Mptx1 (mucosal pentraxin 1) - Rat Genome Database

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Gene: Mptx1 (mucosal pentraxin 1) Mus musculus
Analyze
Symbol: Mptx1
Name: mucosal pentraxin 1
RGD ID: 1614365
MGI Page MGI
Description: Predicted to enable complement component C1q complex binding activity. Predicted to be involved in innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human MPTX1 (mucosal pentraxin 1 (pseudogene)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1810030J14Rik; AV054416; MGC35753; Mptx; mucosal pentraxin
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,158,085 - 174,160,443 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1174,158,084 - 174,160,439 (+)EnsemblGRCm39 Ensembl
GRCm381174,330,518 - 174,332,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,330,518 - 174,332,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv371176,260,649 - 176,263,008 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,167,194 - 176,169,548 (+)NCBIMGSCv36mm8
Celera1180,288,255 - 180,290,613 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mptx1Mouse1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Mptx1Mouse1,2-dimethylhydrazine decreases expressionISOMptx1 (Rattus norvegicus)64804641 and 2-Dimethylhydrazine results in decreased expression of MPTX1 mRNACTDPMID:27840820
Mptx1Mouse1,2-dimethylhydrazine multiple interactionsISOMptx1 (Rattus norvegicus)6480464APC protein affects the reaction [1 and 2-Dimethylhydrazine results in decreased expression of MPTX1 mRNA]CTDPMID:27840820
Mptx1Mouse2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Mptx1Mouse2,2',5,5'-tetrachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Mptx1Mouse2,4,4'-trichlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Mptx1Mousecadmium dichloride increases expressionISOMPTX1 (Homo sapiens)6480464Cadmium Chloride results in increased expression of MPTX1 proteinCTDPMID:26220685
Mptx1Mousechlorpyrifos increases expressionEXP 6480464Chlorpyrifos results in increased expression of MPTX1 mRNACTDPMID:32715474
Mptx1Mouseepoxiconazole increases expressionEXP 6480464epoxiconazole results in increased expression of MPTX1 mRNACTDPMID:35436446
Mptx1Mouseferroheme b decreases expressionISOMptx1 (Rattus norvegicus)6480464Heme results in decreased expression of MPTX1 mRNACTDPMID:15539406
Mptx1Mouseferroheme b multiple interactionsISOMptx1 (Rattus norvegicus)6480464Calcium and Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]CTDPMID:15539406
Mptx1Mouseheme b decreases expressionISOMptx1 (Rattus norvegicus)6480464Heme results in decreased expression of MPTX1 mRNACTDPMID:15539406
Mptx1Mouseheme b multiple interactionsISOMptx1 (Rattus norvegicus)6480464Calcium and Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]CTDPMID:15539406
Mptx1MousePCB138 multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Mptx1Mousetitanium dioxide decreases expressionEXP 6480464titanium dioxide results in decreased expression of MPTX1 mRNACTDPMID:35295148

1 to 15 of 15 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mptx1Mouseinnate immune response involved_inIBAPANTHER:PTN001453725 and UniProtKB:P027432290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mptx1Mouseextracellular region located_inIEAUniProtKB-SubCell:SL-02432290270 UniProtGO_REF:0000044
Mptx1Mouseextracellular space is_active_inIBAPANTHER:PTN001453725 more ...2290270 GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mptx1Mousecomplement component C1q complex binding enablesIBAPANTHER:PTN001453725 more ...2290270 GO_CentralGO_REF:0000033
Mptx1Mousemetal ion binding enablesIEAUniProtKB-KW:KW-04792290270 UniProtGO_REF:0000043


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12040188   PMID:12466851   PMID:12477932   PMID:15489334   PMID:15520881   PMID:16141072   PMID:16141073   PMID:21677750  
PMID:21873635  



