CRP (C-reactive protein) - Rat Genome Database

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Gene: CRP (C-reactive protein) Homo sapiens
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Symbol: CRP
Name: C-reactive protein
RGD ID: 736633
HGNC Page HGNC:2367
Description: Enables several functions, including complement component C1q complex binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including negative regulation of macrophage derived foam cell differentiation; positive regulation of superoxide anion generation; and regulation of gene expression. Acts upstream of or within vasoconstriction. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Biomarker of several diseases, including auditory system disease (multiple); autoimmune disease (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-reactive protein, pentraxin-related; c-reactive protein, petaxin related; MGC149895; MGC88244; pentraxin 1; PTX1
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CRPP1  
Allele / Splice: See ClinVar data
Candidate Gene For: GLUCO117_H GLUCO120_H GLUCO149_H GLUCO177_H GLUCO223_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,712,289 - 159,714,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,712,289 - 159,714,589 (-)EnsemblGRCh38hg38GRCh38
GRCh371159,682,079 - 159,684,379 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,948,703 - 157,951,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,495,152 - 156,497,452NCBI
Celera1132,750,525 - 132,752,817 (-)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,038,539 - 131,040,831 (-)NCBIHuRef
CHM1_11161,076,594 - 161,078,894 (-)NCBICHM1_1
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
CRPHumanabdominal aortic aneurysm  IEP 13782270protein:increased expression:plasmaRGD 
CRPHumanAcute Coronary Syndrome  IEP 9491837protein:increased expression: :RGD 
CRPHumanAcute Coronary Syndrome  IDA 6907401 RGD 
CRPHumanacute kidney failure  ISORGD:24116903282protein:increased expression:serumRGD 
CRPHumanacute kidney failure  IDA 6906888associated with Myocardial Infarction;RGD 
CRPHumanacute stress disorder  IEP 9585647 RGD 
CRPHumanAcute Uveitis  IEP 9491833protein:increased expression:serum:RGD 
CRPHumanAcute Uveitis  ISORGD:24119491782protein:increased expression:plasma:RGD 
CRPHumanaggressive periodontitis  IEP 9491835protein:increased expression:serum:RGD 
CRPHumanAlbuminuria  IEP 6909147associated with hypertensionRGD 
CRPHumanAlbuminuria severityIEP 6907441associated with Anemia, Sickle Cell; protein:increased expression:serumRGD 
CRPHumanalcoholic liver cirrhosis severityIEP 6482305 RGD 
CRPHumanAlzheimer's disease  ISORGD:103986904208 RGD 
CRPHumanankylosing spondylitis disease_progressionIEP 6482308 RGD 
CRPHumanankylosing spondylitis  IEP 9491788protein:increased expression:serum:RGD 
CRPHumanantiphospholipid syndrome  IDA 6907402 RGD 
CRPHumananxiety disorder  IEP 9491832associated with Coronary Disease;RGD 
CRPHumanarthritis  IAGP 5508454associated with Lupus Erythematosus, Systemic;DNA:SNPRGD 
CRPHumanaspergillosis treatmentIEP 9495929 RGD 
CRPHumanasthma  IEP 5131288protein:increased expression:serum RGD 
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Original Reference(s)
CRPHumanautoimmune interstitial lung, joint, and kidney disease  IAGPRGD:1518145408554872ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndromeClinVarPMID:28492532
CRPHumangastrointestinal stromal tumor  IAGPRGD:1267343158554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
CRPHumanInflammation  IAGPRGD:1530021658554872ClinVar Annotator: match by term: InflammationClinVar 
CRPHumanparathyroid carcinoma  IAGPRGD:1267343158554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
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Original Reference(s)
CRPHumanAcute Coronary Syndrome  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15966572|PMID:23305094
CRPHumananxiety disorder  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20194079
CRPHumanArsenic Poisoning  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22521605
CRPHumanatherosclerosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16931792
CRPHumancardiovascular system disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12876635|PMID:16332659|PMID:29114965
CRPHumancerebrovascular disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:29114965
CRPHumanChemical and Drug Induced Liver Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249
CRPHumanchronic obstructive pulmonary disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:29329563
CRPHumancongestive heart failure  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16360360
CRPHumancoronary artery disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:24868163
CRPHumanCOVID-19  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:32534021
CRPHumanCrohn's disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:11339241
CRPHumandiabetic retinopathy  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20012460
CRPHumandisease by infectious agent  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:3285537
CRPHumandisease of metabolism  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19131468
CRPHumanDrug Hypersensitivity Syndrome  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:34142820
CRPHumanend stage renal disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19539174
CRPHumanExperimental Arthritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19330884
CRPHumanheart disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17388968
CRPHumanhepatocellular carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19363144
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Original Reference(s)
CRPHuman(-)-epigallocatechin 3-gallate decreases expressionISORGD:24116480464epigallocatechin gallate results in decreased expression of CRP mRNA; epigallocatechin gallate results in decreased expression more ...CTDPMID:19782057
CRPHuman(1->4)-beta-D-glucan multiple interactionsISORGD:103986480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CRP mRNACTDPMID:36331819
CRPHuman(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid affects expressionEXP 6480464docosapentaenoic acid affects the expression of CRP proteinCTDPMID:22113248
CRPHuman(R)-lipoic acid multiple interactionsISORGD:24116480464Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression more ...CTDPMID:26276312
CRPHuman(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP proteinCTDPMID:18191645
CRPHuman1,1-dichloroethene increases expressionISORGD:24116480464vinylidene chloride results in increased expression of CRP proteinCTDPMID:14565772
CRPHuman1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine increases expressionEXP 64804641-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CRP mRNACTDPMID:16386258
CRPHuman17alpha-ethynylestradiol multiple interactionsEXP 6480464[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CRP protein; [Ethinyl Estradiol more ...CTDPMID:12616983|PMID:14557435|PMID:15769986|PMID:16982228|PMID:17105841|PMID:17903073
CRPHuman17alpha-ethynylestradiol affects expressionISORGD:103986480464Ethinyl Estradiol affects the expression of CRP mRNACTDPMID:14976129
CRPHuman17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of CRP proteinCTDPMID:10959719
CRPHuman17beta-estradiol affects expressionEXP 6480464Estradiol analog affects the expression of CRP proteinCTDPMID:12876635
CRPHuman17beta-estradiol increases expressionISORGD:103986480464Estradiol results in increased expression of CRP mRNACTDPMID:39298647
CRPHuman17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with dienogest] results in increased expression of CRP proteinCTDPMID:15970291
CRPHuman17beta-estradiol increases expressionISORGD:24116480464Estradiol results in increased expression of CRP mRNA; Estradiol results in increased expression of CRP more ...CTDPMID:20838740|PMID:32145629
CRPHuman17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of CRP proteinCTDPMID:12616983
CRPHuman2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:241164804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRP mRNACTDPMID:20056577
CRPHuman2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:24116480464Tetrachlorodibenzodioxin affects the expression of CRP mRNACTDPMID:22298810
CRPHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:24116480464Tetrachlorodibenzodioxin results in decreased expression of CRP mRNACTDPMID:18796159|PMID:21215274|PMID:21724226|PMID:33387578
CRPHuman2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISORGD:1039864804642,2',4,4',5-brominated diphenyl ether affects the expression of CRP mRNACTDPMID:38648751
CRPHuman2-acetyl-1-alkyl-sn-glycero-3-phosphocholine increases expressionEXP 6480464Platelet Activating Factor results in increased expression of CRP mRNACTDPMID:16386258

