NR1I2 (nuclear receptor subfamily 1 group I member 2) - Rat Genome Database

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Gene: NR1I2 (nuclear receptor subfamily 1 group I member 2) Homo sapiens
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Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
RGD ID: 69105
HGNC Page HGNC:7968
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and nuclear receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II; xenobiotic catabolic process; and xenobiotic transport. Acts upstream of or within negative regulation of DNA-templated transcription. Located in intermediate filament cytoskeleton; nuclear body; and transcription regulator complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BXR; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR1; orphan nuclear receptor PAR1; orphan nuclear receptor PXR; PAR; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; pregnane X receptor; PRR; PXR; SAR; steroid and xenobiotic receptor; SXR
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,782,101 - 119,818,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,780,484 - 119,818,487 (+)EnsemblGRCh38hg38GRCh38
GRCh373119,500,948 - 119,537,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,982,021 - 121,020,022 (+)NCBINCBI36Build 36hg18NCBI36
Build 343120,982,020 - 121,020,021NCBI
Celera3117,908,432 - 117,946,438 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,874,950 - 116,913,074 (+)NCBIHuRef
CHM1_13119,462,845 - 119,500,855 (+)NCBICHM1_1
T2T-CHM13v2.03122,501,838 - 122,538,215 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP,ISO)
(+)-trans-(S)-allethrin  (EXP,ISO)
(-)-secoisolariciresinol  (EXP)
(3-phenoxyphenyl)methanol  (EXP,ISO)
(E,E)-germacrone  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (EXP)
(Z)-ligustilide  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-(3-chlorophenyl)piperazine  (EXP)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (EXP)
1-Hydroxypyrene  (EXP,ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (ISO)
10H-phenothiazine  (EXP,ISO)
13-cis-retinal  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-indole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Bisphenol F  (EXP,ISO)
2,2-diphenylacetic acid 2-(diethylamino)ethyl ester  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,5-trichlorophenol  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-Dihydroxybenzophenone  (EXP)
2,5-di-tert-butylbenzene-1,4-diol  (EXP)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (EXP)
2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-benzyl-4-chlorophenol  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-methyl-1H-indole  (EXP)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5,5'-tetraiodothyroacetic acid  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (EXP)
3,3'-Dimethylbenzidine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-xylenol  (EXP)
3-iodoprop-2-yn-1-yl butylcarbamate  (EXP,ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (EXP,ISO)
3-oxo-5beta-cholanic acid  (EXP)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
4-chloro-3,5-dimethylphenol  (EXP,ISO)
4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one  (EXP)
4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-Methyl-3-penten-2-one, 9CI  (EXP)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP)
4-tert-butylphenol  (EXP,ISO)
4-tert-Octylphenol  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-iodo-2'-deoxyuridine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5alpha-pregnane-3,20-dione  (EXP,ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinal  (EXP)
9-cis-retinoic acid  (EXP)
9-phenanthrol  (EXP,ISO)
acetamide  (ISO)
acetochlor  (EXP,ISO)
Acetyl tributyl citrate  (EXP,ISO)
aconitine  (EXP)
actinomycin D  (EXP,ISO)
adenine arabinoside  (EXP)
afimoxifene  (EXP,ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
Aflatoxin G1  (EXP)
aflatoxin M1  (EXP)
alachlor  (EXP,ISO)
aldehydo-D-glucose  (EXP)
aldrin  (EXP)
all-trans-retinoic acid  (EXP)
allethrin  (ISO)
allyl isothiocyanate  (EXP,ISO)
alpha-hexachlorocyclohexane  (EXP,ISO)
alpha-santonin  (EXP)
alpha-tocotrienol  (EXP)
aminoglutethimide  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
amphetamine  (EXP)
amprenavir  (EXP)
androst-4-ene-3,17-dione  (EXP,ISO)
androstane  (EXP)
angiotensin II  (ISO)
Anilofos  (EXP,ISO)
apazone  (EXP)
apigenin  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
azinphos-methyl  (EXP)
azoxystrobin  (EXP,ISO)
beclomethasone  (EXP)
Benfuresate  (EXP)
benidipine  (EXP)
bensulfuron-methyl  (EXP)
Bensulide  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[a]pyrene-7,8-diol  (EXP)
benzo[c]phenanthrene  (EXP)
benzophenone  (ISO)
Benzyl parahydroxybenzoate  (EXP)
berberine  (EXP)
bergomottin  (EXP)
Besigomsin  (EXP)
beta-carotene  (EXP)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (EXP,ISO)
beta-tocotrienol  (EXP)
bezafibrate  (EXP)
bicalutamide  (EXP,ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (EXP,ISO)
biochanin A  (EXP,ISO)
bioresmethrin  (EXP,ISO)
biphenyl-2-ol  (EXP)
biphenyl-4-ol  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol A dimethacrylate  (EXP)
