CASP8 (caspase 8) - Rat Genome Database
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Gene: CASP8 (caspase 8) Canis lupus familiaris
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Symbol: CASP8
Name: caspase 8
RGD ID: 12260125
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity involved in apoptotic process (ortholog); death receptor binding (ortholog); endopeptidase activity (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic process (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cell body (ortholog); cytosol (ortholog); death-inducing signaling complex (ortholog); INTERACTS WITH 1,4-phenylenediamine; marbofloxacin; ofloxacin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: caspase-8
Orthologs:
Homo sapiens (human) : CASP8 (caspase 8)  HGNC  Alliance
Mus musculus (house mouse) : Casp8 (caspase 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp8 (caspase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp8 (caspase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP8 (caspase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp8 (caspase 8)
Sus scrofa (pig) : CASP8 (caspase 8)
Chlorocebus sabaeus (African green monkey) : CASP8 (caspase 8)
Heterocephalus glaber (naked mole-rat) : Casp8 (caspase 8)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3710,391,048 - 10,401,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13710,362,071 - 10,402,108 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcohol-Related Disorders  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
autoimmune disease  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Prostate Cancer  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephritis  (ISO)
Neurodevelopmental Disorders  (ISO)
Osteoarthritis, Experimental  (ISO)
pancreatic cancer  (ISO)
Papillomavirus Infections  (ISO)
pre-malignant neoplasm  (ISO)
primary immunodeficiency disease  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Radiation Injuries, Experimental  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)
Viral Myocarditis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (IEA)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA)
angiogenesis  (ISO)
apoptotic process  (IBA,ISS)
apoptotic signaling pathway  (ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to organic cyclic compound  (ISO)
execution phase of apoptosis  (ISS)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IBA)
heart development  (ISO)
hepatocyte apoptotic process  (ISO)
macrophage differentiation  (IBA)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
negative regulation of necroptotic process  (IEA)
neural tube formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of macrophage differentiation  (IEA)
positive regulation of neuron death  (ISO)
positive regulation of proteolysis  (ISO)
protein processing  (ISO)
proteolysis  (IEA)
proteolysis involved in cellular protein catabolic process  (IEA)
pyroptosis  (ISO)
regulation of apoptotic process  (IEA)
regulation of apoptotic signaling pathway  (ISO)
regulation of thymocyte apoptotic process  (ISO)
response to antibiotic  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to cold  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to tumor necrosis factor  (IEA)
self proteolysis  (ISO)
TRAIL-activated apoptotic signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:17219412   PMID:20198571  


Genomics

Comparative Map Data
CASP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3710,391,048 - 10,401,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13710,362,071 - 10,402,108 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CASP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2201,233,443 - 201,287,711 (+)EnsemblGRCh38hg38GRCh38
GRCh382201,233,443 - 201,287,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372202,098,166 - 202,152,434 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,806,411 - 201,860,679 (+)NCBINCBI36hg18NCBI36
Build 342201,923,718 - 201,972,144NCBI
Celera2195,852,777 - 195,904,249 (+)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,949,530 - 194,000,819 (+)NCBIHuRef
CHM1_12202,104,145 - 202,158,454 (+)NCBICHM1_1
Casp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,834,398 - 58,886,662 (+)NCBI
GRCm38158,795,233 - 58,847,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,795,374 - 58,847,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,852,218 - 58,904,347 (+)NCBIGRCm37mm9NCBIm37
MGSCv36158,740,040 - 58,791,559 (+)NCBImm8
Celera159,314,392 - 59,366,511 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.19NCBI
Casp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Celera957,705,001 - 57,753,027 (+)NCBICelera
Cytogenetic Map9q31NCBI
Casp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403322,555 - 347,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955403322,082 - 348,591 (-)NCBIChiLan1.0ChiLan1.0
CASP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B206,645,803 - 206,696,468 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,669,544 - 206,696,468 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B88,490,611 - 88,542,132 (+)NCBIMhudiblu_PPA_v0panPan3
Casp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936726554,627 - 596,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,923,953 - 104,948,470 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,923,659 - 104,948,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,337,232 - 116,340,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1086,916,527 - 86,943,829 (+)Ensembl
ChlSab1.11086,888,654 - 86,944,159 (+)NCBI
Casp8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 3 5 3 2 3
Low 5 5 19 3 1 3 4 3 10 7 6
Below cutoff 3 2 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000019300   ⟹   ENSCAFP00000017899
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3710,391,048 - 10,401,822 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000083124   ⟹   ENSCAFP00000054007
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3710,391,048 - 10,401,822 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087761   ⟹   ENSCAFP00000066251
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3710,391,048 - 10,401,205 (+)Ensembl
RefSeq Acc Id: NM_001048029   ⟹   NP_001041494
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13710,391,048 - 10,401,822 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005640423   ⟹   XP_005640480
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13710,362,093 - 10,402,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005640424   ⟹   XP_005640481
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13710,380,568 - 10,402,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005640425   ⟹   XP_005640482
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13710,362,071 - 10,402,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005640426   ⟹   XP_005640483
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13710,380,567 - 10,402,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005640427   ⟹   XP_005640484
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13710,362,092 - 10,402,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022414955   ⟹   XP_022270663
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13710,380,567 - 10,402,108 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002623345
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13710,380,567 - 10,401,810 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005640480   ⟸   XM_005640423
- Peptide Label: isoform X1
- UniProtKB: Q38JA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005640484   ⟸   XM_005640427
- Peptide Label: isoform X1
- UniProtKB: Q38JA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005640482   ⟸   XM_005640425
- Peptide Label: isoform X1
- UniProtKB: Q38JA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005640481   ⟸   XM_005640424
- Peptide Label: isoform X1
- UniProtKB: Q38JA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005640483   ⟸   XM_005640426
- Peptide Label: isoform X1
- UniProtKB: Q38JA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001041494   ⟸   NM_001048029
- UniProtKB: Q38JA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022270663   ⟸   XM_022414955
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000066251   ⟸   ENSCAFT00000087761
RefSeq Acc Id: ENSCAFP00000054007   ⟸   ENSCAFT00000083124
RefSeq Acc Id: ENSCAFP00000017899   ⟸   ENSCAFT00000019300
Protein Domains
CASPASE_P10   CASPASE_P20   DED


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025192 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000017899 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000054007 UniProtKB/TrEMBL
  ENSCAFP00000066251 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019300 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000083124 UniProtKB/TrEMBL
  ENSCAFT00000087761 UniProtKB/TrEMBL
InterPro Caspase-like_dom UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom UniProtKB/TrEMBL
  DED_dom UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
KEGG Report cfa:488473 UniProtKB/TrEMBL
NCBI Gene CASP8 ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
Pfam DED UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniGene Cfa.24658 ENTREZGENE
UniProt A0A5F4CHZ5_CANLF UniProtKB/TrEMBL
  A0A5F4DIG2_CANLF UniProtKB/TrEMBL
  Q38JA9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38736 ENTREZGENE