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Biological Process
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Original Reference(s)
CRPHumanacute-phase response  ISORGD:24119068941 RGDPMID:7056568|REF_RGD_ID:9585996
CRPHumanacute-phase response involved_inIEAUniProtKB-KW:KW-0011150520179 UniProtGO_REF:0000043
CRPHumanacute-phase response involved_inTAS 150520179 PMID:2477488BHF-UCLPMID:2477488
CRPHumancellular response to calcium ion  ISORGD:24119068941 RGDPMID:22090504|REF_RGD_ID:6904210
CRPHumancellular response to interleukin-6  ISORGD:24119068941 RGDPMID:20100497|REF_RGD_ID:9586010
CRPHumancellular response to nitric oxide  ISORGD:24119068941 RGDPMID:9704587|REF_RGD_ID:9586007
CRPHumancomplement activation, classical pathway  ISORGD:24119068941 RGDPMID:16367929|REF_RGD_ID:1580273
CRPHumandefense response to Gram-positive bacterium involved_inTAS 150520179 PMID:2477488BHF-UCLPMID:2477488
CRPHumaninflammatory response involved_inTAS 150520179 PMID:10408362PINCPMID:10408362
CRPHumaninnate immune response involved_inIBAPANTHER:PTN001453725|UniProtKB:P02743150520179 GO_CentralGO_REF:0000033
CRPHumannegative regulation of lipid storage involved_inIDA 150520179 PMID:18322245BHF-UCLPMID:18322245
CRPHumannegative regulation of macrophage derived foam cell differentiation involved_inIDA 150520179 PMID:18322245BHF-UCLPMID:18322245
CRPHumannegative regulation of mononuclear cell proliferation involved_inIDA 150520179 PMID:29202702CACAOPMID:29202702
CRPHumannegative regulation of superoxide anion generation  ISORGD:24119068941 RGDPMID:9767445|REF_RGD_ID:9586000
CRPHumanopsonization involved_inTAS 150520179 PMID:2477488BHF-UCLPMID:2477488
CRPHumanpositive regulation of dendrite development  ISORGD:24119068941 RGDPMID:22090504|REF_RGD_ID:6904210
CRPHumanpositive regulation of gene expression involved_inIDA 150520179 PMID:24141169AgBasePMID:24141169
CRPHumanpositive regulation of nitric oxide biosynthetic process  ISORGD:24119068941 RGDPMID:9767445|REF_RGD_ID:9586000
CRPHumanpositive regulation of superoxide anion generation involved_inIDA 150520179 PMID:24141169AgBasePMID:24141169
CRPHumanprotein polymerization  ISORGD:24119068941 RGDPMID:1737750|REF_RGD_ID:1298812
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Cellular Component

