GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CASP8 | increases expression | EXP | | 6480464 | CTD | Methotrexate results in increased expression of CASP8 mRNA; Methotrexate results in increased expression of CASP8 protein | PMID:17400583 PMID:17637740 PMID:25330300 | CASP8 | multiple interactions | EXP | | 6480464 | CTD | [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Antineoplastic Agents; [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Cyclophosphamide metabolite; [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Dexamethasone; [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Doxorubicin; Methotrexate results in increased expression of and results in increased cleavage of CASP8 protein; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP8 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP8 protein]; TP53 protein promotes the reaction [Methotrexate results in increased expression of CASP8 mRNA]; TP53 protein promotes the reaction [Methotrexate results in increased expression of CASP8 protein] | PMID:17637740 PMID:22010212 PMID:25330300 | CASP8 | increases expression | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | Methotrexate results in increased expression of CASP8 protein | PMID:36482745 | CASP8 | multiple interactions | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | ramelteon inhibits the reaction [Methotrexate results in increased expression of CASP8 protein] | PMID:36482745 | | ||||||||||||||||||||||
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