GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CASP8 | affects expression | EXP | | 6480464 | CTD | Hydrogen Peroxide affects the expression of CASP8 protein | PMID:21179406 | CASP8 | increases activity | EXP | | 6480464 | CTD | Hydrogen Peroxide results in increased activity of CASP8 protein | PMID:21431366 | CASP8 | multiple interactions | EXP | | 6480464 | CTD | Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein] | PMID:21431366 | CASP8 | increases activity | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | Hydrogen Peroxide results in increased activity of CASP8 protein | PMID:15799720 PMID:16157298 PMID:16647178 | CASP8 | increases expression | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of CASP8 protein | PMID:20946910 PMID:27525270 | CASP8 | increases expression | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of CASP8 mRNA | PMID:31696622 | CASP8 | multiple interactions | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]; [mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]; Cholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]; Hydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of CASP8 protein]; Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein] | PMID:15799720 PMID:16647178 PMID:20946910 PMID:27525270 | |
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