OCLN (occludin) - Rat Genome Database

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Gene: OCLN (occludin) Canis lupus familiaris
Analyze
Symbol: OCLN
Name: occludin
RGD ID: 12244264
Description: ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN positive regulation of lamellipodium assembly; positive regulation of microtubule polymerization; positive regulation of wound healing; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); amenorrhea (ortholog); Brain Injuries, Traumatic (ortholog); FOUND IN bicellular tight junction; cell leading edge; cell surface; INTERACTS WITH all-trans-retinoic acid; cadmium dichloride
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,500,299 - 54,545,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,500,299 - 54,545,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,466,637 - 51,511,781 (+)NCBI
ROS_Cfam_1.0255,004,936 - 55,058,838 (+)NCBI
ROS_Cfam_1.0 Ensembl255,005,004 - 55,058,769 (+)Ensembl
UMICH_Zoey_3.1252,076,201 - 52,121,488 (+)NCBI
UNSW_CanFamBas_1.0252,843,313 - 52,888,432 (+)NCBI
UU_Cfam_GSD_1.0253,733,721 - 53,779,092 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8601611   PMID:9182670   PMID:9647647   PMID:10679019   PMID:12507281   PMID:17574235   PMID:18768749   PMID:19017651   PMID:19114660   PMID:19635798   PMID:19854171   PMID:20152177  
PMID:21757728   PMID:23762290   PMID:25673908   PMID:27600198   PMID:34269802  


Genomics

Comparative Map Data
OCLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,500,299 - 54,545,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,500,299 - 54,545,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,466,637 - 51,511,781 (+)NCBI
ROS_Cfam_1.0255,004,936 - 55,058,838 (+)NCBI
ROS_Cfam_1.0 Ensembl255,005,004 - 55,058,769 (+)Ensembl
UMICH_Zoey_3.1252,076,201 - 52,121,488 (+)NCBI
UNSW_CanFamBas_1.0252,843,313 - 52,888,432 (+)NCBI
UU_Cfam_GSD_1.0253,733,721 - 53,779,092 (+)NCBI
OCLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,492,547 - 69,558,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl569,492,292 - 69,558,104 (+)EnsemblGRCh38hg38GRCh38
GRCh37568,788,374 - 68,853,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,823,875 - 68,885,889 (+)NCBINCBI36hg18NCBI36
Build 34568,823,874 - 68,885,887NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,744,381 - 65,800,380 (+)NCBIHuRef
HuRef565,800,577 - 65,803,347 (+)NCBIHuRef
CHM1_1568,787,783 - 68,853,763 (+)NCBICHM1_1
T2T-CHM13v2.0570,318,187 - 70,383,882 (+)NCBI
Ocln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,633,012 - 100,689,226 (-)NCBIGRCm39mm39
GRCm39 Ensembl13100,633,015 - 100,689,226 (-)Ensembl
GRCm3813100,496,504 - 100,552,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,496,507 - 100,552,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,267,322 - 101,322,453 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613101,597,624 - 101,652,755 (-)NCBImm8
Celera13104,112,684 - 104,167,697 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ocln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2231,657,217 - 31,707,466 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl231,657,220 - 31,764,150 (-)Ensembl
Rnor_6.0230,527,327 - 30,577,218 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,686,707 - 49,737,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,317,090 - 31,367,485 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1231,237,461 - 31,287,854 (-)NCBI
Celera227,670,881 - 27,719,967 (-)NCBICelera
Cytogenetic Map2q12NCBI
Ocln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955575163,646 - 210,379 (+)NCBIChiLan1.0ChiLan1.0
OCLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1546,022,538 - 46,080,549 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,023,437 - 46,069,342 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0544,447,230 - 44,509,637 (-)NCBIMhudiblu_PPA_v0panPan3
Ocln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,162,311 - 191,216,242 (-)NCBI
SpeTri2.0NW_00493648099,516 - 152,834 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OCLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,600,212 - 47,654,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,547,473 - 51,598,116 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OCLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,581,943 - 65,641,516 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl465,582,460 - 65,644,787 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604914,326,566 - 14,386,556 (+)NCBIVero_WHO_p1.0
Ocln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905333,864 - 388,880 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624905333,853 - 388,990 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 5 6 8 10
Low 2 5 14 6 6 6 3 12 6
Below cutoff 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012459   ⟹   ENSCAFP00000011544
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl254,500,299 - 54,545,430 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000012461   ⟹   ENSCAFP00000011546
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl254,500,369 - 54,545,430 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000046929   ⟹   ENSCAFP00000040354
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl254,503,715 - 54,545,430 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022680   ⟹   ENSCAFP00845017787
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl255,005,004 - 55,058,769 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022789   ⟹   ENSCAFP00845017865
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl255,012,262 - 55,058,769 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022816   ⟹   ENSCAFP00845017883
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl255,015,612 - 55,058,769 (+)Ensembl
RefSeq Acc Id: NM_001003195   ⟹   NP_001003195
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1254,500,299 - 54,545,430 (+)NCBI
Dog10K_Boxer_Tasha251,466,637 - 51,511,781 (+)NCBI
ROS_Cfam_1.0255,012,192 - 55,057,280 (+)NCBI
UMICH_Zoey_3.1252,076,201 - 52,121,488 (+)NCBI
UNSW_CanFamBas_1.0252,843,313 - 52,888,432 (+)NCBI
UU_Cfam_GSD_1.0253,733,721 - 53,779,092 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038657718   ⟹   XP_038513646
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0255,005,152 - 55,058,838 (+)NCBI
RefSeq Acc Id: XM_038657719   ⟹   XP_038513647
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0255,005,163 - 55,058,838 (+)NCBI
RefSeq Acc Id: XM_038657720   ⟹   XP_038513648
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0255,006,127 - 55,058,838 (+)NCBI
RefSeq Acc Id: XM_038657721   ⟹   XP_038513649
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0255,004,936 - 55,058,838 (+)NCBI
RefSeq Acc Id: XM_038657722   ⟹   XP_038513650
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0255,006,514 - 55,058,838 (+)NCBI
RefSeq Acc Id: XM_038657723   ⟹   XP_038513651
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0255,008,277 - 55,058,838 (+)NCBI
RefSeq Acc Id: XM_038657724   ⟹   XP_038513652
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0255,005,152 - 55,058,838 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001003195   ⟸   NM_001003195
- UniProtKB: Q28269 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000011544   ⟸   ENSCAFT00000012459
RefSeq Acc Id: ENSCAFP00000011546   ⟸   ENSCAFT00000012461
RefSeq Acc Id: ENSCAFP00000040354   ⟸   ENSCAFT00000046929
RefSeq Acc Id: XP_038513649   ⟸   XM_038657721
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513646   ⟸   XM_038657718
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513652   ⟸   XM_038657724
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038513647   ⟸   XM_038657719
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513648   ⟸   XM_038657720
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513650   ⟸   XM_038657722
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513651   ⟸   XM_038657723
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845017865   ⟸   ENSCAFT00845022789
RefSeq Acc Id: ENSCAFP00845017883   ⟸   ENSCAFT00845022816
RefSeq Acc Id: ENSCAFP00845017787   ⟸   ENSCAFT00845022680
Protein Domains
MARVEL   OCEL

