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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732985
Species: Homo sapiens
RGD Object: Gene
Symbol: OCLN
Name: occludin
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OCLNdecreases expressionISOOcln (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA; Trinitrobenzenesulfonic Acid results in decreased expression of OCLN proteinPMID:22147983 PMID:22849695 PMID:25307695
OCLNdecreases expressionISOOcln (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA; Trinitrobenzenesulfonic Acid results in decreased expression of OCLN proteinPMID:35290143
OCLNmultiple interactionsISOOcln (Mus musculus)6480464CTDDexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein]PMID:22849695 PMID:25307695
OCLNmultiple interactionsISOOcln (Rattus norvegicus)6480464CTDoxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein]PMID:35290143
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