  
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CRPHumanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
CRPHumanextracellular region located_inNAS 150520179 PMID:14718574UniProtPMID:14718574
CRPHumanextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
CRPHumanextracellular space  ISORGD:24119068941 RGDPMID:1737750|PMID:7056568|REF_RGD_ID:1298812|REF_RGD_ID:9585996
CRPHumanextracellular space is_active_inIBAPANTHER:PTN001453725|RGD:2411|UniProtKB:P02741|UniProtKB:P02743150520179 GO_CentralGO_REF:0000033
CRPHumanextracellular space located_inIDA 150520179 PMID:21323571, PMID:23544079BHF-UCLPMID:21323571|PMID:23544079
CRPHumanfilopodium  ISORGD:24119068941 RGDPMID:22090504|REF_RGD_ID:6904210
CRPHumangrowth cone  ISORGD:24119068941 RGDPMID:22090504|REF_RGD_ID:6904210

Molecular Function
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CRPHumancalcium ion binding enablesIDA 150520179 PMID:23544079BHF-UCLPMID:23544079
CRPHumancholesterol binding  ISORGD:24119068941 RGDPMID:15766555|REF_RGD_ID:1580272
CRPHumancholine binding enablesTAS 150520179 PMID:2477488BHF-UCLPMID:2477488
CRPHumancomplement component C1q complex binding enablesIDA 150520179 PMID:23544079BHF-UCLPMID:23544079
CRPHumancomplement component C1q complex binding enablesIBAPANTHER:PTN001453725|UniProtKB:P02741|UniProtKB:P02743150520179 GO_CentralGO_REF:0000033
CRPHumanidentical protein binding enablesIPIUniProtKB:P02741150520179 PMID:16642000, PMID:18786923, PMID:19084272, PMID:19680263, PMID:19850925IntActPMID:16642000|PMID:18786923|PMID:19084272|PMID:19680263|PMID:19850925
CRPHumanidentical protein binding  ISORGD:24119068941homodimerizationRGDPMID:1737750|REF_RGD_ID:1298812
CRPHumanlow-density lipoprotein particle binding  ISORGD:24119068941 RGDPMID:3800992|REF_RGD_ID:9586005
CRPHumanlow-density lipoprotein particle binding enablesIBAPANTHER:PTN000444391|RGD:2411|UniProtKB:P02741150520179 GO_CentralGO_REF:0000033
CRPHumanlow-density lipoprotein particle binding enablesIDA 150520179 PMID:18322245BHF-UCLPMID:18322245
CRPHumanlow-density lipoprotein particle receptor binding enablesIPIUniProtKB:Q9TTK7150520179 PMID:24141169AgBasePMID:24141169
CRPHumanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
CRPHumanprotein binding  ISORGD:22329068941 RGDPMID:12871224|REF_RGD_ID:5129545
CRPHumanprotein binding enablesIPIUniProtKB:P08603|UniProtKB:Q92496-1|UniProtKB:Q92496-3150520179 PMID:19084272IntActPMID:19084272
CRPHumanprotein binding enablesIPIUniProtKB:P08603|UniProtKB:P08603-PRO_0000005894|UniProtKB:Q02985|UniProtKB:Q03591|UniProtKB:Q92496-1|UniProtKB:Q92496-3|UniProtKB:Q9BXR6-PRO_0000005900150520179 PMID:28533443IntActPMID:28533443
CRPHumanprotein binding enablesIPIUniProtKB:O00602150520179 PMID:21037097UniProtPMID:21037097
CRPHumanprotein binding enablesIPIUniProtKB:Q96IJ6150520179 PMID:25416956IntActPMID:25416956
CRPHumanprotein binding enablesIPIUniProtKB:P27918150520179 PMID:26984957IntActPMID:26984957
CRPHumanprotein binding enablesIPIUniProtKB:P31995150520179 PMID:17785206IntActPMID:17785206
CRPHumanprotein binding enablesIPIUniProtKB:P08603150520179 PMID:17293598, PMID:17339482, PMID:18786923, PMID:19680263, PMID:19850925IntActPMID:17293598|PMID:17339482|PMID:18786923|PMID:19680263|PMID:19850925
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RGD Manual Annotations


