrosodiethylamine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [3 more ... CTD PMID:18544905 more ... CASP8 Human N-nitrosodiethylamine decreases activity ISO Casp8 (Mus musculus) 6480464 Diethylnitrosamine results in decreased activity of CASP8 protein CTD PMID:31067004 CASP8 Human N-nitrosodiethylamine multiple interactions ISO Casp8 (Mus musculus) 6480464 S-allylcysteine inhibits the reaction [Diethylnitrosamine results in decreased activity of CASP8 protein] CTD PMID:31067004 CASP8 Human N-nitrosomorpholine increases expression ISO Casp8 (Rattus norvegicus) 6480464 N-nitrosomorpholine results in increased expression of CASP8 protein CTD PMID:15816005 CASP8 Human nelfinavir increases activity EXP 6480464 Nelfinavir results in increased activity of CASP8 protein CTD PMID:20105315 CASP8 Human neohesperidin dihydrochalcone multiple interactions ISO Casp8 (Mus musculus) 6480464 neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP8 protein] CTD PMID:24530446 CASP8 Human nickel atom increases expression EXP 6480464 Nickel results in increased expression of CASP8 mRNA CTD PMID:21054559 CASP8 Human nickel atom increases expression ISO Casp8 (Rattus norvegicus) 6480464 Nickel analog results in increased expression of CASP8 mRNA CTD PMID:27257140 CASP8 Human nickel atom increases cleavage EXP 6480464 Nickel results in increased cleavage of CASP8 protein CTD PMID:24840272 CASP8 Human nickel atom multiple interactions EXP 6480464 [cobalt ferrite binds to Nickel] which results in increased expression of CASP8 protein modified form more ... CTD PMID:23638002 more ... CASP8 Human nickel dichloride affects expression ISO Casp8 (Rattus norvegicus) 6480464 nickel chloride affects the expression of CASP8 mRNA CTD PMID:22546817 CASP8 Human niclosamide increases cleavage EXP 6480464 Niclosamide results in increased cleavage of CASP8 protein CTD PMID:35115509 CASP8 Human nicotine affects expression ISO Casp8 (Rattus norvegicus) 6480464 Nicotine affects the expression of CASP8 mRNA CTD PMID:20426880 CASP8 Human Niflumic acid multiple interactions EXP 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]] more ... CTD PMID:21067863 CASP8 Human Niflumic acid increases activity EXP 6480464 Niflumic Acid results in increased activity of CASP8 protein CTD PMID:21067863 CASP8 Human nifuroxazide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 nifuroxazide inhibits the reaction [Streptozocin results in increased activity of CASP8 protein] CTD PMID:29606028 CASP8 Human nimesulide multiple interactions EXP 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [nimesulide results in increased cleavage of and results in increased activity of CASP8 protein] more ... CTD PMID:19360361 and PMID:21745461 CASP8 Human nimustine increases cleavage EXP 6480464 Nimustine results in increased cleavage of CASP8 protein CTD PMID:26418950 CASP8 Human nitric oxide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Nitric Oxide results in decreased cleavage of and results in decreased activity of CASP8 protein CTD PMID:10358093 CASP8 Human nitric oxide multiple interactions ISO Casp8 (Mus musculus) 6480464 [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP8 protein CTD PMID:22878015 CASP8 Human nitric oxide increases activity EXP 6480464 Nitric Oxide results in increased activity of CASP8 protein CTD PMID:15126337 CASP8 Human nitroprusside increases activity ISO Casp8 (Rattus norvegicus) 6480464 Nitroprusside results in increased activity of CASP8 protein CTD PMID:18311796 CASP8 Human nitroprusside multiple interactions ISO Casp8 (Mus musculus) 6480464 [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP8 protein CTD PMID:22878015 CASP8 Human nitroprusside multiple interactions EXP 6480464 Nitroprusside inhibits the reaction [Deferoxamine results in increased activity of CASP8 protein] CTD PMID:16374551 CASP8 Human nitroprusside multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein] CTD PMID:18311796 CASP8 Human nobiletin increases cleavage EXP 6480464 nobiletin results in increased cleavage of CASP8 protein CTD PMID:33058988 CASP8 Human nobiletin multiple interactions EXP 6480464 AGN 193109 inhibits the reaction [nobiletin results in increased cleavage of CASP8 protein] CTD PMID:33058988 CASP8 Human nocodazole multiple interactions EXP 6480464 Caspase Inhibitors inhibits the reaction [Nocodazole analog results in increased expression of CASP8 protein modified form] CTD PMID:28412508 CASP8 Human nocodazole increases cleavage EXP 6480464 Nocodazole analog results in increased cleavage of CASP8 protein CTD PMID:28412508 CASP8 Human Nodularin increases expression EXP 6480464 nodularin results in increased expression of CASP8 mRNA CTD PMID:27061667 CASP8 Human Nodularin multiple interactions EXP 6480464 sauchinone inhibits the reaction [nodularin results in increased expression of CASP8 mRNA] CTD PMID:27061667 CASP8 Human Nodularin increases activity ISO Casp8 (Rattus norvegicus) 6480464 nodularin results in increased activity of CASP8 protein CTD PMID:25192816 CASP8 Human NORCANTHARIDIN multiple interactions EXP 6480464 Paclitaxel promotes the reaction [norcantharidin results in increased expression of CASP8 protein modified form] and U 0126 inhibits the reaction [norcantharidin results in increased expression of CASP8 protein modified form] CTD PMID:29193574 and PMID:34272796 CASP8 Human NORCANTHARIDIN increases activity EXP 6480464 norcantharidin results in increased activity of CASP8 protein CTD PMID:20040369 and PMID:21266192 CASP8 Human NORCANTHARIDIN increases expression EXP 6480464 norcantharidin results in increased expression of CASP8 protein modified form CTD PMID:29193574 and PMID:34272796 CASP8 Human norfloxacin affects activity EXP 6480464 Norfloxacin affects the activity of CASP8 protein CTD PMID:32320760 CASP8 Human notoginsenoside R1 multiple interactions ISO Casp8 (Mus musculus) 6480464 notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP8 protein] CTD PMID:23170834 CASP8 Human NS-398 increases activity EXP 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of CASP8 protein CTD PMID:12414664 CASP8 Human Nutlin-3 multiple interactions EXP 6480464 nutlin 3 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16014563 CASP8 Human nystatin multiple interactions EXP 6480464 Nystatin inhibits the reaction [resveratrol affects the localization of CASP8 protein] CTD PMID:12902349 CASP8 Human Obacunone increases cleavage EXP 6480464 obacunone results in increased cleavage of CASP8 protein CTD PMID:25592883 CASP8 Human Obacunone decreases expression EXP 6480464 obacunone results in decreased expression of CASP8 protein CTD PMID:21333732 CASP8 Human obeticholic acid increases expression EXP 6480464 obeticholic acid results in increased expression of CASP8 mRNA CTD PMID:27939613 CASP8 Human ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of CASP8 mRNA CTD PMID:17316727 and PMID:24755393 CASP8 Human ochratoxin A increases activity EXP 6480464 ochratoxin A results in increased activity of CASP8 protein CTD PMID:27193732 CASP8 Human okadaic acid multiple interactions EXP 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Okadaic Acid results in increased cleavage of and results in increased activity of CASP8 protein] more ... CTD PMID:19084044 and PMID:23288922 CASP8 Human okadaic acid decreases expression EXP 6480464 Okadaic Acid results in decreased expression of CASP8 mRNA CTD PMID:31926150 CASP8 Human okadaic acid increases activity EXP 6480464 Okadaic Acid results in increased activity of CASP8 protein CTD PMID:31926150 CASP8 Human okadaic acid increases expression EXP 6480464 Okadaic Acid results in increased expression of CASP8 protein modified form CTD PMID:31926150 CASP8 Human olaparib multiple interactions EXP 6480464 [Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein more ... CTD PMID:25531448 and PMID:26544897 CASP8 Human oleandrin increases activity EXP 6480464 oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 CASP8 Human oleanolic acid increases activity EXP 6480464 Oleanolic Acid results in increased activity of CASP8 protein CTD PMID:20005942 