Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732985
Species: Homo sapiens
RGD Object: Gene
Symbol: OCLN
Name: occludin
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OCLNdecreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of OCLN proteinPMID:35774596
OCLNmultiple interactionsEXP 6480464CTD[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein; alisol B 23-acetate inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein]; IRF3 mutant form inhibits the reaction [[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein]PMID:22906770 PMID:35774596
OCLNincreases expressionISOOcln (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of OCLN mRNAPMID:12057914
OCLNincreases expressionISOOcln (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of OCLN proteinPMID:15763998
OCLNmultiple interactionsISOOcln (Rattus norvegicus)6480464CTD[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of OCLN protein; [Lipopolysaccharides co-treated with TNF protein] results in decreased expression of OCLN protein; Lipopolysaccharides promotes the reaction [Oxygen deficiency results in decreased expression of OCLN protein]; prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides promotes the reaction [Oxygen deficiency results in decreased expression of OCLN protein]]PMID:23082119 PMID:36049518
Go Back to source page   Continue to Ontology report