  
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Original Reference(s)
CRPHumanclassical complement pathway  ISORGD:24111580273 RGD 

Imported Annotations - PID (archival)

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Original Reference(s)
CRPHumaninterleukin-6 signaling pathway   EXP 6484113 PIDPID:200146
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Original Reference(s)
CRPHumanGastrointestinal stroma tumor  IAGPRGD:1267343158554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
CRPHumanParathyroid carcinoma  IAGPRGD:1267343158554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532

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Reference Title
Reference Citation
1. Postoperative atrial fibrillation is not correlated to C-reactive protein. Ahlsson AJ, etal., Ann Thorac Surg. 2007 Apr;83(4):1332-7.
2. Hospitalised patients with Influenza A (H1N1) in the Royal Hospital, Oman: Experience of a tertiary care hospital, July-December 2009. Al-Lawati J, etal., Sultan Qaboos Univ Med J. 2010 Dec;10(3):326-34. Epub 2010 Nov 14.
3. Plasma oxidative and inflammatory markers in patients with idiopathic Parkinson's disease. Andican G, etal., Acta Neurol Belg. 2012 Feb 9.
4. The value of C-reactive protein determination in patients with renal colic to decide urgent urinary diversion. Angulo JC, etal., Urology. 2010 Aug;76(2):301-6. Epub 2010 Mar 5.
5. The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model. Arafa NM, etal., Toxicol Ind Health. 2011 Dec 15.
6. Atheroma plaque, metabolic syndrome and inflammation in patients with psoriasis. Arias-Santiago S, etal., Eur J Dermatol. 2012 Apr 16.
7. C-reactive protein (CRP): An important diagnostic and prognostic tool in nursing-home-associated pneumonia. Arinzon Z, etal., Arch Gerontol Geriatr. 2011 Mar 23.
8. Long-term outcome of tumor necrosis factor alpha antagonist's treatment in pediatric Crohn's disease. Assa A, etal., J Crohns Colitis. 2012 Apr 4.
9. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Bankier B, etal., Eur Heart J. 2008 Sep;29(18):2212-7. doi: 10.1093/eurheartj/ehn326. Epub 2008 Jul 4.
10. The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. Bekyarova G, etal., Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):299-303.
11. Promotion of beta-amyloid production by C-reactive protein and its implications in the early pathogenesis of Alzheimer's disease. Bi BT, etal., Neurochem Int. 2012 Feb;60(3):257-66. Epub 2011 Dec 19.
12. Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease. Biljak VR, etal., Platelets. 2011 Apr 20.
13. Relationship between inflammatory markers, oxidant-antioxidant status and intima-media thickness in prepubertal children with juvenile idiopathic arthritis. Breda L, etal., Clin Res Cardiol. 2012 Aug 11.
14. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation. Bucolo C, etal., J Pharm Pharmacol. 2014 Jul;66(7):954-60. doi: 10.1111/jphp.12224. Epub 2014 Feb 12.
15. Synergistic effects of aminoglycosides and fosfomycin on Pseudomonas aeruginosa in vitro and biofilm infections in a rat model. Cai Y, etal., J Antimicrob Chemother. 2009 Sep;64(3):563-6. Epub 2009 Jun 26.
16. Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis. Caldas JP, etal., J Pediatr (Rio J). 2008 Nov-Dec;84(6):536-42. doi: doi:10.2223/JPED.1838.
17. Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis. Carlucci F, etal., Arthritis Rheum. 2010 Jan;62(1):245-9.
18. Early proinflammatory cytokines and C-reactive protein trends as predictors of outcome in invasive Aspergillosis. Chai L, etal., J Infect Dis. 2010 Nov 1;202(9):1454-62. doi: 10.1086/656527.
19. Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. Chang CC, etal., Clin Chem Lab Med. 2011 Oct;49(10):1655-60. doi: 10.1515/CCLM.2011.650. Epub 2011 Jun 17.
20. Augmented nitric oxide generation in neutrophils: oxidative and pro-inflammatory implications in hypertension. Chatterjee M, etal., Free Radic Res. 2009 Dec;43(12):1195-204.
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PMID:265538   PMID:403526   PMID:762075   PMID:1477104   PMID:1989977   PMID:2477447   PMID:2477488   PMID:2997165   PMID:3759147   PMID:3840479   PMID:6427230   PMID:6685157  
PMID:6693419   PMID:6857266   PMID:7881902   PMID:8144569   PMID:8482924   PMID:8599761   PMID:8613143   PMID:10368284   PMID:10408362   PMID:10490997   PMID:10675363   PMID:11027634  
PMID:11801683   PMID:11947917   PMID:11964845   PMID:11991668   PMID:12033985   PMID:12037301   PMID:12055255   PMID:12102655   PMID:12104096   PMID:12151853   PMID:12186793   PMID:12198121  
PMID:12213988   PMID:12218140   PMID:12234944   PMID:12244213   PMID:12351483   PMID:12390313   PMID:12393563   PMID:12426217   PMID:12426218   PMID:12460042   PMID:12471137   PMID:12477932  
PMID:12529491   PMID:12552583   PMID:12563060   PMID:12594844   PMID:12616974   PMID:12618085   PMID:12637157   PMID:12654086   PMID:12663465   PMID:12701054   PMID:12716818   PMID:12783932  
PMID:12819031   PMID:12821545   PMID:12835213   PMID:12835218   PMID:12842840   PMID:12850811   PMID:12869354   PMID:12892901   PMID:12934049   PMID:12975260   PMID:14500938   PMID:14506615  
PMID:14508181   PMID:14592848   PMID:14634117   PMID:14718574   PMID:14744975   PMID:14967730   PMID:14967837   PMID:14983228   PMID:15044210   PMID:15047644   PMID:15078802   PMID:15136507  
PMID:15271790   PMID:15277326   PMID:15286457   PMID:15304023   PMID:15306744   PMID:15308783   PMID:15337754   PMID:15358216   PMID:15380464   PMID:15448085   PMID:15456743   PMID:15469865  
PMID:15472120   PMID:15489334   PMID:15517131   PMID:15565375   PMID:15579759   PMID:15585208   PMID:15585211   PMID:15585215   PMID:15585218   PMID:15591095   PMID:15653107   PMID:15692104  
PMID:15746456   PMID:15766555   PMID:15772777   PMID:15777561   PMID:15778807   PMID:15795363   PMID:15797975   PMID:15798948   PMID:15798966   PMID:15808312   PMID:15853546   PMID:15859024  
1 to 10 of 204 rows