Bisphenol B  (EXP)
bitertanol  (EXP,ISO)
brefeldin A  (EXP)
Bromadiolone  (EXP,ISO)
bromocresol purple  (EXP)
Bromophos-ethyl  (EXP,ISO)
bromothymol blue  (EXP)
Bromperidol  (EXP)
bromuconazole  (EXP,ISO)
budesonide  (EXP,ISO)
bupirimate  (EXP)
buspirone  (ISO)
buta-1,3-diene  (ISO)
butafenacil  (EXP)
Butamifos  (EXP,ISO)
butein  (EXP)
butoconazole  (EXP)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
cafenstrole  (ISO)
calcitriol  (EXP)
camptothecin  (EXP)
captan  (EXP)
carbamazepine  (EXP,ISO)
carbamazepine-10,11-epoxide  (EXP)
carbaryl  (EXP,ISO)
carbon nanotube  (ISO)
cerivastatin  (EXP)
cetylpyridinium  (EXP)
chenodeoxycholic acid  (EXP)
CHIR 99021  (EXP)
Chlomethoxyfen  (EXP,ISO)
chlordecone  (EXP)
chlorfenvinfos  (EXP)
chlornitrofen  (EXP,ISO)
Chlorobenzilate  (EXP,ISO)
Chloromethyl methyl ether  (EXP,ISO)
chloropropylate  (EXP,ISO)
chlorothalonil  (EXP)
chlorpromazine  (EXP)
chlorpropham  (EXP)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
chrysin  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (EXP)
cinchocaine  (EXP)
cisplatin  (EXP)
clemizole  (EXP)
clobetasol  (EXP)
clofibrate  (ISO)
clomiphene  (EXP,ISO)
clonazepam  (EXP)
clorgyline  (EXP)
clotrimazole  (EXP,ISO)
clozapine  (EXP)
cobicistat  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (EXP)
coumaphos  (EXP,ISO)
coumestrol  (EXP)
Cryptotanshinone  (EXP)
Cuprizon  (ISO)
curcumin  (EXP)
Cyanofenphos  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP,ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP)
cyprodinil  (EXP)
cyproterone acetate  (EXP,ISO)
D-glucose  (EXP)
daidzein  (EXP,ISO)
DDD  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
Decamethylcyclopentasiloxane  (EXP)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (EXP)
delta-tocotrienol  (EXP)
deoxycholic acid  (EXP,ISO)
Deoxyschizandrin  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazepam  (EXP)
diazinon  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (EXP,ISO)
diclofenac  (EXP)
dicloxacillin  (EXP)
dicofol  (EXP,ISO)
Dicyclohexyl phthalate  (EXP,ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
diflubenzuron  (EXP)
dihydroergotamine  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP)
dilazep  (EXP)
dimethomorph  (EXP,ISO)
dimethylarsinous acid  (EXP)
diniconazole  (EXP,ISO)
diosgenin  (ISO)
dioxygen  (EXP)
dipentyl phthalate  (EXP,ISO)
Diphenolic acid  (EXP,ISO)
diphenylamine  (EXP)
diquat  (ISO)
disopyramide  (EXP)
disulfiram  (EXP,ISO)
disulfoton  (ISO)
Dithiopyr  (EXP,ISO)
diuron  (EXP,ISO)
dodecylamine  (EXP,ISO)
doxorubicin  (EXP)
econazole  (EXP)
efavirenz  (ISO)
endosulfan  (EXP,ISO)
endrin  (EXP,ISO)
enilconazole  (EXP,ISO)
Enterolactone  (EXP)
EPN  (EXP,ISO)
epoxiconazole  (ISO)
equilin  (EXP,ISO)
erlotinib hydrochloride  (EXP)
estriol  (EXP)
estrone  (EXP)
Ethalfluralin  (EXP,ISO)
ethanol  (EXP,ISO)
ethion  (EXP,ISO)
ethoprophos  (ISO)
ethotoin  (EXP)
ethoxyquin  (EXP,ISO)
ethylparaben  (EXP,ISO)
eticlopride(1+)  (EXP)
etidronic acid  (EXP)
etofenprox  (EXP,ISO)
etoposide  (EXP)
eugenol  (EXP)
farglitazar  (EXP)
felodipine  (EXP,ISO)
fenamiphos  (EXP,ISO)
fenarimol  (EXP,ISO)
fenbuconazole  (EXP)
fenhexamid  (EXP)
fenitrothion  (EXP,ISO)
fenofibrate  (EXP)
fenthion  (EXP,ISO)
fentin chloride  (EXP,ISO)
fenvalerate  (EXP,ISO)
Fexofenadine hydrochloride  (EXP)
finasteride  (EXP,ISO)
fipronil  (EXP,ISO)
fisetin  (EXP)
flavonol  (EXP,ISO)
fluconazole  (EXP)
flucythrinate  (EXP,ISO)
fludioxonil  (EXP,ISO)
flufenacet  (EXP)
Flumetralin  (EXP,ISO)
flunisolide  (EXP)
fluoranthene  (EXP,ISO)
flutamide  (EXP,ISO)
fluticasone  (EXP)
flutolanil  (EXP,ISO)
fluvalinate  (EXP,ISO)
fluvastatin  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (EXP)
galangin  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
Ginkgolide A  (EXP,ISO)
ginkgolide B  (EXP)
glimepiride  (EXP)
glucose  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhizinic acid  (EXP)
guggulsterone  (EXP,ISO)
GW 4064  (ISO)
heptachlor  (EXP,ISO)
Heptachlor epoxide  (EXP,ISO)
hesperetin  (EXP)
hexestrol  (EXP)
hycanthone  (EXP)
Hydrastine  (EXP)
hydroxyflutamide  (EXP)
hydroxyitraconazole  (EXP)
Hypaconitine  (EXP)
hyperforin  (EXP)
ifosfamide  (EXP)
Ile(5)-angiotensin II  (ISO)
imazamox  (EXP)
imipenem hydrate  (EXP)
Indanofan  (EXP,ISO)
indole-3-acetamide  (EXP)
indoprofen  (EXP)
iprobenfos  (EXP,ISO)
iprodione  (EXP,ISO)
irinotecan  (ISO)
Isobutylparaben  (EXP,ISO)
Isoetharine  (EXP)
isofenphos  (EXP,ISO)
isoliquiritigenin  (EXP)
isopimpinellin  (EXP,ISO)
isoprothiolane  (EXP,ISO)
isoproturon  (EXP)
isorhamnetin  (EXP,ISO)
isotretinoin  (EXP)
isoxaben  (EXP)
isoxazoles  (EXP)
Isradipine  (EXP)
itraconazole  (EXP)
kaempferol  (EXP,ISO)
ketoconazole  (EXP,ISO)
kojic acid  (ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
leflunomide  (EXP)
leptophos  (EXP,ISO)
levonorgestrel  (EXP,ISO)
lidocaine  (EXP)
lignan  (EXP)
linuron  (EXP,ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
loperamide  (EXP)
lovastatin  (EXP)
lycopene  (ISO)
Maleic hydrazide  (EXP)
MC-4379  (EXP,ISO)
mecarbam  (EXP,ISO)
Medazepam  (EXP)
medroxyprogesterone acetate  (EXP)
mefenacet  (EXP,ISO)
mefenamic acid  (EXP)
megestrol  (EXP)
melatonin  (ISO)