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
2 54504605 54504606 G A snv Weimaraner (WE006)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007805 Ensembl
  ENSCAFG00030003692 UniProtKB/TrEMBL
  ENSCAFG00040004456 UniProtKB/TrEMBL
  ENSCAFG00845012752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030006071.1 UniProtKB/TrEMBL
  ENSCAFP00030006087.1 UniProtKB/TrEMBL
  ENSCAFP00030006104.1 UniProtKB/TrEMBL
  ENSCAFP00040007334 UniProtKB/TrEMBL
  ENSCAFP00040007359 UniProtKB/TrEMBL
  ENSCAFP00040007482 UniProtKB/TrEMBL
  ENSCAFP00845017787 ENTREZGENE
  ENSCAFP00845017787.1 UniProtKB/TrEMBL
  ENSCAFP00845017865 ENTREZGENE
  ENSCAFP00845017865.1 UniProtKB/TrEMBL
  ENSCAFP00845017883.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030006911.1 UniProtKB/TrEMBL
  ENSCAFT00030006928.1 UniProtKB/TrEMBL
  ENSCAFT00030006946.1 UniProtKB/TrEMBL
  ENSCAFT00040008447 UniProtKB/TrEMBL
  ENSCAFT00040008475 UniProtKB/TrEMBL
  ENSCAFT00040008613 UniProtKB/TrEMBL
  ENSCAFT00845022680 ENTREZGENE
  ENSCAFT00845022680.1 UniProtKB/TrEMBL
  ENSCAFT00845022789 ENTREZGENE
  ENSCAFT00845022789.1 UniProtKB/TrEMBL
  ENSCAFT00845022816.1 UniProtKB/TrEMBL
InterPro ELL/occludin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Marvel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Occludin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403844 UniProtKB/Swiss-Prot
NCBI Gene OCLN ENTREZGENE
PANTHER PTHR23288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23288:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MARVEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Occludin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS OCCLUDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MARVEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OCEL UniProtKB/Swiss-Prot
UniProt A0A8C0M4A4_CANLF UniProtKB/TrEMBL
  A0A8C0Q9S1_CANLF UniProtKB/TrEMBL
  A0A8C0Q9U2_CANLF UniProtKB/TrEMBL
  A0A8I3NDN4_CANLF UniProtKB/TrEMBL
  A0A8I3NDV4_CANLF UniProtKB/TrEMBL
  A0A8I3NPT4_CANLF UniProtKB/TrEMBL
  OCLN_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:44094 ENTREZGENE