Mptx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,158,085 - 174,160,443 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1174,158,084 - 174,160,439 (+)EnsemblGRCm39 Ensembl
GRCm381174,330,518 - 174,332,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,330,518 - 174,332,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv371176,260,649 - 176,263,008 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,167,194 - 176,169,548 (+)NCBIMGSCv36mm8
Celera1180,288,255 - 180,290,613 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.01NCBI
MPTX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,276,507 - 159,277,182 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,268,623 - 159,277,111 (+)EnsemblGRCh38hg38GRCh38
GRCh371159,246,297 - 159,246,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,502,757 - 157,513,525 (+)NCBINCBI36Build 36hg18NCBI36
Celera1132,306,376 - 132,317,144 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1130,603,448 - 130,604,123 (+)NCBIHuRef
CHM1_11160,641,726 - 160,642,401 (+)NCBICHM1_1
T2T-CHM13v2.01158,413,540 - 158,414,215 (+)NCBIT2T-CHM13v2.0
Mptx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,260,335 - 88,263,869 (-)NCBIGRCr8
mRatBN7.21385,727,989 - 85,731,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,728,076 - 85,731,469 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1388,226,136 - 88,229,530 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,626,452 - 89,629,846 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,811,128 - 86,814,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,772,927 - 91,827,231 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,773,004 - 91,776,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01396,287,420 - 96,290,813 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1385,332,123 - 85,335,516 (-)NCBICelera
Cytogenetic Map13q24NCBI

.

.
Variants in Mptx1
198 total Variants

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSMUST00000027816
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 106 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
4141878Qrr1_mQTL rich region on chromosome 1 (mouse)Not determined170878743175320066Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357854Sle16_msystematic lupus erythematosus susceptibility 16 (mouse)Not determined1169038741177377587Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
1301016Szs1_mseizure susceptibility 1 (mouse)Not determined1170878743174456436Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse

1 to 10 of 106 rows
AV054416  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371176,262,769 - 176,262,914UniSTSGRCm37
MGSCv371175,204,598 - 175,204,743UniSTSGRCm37
Celera1181,425,565 - 181,425,710UniSTS
Celera1180,290,374 - 180,290,519UniSTS
Celera1176,122,084 - 176,122,229UniSTS
Cytogenetic Map1H3UniSTS
Whitehead/MRC_RH12191.93UniSTS







Ensembl Acc Id: ENSMUST00000027816   ⟹   ENSMUSP00000027816
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1174,158,084 - 174,160,439 (+)Ensembl
GRCm38.p6 Ensembl1174,330,518 - 174,332,873 (+)Ensembl
RefSeq Acc Id: NM_025470   ⟹   NP_079746
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391174,158,085 - 174,160,443 (+)NCBI
GRCm381174,330,518 - 174,332,877 (+)ENTREZGENE
MGSCv371176,260,649 - 176,263,008 (+)RGD
Celera1180,288,255 - 180,290,613 (+)NCBI
Celera1181,422,551 - 181,425,804 (+)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
Protein RefSeqs NP_079746 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH24348 (Get FASTA)   NCBI Sequence Viewer  
  BAB25374 (Get FASTA)   NCBI Sequence Viewer  
  EDL13219 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000027816
GenBank Protein Q8R1M8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_079746   ⟸   NM_025470
- Peptide Label: precursor
- UniProtKB: Q9D8J8 (UniProtKB/Swiss-Prot),   Q8R1M8 (UniProtKB/Swiss-Prot),   A0A0R4J077 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027816   ⟸   ENSMUST00000027816
Pentraxin (PTX)

Name Modeler Protein Id AA Range Protein Structure
AF-Q8R1M8-F1-model_v2 AlphaFold Q8R1M8 1-219 view protein structure

RGD ID:6875830
Promoter ID:EPDNEW_M1366
Type:single initiation site
Name:Mptx1_1
Description:Mus musculus mucosal pentraxin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381174,330,519 - 174,330,579EPDNEW


1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000026531 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000027816 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Pentraxin-related UniProtKB/Swiss-Prot
  Pentraxin_domain UniProtKB/Swiss-Prot
KEGG Report mmu:66289 UniProtKB/Swiss-Prot
MGD MGI:1913539 ENTREZGENE
NCBI Gene 66289 ENTREZGENE
PANTHER C-REACTIVE PROTEIN-RELATED UniProtKB/Swiss-Prot
  MUCOSAL PENTRAXIN-RELATED UniProtKB/Swiss-Prot
Pfam Pentaxin UniProtKB/Swiss-Prot
PhenoGen Mptx1 PhenoGen
PRINTS PENTAXIN UniProtKB/Swiss-Prot
PROSITE PTX_2 UniProtKB/Swiss-Prot
SMART PTX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt A0A0R4J077 ENTREZGENE, UniProtKB/TrEMBL
  MPTX_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9D8J8 ENTREZGENE
UniProt Secondary Q9D8J8 UniProtKB/Swiss-Prot
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-20 Mptx1  mucosal pentraxin 1  1810030J14Rik  RIKEN cDNA 1810030J14 gene  Symbol and/or name change 5135510 APPROVED