Melengestrol acetate  (EXP,ISO)
menaquinone  (EXP)
menaquinone-4  (EXP)
mephenytoin  (EXP)
mephobarbital  (EXP)
mercury dichloride  (ISO)
Mesaconitine  (EXP)
mestranol  (EXP,ISO)
metconazole  (EXP,ISO)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methiocarb  (ISO)
methotrexate  (ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyltestosterone  (EXP)
metolachlor  (EXP,ISO)
metolazone  (EXP)
metyrapone  (EXP,ISO)
mevastatin  (EXP)
miconazole  (EXP,ISO)
midazolam  (EXP)
mifepristone  (EXP,ISO)
Mitotane  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzone  (EXP)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monocrotophos  (EXP)
mycophenolic acid  (EXP)
N-nitrosodiethylamine  (ISO)
nabumetone  (EXP)
nafcillin  (EXP)
napropamide  (EXP,ISO)
nefazodone  (EXP)
nelfinavir  (EXP)
nicardipine  (EXP)
nifedipine  (EXP)
nilutamide  (EXP,ISO)
nimodipine  (EXP)
nitrofen  (EXP,ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (EXP,ISO)
norgestrel  (EXP)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (EXP)
octamethylcyclotetrasiloxane  (EXP)
okadaic acid  (EXP)
omeprazole  (EXP,ISO)
orlistat  (EXP)
oryzalin  (EXP,ISO)
Oxadiazon  (EXP,ISO)
oxiconazole  (EXP)
oxolane  (ISO)
oxybenzone  (EXP,ISO)
oxybuprocaine  (EXP)
oxycodone  (ISO)
Oxyfluorfen  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP,ISO)
parathion-methyl  (EXP,ISO)
parthenolide  (EXP)
pazopanib  (EXP)
PCB138  (EXP,ISO)
penconazole  (EXP)
pencycuron  (EXP)
pendimethalin  (EXP,ISO)
pentachloronitrobenzene  (EXP)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorobutanesulfonic acid  (EXP)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
permethrin  (EXP,ISO)
phenanthrene  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenolphthalein  (EXP)
phenothrin  (ISO)
Phenoxybenzamine  (EXP)
phenthoate  (EXP,ISO)
phenylephrine  (ISO)
phenytoin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (EXP,ISO)
phoxim  (EXP,ISO)
phthalic acid  (EXP)
picoxystrobin  (EXP)
pimecrolimus  (EXP)
pioglitazone  (EXP)
piperine  (EXP)
piperonyl butoxide  (ISO)
Piperophos  (EXP,ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
PK-11195  (EXP)
prallethrin  (EXP,ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Pretilachlor  (EXP,ISO)
procaine  (EXP)
prochloraz  (EXP,ISO)
procymidone  (EXP,ISO)
progesterone  (EXP,ISO)
prometryn  (EXP)
propanil  (EXP,ISO)
propaphos  (EXP,ISO)
propargite  (EXP,ISO)
propiconazole  (EXP,ISO)
propranolol  (EXP)
propylparaben  (EXP,ISO)
propyzamide  (EXP,ISO)
prothiofos  (EXP,ISO)
pterostilbene  (EXP)
pyrene  (EXP,ISO)
pyrethrins  (EXP,ISO)
pyridaben  (EXP,ISO)
pyridaphenthion  (EXP,ISO)
pyrimethanil  (EXP)
quercetin  (EXP,ISO)
quinalphos  (EXP,ISO)
quinoxyfen  (EXP)
reserpine  (EXP)
resveratrol  (EXP)
rifabutin  (EXP)
rifampicin  (EXP,ISO)
rifaximin  (EXP,ISO)
Riluzole  (EXP)
risperidone  (EXP)
ritonavir  (EXP,ISO)
saquinavir  (EXP)
secobarbital  (EXP)
sevoflurane  (ISO)
silibinin  (EXP)
simvastatin  (EXP)
skatole  (EXP)
sodium arsenite  (EXP,ISO)
spironolactone  (EXP,ISO)
steviol  (EXP)
stilbene oxide  (EXP)
sulconazole  (EXP)
sulfamethazine  (EXP)
sulfinpyrazone  (EXP)
sulfluramid  (EXP)
sulforaphane  (EXP,ISO)
sulfoxaflor  (ISO)
tamarixetin  (EXP,ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP)
tartrazine  (EXP)
taurocholic acid  (EXP,ISO)
tebuconazole  (EXP,ISO)
terbufos  (EXP,ISO)
terbutryn  (EXP)
terbutylazine  (EXP)
testosterone  (ISO)
Testosterone propionate  (EXP,ISO)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (ISO)
tetrachlorvinphos  (EXP,ISO)
tetramethrin  (EXP,ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
thiabendazole  (EXP)
Thiazopyr  (EXP)
thioacetamide  (ISO)
Thiobencarb  (EXP,ISO)
Thymophthalein  (EXP)
thyroxine  (EXP)
tiaprofenic acid  (EXP)
tiracizine  (EXP)
tiratricol  (EXP)
titanium dioxide  (ISO)
tolclofos-methyl  (EXP)
tolylfluanid  (EXP)
topiramate  (EXP)
toxaphene  (EXP,ISO)
tralomethrin  (EXP,ISO)
TRAM-34  (EXP)
trans-cinnamic acid  (EXP)
trenbolone  (EXP)
Tri-2-ethylhexyl trimellitate  (EXP,ISO)
triadimefon  (EXP,ISO)
Tributyl citrate  (EXP)
tributyl phosphate  (EXP,ISO)
tributylstannane  (EXP,ISO)
trichostatin A  (EXP)
triclosan  (EXP,ISO)
triflumizole  (EXP,ISO)
trifluralin  (EXP,ISO)
trifluridine  (EXP)
triforine  (EXP,ISO)
trimethobenzamide  (EXP)
triphenyl phosphate  (EXP,ISO)
Triphenylethylene  (EXP)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
Tris(2-ethylhexyl) phosphate  (EXP)
triticonazole  (EXP,ISO)
troglitazone  (EXP,ISO)
troleandomycin  (EXP)
tryptamine  (EXP)
tryptophol  (EXP)
uranium atom  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vincaleukoblastine  (EXP)
vinclozolin  (EXP,ISO)
vincristine  (EXP)
vitamin D  (EXP)
voriconazole  (ISO)
warfarin  (EXP)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. Gabbia D, etal., World J Gastroenterol. 2017 Nov 14;23(42):7519-7530. doi: 10.3748/wjg.v23.i42.7519.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid. Yu N, etal., Neurochem Res. 2017 Aug;42(8):2167-2177. doi: 10.1007/s11064-017-2224-x. Epub 2017 Mar 16.
6. Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury. Zhang J, etal., PLoS One. 2019 Sep 6;14(9):e0222033. doi: 10.1371/journal.pone.0222033. eCollection 2019.
