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Gene: MCL1 (MCL1 apoptosis regulator, BCL2 family member) Homo sapiens
Symbol: MCL1
Name: MCL1 apoptosis regulator, BCL2 family member
RGD ID: 735512
Description: Exhibits BH3 domain binding activity and protein heterodimerization activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of autophagy; and regulation of apoptotic process. Localizes to several cellular components, including Bcl-2 family protein complex; mitochondrion; and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; BCL2 family apoptosis regulator; bcl2-L-3; BCL2L3; EAT; induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; MCL1, BCL2 family apoptosis regulator; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia sequence 1, isoform 1; TM
Mus musculus (house mouse) : Mcl1 (myeloid cell leukemia sequence 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)
Pan paniscus (bonobo/pygmy chimpanzee) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Canis lupus familiaris (dog) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)
Sus scrofa (pig) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Chlorocebus sabaeus (African green monkey) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Heterocephalus glaber (naked mole-rat) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1150,574,551 - 150,579,738 (-)EnsemblGRCh38hg38GRCh38
GRCh381150,574,558 - 150,579,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371150,547,027 - 150,552,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,813,658 - 148,818,760 (-)NCBINCBI36hg18NCBI36
Build 341147,360,106 - 147,365,209NCBI
Celera1123,662,793 - 123,667,900 (-)NCBI
Cytogenetic Map1q21.2NCBI
HuRef1121,925,157 - 121,930,349 (-)NCBIHuRef
CHM1_11151,942,802 - 151,947,994 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MCL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735512
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.