RGD Reference Report - The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients. - Rat Genome Database

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The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients.

Authors: Yuan, Jing  Zou, Rougrong  Zeng, Lijiao  Kou, Shanglong  Lan, Jianfeng  Li, Xiaohe  Liang, Yanhua  Ding, Xiaoyan  Tan, Guoyu  Tang, Shenghong  Liu, Lei  Liu, Yingxia  Pan, Yanchao  Wang, Zhaoqin 
Citation: Yuan J, etal., Inflamm Res. 2020 Jun;69(6):599-606. doi: 10.1007/s00011-020-01342-0. Epub 2020 Mar 29.
RGD ID: 27226695
Pubmed: PMID:32227274   (View Abstract at PubMed)
PMCID: PMC7103893   (View Article at PubMed Central)
DOI: DOI:10.1007/s00011-020-01342-0   (Journal Full-text)


OBJECTIVE: This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People's Hospital, enrolled from Jan 5 to Feb 13, 2020.
METHODS: The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected.
RESULTS: COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin.
CONCLUSIONS: Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CRPHumanCOVID-19 severityIEP protein:increased expression:serum (human)RGD 
CrpRatCOVID-19 severityISOCRP (Homo sapiens)protein:increased expression:serum (human)RGD 
CrpMouseCOVID-19 severityISOCRP (Homo sapiens)protein:increased expression:serum (human)RGD 
IL6HumanCOVID-19 severityIEP protein:increased expression:serum (human)RGD 
Il6RatCOVID-19 severityISOIL6 (Homo sapiens)protein:increased expression:serum (human)RGD 
Il6MouseCOVID-19 severityISOIL6 (Homo sapiens)protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crp  (C-reactive protein)
Il6  (interleukin 6)

Genes (Mus musculus)
Crp  (C-reactive protein, pentraxin-related)
Il6  (interleukin 6)

Genes (Homo sapiens)
CRP  (C-reactive protein)
IL6  (interleukin 6)


Additional Information