CASP8 Human oleanolic acid multiple interactions EXP 6480464 [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of CASP8 mRNA CTD PMID:37345903 CASP8 Human omeprazole increases cleavage EXP 6480464 Omeprazole analog results in increased cleavage of CASP8 protein CTD PMID:18336733 CASP8 Human omethoate decreases expression EXP 6480464 dimethoxon results in decreased expression of CASP8 mRNA CTD PMID:26688254 CASP8 Human orlistat multiple interactions EXP 6480464 orlistat analog results in increased cleavage of and results in increased activity of CASP8 protein and orlistat results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:18796435 and PMID:20577697 CASP8 Human orlistat multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP8 mRNA] CTD PMID:32450208 CASP8 Human oroxylin A increases cleavage EXP 6480464 5 and 7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased cleavage of CASP8 protein CTD PMID:19135124 CASP8 Human osthole increases cleavage EXP 6480464 osthol results in increased cleavage of CASP8 protein CTD PMID:29319219 CASP8 Human ouabain multiple interactions EXP 6480464 Ouabain results in increased expression of and results in increased activity of CASP8 protein CTD PMID:31436044 CASP8 Human oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of and results in increased activity of CASP8 protein more ... CTD PMID:19728331 CASP8 Human ozone increases expression ISO Casp8 (Rattus norvegicus) 6480464 Ozone results in increased expression of CASP8 mRNA CTD PMID:35533050 CASP8 Human p-chloromercuribenzoic acid increases expression EXP 6480464 p-Chloromercuribenzoic Acid results in increased expression of CASP8 mRNA CTD PMID:26272509 CASP8 Human p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA CTD PMID:27188386 CASP8 Human p-cresol multiple interactions EXP 6480464 SQSTM1 mutant form inhibits the reaction [4-cresol results in increased cleavage of CASP8 protein] CTD PMID:25668154 CASP8 Human p-cresol increases cleavage EXP 6480464 4-cresol results in increased cleavage of CASP8 protein CTD PMID:25668154 CASP8 Human p-menthan-3-ol decreases expression EXP 6480464 Menthol results in decreased expression of CASP8 mRNA CTD PMID:26760959 CASP8 Human Pachymic acid multiple interactions EXP 6480464 pachymic acid promotes the reaction [TP53INP2 protein binds to CASP8 protein] more ... CTD PMID:38560766 CASP8 Human paclitaxel multiple interactions EXP 6480464 [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP8 protein more ... CTD PMID:14749477 more ... CASP8 Human paclitaxel increases expression EXP 6480464 Paclitaxel results in increased expression of CASP8 mRNA more ... CTD PMID:15907983 more ... CASP8 Human paclitaxel increases activity EXP 6480464 Paclitaxel results in increased activity of CASP8 protein CTD PMID:11716366 CASP8 Human paclitaxel increases expression ISO Casp8 (Mus musculus) 6480464 Paclitaxel results in increased expression of CASP8 mRNA CTD PMID:26091902 CASP8 Human paclitaxel increases cleavage EXP 6480464 Paclitaxel results in increased cleavage of CASP8 protein CTD PMID:18071906 more ... CASP8 Human Panduratin A increases cleavage EXP 6480464 panduratin A results in increased cleavage of CASP8 protein CTD PMID:16497706 CASP8 Human panobinostat multiple interactions EXP 6480464 [Cisplatin co-treated with Panobinostat] affects the expression of CASP8 mRNA more ... CTD PMID:21791302 more ... CASP8 Human panobinostat increases expression EXP 6480464 panobinostat results in increased expression of CASP8 mRNA CTD PMID:26272509 CASP8 Human paracetamol affects expression ISO Casp8 (Mus musculus) 6480464 Acetaminophen affects the expression of CASP8 mRNA CTD PMID:17562736 CASP8 Human paracetamol decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of CASP8 mRNA CTD PMID:33387578 CASP8 Human paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of CASP8 mRNA CTD PMID:21420995 and PMID:29067470 CASP8 Human paracetamol increases expression ISO Casp8 (Mus musculus) 6480464 Acetaminophen results in increased expression of CASP8 protein CTD PMID:12540782 CASP8 Human paracetamol multiple interactions ISO Casp8 (Mus musculus) 6480464 [Acetaminophen co-treated with TNF protein] results in increased activity of CASP8 protein more ... CTD PMID:12085349 and PMID:12540782 CASP8 Human paracetamol increases activity EXP 6480464 Acetaminophen results in increased activity of CASP8 CTD PMID:12005112 CASP8 Human paraoxon multiple interactions ISO Casp8 (Mus musculus) 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein] more ... CTD PMID:12831782 CASP8 Human paraquat increases expression EXP 6480464 Paraquat results in increased expression of CASP8 mRNA and Paraquat results in increased expression of CASP8 mRNA alternative form CTD PMID:17064354 and PMID:20883675 CASP8 Human paraquat increases expression ISO Casp8 (Rattus norvegicus) 6480464 Paraquat results in increased expression of CASP8 protein CTD PMID:35236239 CASP8 Human paraquat increases cleavage EXP 6480464 Paraquat results in increased cleavage of CASP8 protein CTD PMID:28414160 CASP8 Human paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of CASP8 mRNA CTD PMID:26468117 CASP8 Human paraquat multiple interactions EXP 6480464 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of CASP8 protein modified form] and Paraquat promotes the reaction [TNFRSF10B protein binds to CASP8 protein] CTD PMID:28414160 CASP8 Human paraquat increases activity ISO Casp8 (Rattus norvegicus) 6480464 Paraquat results in increased activity of CASP8 protein CTD PMID:17561093 and PMID:24912633 CASP8 Human paraquat multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 MIR136 promotes the reaction [Paraquat results in increased expression of CASP8 protein] more ... CTD PMID:17561093 and PMID:35236239 CASP8 Human paroxetine increases activity ISO Casp8 (Mus musculus) 6480464 Paroxetine results in increased activity of CASP8 protein CTD PMID:28482088 CASP8 Human Parthenin increases activity EXP 6480464 parthenin analog results in increased activity of CASP8 protein CTD PMID:25196075 CASP8 Human parthenolide multiple interactions EXP 6480464 [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen and [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein CTD PMID:20154269 CASP8 Human patulin increases activity EXP 6480464 Patulin results in increased activity of CASP8 protein CTD PMID:33577942 CASP8 Human patulin multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP8 protein] CTD PMID:33577942 CASP8 Human Pendulone increases activity EXP 6480464 pendulone results in increased activity of CASP8 protein CTD PMID:35288263 CASP8 Human pentachlorophenol increases expression ISO Casp8 (Rattus norvegicus) 6480464 Pentachlorophenol results in increased expression of CASP8 mRNA CTD PMID:19442831 CASP8 Human pentobarbital decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Pentobarbital results in decreased expression of CASP8 mRNA CTD PMID:16978161 CASP8 Human Pentoxifylline multiple interactions EXP 6480464 Pentoxifylline promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein] CTD PMID:20804743 CASP8 Human pepstatin A multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein] CTD PMID:28378122 CASP8 Human perfluorohexanesulfonic acid increases expression ISO Casp8 (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of CASP8 mRNA CTD PMID:37995155 CASP8 Human perfluorononanoic acid decreases expression ISO Casp8 (Rattus norvegicus) 6480464 perfluoro-n-nonanoic acid results in decreased expression of CASP8 protein CTD PMID:19878704 CASP8 Human perfluorononanoic acid increases activity ISO Casp8 (Rattus norvegicus) 6480464 perfluoro-n-nonanoic acid results in increased activity of CASP8 protein CTD PMID:19646514 CASP8 Human perfluorooctane-1-sulfonic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CASP8 mRNA CTD PMID:36331819 CASP8 Human perfluorooctanoic acid increases cleavage ISO Casp8 (Mus musculus) 6480464 perfluorooctanoic acid results in increased cleavage of CASP8 protein CTD PMID:37044272 CASP8 Human perifosine multiple interactions EXP 6480464 [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein more ... CTD PMID:15781658 and PMID:32587277 CASP8 Human perifosine increases expression EXP 6480464 perifosine results in increased expression of CASP8 protein modified form CTD PMID:32587277 CASP8 Human phenethyl caffeate multiple interactions ISO Casp8 (Mus musculus) 6480464 caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein] CTD PMID:18436364 CASP8 Human phenethyl isothiocyanate increases activity EXP 6480464 phenethyl isothiocyanate results in increased activity of CASP8 protein CTD PMID:16054126 CASP8 Human phenobarbital multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [3 more ... CTD PMID:27048571 CASP8 Human phenol increases activity EXP 6480464 Phenol results in increased activity of CASP8 protein CTD PMID:23776099 CASP8 Human phenylephrine affects activity EXP 6480464 Phenylephrine affects the activity of CASP8 protein CTD PMID:31605733 CASP8 Human phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of CASP8 mRNA CTD PMID:26272509 CASP8 Human phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA CTD PMID:27188386 CASP8 Human PhIP decreases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in decreased expression of CASP8 mRNA CTD PMID:20816883 CASP8 Human phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA] more ... CTD PMID:12165276 more ... CASP8 Human phosphatidylcholine multiple interactions EXP 6480464 [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein CTD PMID:21695227 CASP8 Human phylloquinone multiple interactions EXP 6480464 [sorafenib co-treated with Vitamin K 1] results in increased cleavage of CASP8 protein CTD PMID:20301194 CASP8 Human pifithrin-? multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein] CTD PMID:16687611 CASP8 Human pifithrin-? multiple interactions EXP 6480464 pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP8 protein] more ... CTD PMID:16777994 more ... CASP8 Human Pinacidil decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Pinacidil results in decreased expression of CASP8 mRNA CTD PMID:17612592 CASP8 Human pinostrobin increases expression EXP 6480464 pinostrobin results in increased expression of CASP8 mRNA CTD PMID:37208425 CASP8 Human pirinixic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CASP8 mRNA more ... CTD PMID:17483499 and PMID:19710929 CASP8 Human pirinixic acid increases expression ISO Casp8 (Mus musculus) 6480464 pirinixic acid results in increased expression of CASP8 mRNA CTD PMID:18301758 and PMID:23811191 CASP8 Human pirinixic acid decreases expression ISO Casp8 (Mus musculus) 6480464 pirinixic acid results in decreased expression of CASP8 protein CTD PMID:17483499 CASP8 Human platycodin D increases activity EXP 6480464 platycodin D results in increased activity of CASP8 protein CTD PMID:16631160 and PMID:20412017 CASP8 Human plumbagin increases activity ISO Casp8 (Mus musculus) 6480464 plumbagin results in increased activity of CASP8 protein CTD PMID:20576514 CASP8 Human plumbagin multiple interactions ISO Casp8 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein] CTD PMID:20576514 CASP8 Human poly(I:C) increases activity EXP 6480464 Poly I-C results in increased activity of CASP8 protein CTD PMID:21418039 CASP8 Human poly(I:C) multiple interactions EXP 6480464 arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP8 protein] and Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein] CTD PMID:21418039 CASP8 Human pomalidomide multiple interactions EXP 6480464 [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein CTD PMID:29928335 CASP8 Human porphyrins increases expression EXP 6480464 Porphyrins results in increased expression of CASP8 mRNA CTD PMID:26468117 CASP8 Human potassium chromate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CASP8 mRNA CTD PMID:22079256 CASP8 Human potassium chromate decreases expression EXP 6480464 potassium chromate(VI) results in decreased expression of CASP8 mRNA CTD PMID:22079256 CASP8 Human Pranoprofen increases activity EXP 6480464 pyranoprofen results in increased activity of CASP8 protein CTD PMID:31765691 CASP8 Human prazosin increases activity EXP 6480464 Prazosin results in increased activity of CASP8 protein CTD PMID:26449523 CASP8 Human prodigiosin increases cleavage EXP 6480464 Prodigiosin results in increased cleavage of CASP8 protein CTD PMID:15746575 CASP8 Human prodigiosin increases activity EXP 6480464 Prodigiosin results in increased activity of CASP8 protein CTD PMID:31077745 CASP8 Human progesterone increases expression ISO Casp8 (Mus musculus) 6480464 Progesterone results in increased expression of CASP8 mRNA CTD PMID:21549006 CASP8 Human progesterone multiple interactions EXP 6480464 Progesterone inhibits the reaction [Cisplatin results in increased activity of CASP8 protein] CTD PMID:23482746 CASP8 Human progesterone increases expression ISO Casp8 (Rattus norvegicus) 6480464 Progesterone results in increased expression of CASP8 mRNA CTD PMID:21770760 CASP8 Human progesterone multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP8 protein and [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP8 mRNA CTD PMID:20732338 and PMID:22465879 CASP8 Human propylparaben increases expression EXP 6480464 propylparaben results in increased expression of CASP8 mRNA and propylparaben results in increased expression of CASP8 protein CTD PMID:24481588 CASP8 Human prostaglandin E2 multiple interactions ISO Casp8 (Mus musculus) 6480464 Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]] CTD PMID:25432964 CASP8 Human protoporphyrin decreases activity EXP 6480464 protoporphyrin IX results in decreased activity of CASP8 protein CTD PMID:16051694 CASP8 Human psoralen multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP8 protein] CTD PMID:31364909 CASP8 Human psoralen increases activity EXP 6480464 Ficusin results in increased activity of CASP8 protein CTD PMID:31364909 CASP8 Human Psymberin increases response to substance EXP 6480464 CASP8 protein results in increased susceptibility to psymberin CTD PMID:20920557 CASP8 Human pterostilbene multiple interactions ISO Casp8 (Mus musculus) 6480464 pterostilbene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:20681671 CASP8 Human puerarin multiple interactions EXP 6480464 arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP8 protein] CTD PMID:20416161 CASP8 Human puerarin increases expression EXP 6480464 puerarin results in increased expression of CASP8 protein CTD PMID:20416161 CASP8 Human Punicalagin increases expression EXP 6480464 punicalagin results in increased expression of CASP8 protein CTD PMID:28709945 CASP8 Human Pyridostigmine bromide multiple interactions EXP 6480464 SOD2 protein SNP affects the reaction [Pyridostigmine Bromide affects the expression of CASP8 mRNA] CTD PMID:31175926 CASP8 Human Pyridostigmine bromide decreases expression EXP 6480464 Pyridostigmine Bromide results in decreased expression of CASP8 protein CTD PMID:31175926 CASP8 Human Pyridostigmine bromide affects expression EXP 6480464 Pyridostigmine Bromide affects the expression of CASP8 mRNA CTD PMID:31175926 CASP8 Human pyridoxine increases expression EXP 6480464 Pyridoxine results in increased expression of CASP8 mRNA CTD PMID:28716455 CASP8 Human pyrimethamine increases activity EXP 6480464 Pyrimethamine results in increased activity of CASP8 protein CTD PMID:18593930 CASP8 Human pyrogallol increases activity EXP 6480464 Pyrogallol results in increased activity of CASP8 protein CTD PMID:19000662 CASP8 Human pyrrolidine dithiocarbamate multiple interactions EXP 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA] more ... CTD PMID:15477007 CASP8 Human quercetin multiple interactions ISO Casp8 (Mus musculus) 6480464 Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]] CTD PMID:15914627 CASP8 Human quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of CASP8 mRNA CTD PMID:30152185 CASP8 Human quercetin increases expression EXP 6480464 Quercetin results in increased expression of CASP8 protein CTD PMID:25339540 CASP8 Human quercetin increases cleavage EXP 6480464 Quercetin results in increased cleavage