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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730846
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8decreases expressionEXP 6480464CTDOkadaic Acid results in decreased expression of CASP8 mRNAPMID:31926150
CASP8increases activityEXP 6480464CTDOkadaic Acid results in increased activity of CASP8 proteinPMID:31926150
CASP8increases expressionEXP 6480464CTDOkadaic Acid results in increased expression of CASP8 protein modified formPMID:31926150
CASP8multiple interactionsEXP 6480464CTDacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Okadaic Acid results in increased cleavage of and results in increased activity of CASP8 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Okadaic Acid results in increased cleavage of and results in increased activity of CASP8 protein]; Okadaic Acid inhibits the reaction [hydroquinone results in increased cleavage of CASP8 protein]; Okadaic Acid results in increased cleavage of and results in increased activity of CASP8 proteinPMID:19084044 PMID:23288922
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