Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MCL1 (MCL1 apoptosis regulator, BCL2 family member) Homo sapiens
Analyze
Symbol: MCL1
Name: MCL1 apoptosis regulator, BCL2 family member
Description: Exhibits BH3 domain binding activity and protein heterodimerization activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of autophagy; and regulation of apoptotic process. Localizes to several cellular components, including the Bcl-2 family protein complex; mitochondrion; and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; BCL2 family apoptosis regulator; bcl2-L-3; BCL2L3; EAT; induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; MCL1, BCL2 family apoptosis regulator; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia sequence 1, isoform 1; TM
Orthologs:
Mus musculus (house mouse) : Mcl1 (myeloid cell leukemia sequence 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)
Pan paniscus (bonobo/pygmy chimpanzee) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Canis lupus familiaris (dog) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)
Sus scrofa (pig) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,574,551 - 150,579,738 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371150,547,027 - 150,552,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,813,658 - 148,818,760 (-)NCBINCBI36hg18NCBI36
Build 341147,360,106 - 147,365,209NCBI
Celera1123,662,793 - 123,667,900 (-)NCBI
Cytogenetic Map1q21.2NCBI
HuRef1121,925,157 - 121,930,349 (-)NCBIHuRef
CHM1_11151,942,802 - 151,947,994 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MCL1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735512
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.