RGD Reference Report - [The relationship between inflammatory mediators and pulmonary hypertension in patients with chronic obstructive pulmonary disease]. - Rat Genome Database

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[The relationship between inflammatory mediators and pulmonary hypertension in patients with chronic obstructive pulmonary disease].

Authors: Jiang, Yan-wen  Pang, Li  Fang, Qiu-hong  Ma, Ying-min 
Citation: Jiang YW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2011 Dec;34(12):904-8.
RGD ID: 6482312
Pubmed: PMID:22333502   (View Abstract at PubMed)


OBJECTIVE: The levels of C-reactive protein (CRP), tumor necrosis factor (TNF)-a, brain natriuretic peptide (BNP) and endothelin-1 (ET-1) were investigated to analyze the systemic inflammation in chronic obstructive pulmonary disease (COPD) patients with and without pulmonary hypertension.
METHODS: From January 2006 to December 2010, 89 patients with COPD were enrolled in our hospital. There were 67 males and 22 females, with a mean age of (70 ± 7) and a mean FEV(1) of (47 ± 13)%. Pulmonary pressure was assessed by Doppler echocardiography. The levels of plasma BNP, TNF-a and ET-1 were measured by enzyme-linked immunosorbent assay kits. High-sensitivity plasma CRP level was assessed by chemiluminescent immunoassay.
RESULTS: Forty-two patients were classified as COPD with pulmonary hypertension group and 47 patients as COPD without pulmonary hypertension group. The level of CRP [51.4 mg/L (20.1 - 92.0) mg/L], ET-1 [5.9 ng/L (3.7 - 10.4) ng/L] and BNP [303.2 ng/L (112.5 - 824.7) ng/L] in patients with pulmonary hypertension were significantly higher than in that in patients without hypertension, CRP [26.7 mg/L (11.5 - 62.9) mg/L], ET-1 [2.1 ng/L (1.3 - 4.7) ng/L] and BNP [143.7 ng/L (85.5 - 306.7) ng/L]. The level of TNF-a showed no difference between the 2 groups [8.5 ng/L (4.8 - 13.7) ng/L and 6.7 ng/L (3.2 - 10.3) ng/L], respectively. Multivariate analysis showed that PaO2 (P < 0.05), CRP (P < 0.05) and BNP (P < 0.05) could predict pulmonary hypertension independently.
CONCLUSION: The level of CRP, ET-1 and BNP were related to pulmonary hypertension in COPD patients, suggesting that systemic inflammation play a role in the pathogenesis of pulmonary hypertension in COPD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary hypertension  IEP 6482312associated with Pulmonary Disease and Chronic ObstructiveRGD 
pulmonary hypertension  ISOCRP (Homo sapiens)6482312; 6482312associated with Pulmonary Disease and Chronic ObstructiveRGD 

Objects Annotated

Genes (Rattus norvegicus)
Crp  (C-reactive protein)

Genes (Mus musculus)
Crp  (C-reactive protein, pentraxin-related)

Genes (Homo sapiens)
CRP  (C-reactive protein)


Additional Information