of CASP8 protein CTD PMID:18455702 more ... CASP8 Human quercetin multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased cleavage of CASP8 protein] more ... CTD PMID:17548900 more ... CASP8 Human quercetin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Chlorpyrifos results in increased expression of CASP8 protein] more ... CTD PMID:16647178 more ... CASP8 Human quercetin increases activity EXP 6480464 Quercetin results in increased activity of CASP8 protein CTD PMID:16158945 more ... CASP8 Human quercetin affects localization EXP 6480464 Quercetin affects the localization of CASP8 protein CTD PMID:17876056 CASP8 Human quercetin 3-O-beta-D-glucofuranoside decreases expression EXP 6480464 isoquercitrin results in decreased expression of CASP8 mRNA CTD PMID:30597948 CASP8 Human quercetin 3-O-beta-D-glucopyranoside decreases expression EXP 6480464 isoquercitrin results in decreased expression of CASP8 mRNA CTD PMID:30597948 CASP8 Human quercitrin increases expression EXP 6480464 quercitrin results in increased expression of CASP8 mRNA CTD PMID:25193878 CASP8 Human raloxifene increases expression EXP 6480464 Raloxifene Hydrochloride results in increased expression of CASP8 mRNA CTD PMID:29705353 CASP8 Human raloxifene multiple interactions EXP 6480464 [Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of CASP8 mRNA CTD PMID:29705353 CASP8 Human raloxifene decreases expression EXP 6480464 Raloxifene Hydrochloride results in decreased expression of CASP8 mRNA and Raloxifene Hydrochloride results in decreased expression of CASP8 protein CTD PMID:27999800 CASP8 Human reactive oxygen species multiple interactions EXP 6480464 [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein more ... CTD PMID:19054763 and PMID:19464277 CASP8 Human reactive oxygen species multiple interactions ISO Casp8 (Mus musculus) 6480464 [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 mRNA]] more ... CTD PMID:35833596 CASP8 Human regorafenib increases activity EXP 6480464 regorafenib results in increased activity of CASP8 protein CTD PMID:30801954 CASP8 Human reserpine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein] CTD PMID:19463876 CASP8 Human reserpine increases activity ISO Casp8 (Rattus norvegicus) 6480464 Reserpine results in increased activity of CASP8 protein CTD PMID:19463876 CASP8 Human resveratrol multiple interactions EXP 6480464 [2 more ... CTD PMID:12902349 more ... CASP8 Human resveratrol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Resveratrol inhibits the reaction [bisphenol A analog results in increased expression of CASP8 mRNA] more ... CTD PMID:33582552 and PMID:35236239 CASP8 Human resveratrol increases expression EXP 6480464 Resveratrol results in increased expression of CASP8 mRNA CTD PMID:29705353 CASP8 Human resveratrol decreases expression ISO Casp8 (Rattus norvegicus) 6480464 resveratrol results in decreased expression of CASP8 protein modified form CTD PMID:24040416 CASP8 Human resveratrol increases activity ISO Casp8 (Rattus norvegicus) 6480464 resveratrol results in increased activity of CASP8 protein CTD PMID:24534837 and PMID:24669252 CASP8 Human resveratrol multiple interactions ISO Casp8 (Mus musculus) 6480464 resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP8 protein] CTD PMID:23922164 CASP8 Human resveratrol increases activity EXP 6480464 [resveratrol results in increased activity of CASP8 protein] which results in increased activity of CASP3 protein more ... CTD PMID:18276737 more ... CASP8 Human resveratrol increases cleavage EXP 6480464 resveratrol results in increased cleavage of CASP8 protein CTD PMID:18347188 and PMID:22923501 CASP8 Human resveratrol affects response to substance EXP 6480464 CASP8 protein affects the susceptibility to resveratrol CTD PMID:22923501 CASP8 Human resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of CASP8 protein CTD PMID:18089832 and PMID:19846903 CASP8 Human resveratrol increases cleavage ISO Casp8 (Mus musculus) 6480464 resveratrol results in increased cleavage of CASP8 protein CTD PMID:17872969 CASP8 Human resveratrol affects localization EXP 6480464 resveratrol affects the localization of CASP8 protein CTD PMID:12902349 CASP8 Human resveratrol increases expression ISO Casp8 (Mus musculus) 6480464 resveratrol results in increased expression of CASP8 mRNA CTD PMID:22610192 CASP8 Human resveratrol decreases activity EXP 6480464 resveratrol results in decreased activity of CASP8 protein CTD PMID:12925042 CASP8 Human Rhein increases cleavage EXP 6480464 rhein results in increased cleavage of CASP8 protein CTD PMID:31436023 CASP8 Human ribavirin multiple interactions EXP 6480464 Ribavirin promotes the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:12760867 CASP8 Human riboflavin increases activity ISO Casp8 (Mus musculus) 6480464 Riboflavin analog results in increased activity of CASP8 protein CTD PMID:20688149 CASP8 Human ricolinostat multiple interactions EXP 6480464 ricolinostat promotes the reaction [Bortezomib results in increased cleavage of CASP8 protein] CTD PMID:22262760 CASP8 Human rifampicin multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]] and Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:11958592 and PMID:12645856 CASP8 Human Riluzole increases activity EXP 6480464 Riluzole results in increased activity of CASP8 protein CTD PMID:19528481 CASP8 Human Risedronate sodium increases activity ISO Casp8 (Rattus norvegicus) 6480464 Risedronic Acid results in increased activity of CASP8 protein CTD PMID:19505369 CASP8 Human Ro 31-8220 increases activity EXP 6480464 Ro 31-8220 results in increased activity of CASP8 protein CTD PMID:18054255 CASP8 Human rolipram multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein] CTD PMID:31161640 CASP8 Human rosmarinic acid increases activity EXP 6480464 Rosmarinic Acid results in increased activity of CASP8 protein CTD PMID:36863647 CASP8 Human rosmarinic acid increases expression EXP 6480464 Rosmarinic Acid results in increased expression of CASP8 mRNA CTD PMID:36863647 CASP8 Human rotenone increases expression ISO Casp8 (Mus musculus) 6480464 Rotenone results in increased expression of CASP8 mRNA CTD PMID:23186747 CASP8 Human rotenone increases expression ISO Casp8 (Rattus norvegicus) 6480464 Rotenone results in increased expression of CASP8 protein CTD PMID:25502462 CASP8 Human rotenone multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP8 protein] CTD PMID:25502462 CASP8 Human rotenone multiple interactions ISO Casp8 (Mus musculus) 6480464 Rotenone inhibits the reaction [[lipopolysaccharide and E coli O55-B5 co-treated with Galactosamine] results in increased activity of CASP8 protein] CTD PMID:24830863 CASP8 Human rubimaillin increases activity EXP 6480464 rubimaillin results in increased activity of CASP8 protein CTD PMID:19716835 CASP8 Human rubimaillin multiple interactions EXP 6480464 BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein] and benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein] CTD PMID:19716835 CASP8 Human rubitecan multiple interactions EXP 6480464 [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein CTD PMID:21695227 CASP8 Human rubitecan increases expression EXP 6480464 rubitecan results in increased expression of CASP8 protein CTD PMID:21695227 CASP8 Human rutin multiple interactions ISO Casp8 (Mus musculus) 6480464 [Rutin binds to Zinc] which results in increased expression of CASP8 mRNA CTD PMID:26091902 CASP8 Human rutin increases expression ISO Casp8 (Mus musculus) 6480464 Rutin results in increased expression of CASP8 mRNA CTD PMID:26091902 CASP8 Human S-(1,2-dichlorovinyl)-L-cysteine increases activity EXP 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased activity of CASP8 protein CTD PMID:29129777 CASP8 Human S-allylcysteine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein] and S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein] CTD PMID:16030430 CASP8 Human S-allylcysteine increases activity EXP 6480464 S-allylcysteine results in increased activity of CASP8 protein CTD PMID:31067004 CASP8 Human S-allylcysteine multiple