Additional References at PubMed
PMID:8125298   PMID:9489701   PMID:9727070   PMID:9770465   PMID:9784494   PMID:10473093   PMID:11114890   PMID:11297522   PMID:11408620   PMID:11668216   PMID:11865669   PMID:11891224  
PMID:12072427   PMID:12397176   PMID:12413960   PMID:12477932   PMID:12485946   PMID:12569201   PMID:12578355   PMID:12606758   PMID:12644700   PMID:12760308   PMID:12909012   PMID:12920130  
PMID:14702340   PMID:14977869   PMID:14977870   PMID:15252010   PMID:15316010   PMID:15322103   PMID:15331348   PMID:15489334   PMID:15535420   PMID:15604093   PMID:15610065   PMID:15618712  
PMID:15630458   PMID:15690482   PMID:15713537   PMID:15772695   PMID:15919766   PMID:15933212   PMID:15985196   PMID:16085054   PMID:16144941   PMID:16219912   PMID:16297466   PMID:16328955  
PMID:16452398   PMID:16455805   PMID:16472590   PMID:16507781   PMID:16556603   PMID:16606623   PMID:16608838   PMID:16691293   PMID:16831602   PMID:16834332   PMID:16837625   PMID:16841097  
PMID:16857725   PMID:16952547   PMID:16973756   PMID:17028159   PMID:17048007   PMID:17050801   PMID:17088262   PMID:17262809   PMID:17279585   PMID:17327420   PMID:17404718   PMID:17418145  
PMID:17429319   PMID:17436120   PMID:17438109   PMID:17507630   PMID:17526937   PMID:17573484   PMID:17576789   PMID:17635106   PMID:17712488   PMID:17761971   PMID:17764444   PMID:17827782  
PMID:17828778   PMID:17876342   PMID:17924830   PMID:17925385   PMID:17962194   PMID:18056193   PMID:18095058   PMID:18096694   PMID:18192894   PMID:18220558   PMID:18268015   PMID:18276839  
PMID:18294295   PMID:18305370   PMID:18305375   PMID:18381611   PMID:18391510   PMID:18502461   PMID:18518855   PMID:18765524   PMID:18784074   PMID:18800312   PMID:18831695   PMID:18978041  
PMID:18981011   PMID:19010908   PMID:19011999   PMID:19034627   PMID:19115096   PMID:19124506   PMID:19129222   PMID:19141612   PMID:19144646   PMID:19171678   PMID:19173680   PMID:19232333  
PMID:19274049   PMID:19297428   PMID:19401882   PMID:19460945   PMID:19470925   PMID:19505191   PMID:19516190   PMID:19593667   PMID:19617467   PMID:19702932   PMID:19739075   PMID:19746521  
PMID:19833192   PMID:19842932   PMID:19878569   PMID:19898482   PMID:19902988   PMID:19913121   PMID:19934400   PMID:19940802   PMID:19958310   PMID:20082578   PMID:20107201   PMID:20171174  
PMID:20218903   PMID:20222094   PMID:20346360   PMID:20354687   PMID:20361990   PMID:20379614   PMID:20413580   PMID:20518891   PMID:20531417   PMID:20538049   PMID:20538721   PMID:20624854  
PMID:20628086   PMID:20635135   PMID:20719936   PMID:20818746   PMID:20819778   PMID:20836841   PMID:20840328   PMID:20846001   PMID:20861742   PMID:20876786   PMID:20970601   PMID:21127053  
PMID:21245992   PMID:21292004   PMID:21316268   PMID:21323950   PMID:21329659   PMID:21342487   PMID:21359593   PMID:21391917   PMID:21402137   PMID:21438836   PMID:21461878   PMID:21517853  
PMID:21532337   PMID:21596433   PMID:21733184   PMID:21742782   PMID:21747170   PMID:21805522   PMID:21808872   PMID:21830270   PMID:21873635   PMID:21913896   PMID:21918980   PMID:21954916  
PMID:21977915   PMID:21988832   PMID:22000295   PMID:22023334   PMID:22050110   PMID:22076448   PMID:22093699   PMID:22126990   PMID:22166712   PMID:22185585   PMID:22285937   PMID:22292071  
PMID:22333269   PMID:22453080   PMID:22453193   PMID:22750628   PMID:22829544   PMID:22939624   PMID:22952895   PMID:22968811   PMID:22976785   PMID:23160820   PMID:23160821   PMID:23288240  
PMID:23303387   PMID:23479137   PMID:23503472   PMID:23525103   PMID:23527115   PMID:23536728   PMID:23562850   PMID:23574760   PMID:23602807   PMID:23609392   PMID:23614276   PMID:23840296  
PMID:23878263   PMID:23977680   PMID:24052258   PMID:24088131   PMID:24097976   PMID:24166671   PMID:24184507   PMID:24204015   PMID:24232815   PMID:24315978   PMID:24316275   PMID:24329114  
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PMID:26534988   PMID:26535635   PMID:26549688   PMID:26783937   PMID:26855179   PMID:26879815   PMID:26920453   PMID:26924429   PMID:26934120   PMID:26936634   PMID:26962022   PMID:26994748  
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PMID:35723590   PMID:35742805   PMID:35906200   PMID:36233042   PMID:36503926   PMID:36657504   PMID:36951964   PMID:37349114  


Genomics

Comparative Map Data
NR1I2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,782,101 - 119,818,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,780,484 - 119,818,487 (+)EnsemblGRCh38hg38GRCh38
GRCh373119,500,948 - 119,537,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,982,021 - 121,020,022 (+)NCBINCBI36Build 36hg18NCBI36
Build 343120,982,020 - 121,020,021NCBI
Celera3117,908,432 - 117,946,438 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,874,950 - 116,913,074 (+)NCBIHuRef
CHM1_13119,462,845 - 119,500,855 (+)NCBICHM1_1
T2T-CHM13v2.03122,501,838 - 122,538,215 (+)NCBIT2T-CHM13v2.0
Nr1i2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391638,068,711 - 38,115,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1638,068,685 - 38,115,186 (-)EnsemblGRCm39 Ensembl
GRCm381638,248,349 - 38,294,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,248,323 - 38,294,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv371638,248,435 - 38,294,910 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,167,590 - 38,214,062 (-)NCBIMGSCv36mm8
Celera1638,657,356 - 38,703,953 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.64NCBI
Nr1i2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,965,717 - 76,006,733 (+)NCBIGRCr8