CRP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,712,289 - 159,714,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,712,289 - 159,714,589 (-)EnsemblGRCh38hg38GRCh38
GRCh371159,682,079 - 159,684,379 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,948,703 - 157,951,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,495,152 - 156,497,452NCBI
Celera1132,750,525 - 132,752,817 (-)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,038,539 - 131,040,831 (-)NCBIHuRef
CHM1_11161,076,594 - 161,078,894 (-)NCBICHM1_1
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBIT2T-CHM13v2.0
Crp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,525,623 - 172,527,533 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,525,622 - 172,660,598 (+)EnsemblGRCm39 Ensembl
GRCm381172,698,056 - 172,699,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,698,055 - 172,833,031 (+)EnsemblGRCm38mm10GRCm38
MGSCv371174,628,187 - 174,630,097 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361174,534,741 - 174,536,635 (+)NCBIMGSCv36mm8
Celera1175,548,254 - 175,550,142 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.13NCBI
Crp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,694,062 - 87,695,978 (+)NCBIGRCr8
mRatBN7.21385,135,384 - 85,175,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,124,977 - 85,175,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,664,967 - 87,666,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,065,246 - 89,067,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,249,976 - 86,251,928 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,080,448 - 91,081,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,599,418 - 95,600,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,702,243 - 88,703,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,891,058 - 88,892,928 (+)NCBI
Celera1384,770,843 - 84,771,753 (+)NCBICelera
Cytogenetic Map13q24NCBI
CRP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,140,428 - 90,143,900 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,880,463 - 89,883,937 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,062,102 - 135,064,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11138,858,353 - 138,860,652 (-)NCBIpanpan1.1PanPan1.1panPan2
CRP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,396,787 - 22,398,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,396,263 - 22,399,166 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,473,724 - 22,475,116 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03822,519,785 - 22,521,176 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,519,714 - 22,522,146 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,286,369 - 22,287,757 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,818,770 - 22,820,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,230,160 - 23,231,548 (+)NCBIUU_Cfam_GSD_1.0
Crp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050585,866,551 - 5,870,192 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740883,272 - 890,606 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936740885,855 - 888,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,793,350 - 90,805,218 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,793,361 - 90,801,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,764,964 - 98,772,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,232,262 - 4,235,826 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,232,913 - 4,235,377 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660383,340,251 - 3,342,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,531,571 - 1,533,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247941,531,555 - 1,533,804 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in CRP
25 total Variants