interactions ISO Casp8 (Mus musculus) 6480464 [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein] more ... CTD PMID:22033380 and PMID:31067004 CASP8 Human S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein and pyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein] CTD PMID:17145888 CASP8 Human S-nitrosoglutathione increases activity EXP 6480464 S-Nitrosoglutathione results in increased activity of CASP8 protein CTD PMID:20153346 CASP8 Human safrole increases expression EXP 6480464 Safrole results in increased expression of CASP8 mRNA CTD PMID:21591240 CASP8 Human Salinomycin decreases expression EXP 6480464 salinomycin results in decreased expression of CASP8 mRNA CTD PMID:19682730 CASP8 Human Salmeterol xinafoate multiple interactions EXP 6480464 [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein CTD PMID:15536434 CASP8 Human sanguinarine increases activity EXP 6480464 sanguinarine results in increased activity of CASP8 protein CTD PMID:19346183 and PMID:23660334 CASP8 Human sanguinarine multiple interactions EXP 6480464 [sanguinarine co-treated with Arsenic Trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein more ... CTD PMID:24345465 CASP8 Human sappanchalcone increases cleavage EXP 6480464 sappanchalcone results in increased cleavage of CASP8 protein CTD PMID:32590072 CASP8 Human SB 203580 multiple interactions EXP 6480464 [Resveratrol co-treated with SB 203580] results in increased activity of CASP8 protein more ... CTD PMID:22644961 more ... CASP8 Human SB 415286 multiple interactions EXP 6480464 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2 more ... CTD PMID:15475000 and PMID:15942663 CASP8 Human SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 CASP8 Human Se-methyl-L-selenocysteine increases expression EXP 6480464 selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form CTD PMID:25321483 CASP8 Human Se-methylselenocysteine increases expression EXP 6480464 selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form CTD PMID:25321483 CASP8 Human selenium atom multiple interactions EXP 6480464 [Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein] more ... CTD PMID:17970047 and PMID:27920530 CASP8 Human selenium atom increases activity EXP 6480464 Selenium results in increased activity of CASP8 protein CTD PMID:12432279 CASP8 Human selenium atom decreases expression EXP 6480464 Selenium results in decreased expression of CASP8 mRNA CTD PMID:19244175 CASP8 Human selenocystine decreases expression EXP 6480464 selenocystine results in decreased expression of CASP8 protein CTD PMID:35863474 CASP8 Human selumetinib multiple interactions EXP 6480464 AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP8 protein]] CTD PMID:27222248 CASP8 Human semilicoisoflavone B increases cleavage EXP 6480464 semilicoisoflavone B results in increased cleavage of CASP8 protein CTD PMID:36901935 CASP8 Human senecionine multiple interactions EXP 6480464 senecionine results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:29458164 CASP8 Human Senkirkine increases cleavage EXP 6480464 senkirkine results in increased cleavage of CASP8 protein CTD PMID:29458164 CASP8 Human Sesamol increases activity EXP 6480464 sesamol results in increased activity of CASP8 protein CTD PMID:27270451 CASP8 Human sesquiterpene increases activity EXP 6480464 Sesquiterpenes results in increased activity of CASP8 protein CTD PMID:18070620 CASP8 Human silibinin multiple interactions EXP 6480464 benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein] more ... CTD PMID:16777994 CASP8 Human simvastatin increases activity EXP 6480464 Simvastatin results in increased activity of CASP8 protein CTD PMID:15705602 CASP8 Human simvastatin multiple interactions EXP 6480464 Simvastatin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21910007 CASP8 Human simvastatin increases cleavage EXP 6480464 Simvastatin results in increased cleavage of CASP8 protein CTD PMID:12962723 and PMID:20464445 CASP8 Human simvastatin increases activity ISO Casp8 (Mus musculus) 6480464 Simvastatin results in increased activity of CASP8 protein CTD PMID:20883752 CASP8 Human simvastatin multiple interactions ISO Casp8 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein] CTD PMID:20883752 CASP8 Human sirolimus multiple interactions EXP 6480464 [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP8 protein more ... CTD PMID:15767555 more ... CASP8 Human sirolimus multiple interactions ISO Casp8 (Mus musculus) 6480464 Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]] CTD PMID:28342888 CASP8 Human sirolimus increases cleavage EXP 6480464 Sirolimus results in increased cleavage of CASP8 protein CTD PMID:25307878 CASP8 Human SNX-2112 increases activity EXP 6480464 SNX 2112 results in increased activity of CASP8 protein CTD PMID:23777986 CASP8 Human sodium arsenite increases activity ISO Casp8 (Mus musculus) 6480464 sodium arsenite results in increased activity of CASP8 protein CTD PMID:16421179 and PMID:20006689 CASP8 Human sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of CASP8 protein CTD PMID:34861471 CASP8 Human sodium arsenite increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 sodium arsenite results in increased cleavage of CASP8 protein CTD PMID:35939230 CASP8 Human sodium arsenite increases cleavage ISO Casp8 (Mus musculus) 6480464 sodium arsenite results in increased cleavage of CASP8 protein CTD PMID:29854073 CASP8 Human sodium arsenite multiple interactions EXP 6480464 [delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP8 protein more ... CTD PMID:30125548 more ... CASP8 Human sodium arsenite decreases methylation EXP 6480464 sodium arsenite results in decreased methylation of CASP8 gene CTD PMID:25199682 CASP8 Human sodium arsenite increases cleavage EXP 6480464 sodium arsenite results in increased cleavage of CASP8 protein CTD PMID:24100277 and PMID:29039521 CASP8 Human sodium arsenite multiple interactions ISO Casp8 (Mus musculus) 6480464 [Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased activity of CASP8 protein and salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein] CTD PMID:16421179 and PMID:29854073 CASP8 Human sodium arsenite increases expression ISO Casp8 (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of CASP8 protein CTD PMID:20946910 CASP8 Human sodium arsenite increases activity ISO Casp8 (Rattus norvegicus) 6480464 sodium arsenite results in increased activity of CASP8 protein CTD PMID:20946910 CASP8 Human sodium arsenite decreases expression ISO Casp8 (Mus musculus) 6480464 sodium arsenite results in decreased expression of CASP8 mRNA CTD PMID:14691202 CASP8 Human sodium arsenite multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein] more ... CTD PMID:20946910 more ... CASP8 Human sodium chloride increases expression EXP 6480464 Sodium Chloride results in increased expression of CASP8 mRNA CTD PMID:23634900 CASP8 Human sodium chloride multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein more ... CTD PMID:16030430 CASP8 Human sodium dichromate multiple interactions ISO Casp8 (Mus musculus) 6480464 CAT protein inhibits the reaction [sodium bichromate results in increased degradation of CASP8 protein] and TRP53 mutant form inhibits the reaction [sodium bichromate results in increased degradation of CASP8 protein] CTD PMID:20298709 CASP8 Human sodium dichromate increases activity EXP 6480464 sodium bichromate results in increased activity of CASP8 protein CTD PMID:18544562 CASP8 Human sodium dichromate increases degradation ISO Casp8 (Mus musculus) 6480464 sodium bichromate results in increased degradation of CASP8 protein CTD PMID:20298709 CASP8 Human sodium disulfite multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of CASP8 protein] CTD PMID:25486021 CASP8 Human sodium disulfite increases activity ISO Casp8 (Rattus norvegicus) 6480464 sodium metabisulfite results in increased activity of CASP8 protein CTD PMID:25486021 CASP8 Human sodium disulfite increases expression EXP 6480464 sodium metabisulfite results in increased expression of CASP8 mRNA CTD PMID:33957602 CASP8 Human sodium