mRatBN7.21162,460,213 - 62,496,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,460,213 - 62,496,658 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,272,711 - 71,309,163 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,934,940 - 63,971,386 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,985,406 - 63,021,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,022,100 - 65,058,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,022,100 - 65,058,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,024,185 - 67,060,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,239,918 - 64,276,702 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,297,534 - 64,333,716 (+)NCBI
Celera1161,960,674 - 61,997,009 (+)NCBICelera
Cytogenetic Map11q21NCBI
Nr1i2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,459,936 - 19,487,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,459,936 - 19,487,276 (+)NCBIChiLan1.0ChiLan1.0
NR1I2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,759,374 - 117,799,567 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,764,152 - 117,804,345 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,901,579 - 116,940,366 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,815,135 - 123,853,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,815,135 - 123,853,129 (+)Ensemblpanpan1.1panPan2
NR1I2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,444,367 - 23,456,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,432,690 - 23,455,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,474,457 - 23,486,487 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,682,177 - 23,694,192 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,669,760 - 23,694,177 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,486,165 - 23,498,350 (+)NCBIUMICH_Zoey_3.1
Nr1i2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,794,594 - 130,830,392 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,691,590 - 6,726,704 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,691,590 - 6,726,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR1I2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,364,075 - 140,406,112 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,373,571 - 140,406,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,710,912 - 149,743,466 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR1I2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12261,005,404 - 61,043,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2261,006,667 - 61,040,832 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,267,620 - 105,304,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr1i2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,371,707 - 28,381,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,371,707 - 28,405,327 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NR1I2
36 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_003889.3(NR1I2):c.-23+4835A>G single nucleotide variant Lung cancer [RCV000092846] Chr3:119787135 [GRCh38]
Chr3:119505982 [GRCh37]
Chr3:3q13.33		 uncertain significance
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1		 pathogenic
GRCh38/hg38 3q13.32-21.2(chr3:119117166-125920734)x1 copy number loss See cases [RCV000051546] Chr3:119117166..125920734 [GRCh38]
Chr3:118836013..125639577 [GRCh37]
Chr3:120318703..127122267 [NCBI36]
Chr3:3q13.32-21.2		 pathogenic
NM_003889.3(NR1I2):c.1077C>T (p.His359=) single nucleotide variant Malignant melanoma [RCV000065788] Chr3:119815748 [GRCh38]
Chr3:119534595 [GRCh37]
Chr3:121017285 [NCBI36]
Chr3:3q13.33		 not provided
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29		 pathogenic
GRCh38/hg38 3q13.32-13.33(chr3:117844958-120797026)x4 copy number gain See cases [RCV000135591] Chr3:117844958..120797026 [GRCh38]
Chr3:117563805..120515873 [GRCh37]
Chr3:119046495..121998563 [NCBI36]
Chr3:3q13.32-13.33		 uncertain significance
GRCh38/hg38 3q13.31-21.1(chr3:115019074-122513398)x1 copy number loss See cases [RCV000135961] Chr3:115019074..122513398 [GRCh38]
Chr3:114737921..122232245 [GRCh37]
Chr3:116220611..123714935 [NCBI36]
Chr3:3q13.31-21.1		 pathogenic
GRCh38/hg38 3q13.2-21.3(chr3:112620977-128734134)x1 copy number loss See cases [RCV000139033] Chr3:112620977..128734134 [GRCh38]
Chr3:112339824..128452977 [GRCh37]
Chr3:113822514..129935667 [NCBI36]
Chr3:3q13.2-21.3		 pathogenic
GRCh38/hg38 3q13.31-21.2(chr3:114122562-124532374)x1 copy number loss See cases [RCV000142009] Chr3:114122562..124532374 [GRCh38]
Chr3:113841409..124251221 [GRCh37]
Chr3:115324099..125733911 [NCBI36]
Chr3:3q13.31-21.2		 pathogenic
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24		 pathogenic
GRCh38/hg38 3q13.32-13.33(chr3:117844958-120826621)x4 copy number gain See cases [RCV000142877] Chr3:117844958..120826621 [GRCh38]
Chr3:117563805..120545468 [GRCh37]
Chr3:119046495..122028158 [NCBI36]
Chr3:3q13.32-13.33		 uncertain significance
GRCh38/hg38 3q13.2-13.33(chr3:112520553-120031022)x1 copy number loss See cases [RCV000142725] Chr3:112520553..120031022 [GRCh38]
Chr3:112239400..119749869 [GRCh37]
Chr3:113722090..121232559 [NCBI36]
Chr3:3q13.2-13.33		 pathogenic
GRCh38/hg38 3q13.32-21.3(chr3:118673898-126540730)x1 copy number loss See cases [RCV000143695] Chr3:118673898..126540730 [GRCh38]
Chr3:118392745..126259573 [GRCh37]
Chr3:119875435..127742263 [NCBI36]
Chr3:3q13.32-21.3		 pathogenic
GRCh37/hg19 3q13.33(chr3:119188677-119500810)x3 copy number gain See cases [RCV000240551] Chr3:119188677..119500810 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.352G>A (p.Val118Met) single nucleotide variant not specified [RCV004282394] Chr3:119811559 [GRCh38]
Chr3:119530406 [GRCh37]
Chr3:3q13.33		 uncertain significance
GRCh37/hg19 3q13.33(chr3:119188677-119500751)x3 copy number gain See cases [RCV000445965] Chr3:119188677..119500751 [GRCh37]
Chr3:3q13.33		 uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3q13.31-21.1(chr3:115518341-122129283)x1 copy number loss not provided [RCV000682298] Chr3:115518341..122129283 [GRCh37]
Chr3:3q13.31-21.1		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3q13.33(chr3:119433300-119606078)x3 copy number gain not provided [RCV000742713] Chr3:119433300..119606078 [GRCh37]
