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Gene: OCLN (occludin) Homo sapiens
Symbol: OCLN
Name: occludin
Description: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BLCPMG; FLJ08163; FLJ18079; FLJ77961; FLJ94056; MGC34277; phosphatase 1, regulatory subunit 115; PPP1R115; PTORCH1; tight junction protein occludin; tight junction protein occludin TM4 minus
Mus musculus (house mouse) : Ocln (occludin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ocln (occludin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ocln (occludin)
Pan paniscus (bonobo/pygmy chimpanzee) : OCLN (occludin)
Canis lupus familiaris (dog) : OCLN (occludin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ocln (occludin)
Sus scrofa (pig) : OCLN (occludin)
more info ...
Related Pseudogenes: OCLNP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38569,492,292 - 69,558,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37568,788,119 - 68,853,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,823,875 - 68,885,889 (+)NCBINCBI36hg18NCBI36
Build 34568,823,874 - 68,885,887NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,744,381 - 65,800,380 (+)NCBIHuRef
HuRef565,800,577 - 65,803,347 (+)NCBIHuRef
CHM1_1568,787,783 - 68,853,763 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on OCLN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732985
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.