1 to 10 of 36 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1 copy number loss See cases [RCV000051172] Chr1:159479887..166895086 [GRCh38]
Chr1:159449677..166864323 [GRCh37]
Chr1:157716301..165130947 [NCBI36]
Chr1:1q23.2-24.1
pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1
pathogenic
GRCh38/hg38 1q23.1-23.3(chr1:156664483-160727411)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|See cases [RCV000051851] Chr1:156664483..160727411 [GRCh38]
Chr1:156634275..160697201 [GRCh37]
Chr1:154900899..158963825 [NCBI36]
Chr1:1q23.1-23.3
pathogenic
NM_000567.2(CRP):c.31A>C (p.Thr11Pro) single nucleotide variant Malignant melanoma [RCV000064246] Chr1:159714455 [GRCh38]
Chr1:159684245 [GRCh37]
Chr1:157950869 [NCBI36]
Chr1:1q23.2
not provided
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_000567.3(CRP):c.576C>G (p.Ile192Met) single nucleotide variant not specified [RCV004299255] Chr1:159713624 [GRCh38]
Chr1:159683414 [GRCh37]
Chr1:1q23.2
uncertain significance
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
1 to 10 of 36 rows

Predicted Target Of
Summary Value
Count of predictions:2538
Count of miRNA genes:796
Interacting mature miRNAs:901
Transcripts:ENST00000255030, ENST00000343919, ENST00000368110, ENST00000368111, ENST00000368112, ENST00000437342, ENST00000473196, ENST00000489317
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 12 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
596956916GWAS1076435_HC-reactive protein measurement QTL GWAS1076435 (human)1e-48C-reactive protein measurement1159713648159713649Human
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human
597099445GWAS1195519_HC-reactive protein measurement QTL GWAS1195519 (human)2e-157C-reactive protein measurementblood C-reactive protein level (CMO:0003160)1159712443159712444Human
597116658GWAS1212732_HC-reactive protein measurement QTL GWAS1212732 (human)5e-23C-reactive protein measurementblood C-reactive protein level (CMO:0003160)1159714026159714027Human
597147505GWAS1243579_Hlow density lipoprotein cholesterol measurement QTL GWAS1243579 (human)2e-205low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)1159712443159712444Human
597115793GWAS1211867_HC-reactive protein measurement QTL GWAS1211867 (human)2e-200C-reactive protein measurementblood C-reactive protein level (CMO:0003160)1159713648159713649Human
597116657GWAS1212731_HC-reactive protein measurement QTL GWAS1212731 (human)6e-09C-reactive protein measurementblood C-reactive protein level (CMO:0003160)1159714007159714008Human
597222863GWAS1318937_HC-reactive protein measurement QTL GWAS1318937 (human)4e-287C-reactive protein measurementblood C-reactive protein level (CMO:0003160)1159714024159714025Human
597232625GWAS1328699_Herythropoetin measurement QTL GWAS1328699 (human)4e-23blood hormone amount (VT:0005418)1159713301159713302Human
597250608GWAS1346682_HC-reactive protein measurement QTL GWAS1346682 (human)1e-48C-reactive protein measurementblood C-reactive protein level (CMO:0003160)1159713648159713649Human