Chr3:3q13.33		 likely benign
NM_003889.4(NR1I2):c.369C>T (p.Ala123=) single nucleotide variant not provided [RCV000881989] Chr3:119811576 [GRCh38]
Chr3:119530423 [GRCh37]
Chr3:3q13.33		 benign
NM_003889.4(NR1I2):c.834G>A (p.Gly278=) single nucleotide variant not provided [RCV000970824] Chr3:119815018 [GRCh38]
Chr3:119533865 [GRCh37]
Chr3:3q13.33		 benign
NM_003889.4(NR1I2):c.681C>A (p.Pro227=) single nucleotide variant not provided [RCV000901120] Chr3:119812847 [GRCh38]
Chr3:119531694 [GRCh37]
Chr3:3q13.33		 likely benign
NM_003889.4(NR1I2):c.792C>T (p.Phe264=) single nucleotide variant not provided [RCV000909447] Chr3:119812958 [GRCh38]
Chr3:119531805 [GRCh37]
Chr3:3q13.33		 likely benign
NM_003889.4(NR1I2):c.696C>T (p.Gly232=) single nucleotide variant not provided [RCV000969353] Chr3:119812862 [GRCh38]
Chr3:119531709 [GRCh37]
Chr3:3q13.33		 benign
NM_003889.4(NR1I2):c.315C>T (p.Ser105=) single nucleotide variant not provided [RCV000952838] Chr3:119810178 [GRCh38]
Chr3:119529025 [GRCh37]
Chr3:3q13.33		 benign
NM_003889.4(NR1I2):c.492T>C (p.Thr164=) single nucleotide variant not provided [RCV000956129] Chr3:119811699 [GRCh38]
Chr3:119530546 [GRCh37]
Chr3:3q13.33		 benign
GRCh37/hg19 3q13.31-26.31(chr3:116620308-172042292)x3 copy number gain not provided [RCV002472621] Chr3:116620308..172042292 [GRCh37]
Chr3:3q13.31-26.31		 pathogenic
GRCh37/hg19 3q13.33(chr3:119354755-119773920) copy number gain not specified [RCV002053370] Chr3:119354755..119773920 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.1247A>T (p.Asp416Val) single nucleotide variant not specified [RCV004321247] Chr3:119817154 [GRCh38]
Chr3:119536001 [GRCh37]
Chr3:3q13.33		 uncertain significance
GRCh37/hg19 3q13.31-13.33(chr3:116109191-120328013)x1 copy number loss not provided [RCV002473909] Chr3:116109191..120328013 [GRCh37]
Chr3:3q13.31-13.33		 uncertain significance
NM_003889.4(NR1I2):c.608G>A (p.Arg203Gln) single nucleotide variant not specified [RCV004235706] Chr3:119812774 [GRCh38]
Chr3:119531621 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.248C>A (p.Ala83Asp) single nucleotide variant not specified [RCV004090056] Chr3:119810111 [GRCh38]
Chr3:119528958 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.547G>A (p.Glu183Lys) single nucleotide variant not specified [RCV004220858] Chr3:119812713 [GRCh38]
Chr3:119531560 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.1279G>C (p.Glu427Gln) single nucleotide variant not specified [RCV004229989] Chr3:119817186 [GRCh38]
Chr3:119536033 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.401G>C (p.Gly134Ala) single nucleotide variant not specified [RCV004074332] Chr3:119811608 [GRCh38]
Chr3:119530455 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.1058G>A (p.Arg353His) single nucleotide variant not specified [RCV004211061] Chr3:119815729 [GRCh38]
Chr3:119534576 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.647G>A (p.Arg216Gln) single nucleotide variant not specified [RCV004237284] Chr3:119812813 [GRCh38]
Chr3:119531660 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.788A>G (p.Tyr263Cys) single nucleotide variant not specified [RCV004207444] Chr3:119812954 [GRCh38]
Chr3:119531801 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.1078C>T (p.Arg360Cys) single nucleotide variant not specified [RCV004073013] Chr3:119815749 [GRCh38]
Chr3:119534596 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.298C>T (p.Arg100Cys) single nucleotide variant not specified [RCV004072850] Chr3:119810161 [GRCh38]
Chr3:119529008 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.46C>T (p.His16Tyr) single nucleotide variant not specified [RCV004142484] Chr3:119807296 [GRCh38]
Chr3:119526143 [GRCh37]
Chr3:3q13.33		 likely benign
NM_003889.4(NR1I2):c.437A>G (p.Glu146Gly) single nucleotide variant not specified [RCV004141098] Chr3:119811644 [GRCh38]
Chr3:119530491 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.787T>C (p.Tyr263His) single nucleotide variant not specified [RCV004215965] Chr3:119812953 [GRCh38]
Chr3:119531800 [GRCh37]
Chr3:3q13.33		 likely benign
NM_003889.4(NR1I2):c.1064G>T (p.Gly355Val) single nucleotide variant not specified [RCV004171149] Chr3:119815735 [GRCh38]
Chr3:119534582 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.808G>A (p.Glu270Lys) single nucleotide variant not specified [RCV004079205] Chr3:119814992 [GRCh38]
Chr3:119533839 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.827T>A (p.Leu276Gln) single nucleotide variant not specified [RCV004321700] Chr3:119815011 [GRCh38]
Chr3:119533858 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.178G>A (p.Gly60Arg) single nucleotide variant not specified [RCV004254328] Chr3:119807428 [GRCh38]
Chr3:119526275 [GRCh37]
Chr3:3q13.33		 uncertain significance
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2		 pathogenic
NM_003889.4(NR1I2):c.811G>A (p.Asp271Asn) single nucleotide variant not specified [RCV004342828] Chr3:119814995 [GRCh38]
Chr3:119533842 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.346G>A (p.Glu116Lys) single nucleotide variant not specified [RCV004339097] Chr3:119811553 [GRCh38]
Chr3:119530400 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.543C>T (p.Gly181=) single nucleotide variant not provided [RCV003427292] Chr3:119812709 [GRCh38]
Chr3:119531556 [GRCh37]
Chr3:3q13.33		 likely benign
NM_003889.4(NR1I2):c.1142G>A (p.Arg381Gln) single nucleotide variant not specified [RCV004491238] Chr3:119815813 [GRCh38]
Chr3:119534660 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.124C>T (p.Arg42Cys) single nucleotide variant not specified [RCV004491239] Chr3:119807374 [GRCh38]
Chr3:119526221 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.91G>A (p.Ala31Thr) single nucleotide variant not specified [RCV004491245] Chr3:119807341 [GRCh38]
