RGD Reference Report - Diagnostic markers of serious bacterial infections in febrile infants younger than 90 days old. - Rat Genome Database

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Diagnostic markers of serious bacterial infections in febrile infants younger than 90 days old.

Authors: Nosrati, A  Ben Tov, A  Reif, S 
Citation: Nosrati A, etal., Pediatr Int. 2014 Feb;56(1):47-52. doi: 10.1111/ped.12191.
RGD ID: 9495911
Pubmed: PMID:23937512   (View Abstract at PubMed)
DOI: DOI:10.1111/ped.12191   (Journal Full-text)

BACKGROUND: The aim of this study was to assess correlations between demographic, clinical and laboratory characteristics and the risk of serious bacterial infection (SBI) in febrile <90-day-old infants. METHODS: Medical records of all infants younger than 90 days old hospitalized at Dana-Dwek Children's Hospital (2006-2008) for evaluation of fever were retrospectively reviewed. Data on clinical, laboratory and demographic characteristics were retrieved and evaluated. RESULTS: Forty-eight of the 401 study infants (12%) had SBI: most of them had urinary tract infection (43 infants; 90% of all SBI), three infants had bacteremia, one had bacterial pneumonia and one had bacterial meningitis. Significant independent clinical predictors for the diagnosis of SBI included duration of fever, absence of rhinitis and the absence of lung and skin manifestations. Significant independent laboratory predictors were absolute neutrophil count (ANC), platelets, blood urea nitrogen and C-reactive protein (CRP) level. On receiver operating characteristic curve analysis, the CRP area under the curve (0.819) was significantly superior to ANC and leukocyte count. CONCLUSION: Of the clinical and laboratory variables selected for evaluation, qualitative CRP was the strongest independent predictor for diagnosing SBI and a significantly better diagnostic marker than clinical characteristics, ANC and white blood cell count.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bacterial infectious disease  IEP 9495911 RGD 
bacterial infectious disease  ISOCRP (Homo sapiens)9495911; 9495911 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crp  (C-reactive protein)

Genes (Mus musculus)
Crp  (C-reactive protein, pentraxin-related)

Genes (Homo sapiens)
CRP  (C-reactive protein)


Additional Information