1 to 10 of 12 rows
D1S3335  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,085 - 159,682,407UniSTSGRCh37
Build 361157,948,709 - 157,949,031RGDNCBI36
Celera1132,750,531 - 132,750,853RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,038,545 - 131,038,867UniSTS
GeneMap99-GB4 RH Map1587.74UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map11436.5UniSTS
RH11610  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,143 - 159,682,280UniSTSGRCh37
Build 361157,948,767 - 157,948,904RGDNCBI36
Celera1132,750,589 - 132,750,726RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,038,603 - 131,038,740UniSTS
GeneMap99-GB4 RH Map1574.66UniSTS
NCBI RH Map11436.5UniSTS
G54038  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,155 - 159,682,306UniSTSGRCh37
Build 361157,948,779 - 157,948,930RGDNCBI36
Celera1132,750,601 - 132,750,752RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,038,615 - 131,038,766UniSTS
PMC311069P8  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,194 - 159,682,273UniSTSGRCh37
Build 361157,948,818 - 157,948,897RGDNCBI36
Celera1132,750,640 - 132,750,719RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,038,654 - 131,038,733UniSTS
PMC98081P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,683,463 - 159,683,784UniSTSGRCh37
Build 361157,950,087 - 157,950,408RGDNCBI36
Celera1132,751,909 - 132,752,230RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,039,923 - 131,040,244UniSTS
PMC98081P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,683,329 - 159,683,922UniSTSGRCh37
Build 361157,949,953 - 157,950,546RGDNCBI36
Celera1132,751,775 - 132,752,368RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,039,789 - 131,040,382UniSTS
CRP_559  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,384 - 159,683,084UniSTSGRCh37
Build 361157,949,008 - 157,949,708RGDNCBI36
Celera1132,750,830 - 132,751,530RGD
HuRef1131,038,844 - 131,039,544UniSTS
GDB:190880  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,683,978 - 159,684,116UniSTSGRCh37
Build 361157,950,602 - 157,950,740RGDNCBI36
Celera1132,752,424 - 132,752,554RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,040,438 - 131,040,568UniSTS
Marshfield Genetic Map1165.62UniSTS
WIAF-2117  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,130 - 159,682,357UniSTSGRCh37
Build 361157,948,754 - 157,948,981RGDNCBI36
Celera1132,750,576 - 132,750,803RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,038,590 - 131,038,817UniSTS
GeneMap99-GB4 RH Map1588.98UniSTS
RH18109  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,514 - 159,682,748UniSTSGRCh37
Build 361157,949,138 - 157,949,372RGDNCBI36
Celera1132,750,960 - 132,751,194RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,038,974 - 131,039,208UniSTS
GeneMap99-GB4 RH Map1574.66UniSTS
NCBI RH Map11436.5UniSTS
RH11065  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,683,281 - 159,683,541UniSTSGRCh37
Build 361157,949,905 - 157,950,165RGDNCBI36
Celera1132,751,727 - 132,751,987RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,039,741 - 131,040,001UniSTS
GeneMap99-GB4 RH Map1587.43UniSTS
NCBI RH Map11436.5UniSTS
D1S2384  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,467 - 159,682,815UniSTSGRCh37
Build 361157,949,091 - 157,949,439RGDNCBI36
Celera1132,750,913 - 132,751,261RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,038,927 - 131,039,275UniSTS
Whitehead-YAC Contig Map1 UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1176 1952 2311 1795 3387 1517 1889 2 593 975 444 1713 5191 4908 1 2686 605 1377 1217 152


1 to 30 of 31 rows
RefSeq Transcripts NG_013007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF442818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF449713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI609949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL445528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG533281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG618397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG618967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA514417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K00518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC276934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC276935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC276936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC276937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC276938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M35163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 31 rows

