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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732985
Species: Homo sapiens
RGD Object: Gene
Symbol: OCLN
Name: occludin
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OCLNdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of OCLN mRNA; Arsenic Trioxide results in decreased expression of OCLN proteinPMID:32683294
OCLNmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN protein]; Resveratrol inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN protein]PMID:32683294
OCLNdecreases expressionISOOcln (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of OCLN mRNA; Arsenic Trioxide results in decreased expression of OCLN proteinPMID:30032600 PMID:30225639 PMID:32683294 PMID:36473683
OCLNmultiple interactionsISOOcln (Mus musculus)6480464CTD[Arsenic Trioxide results in increased abundance of arsenite] which results in decreased expression of OCLN mRNA; Butyrates inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN protein]; MIR122 mRNA affects the reaction [Butyrates inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN protein]]PMID:36473683 PMID:36791901
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