GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CASP8 | affects expression | EXP | | 6480464 | CTD | Diclofenac affects the expression of CASP8 mRNA | PMID:24752500 | CASP8 | increases activity | EXP | | 6480464 | CTD | Diclofenac results in increased activity of CASP8 protein | PMID:27313093 | CASP8 | multiple interactions | EXP | | 6480464 | CTD | [Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein] | PMID:20237495 PMID:27313093 | CASP8 | increases activity | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | Diclofenac results in increased activity of CASP8 protein | PMID:14609740 | | ||||||||||||||||||||||
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