Ensembl Acc Id: ENST00000255030   ⟹   ENSP00000255030
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,712,289 - 159,714,589 (-)Ensembl
Ensembl Acc Id: ENST00000368110   ⟹   ENSP00000357091
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,712,563 - 159,714,589 (-)Ensembl
Ensembl Acc Id: ENST00000368111   ⟹   ENSP00000357092
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,712,504 - 159,714,589 (-)Ensembl
Ensembl Acc Id: ENST00000368112   ⟹   ENSP00000357093
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,712,410 - 159,714,589 (-)Ensembl
Ensembl Acc Id: ENST00000437342   ⟹   ENSP00000402788
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,712,293 - 159,714,589 (-)Ensembl
Ensembl Acc Id: ENST00000473196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,712,291 - 159,713,767 (-)Ensembl
Ensembl Acc Id: ENST00000489317
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,712,535 - 159,714,080 (-)Ensembl
RefSeq Acc Id: NM_000567   ⟹   NP_000558
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,712,289 - 159,714,589 (-)NCBI
GRCh371159,682,079 - 159,684,396 (-)NCBI
Build 361157,948,703 - 157,951,003 (-)NCBI Archive
HuRef1131,038,539 - 131,040,831 (-)ENTREZGENE
CHM1_11161,076,594 - 161,078,894 (-)NCBI
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329057   ⟹   NP_001315986
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,712,289 - 159,714,589 (-)NCBI
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329058   ⟹   NP_001315987
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,712,289 - 159,714,589 (-)NCBI
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001382703   ⟹   NP_001369632
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,712,289 - 159,714,589 (-)NCBI
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBI
Sequence:
RefSeq Acc Id: NP_000558   ⟸   NM_000567
- Peptide Label: isoform 1 precursor
- UniProtKB: Q08AK3 (UniProtKB/Swiss-Prot),   D3DVE0 (UniProtKB/Swiss-Prot),   D3DVD9 (UniProtKB/Swiss-Prot),   A8K078 (UniProtKB/Swiss-Prot),   Q8WW75 (UniProtKB/Swiss-Prot),   P02741 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001315987   ⟸   NM_001329058
- Peptide Label: isoform 2 precursor
- UniProtKB: P02741 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001315986   ⟸   NM_001329057
- Peptide Label: isoform 1 precursor
- UniProtKB: Q08AK3 (UniProtKB/Swiss-Prot),   D3DVE0 (UniProtKB/Swiss-Prot),   D3DVD9 (UniProtKB/Swiss-Prot),   A8K078 (UniProtKB/Swiss-Prot),   Q8WW75 (UniProtKB/Swiss-Prot),   P02741 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001369632   ⟸   NM_001382703
- Peptide Label: isoform 3 precursor
- UniProtKB: Q5VVP7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000255030   ⟸   ENST00000255030
Pentraxin (PTX)

Name Modeler Protein Id AA Range Protein Structure
AF-P02741-F1-model_v2 AlphaFold P02741 1-224 view protein structure

RGD ID:6849600
Promoter ID:EP26029
Type:single initiation site
Name:HS_CRP
Description:C-reactive protein.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Primer extension; Primer extension; transgenic organisms
Regulation:liver; (induced by or strongly expressed in) acute phase
Position:
Human AssemblyChrPosition (strand)Source
Build 361157,951,003 - 157,951,063EPD
RGD ID:6857722
Promoter ID:EPDNEW_H2026
Type:multiple initiation site
Name:CRP_1
Description:C-reactive protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,714,589 - 159,714,649EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
COSMIC CRP COSMIC
Ensembl Genes ENSG00000132693 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000255030 ENTREZGENE
  ENST00000255030.9 UniProtKB/Swiss-Prot
  ENST00000368110 ENTREZGENE
  ENST00000368112 ENTREZGENE
  ENST00000368112.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
GTEx ENSG00000132693 GTEx
HGNC ID HGNC:2367 ENTREZGENE
Human Proteome Map CRP Human Proteome Map
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Pentaxin_CS UniProtKB/Swiss-Prot
  Pentraxin-related UniProtKB/Swiss-Prot
  Pentraxin_domain UniProtKB/Swiss-Prot
KEGG Report hsa:1401 UniProtKB/Swiss-Prot
NCBI Gene 1401 ENTREZGENE
OMIM 123260 OMIM
PANTHER C-REACTIVE PROTEIN UniProtKB/Swiss-Prot
  C-REACTIVE PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam Pentaxin UniProtKB/Swiss-Prot
PharmGKB CRP RGD, PharmGKB
PRINTS PENTAXIN UniProtKB/Swiss-Prot
PROSITE PTX_1 UniProtKB/Swiss-Prot
  PTX_2 UniProtKB/Swiss-Prot
SMART PTX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt A8K078 ENTREZGENE
  C9JRE9_HUMAN UniProtKB/TrEMBL
  CRP_HUMAN UniProtKB/Swiss-Prot
  D3DVD9 ENTREZGENE
  D3DVE0 ENTREZGENE
  P02741 ENTREZGENE
  Q08AK3 ENTREZGENE
  Q5VVP7 ENTREZGENE, UniProtKB/TrEMBL
  Q8WW75 ENTREZGENE
UniProt Secondary A8K078 UniProtKB/Swiss-Prot
  D3DVD9 UniProtKB/Swiss-Prot
  D3DVE0 UniProtKB/Swiss-Prot
  Q08AK3 UniProtKB/Swiss-Prot
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-23 CRP  C-reactive protein    C-reactive protein, pentraxin-related  Symbol and/or name change 5135510 APPROVED