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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730846
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: CHEBI:50694
Term: minocycline
Definition: A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Chemical ID: MESH:D008911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8decreases expressionISOCasp8 (Rattus norvegicus)6480464CTDMinocycline results in decreased expression of CASP8 mRNAPMID:14998631
CASP8multiple interactionsISOCasp8 (Rattus norvegicus)6480464CTDMinocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP8 proteinPMID:12930891 PMID:14998631 PMID:35939230
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