RGD Reference Report - Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. - Rat Genome Database

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Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients.

Authors: Bankier, B  Barajas, J  Martinez-Rumayor, A  Januzzi, JL 
Citation: Bankier B, etal., Eur Heart J. 2008 Sep;29(18):2212-7. doi: 10.1093/eurheartj/ehn326. Epub 2008 Jul 4.
RGD ID: 9491832
Pubmed: PMID:18603621   (View Abstract at PubMed)
DOI: DOI:10.1093/eurheartj/ehn326   (Journal Full-text)

AIMS: Comprehensive evaluation of major depressive disorder (MDD), anxiety disorder, and MDD in conjunction with anxiety disorder in stable coronary heart disease (CHD) patients, including cardiac biomarkers such as C-reactive protein (CRP), troponin T (TnT), and amino-terminal pro-B-type brain natriuretic peptide (NT-proBNP). METHODS AND RESULTS: Cross-sectional study of a consecutive series of 120 stable CHD outpatients (n = 30 with MDD, n = 30 with anxiety disorder, n = 30 with MDD and anxiety disorder, n = 30 with no psychiatric disorder). Psychiatric diagnoses were established by using the structured clinical interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-IV). Binomial logistic regression analyses using cut-off scores of biomarkers as dependent variables showed associations between CRP and generalized anxiety disorder (GAD) (P = 0.04), and education (P = 0.004), whereas MDD, and MDD and anxiety disorder did not reach the significance level. TnT showed relationships with hyperlipidaemia (P = 0.009), history of obesity or overweight (P = 0.04), and education (P = 0.04). NT-proBNP was associated with type II diabetes (P = 0.005). CONCLUSION: After adjusting for relevant demographic, medical, and psychiatric co-variables, CRP was associated with GAD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
anxiety disorder  IEP 9491832associated with Coronary DiseaseRGD 
anxiety disorder  ISOCRP (Homo sapiens)9491832; 9491832associated with Coronary DiseaseRGD 

Objects Annotated

Genes (Rattus norvegicus)
Crp  (C-reactive protein)

Genes (Mus musculus)
Crp  (C-reactive protein, pentraxin-related)

Genes (Homo sapiens)
CRP  (C-reactive protein)


Additional Information