OCLN (occludin) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: OCLN (occludin) Sus scrofa
Analyze
Symbol: OCLN
Name: occludin
RGD ID: 14021365
Description: ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN cell-cell junction organization (ortholog); cellular response to tumor necrosis factor (ortholog); positive regulation of lamellipodium assembly (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); amenorrhea (ortholog); Brain Injuries, Traumatic (ortholog); FOUND IN cell junction (ortholog); cell leading edge (ortholog); cell surface (ortholog); INTERACTS WITH (S)-nicotine; deoxynivalenol; diquat
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,600,498 - 47,654,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,547,473 - 51,598,116 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
deoxynivalenol  (EXP)
diquat  (EXP)
fumonisin B1  (EXP)
melamine  (EXP)
nicotine  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9247194   PMID:14681463   PMID:19267955   PMID:20197061   PMID:21338560  


Genomics

Comparative Map Data
OCLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,600,498 - 47,654,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,547,473 - 51,598,116 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OCLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl569,492,292 - 69,558,104 (+)EnsemblGRCh38hg38GRCh38
GRCh38569,492,547 - 69,558,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37568,788,119 - 68,853,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,823,875 - 68,885,889 (+)NCBINCBI36hg18NCBI36
Build 34568,823,874 - 68,885,887NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,800,577 - 65,803,347 (+)NCBIHuRef
HuRef565,744,381 - 65,800,380 (+)NCBIHuRef
CHM1_1568,787,783 - 68,853,763 (+)NCBICHM1_1
Ocln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,633,012 - 100,689,226 (-)NCBIGRCm39mm39
GRCm3813100,496,504 - 100,552,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,496,507 - 100,552,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,267,322 - 101,322,453 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613101,597,624 - 101,652,755 (-)NCBImm8
Celera13104,112,684 - 104,167,697 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ocln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0230,527,327 - 30,577,218 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,686,707 - 49,737,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,317,090 - 31,367,485 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1231,237,461 - 31,287,854 (-)NCBI
Celera227,670,881 - 27,719,967 (-)NCBICelera
Cytogenetic Map2q12NCBI
Ocln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955575163,646 - 210,379 (+)NCBIChiLan1.0ChiLan1.0
OCLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1546,022,538 - 46,080,549 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,023,437 - 46,069,342 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0544,447,230 - 44,509,637 (-)NCBIMhudiblu_PPA_v0panPan3
OCLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl254,500,299 - 54,545,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1254,500,299 - 54,545,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ocln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648099,516 - 152,834 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OCLN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,581,943 - 65,641,516 (+)NCBI
ChlSab1.1 Ensembl465,582,460 - 65,644,787 (+)Ensembl
Ocln
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624905333,853 - 388,990 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 7 1 3
Low 3 3 3 2 2 23 1 1
Below cutoff 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000057617   ⟹   ENSSSCP00000044638
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,612,815 - 47,654,033 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000060865   ⟹   ENSSSCP00000041435
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,600,498 - 47,654,033 (+)Ensembl
RefSeq Acc Id: NM_001163647   ⟹   NP_001157119
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,522 - 47,650,674 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672521   ⟹   XP_005672578
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,491 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672522   ⟹   XP_005672579
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672523   ⟹   XP_005672580
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,599 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672524   ⟹   XP_005672581
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,504 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672525   ⟹   XP_005672582
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,601,367 - 47,652,435 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005672579   ⟸   XM_005672522
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672578   ⟸   XM_005672521
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672581   ⟸   XM_005672524
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157119   ⟸   NM_001163647
- UniProtKB: C5JA71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672580   ⟸   XM_005672523
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672582   ⟸   XM_005672525
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000041435   ⟸   ENSSSCT00000060865
RefSeq Acc Id: ENSSSCP00000044638   ⟸   ENSSSCT00000057617
Protein Domains
MARVEL   Occludin_ELL


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021514 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070017114 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000041435 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000044638 UniProtKB/TrEMBL
  ENSSSCP00070028181 UniProtKB/TrEMBL
  ENSSSCP00070028191 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000057617 UniProtKB/TrEMBL
  ENSSSCT00000060865 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070033757 UniProtKB/TrEMBL
  ENSSSCT00070033768 UniProtKB/TrEMBL
InterPro ELL/occludin UniProtKB/TrEMBL
  Marvel UniProtKB/TrEMBL
  Occludin UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/TrEMBL
NCBI Gene OCLN ENTREZGENE
PANTHER PTHR23288 UniProtKB/TrEMBL
  PTHR23288:SF4 UniProtKB/TrEMBL
Pfam MARVEL UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/TrEMBL
PIRSF Occludin UniProtKB/TrEMBL
PRINTS OCCLUDIN UniProtKB/TrEMBL
PROSITE MARVEL UniProtKB/TrEMBL
UniGene Ssc.42509 ENTREZGENE
UniProt A0A287AL69_PIG UniProtKB/TrEMBL
  A0A4X1UHY5_PIG UniProtKB/TrEMBL
  A0A4X1UHZ7_PIG UniProtKB/TrEMBL
  C5JA71 ENTREZGENE
  F1SK31 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary I3LGZ9 UniProtKB/TrEMBL
VGNC ID VGNC:91013 ENTREZGENE