fluoride multiple interactions EXP 6480464 Sodium Fluoride results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21708216 CASP8 Human sodium fluoride increases cleavage ISO Casp8 (Mus musculus) 6480464 Sodium Fluoride results in increased cleavage of CASP8 protein CTD PMID:30130527 CASP8 Human sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of CASP8 mRNA CTD PMID:19852076 CASP8 Human sodium propionate multiple interactions ISO Casp8 (Mus musculus) 6480464 sodium propionate inhibits the reaction [Ethanol results in increased expression of CASP8 mRNA] CTD PMID:35639301 CASP8 Human Sodium salicylate increases activity ISO Casp8 (Rattus norvegicus) 6480464 Sodium Salicylate results in increased activity of CASP8 protein CTD PMID:17561093 CASP8 Human Sodium salicylate multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein] CTD PMID:17561093 CASP8 Human sorafenib multiple interactions EXP 6480464 [sorafenib co-treated with TNFSF10 protein] promotes the reaction [CASP8 protein modified form results in increased cleavage of BID protein] more ... CTD PMID:16007148 more ... CASP8 Human sorafenib increases cleavage EXP 6480464 sorafenib results in increased cleavage of CASP8 protein CTD PMID:18200035 CASP8 Human sorafenib affects localization EXP 6480464 sorafenib affects the localization of CASP8 protein modified form CTD PMID:17909059 CASP8 Human spermine multiple interactions ISO Casp8 (Mus musculus) 6480464 Spermine inhibits the reaction [Dexamethasone results in increased activity of CASP8 protein] CTD PMID:11399061 CASP8 Human spironolactone multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]] CTD PMID:20609311 CASP8 Human Spiruchostatin A increases activity EXP 6480464 spiruchostatin A results in increased activity of CASP8 protein CTD PMID:25078973 CASP8 Human spiruchostatin B increases activity EXP 6480464 spiruchostatin B results in increased activity of CASP8 protein CTD PMID:25078973 CASP8 Human staurosporine multiple interactions EXP 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Staurosporine results in increased cleavage of CASP8 protein] and Staurosporine results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16007152 and PMID:24658017 CASP8 Human staurosporine increases cleavage EXP 6480464 Staurosporine results in increased cleavage of CASP8 protein CTD PMID:24658017 CASP8 Human staurosporine increases activity EXP 6480464 Staurosporine results in increased activity of CASP8 protein CTD PMID:19352495 more ... CASP8 Human streptozocin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP8 protein] more ... CTD PMID:23267840 more ... CASP8 Human streptozocin increases activity ISO Casp8 (Rattus norvegicus) 6480464 Streptozocin results in increased activity of CASP8 protein CTD PMID:29606028 CASP8 Human streptozocin increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Streptozocin results in increased cleavage of CASP8 protein CTD PMID:25541178 CASP8 Human streptozocin increases expression ISO Casp8 (Rattus norvegicus) 6480464 Streptozocin results in increased expression of CASP8 mRNA and Streptozocin results in increased expression of CASP8 protein CTD PMID:23267840 and PMID:28856781 CASP8 Human styrene increases activity ISO Casp8 (Rattus norvegicus) 6480464 Styrene results in increased activity of CASP8 protein CTD PMID:17420221 CASP8 Human Suillin multiple interactions EXP 6480464 suillin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:19616521 CASP8 Human sulforaphane multiple interactions EXP 6480464 [sulforaphane co-treated with TNFSF10 protein] results in decreased expression of CASP8 protein and sulforaphane results in increased expression of and results in increased activity of CASP8 protein CTD PMID:26833863 and PMID:29792947 CASP8 Human sulforaphane increases expression EXP 6480464 sulforaphane results in increased expression of CASP8 mRNA CTD PMID:31838189 CASP8 Human sulfur dioxide increases expression ISO Casp8 (Rattus norvegicus) 6480464 Sulfur Dioxide results in increased expression of CASP8 mRNA CTD PMID:19621461 and PMID:35533050 CASP8 Human sulfur dioxide multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA CTD PMID:31268311 CASP8 Human sulfur dioxide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Sulfur Dioxide inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CASP8 protein modified form] and Sulfur Dioxide results in increased expression of and results in increased activity of CASP8 protein CTD PMID:19621461 and PMID:30503585 CASP8 Human sulindac multiple interactions EXP 6480464 [Sulindac co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:21171083 CASP8 Human sulindac sulfide multiple interactions EXP 6480464 BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]] more ... CTD PMID:12203115 and PMID:12414664 CASP8 Human sulindac sulfide increases activity ISO Casp8 (Mus musculus) 6480464 sulindac sulfide results in increased activity of CASP8 protein CTD PMID:16886631 CASP8 Human sulindac sulfide increases activity EXP 6480464 sulindac sulfide results in increased activity of CASP8 protein CTD PMID:11559570 and PMID:12414664 CASP8 Human sulindac sulfone increases activity EXP 6480464 sulindac sulfone results in increased activity of CASP8 protein CTD PMID:11559570 CASP8 Human swainsonine increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Swainsonine results in increased cleavage of CASP8 protein CTD PMID:33186601 CASP8 Human syringic acid increases expression EXP 6480464 syringic acid results in increased expression of CASP8 mRNA CTD PMID:33759321 CASP8 Human T-2 toxin increases expression ISO Casp8 (Rattus norvegicus) 6480464 T-2 Toxin results in increased expression of CASP8 mRNA CTD PMID:26141394 more ... CASP8 Human T-2 toxin increases activity ISO Casp8 (Mus musculus) 6480464 T-2 Toxin results in increased activity of CASP8 protein CTD PMID:29432840 CASP8 Human T-2 toxin increases expression ISO Casp8 (Mus musculus) 6480464 T-2 Toxin results in increased expression of CASP8 mRNA CTD PMID:29432840 CASP8 Human T-2 toxin multiple interactions ISO Casp8 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [T-2 Toxin results in increased activity of CASP8 protein] CTD PMID:29432840 CASP8 Human tacedinaline multiple interactions EXP 6480464 tacedinaline promotes the reaction [Decitabine results in increased expression of CASP8 protein] CTD PMID:21771726 CASP8 Human tacrolimus hydrate multiple interactions EXP 6480464 Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:15548389 CASP8 Human tacrolimus hydrate increases expression ISO Casp8 (Mus musculus) 6480464 Tacrolimus results in increased expression of CASP8 protein CTD PMID:27606422 CASP8 Human tamoxifen multiple interactions EXP 6480464 [[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein more ... CTD PMID:17767197 more ... CASP8 Human tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of CASP8 protein CTD PMID:17767197 CASP8 Human tanespimycin multiple interactions EXP 6480464 [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein CTD PMID:17121904 CASP8 Human tanespimycin increases cleavage EXP 6480464 tanespimycin results in increased cleavage of CASP8 protein CTD PMID:17121904 CASP8 Human tangeretin increases cleavage EXP 6480464 tangeretin results in increased cleavage of CASP8 protein CTD PMID:33058988 CASP8 Human tangeretin multiple interactions EXP 6480464 AGN 193109 inhibits the reaction [tangeretin results in increased cleavage of CASP8 protein] CTD PMID:33058988 CASP8 Human Tanshinone I multiple interactions EXP 6480464 tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein] CTD PMID:26203587 CASP8 Human taurocholic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein] CTD PMID:12388182 CASP8 Human tellurium atom decreases activity ISO Casp8 (Rattus norvegicus) 6480464 Tellurium results in decreased activity of CASP8 protein CTD PMID:18571097 CASP8 Human temozolomide multiple interactions EXP 6480464 [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 mRNA more ... CTD PMID:21514314 and PMID:32800223 CASP8 Human temozolomide increases cleavage EXP 6480464 temozolomide results