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Gene: OCLN (occludin) Homo sapiens
Symbol: OCLN
Name: occludin
Description: Exhibits protein domain specific binding activity. Involved in several processes, including bicellular tight junction assembly; negative regulation of macromolecule metabolic process; and positive regulation of blood-brain barrier permeability. Localizes to several cellular components, including bicellular tight junction; cytoplasmic vesicle; and lysosomal membrane. Implicated in Crohn's disease and pseudo-TORCH syndrome 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BLCPMG; FLJ08163; FLJ18079; FLJ77961; FLJ94056; MGC34277; phosphatase 1, regulatory subunit 115; PPP1R115; PTORCH1; tight junction protein occludin; tight junction protein occludin TM4 minus
Mus musculus (house mouse) : Ocln (occludin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ocln (occludin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ocln (occludin)
Pan paniscus (bonobo/pygmy chimpanzee) : OCLN (occludin)
Canis lupus familiaris (dog) : OCLN (occludin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ocln (occludin)
Sus scrofa (pig) : OCLN (occludin)
Chlorocebus sabaeus (African green monkey) : OCLN (occludin)
Heterocephalus glaber (naked mole-rat) : Ocln (occludin)
more info ...
Related Pseudogenes: OCLNP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl569,492,292 - 69,558,104 (+)EnsemblGRCh38hg38GRCh38
GRCh38569,492,547 - 69,558,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37568,788,119 - 68,853,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,823,875 - 68,885,889 (+)NCBINCBI36hg18NCBI36
Build 34568,823,874 - 68,885,887NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,800,577 - 65,803,347 (+)NCBIHuRef
HuRef565,744,381 - 65,800,380 (+)NCBIHuRef
CHM1_1568,787,783 - 68,853,763 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on OCLN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732985
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.