Chr3:119526188 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.78G>T (p.Lys26Asn) single nucleotide variant not specified [RCV004491244] Chr3:119807328 [GRCh38]
Chr3:119526175 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.379C>T (p.Arg127Trp) single nucleotide variant not specified [RCV004491241] Chr3:119811586 [GRCh38]
Chr3:119530433 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.628A>G (p.Lys210Glu) single nucleotide variant not specified [RCV004491243] Chr3:119812794 [GRCh38]
Chr3:119531641 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.484T>G (p.Phe162Val) single nucleotide variant not specified [RCV004491242] Chr3:119811691 [GRCh38]
Chr3:119530538 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_003889.4(NR1I2):c.1019A>G (p.Tyr340Cys) single nucleotide variant not specified [RCV004491237] Chr3:119815404 [GRCh38]
Chr3:119534251 [GRCh37]
Chr3:3q13.33		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR148Ahsa-miR-148a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI18268015
MIR148Ahsa-miR-148a-3pMirecordsexternal_infoNANA18268015

Predicted Target Of
Summary Value
Count of predictions:2063
Count of miRNA genes:679
Interacting mature miRNAs:765
Transcripts:ENST00000337940, ENST00000393716, ENST00000466380, ENST00000474090, ENST00000493757
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D3S3620  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,515,999 - 119,516,101UniSTSGRCh37
Build 363120,998,689 - 120,998,791RGDNCBI36
Celera3117,925,103 - 117,925,214RGD
Cytogenetic Map3q12-q13.3UniSTS
HuRef3116,891,631 - 116,891,739UniSTS
Marshfield Genetic Map3138.0RGD
Marshfield Genetic Map3138.0UniSTS
Genethon Genetic Map3139.5UniSTS
deCODE Assembly Map3126.98UniSTS
Stanford-G3 RH Map35374.0UniSTS
GeneMap99-G3 RH Map35844.0UniSTS
STS-T26531  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,511,324 - 119,511,556UniSTSGRCh37
Build 363120,994,014 - 120,994,246RGDNCBI36
Celera3117,920,427 - 117,920,659RGD
Cytogenetic Map3q12-q13.3UniSTS
HuRef3116,886,955 - 116,887,187UniSTS
GeneMap99-GB4 RH Map3421.43UniSTS
NCBI RH Map3929.8UniSTS
NR1I3_2131  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,535,914 - 119,536,767UniSTSGRCh37
Build 363121,018,604 - 121,019,457RGDNCBI36
Celera3117,945,020 - 117,945,873RGD
HuRef3116,911,656 - 116,912,509UniSTS
SHGC-56597  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,536,913 - 119,537,019UniSTSGRCh37
Build 363121,019,603 - 121,019,709RGDNCBI36
Celera3117,946,019 - 117,946,125RGD
Cytogenetic Map3q12-q13.3UniSTS
HuRef3116,912,655 - 116,912,761UniSTS
TNG Radiation Hybrid Map368221.0UniSTS
SHGC-77233  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,511,308 - 119,511,443UniSTSGRCh37
Build 363120,993,998 - 120,994,133RGDNCBI36
Celera3117,920,411 - 117,920,546RGD
Cytogenetic Map3q12-q13.3UniSTS
HuRef3116,886,939 - 116,887,074UniSTS
TNG Radiation Hybrid Map368196.0UniSTS
GeneMap99-GB4 RH Map3418.72UniSTS
A005P48  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,511,445 - 119,511,547UniSTSGRCh37
Build 363120,994,135 - 120,994,237RGDNCBI36
Celera3117,920,548 - 117,920,650RGD
Cytogenetic Map3q12-q13.3UniSTS
HuRef3116,887,076 - 116,887,178UniSTS
GeneMap99-GB4 RH Map3418.72UniSTS
NCBI RH Map3929.8UniSTS
AFMA323WF9  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,518,784 - 119,518,892UniSTSGRCh37
Build 363121,001,474 - 121,001,582RGDNCBI36
Celera3117,927,898 - 117,928,006RGD
Cytogenetic Map3q12-q13.3UniSTS
HuRef3116,894,424 - 116,894,532UniSTS
Whitehead-YAC Contig Map3 UniSTS
MARC_4339-4340:996679552:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,511,027 - 119,511,212UniSTSGRCh37
GRCh3710102,008,374 - 102,008,559UniSTSGRCh37
Build 363120,993,717 - 120,993,902RGDNCBI36
Celera1095,746,331 - 95,746,516UniSTS
Celera3117,920,129 - 117,920,314RGD
HuRef1095,637,332 - 95,637,517UniSTS
HuRef3116,886,658 - 116,886,843UniSTS
G32262  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,511,445 - 119,511,547UniSTSGRCh37
Celera3117,920,548 - 117,920,650UniSTS
Cytogenetic Map3q12-q13.3UniSTS
HuRef3116,887,076 - 116,887,178UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 415 333 333 109 334 1 2 2
Low 326 12 286 89 625 90 196 9 260 37 250 102 5 22
Below cutoff 1590 2661 1071 175 976 19 3232 1643 3310 269 1072 1322 157 1116 2116 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB307701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC069444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF364606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ009936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ009937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY007189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY091855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ911122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ923326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF614253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ692837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ709177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF457674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000337940   ⟹   ENSP00000336528
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,782,710 - 119,818,485 (+)Ensembl
RefSeq Acc Id: ENST00000393716   ⟹   ENSP00000377319
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,782,101 - 119,818,487 (+)Ensembl
RefSeq Acc Id: ENST00000466380   ⟹   ENSP00000420297
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,780,484 - 119,818,485 (+)Ensembl
RefSeq Acc Id: ENST00000474090
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,782,035 - 119,810,552 (+)Ensembl
RefSeq Acc Id: ENST00000493757
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,811,076 - 119,818,484 (+)Ensembl
RefSeq Acc Id: NM_003889   ⟹   NP_003880
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,782,101 - 119,818,487 (+)NCBI