in increased cleavage of CASP8 protein CTD PMID:26418950 CASP8 Human Terfenadine increases activity EXP 6480464 Terfenadine results in increased activity of CASP8 protein CTD PMID:16569656 CASP8 Human Terfenadine increases activity ISO Casp8 (Rattus norvegicus) 6480464 Terfenadine results in increased activity of CASP8 protein CTD PMID:15288570 CASP8 Human Terfenadine increases cleavage EXP 6480464 Terfenadine results in increased cleavage of CASP8 protein CTD PMID:20570632 CASP8 Human tert-butyl hydroperoxide multiple interactions EXP 6480464 [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP8 mRNA more ... CTD PMID:35690295 CASP8 Human testosterone multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]] more ... CTD PMID:20609311 and PMID:29625166 CASP8 Human testosterone increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Testosterone results in increased cleavage of CASP8 protein CTD PMID:24658017 CASP8 Human tetrachloromethane multiple interactions ISO Casp8 (Mus musculus) 6480464 2 more ... CTD PMID:18291569 more ... CASP8 Human tetrachloromethane increases cleavage ISO Casp8 (Mus musculus) 6480464 Carbon Tetrachloride results in increased cleavage of CASP8 protein CTD PMID:25432964 CASP8 Human tetrachloromethane increases expression ISO Casp8 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of CASP8 protein CTD PMID:24530446 CASP8 Human tetrachloromethane increases activity ISO Casp8 (Mus musculus) 6480464 Carbon Tetrachloride results in increased activity of CASP8 protein CTD PMID:18291569 and PMID:18436364 CASP8 Human tetrachloromethane multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein] CTD PMID:12388182 CASP8 Human tetrachloromethane increases activity ISO Casp8 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased activity of CASP8 protein CTD PMID:12388182 CASP8 Human tetramethylpyrazine multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP8 protein] and tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]] CTD PMID:17132701 CASP8 Human tetrathiomolybdate(2-) multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein and [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein CTD PMID:22276220 CASP8 Human tetrazolium violet increases activity ISO Casp8 (Mus musculus) 6480464 tetrazolium violet results in increased activity of CASP8 protein CTD PMID:18547555 CASP8 Human thalidomide increases cleavage EXP 6480464 Thalidomide analog results in increased cleavage of CASP8 protein CTD PMID:15858615 CASP8 Human thalidomide decreases expression ISO Casp8 (Mus musculus) 6480464 Thalidomide results in decreased expression of CASP8 mRNA CTD PMID:26217789 CASP8 Human thapsigargin increases activity ISO Casp8 (Mus musculus) 6480464 Thapsigargin results in increased activity of CASP8 protein CTD PMID:16018998 CASP8 Human Theaflavin 3,3'-digallate increases activity EXP 6480464 theaflavin-3 and 3'-digallate results in increased activity of CASP8 protein CTD PMID:30769778 CASP8 Human thiabendazole increases activity ISO Casp8 (Rattus norvegicus) 6480464 Thiabendazole results in increased activity of CASP8 protein CTD PMID:26748015 CASP8 Human thiazoles multiple interactions EXP 6480464 [Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein and Acetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein] CTD PMID:19014919 CASP8 Human thioacetamide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA more ... CTD PMID:23830814 and PMID:29133031 CASP8 Human thioacetamide decreases expression ISO Casp8 (Rattus norvegicus) 6480464 Thioacetamide results in decreased expression of CASP8 mRNA CTD PMID:29133031 CASP8 Human thiosalicylic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP8 protein CTD PMID:19427195 CASP8 Human thymol increases activity EXP 6480464 Thymol results in increased activity of CASP8 protein CTD PMID:21640085 CASP8 Human thymol multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA] CTD PMID:26996544 CASP8 Human thymol sulfate(1-) multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA] CTD PMID:26996544 CASP8 Human thymol sulfate(1-) increases activity EXP 6480464 Thymol results in increased activity of CASP8 protein CTD PMID:21640085 CASP8 Human thymoquinone multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein] CTD PMID:29085585 CASP8 Human tioguanine increases response to substance EXP 6480464 CASP8 protein results in increased susceptibility to Thioguanine CTD PMID:22010212 CASP8 Human tioguanine increases expression EXP 6480464 Thioguanine results in increased expression of CASP8 protein CTD PMID:22010212 CASP8 Human Tiron multiple interactions EXP 6480464 1 more ... CTD PMID:19481559 CASP8 Human titanium dioxide increases expression ISO Casp8 (Rattus norvegicus) 6480464 titanium dioxide results in increased expression of CASP8 mRNA and titanium dioxide results in increased expression of CASP8 protein CTD PMID:34874108 CASP8 Human titanium dioxide multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 carboxymethyl-chitosan inhibits the reaction [titanium dioxide results in increased expression of CASP8 mRNA] and carboxymethyl-chitosan inhibits the reaction [titanium dioxide results in increased expression of CASP8 protein] CTD PMID:34874108 CASP8 Human Tomentosin decreases expression EXP 6480464 tomentosin results in decreased expression of CASP8 protein CTD PMID:30917517 CASP8 Human Tomentosin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP8 protein] CTD PMID:30917517 CASP8 Human topotecan multiple interactions EXP 6480464 [Amlodipine co-treated with Topotecan] results in increased activity of CASP8 protein and chrysin inhibits the reaction [Topotecan results in increased activity of CASP8 protein] CTD PMID:16516327 and PMID:20457140 CASP8 Human topotecan increases activity EXP 6480464 Topotecan results in increased activity of CASP8 protein CTD PMID:20457140 CASP8 Human tranilast multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 tranilast inhibits the reaction [Cisplatin results in increased expression of CASP8 protein] CTD PMID:34047436 CASP8 Human trans-chalcone increases cleavage EXP 6480464 Chalcone results in increased cleavage of CASP8 protein CTD PMID:20620131 CASP8 Human trans-chalcone multiple interactions EXP 6480464 MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein] CTD PMID:20620131 CASP8 Human triamcinolone acetonide increases activity ISO Casp8 (Rattus norvegicus) 6480464 Triamcinolone Acetonide results in increased activity of CASP8 protein CTD PMID:15987869 CASP8 Human tributylstannane increases expression ISO Casp8 (Rattus norvegicus) 6480464 tributyltin results in increased expression of CASP8 protein CTD PMID:23743147 CASP8 Human tributylstannane decreases expression ISO Casp8 (Rattus norvegicus) 6480464 tributyltin results in decreased expression of CASP8 protein CTD PMID:28707438 CASP8 Human Tributyltin oxide increases expression ISO Casp8 (Mus musculus) 6480464 bis(tri-n-butyltin)oxide results in increased expression of CASP8 mRNA CTD PMID:25270620 CASP8 Human Tributyltin oxide increases expression EXP 6480464 bis(tri-n-butyltin)oxide results in increased expression of CASP8 mRNA CTD PMID:24247028 CASP8 Human trichostatin A multiple interactions EXP 6480464 [[Decitabine co-treated with trichostatin A] affects the methylation of CASP8 promoter] which affects the expression of CASP8 mRNA more ... CTD PMID:15781658 more ... CASP8 Human trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of CASP8 mRNA CTD PMID:24935251 and PMID:26272509 CASP8 Human trifluridine increases cleavage EXP 6480464 Trifluridine results in increased cleavage of CASP8 protein CTD PMID:19816940 CASP8 Human triphenyl phosphate affects expression EXP 6480464 triphenyl phosphate affects the expression of CASP8 mRNA CTD PMID:37042841 CASP8 Human Triptolide multiple interactions ISO Casp8 (Mus musculus) 6480464 [triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form and triptolide results in increased expression of and results in increased activity of CASP8 protein CTD PMID:26990902 and PMID:30633930 CASP8 Human troglitazone increases activity EXP 6480464 