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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730846
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: CHEBI:567361
Term: cladribine
Definition: 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Chemical ID: MESH:D017338
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8increases activityEXP 6480464CTDCladribine results in increased activity of CASP8 proteinPMID:11672427 PMID:12948851 PMID:21679466
CASP8increases cleavageEXP 6480464CTDCladribine results in increased cleavage of CASP8 proteinPMID:15516989
CASP8multiple interactionsEXP 6480464CTD[Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP8 protein]PMID:12948851 PMID:15516989 PMID:19006566
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