GRCh373119,499,331 - 119,552,295 (+)NCBI
Build 363120,982,021 - 121,020,022 (+)NCBI Archive
HuRef3116,874,950 - 116,913,074 (+)ENTREZGENE
CHM1_13119,462,845 - 119,500,855 (+)NCBI
T2T-CHM13v2.03122,501,838 - 122,538,215 (+)NCBI
Sequence:
RefSeq Acc Id: NM_022002   ⟹   NP_071285
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,782,710 - 119,818,487 (+)NCBI
GRCh373119,499,331 - 119,552,295 (+)NCBI
Build 363120,984,247 - 121,020,022 (+)NCBI Archive
HuRef3116,874,950 - 116,913,074 (+)ENTREZGENE
CHM1_13119,465,071 - 119,500,855 (+)NCBI
T2T-CHM13v2.03122,502,447 - 122,538,215 (+)NCBI
Sequence:
RefSeq Acc Id: NM_033013   ⟹   NP_148934
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,782,101 - 119,818,487 (+)NCBI
GRCh373119,499,331 - 119,552,295 (+)NCBI
Build 363120,982,021 - 121,020,022 (+)NCBI Archive
HuRef3116,874,950 - 116,913,074 (+)ENTREZGENE
CHM1_13119,462,845 - 119,500,855 (+)NCBI
T2T-CHM13v2.03122,501,838 - 122,538,215 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_003880 (Get FASTA)   NCBI Sequence Viewer  
  NP_071285 (Get FASTA)   NCBI Sequence Viewer  
  NP_148934 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC64557 (Get FASTA)   NCBI Sequence Viewer  
  AAC64558 (Get FASTA)   NCBI Sequence Viewer  
  AAD05436 (Get FASTA)   NCBI Sequence Viewer  
  AAG23345 (Get FASTA)   NCBI Sequence Viewer  
  AAH17304 (Get FASTA)   NCBI Sequence Viewer  
  AAK38720 (Get FASTA)   NCBI Sequence Viewer  
  AAK38721 (Get FASTA)   NCBI Sequence Viewer  
  AAK38722 (Get FASTA)   NCBI Sequence Viewer  
  AAM26736 (Get FASTA)   NCBI Sequence Viewer  
  ABJ52965 (Get FASTA)   NCBI Sequence Viewer  
  ABJ52966 (Get FASTA)   NCBI Sequence Viewer  
  ABR09276 (Get FASTA)   NCBI Sequence Viewer  
  ADZ17348 (Get FASTA)   NCBI Sequence Viewer  
  ADZ17384 (Get FASTA)   NCBI Sequence Viewer  
  BAG53837 (Get FASTA)   NCBI Sequence Viewer  
  BAH02292 (Get FASTA)   NCBI Sequence Viewer  
  CAB55489 (Get FASTA)   NCBI Sequence Viewer  
  CAB55490 (Get FASTA)   NCBI Sequence Viewer  
  CAB55491 (Get FASTA)   NCBI Sequence Viewer  
  CAB55492 (Get FASTA)   NCBI Sequence Viewer  
  CAB55493 (Get FASTA)   NCBI Sequence Viewer  
  CAB55494 (Get FASTA)   NCBI Sequence Viewer  
  EAW79537 (Get FASTA)   NCBI Sequence Viewer  
  EAW79538 (Get FASTA)   NCBI Sequence Viewer  
  EAW79539 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000336528
  ENSP00000336528.4
  ENSP00000377319
  ENSP00000377319.3
  ENSP00000420297
  ENSP00000420297.2
GenBank Protein O75469 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_003880   ⟸   NM_003889
- Peptide Label: isoform 1
- UniProtKB: Q9UJ27 (UniProtKB/Swiss-Prot),   Q9UJ26 (UniProtKB/Swiss-Prot),   Q9UJ25 (UniProtKB/Swiss-Prot),   Q9UJ24 (UniProtKB/Swiss-Prot),   Q9UJ23 (UniProtKB/Swiss-Prot),   Q9UJ22 (UniProtKB/Swiss-Prot),   Q96AC7 (UniProtKB/Swiss-Prot),   Q008C8 (UniProtKB/Swiss-Prot),   Q006P5 (UniProtKB/Swiss-Prot),   Q9UNW4 (UniProtKB/Swiss-Prot),   O75469 (UniProtKB/Swiss-Prot),   J3KPQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_148934   ⟸   NM_033013
- Peptide Label: isoform 3
- UniProtKB: H0Y8E2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_071285   ⟸   NM_022002
- Peptide Label: isoform 2
- UniProtKB: F1D8P9 (UniProtKB/TrEMBL),   F1DAL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000420297   ⟸   ENST00000466380
RefSeq Acc Id: ENSP00000336528   ⟸   ENST00000337940
RefSeq Acc Id: ENSP00000377319   ⟸   ENST00000393716
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O75469-F1-model_v2 AlphaFold O75469 1-434 view protein structure

Promoters
RGD ID:6865362
Promoter ID:EPDNEW_H5846
Type:initiation region
Name:NR1I2_1
Description:nuclear receptor subfamily 1 group I member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,782,101 - 119,782,161EPDNEW
RGD ID:6801359
Promoter ID:HG_KWN:45935
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:UC003EDL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 363121,011,529 - 121,012,029 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7968 AgrOrtholog
COSMIC NR1I2 COSMIC
Ensembl Genes ENSG00000144852 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000337940 ENTREZGENE
  ENST00000337940.4 UniProtKB/Swiss-Prot
  ENST00000393716 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000393716.8 UniProtKB/Swiss-Prot
  ENST00000466380 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000466380.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000144852 GTEx
HGNC ID HGNC:7968 ENTREZGENE
Human Proteome Map NR1I2 Human Proteome Map
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThyrH_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8856 UniProtKB/Swiss-Prot
NCBI Gene 8856 ENTREZGENE
OMIM 603065 OMIM
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NR1I2 RGD, PharmGKB
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROIDHORMR UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B6ZGT1_HUMAN UniProtKB/TrEMBL
  F1D8P9 ENTREZGENE, UniProtKB/TrEMBL
  F1DAL3 ENTREZGENE, UniProtKB/TrEMBL
  H0Y8E2 ENTREZGENE, UniProtKB/TrEMBL
  J3KPQ3 ENTREZGENE, UniProtKB/TrEMBL
  NR1I2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q006P5 ENTREZGENE
  Q008C8 ENTREZGENE
  Q96AC7 ENTREZGENE
  Q9H4M8_HUMAN UniProtKB/TrEMBL
  Q9UJ22 ENTREZGENE
  Q9UJ23 ENTREZGENE
  Q9UJ24 ENTREZGENE
  Q9UJ25 ENTREZGENE
  Q9UJ26 ENTREZGENE
  Q9UJ27 ENTREZGENE
  Q9UNW4 ENTREZGENE
UniProt Secondary Q006P5 UniProtKB/Swiss-Prot
  Q008C8 UniProtKB/Swiss-Prot
  Q96AC7 UniProtKB/Swiss-Prot
  Q9UJ22 UniProtKB/Swiss-Prot
  Q9UJ23 UniProtKB/Swiss-Prot
  Q9UJ24 UniProtKB/Swiss-Prot
  Q9UJ25 UniProtKB/Swiss-Prot
  Q9UJ26 UniProtKB/Swiss-Prot
  Q9UJ27 UniProtKB/Swiss-Prot
  Q9UNW4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 NR1I2  nuclear receptor subfamily 1 group I member 2  NR1I2  nuclear receptor subfamily 1, group I, member 2  Symbol and/or name change 5135510 APPROVED