troglitazone results in increased activity of CASP8 protein CTD PMID:14508522 CASP8 Human troglitazone increases expression ISO Casp8 (Mus musculus) 6480464 troglitazone results in increased expression of CASP8 mRNA CTD PMID:28973697 CASP8 Human troglitazone increases expression EXP 6480464 Troglitazone results in increased expression of CASP8 more ... CTD PMID:12680223 more ... CASP8 Human troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of CASP8 mRNA CTD PMID:19631733 CASP8 Human trovafloxacin multiple interactions EXP 6480464 [trovafloxacin co-treated with TNF protein] results in increased activity of CASP8 protein CTD PMID:24097668 CASP8 Human ursodeoxycholic acid multiple interactions EXP 6480464 [oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of and results in increased activity of CASP8 protein more ... CTD PMID:16432164 more ... CASP8 Human ursodeoxycholic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP8 protein] CTD PMID:25502462 CASP8 Human ursodeoxycholic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein] CTD PMID:21146893 CASP8 Human ursodeoxycholic acid increases activity EXP 6480464 Ursodeoxycholic Acid results in increased activity of CASP8 protein CTD PMID:21362627 CASP8 Human ursolic acid increases activity EXP 6480464 Ursolic Acid results in increased activity of CASP8 protein CTD PMID:20005942 CASP8 Human valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:19006566 more ... CASP8 Human valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of CASP8 mRNA and Valproic Acid results in increased expression of CASP8 protein CTD PMID:21771726 more ... CASP8 Human valproic acid increases expression ISO Casp8 (Mus musculus) 6480464 Valproic Acid results in increased expression of CASP8 mRNA CTD PMID:24896083 CASP8 Human valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of CASP8 mRNA CTD PMID:25979313 CASP8 Human valproic acid affects expression ISO Casp8 (Mus musculus) 6480464 Valproic Acid affects the expression of CASP8 mRNA CTD PMID:17292431 CASP8 Human valproic acid increases cleavage EXP 6480464 Valproic Acid results in increased cleavage of CASP8 protein CTD PMID:19006566 CASP8 Human vanillic acid multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA] CTD PMID:25794854 CASP8 Human vemurafenib multiple interactions EXP 6480464 [KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP8 protein] more ... CTD PMID:27222248 CASP8 Human venom increases cleavage EXP 6480464 Viper Venoms results in increased cleavage of CASP8 protein CTD PMID:25417048 CASP8 Human verapamil multiple interactions EXP 6480464 [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:24373880 CASP8 Human vincristine increases expression EXP 6480464 Vincristine results in increased expression of CASP8 mRNA CTD PMID:16001973 CASP8 Human vincristine increases response to substance EXP 6480464 CASP8 protein results in increased susceptibility to Vincristine CTD PMID:22010212 CASP8 Human vincristine multiple interactions EXP 6480464 Vincristine results in increased expression of and results in increased cleavage of CASP8 protein CTD PMID:22010212 CASP8 Human vorinostat multiple interactions EXP 6480464 [Bortezomib co-treated with Vorinostat] results in increased activity of CASP8 protein more ... CTD PMID:12893773 more ... CASP8 Human vorinostat increases cleavage EXP 6480464 vorinostat results in increased cleavage of CASP8 protein CTD PMID:15897598 and PMID:17351739 CASP8 Human vorinostat increases expression EXP 6480464 vorinostat results in increased expression of CASP8 mRNA CTD PMID:26272509 CASP8 Human vorinostat increases activity EXP 6480464 vorinostat results in increased activity of CASP8 protein CTD PMID:15173093 more ... CASP8 Human WIN 55212-2 decreases cleavage EXP 6480464 (3R)-((2 more ... CTD PMID:30776504 CASP8 Human wogonin multiple interactions ISO Casp8 (Mus musculus) 6480464 wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein] CTD PMID:26756871 CASP8 Human wortmannin multiple interactions EXP 6480464 ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]] and Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein] CTD PMID:20104024 CASP8 Human wortmannin multiple interactions ISO Casp8 (Rattus norvegicus) 6480464 wortmannin inhibits the reaction [2 more ... CTD PMID:24726520 CASP8 Human xanthohumol multiple interactions EXP 6480464 xanthohumol results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15995977 CASP8 Human xanthohumol increases cleavage EXP 6480464 xanthohumol results in increased cleavage of CASP8 protein CTD PMID:35229981 CASP8 Human xanthohumol increases activity EXP 6480464 xanthohumol results in increased activity of CASP8 protein CTD PMID:26297991 CASP8 Human Y-27632 multiple interactions EXP 6480464 Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP8 protein] CTD PMID:28743511 CASP8 Human zearalenone increases cleavage ISO Casp8 (Rattus norvegicus) 6480464 Zearalenone results in increased cleavage of CASP8 protein CTD PMID:30600648 CASP8 Human zearalenone increases expression EXP 6480464 Zearalenone results in increased expression of CASP8 mRNA CTD PMID:30668976 CASP8 Human zearalenone multiple interactions EXP 6480464 [Aflatoxin B1 co-treated with deoxynivalenol] promotes the reaction [Zearalenone results in increased expression of CASP8 mRNA] more ... CTD PMID:30668976 CASP8 Human zearalenone increases expression ISO Casp8 (Rattus norvegicus) 6480464 Zearalenone results in increased expression of CASP8 mRNA CTD PMID:30600648 CASP8 Human zebularine increases activity EXP 6480464 pyrimidin-2-one beta-ribofuranoside results in increased activity of CASP8 protein CTD PMID:23320119 CASP8 Human zidovudine increases cleavage EXP 6480464 Zidovudine results in increased cleavage of CASP8 protein CTD PMID:27238871 CASP8 Human zidovudine multiple interactions EXP 6480464 Acrolein promotes the reaction [Zidovudine results in increased cleavage of CASP8 protein] and Zidovudine promotes the reaction [Acrolein results in increased cleavage of CASP8 protein] CTD PMID:27238871 CASP8 Human zinc atom multiple interactions ISO Casp8 (Mus musculus) 6480464 [Rutin binds to Zinc] which results in increased expression of CASP8 mRNA CTD PMID:26091902 CASP8 Human zinc oxide multiple interactions EXP 6480464 benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein] and Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein] CTD PMID:27544635 CASP8 Human zinc oxide increases cleavage ISO Casp8 (Mus musculus) 6480464 Zinc Oxide analog results in increased cleavage of CASP8 protein CTD PMID:24614525 CASP8 Human zinc oxide multiple interactions ISO Casp8 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein] CTD PMID:24614525 CASP8 Human zinc oxide increases activity EXP 6480464 Zinc Oxide analog results in increased activity of CASP8 protein CTD PMID:27544635 CASP8 Human zinc protoporphyrin multiple interactions EXP 6480464 zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein] CTD PMID:16051694 CASP8 Human zinc pyrithione increases activity EXP 6480464 pyrithione zinc results in increased activity of CASP8 protein CTD PMID:20151177 CASP8 Human zinc pyrithione increases expression EXP 6480464 pyrithione zinc results in increased expression of CASP8 mRNA CTD PMID:21424779 CASP8 Human zinc sulfate multiple interactions EXP 6480464 [gluconic acid co-treated with Zinc Sulfate] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA] and Zinc Sulfate inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA] CTD PMID:27017951 CASP8 Human zinc(0) multiple interactions ISO Casp8 (Mus musculus) 6480464 [Rutin binds to Zinc] which results in increased expression of CASP8 mRNA CTD PMID:26091902 CASP8 Human ziram increases activity EXP 6480464 Ziram results in increased activity of CASP8 protein CTD PMID:22159898 CASP8 Human zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of CASP8 mRNA CTD PMID:19036117 and PMID:20977926 CASP8 Human zoledronic acid multiple interactions ISO Casp8 (Mus musculus) 6480464 [zoledronic acid co-treated with Doxorubicin] results in increased activity of CASP8 protein CTD PMID:19789217
