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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730846
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8multiple interactionsEXP 6480464CTDALDH2 protein inhibits the reaction [Ethanol results in increased expression of CASP8 protein]PMID:19429258
CASP8increases activityISOCasp8 (Rattus norvegicus)6480464CTDEthanol results in increased activity of CASP8 proteinPMID:25289771
CASP8increases cleavageISOCasp8 (Rattus norvegicus)6480464CTDEthanol results in increased cleavage of CASP8 proteinPMID:25859307 PMID:29085585
CASP8increases expressionISOCasp8 (Rattus norvegicus)6480464CTDEthanol results in increased expression of CASP8 mRNAPMID:36085217
CASP8increases expressionISOCasp8 (Mus musculus)6480464CTDEthanol results in increased expression of CASP8 mRNA; Ethanol results in increased expression of CASP8 proteinPMID:19429258 PMID:35639301
CASP8multiple interactionsISOCasp8 (Rattus norvegicus)6480464CTD[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] affects the reaction [Ethanol results in increased expression of CASP8 mRNA]; caraway oil inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein]; Ethanol affects the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of CASP8 mRNA]; nymphayol inhibits the reaction [Ethanol results in increased activity of CASP8 protein]; thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein]PMID:25289771 PMID:25859307 PMID:29085585 PMID:36085217
CASP8multiple interactionsISOCasp8 (Mus musculus)6480464CTDsodium propionate inhibits the reaction [Ethanol results in increased expression of CASP8 mRNA]PMID:35639301
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